Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3

Therapeutic approaches in Parkinson's disease and related disorders

(2016) Elvira Valera et al.   JOURNAL OF NEUROCHEMISTRY

Beneficial action of resveratrol: How and why?

(2016) Gustavo Tomas Diaz-Gerevini et al.   NUTRITION

Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells

(2015) Ya Feng et al.   JOURNAL OF NEUROCHEMISTRY

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease

(2015) Qing He et al.   MOLECULAR NEUROBIOLOGY

Teasaponin improves leptin sensitivity in the prefrontal cortex of obese mice

(2015) Yinghua Yu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway

(2015) Yong Zhang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease

(2015) Haiyun Suo et al.   NEUROPHARMACOLOGY

Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications

(2015) Xiao-Hong Shu et al.   Neurotherapeutics

Effect of resveratrol on mitochondrial function: Implications in parkin-associated familiar Parkinson's disease

(2014) Anna Ferretta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol: review on therapeutic potential and recent advances in drug delivery

(2014) Rudra Pangeni et al.   Expert Opinion on Drug Delivery

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

(2014) Marianne R. Smith et al.   HUMAN MOLECULAR GENETICS

Resveratrol Partially Prevents Rotenone-Induced Neurotoxicity in Dopaminergic SH-SY5Y Cells through Induction of Heme Oxygenase-1 Dependent Autophagy

(2014) Tsu-Kung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death

(2014) Mathieu Bourdenx et al.   Frontiers in Neuroanatomy

Neuroprotective Properties and Mechanisms of Resveratrol in in Vitro and in Vivo Experimental Cerebral Stroke Models

(2013) Nilendra Singh et al.   ACS Chemical Neuroscience

Human APOE genotype affects intraneuronal A 1-42 accumulation in a lentiviral gene transfer model

(2013) W. Zhao et al.   HUMAN MOLECULAR GENETICS

Neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson's-like disease: Possible role of SOCS-1 in reducing pro-inflammatory responses

(2013) Dario D Lofrumento et al.   Innate Immunity

Lysosomal impairment in Parkinson's disease

(2013) Benjamin Dehay et al.   MOVEMENT DISORDERS

Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway

(2013) Jieming Ye et al.   NEUROSCIENCE LETTERS

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Sulfate Metabolites Provide an Intracellular Pool for Resveratrol Generation and Induce Autophagy with Senescence

(2013) K. R. Patel et al.   Science Translational Medicine

Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease

(2013) Samantha Giordano et al.   Redox Biology

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROBIOLOGY OF AGING

Neuroprotective properties of resveratrol and derivatives

(2011) Tristan Richard et al.   Annals of the New York Academy of Sciences

Preclinical Biomarkers of Parkinson Disease

(2011) Yuncheng Wu et al.   ARCHIVES OF NEUROLOGY

Effects of d-cycloserine on MPTP-induced behavioral and neurological changes: Potential for treatment of Parkinson's disease dementia

(2011) Ying-Jui Ho et al.   BEHAVIOURAL BRAIN RESEARCH

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

(2011) Giuseppa Mudò et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Analytical method development for synthesized conjugated metabolites of trans-resveratrol, and application to pharmacokinetic studies

(2011) Otito F. Iwuchukwu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in Parkinsonian rats

(2011) Yanchun Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Enhancing the bioavailability of resveratrol by combining it with piperine

(2011) Jeremy J. Johnson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

Pleiotropic mechanisms facilitated by resveratrol and its metabolites

(2010) Barbara Calamini et al.   BIOCHEMICAL JOURNAL

Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease

(2010) Mohd.Moshahid Khan et al.   BRAIN RESEARCH

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

(2010) M. O. Dietrich et al.   JOURNAL OF NEUROSCIENCE

Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases

(2010) Albert Y. Sun et al.   MOLECULAR NEUROBIOLOGY

trans-Resveratrol as A Neuroprotectant

(2010) Ellen L. Robb et al.   MOLECULES

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide

(2009) Diego Albani et al.   JOURNAL OF NEUROCHEMISTRY

Quantification of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC

(2009) M. Emília Juan et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats

(2008) Feng Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity

(2008) Jianfei Chao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective Effects of Resveratrol on MPTP-Induced Neuron Loss Mediated by Free Radical Scavenging

(2008) Kwok-Tung Lu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice

(2008) Julie Blanchet et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY