Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline

(2018) Claudia Schwarz et al.   Aging-US

Higher spermidine intake is linked to lower mortality: a prospective population-based study

(2018) Stefan Kiechl et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

The Precision Control of Autophagic Flux and Vesicle Dynamics—A Micropattern Approach

(2018) André du Toit et al.   Cells

Histone deacetylase 10 structure and molecular function as a polyamine deacetylase

(2017) Yang Hai et al.   Nature Communications

The crucial impact of lysosomes in aging and longevity

(2016) Didac Carmona-Gutierrez et al.   AGEING RESEARCH REVIEWS

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages

(2016) Q Yang et al.   CELL DEATH AND DIFFERENTIATION

Functions of Polyamines in Mammals

(2016) Anthony E. Pegg   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Autophagy and neurodegeneration

(2015) Rebecca A. Frake et al.   JOURNAL OF CLINICAL INVESTIGATION

Spermidine induces autophagy by inhibiting the acetyltransferase EP300

(2014) F Pietrocola et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice

(2014) Ryoko Kibe et al.   Scientific Reports

Polyamines and cancer: implications for chemotherapy and chemoprevention

(2013) Shannon L. Nowotarski et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Rapamycin extends murine lifespan but has limited effects on aging

(2013) Frauke Neff et al.   JOURNAL OF CLINICAL INVESTIGATION

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

(2013) Varun K Gupta et al.   NATURE NEUROSCIENCE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

(2012) I.-F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spermidine and Spermine Are Enriched in Whole Blood of Nona/Centenarians

(2012) Stefania Pucciarelli et al.   REJUVENATION RESEARCH

Impact of Intestinal Microbiota on Intestinal Luminal Metabolome

(2012) Mitsuharu Matsumoto et al.   Scientific Reports

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Longevity in Mice Is Promoted by Probiotic-Induced Suppression of Colonic Senescence Dependent on Upregulation of Gut Bacterial Polyamine Production

(2011) Mitsuharu Matsumoto et al.   PLoS One

Modulation of cellular function by polyamines

(2009) Kazuei Igarashi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Long-Term Oral Polyamine Intake Increases Blood Polyamine Concentrations

(2009) Kuniyasu SODA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE