Alleviating hypoxia to improve cancer immunotherapy

Apoptotic cell death in disease—Current understanding of the NCCD 2023

(2023) Ilio Vitale et al.   CELL DEATH AND DIFFERENTIATION

Novel Genetic Subtypes of Urothelial Carcinoma With Differential Outcomes on Immune Checkpoint Blockade

(2023) Michal Sarfaty et al.   JOURNAL OF CLINICAL ONCOLOGY

HIF-1 inhibitor-based one-stone-two-birds strategy for enhanced cancer chemodynamic-immunotherapy

(2023) Xiaojuan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

The role of DLL1 in long-term vascular normalization and cancer immunotherapy

(2022) Qiaozhen Wu et al.   Cancer Biology & Medicine

The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein

(2022) David Hoyos et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation

(2022) Kun Liu et al.   CELL DEATH AND DIFFERENTIATION

Exploring the future of research in the Tp53 field

(2022) Arnold J. Levine   CELL DEATH AND DIFFERENTIATION

The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute

(2022) Kelvin César de Andrade et al.   CELL DEATH AND DIFFERENTIATION

Mutant p53: it’s not all one and the same

(2022) Margaret C. Kennedy et al.   CELL DEATH AND DIFFERENTIATION

A novel HIF-2α targeted inhibitor suppresses hypoxia-induced breast cancer stemness via SOD2-mtROS-PDI/GPR78-UPRER axis

(2022) Yuanyuan Yan et al.   CELL DEATH AND DIFFERENTIATION

Cell cycle regulation: p53-p21-RB signaling

(2022) Kurt Engeland   CELL DEATH AND DIFFERENTIATION

Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death

(2022) Farrah El-Saafin et al.   CELL DEATH AND DIFFERENTIATION

Immune response in COVID-19: what is next?

(2022) Qing Li et al.   CELL DEATH AND DIFFERENTIATION

p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways

(2022) Mikael S. Lindström et al.   CELL DEATH AND DIFFERENTIATION

Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?

(2022) Annabella F. Thomas et al.   CELL DEATH AND DIFFERENTIATION

Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment

(2022) Carolina J. Garcia Garcia et al.   GASTROENTEROLOGY

A positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression

(2022) Haiyan Piao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Blocking CD47 promotes antitumour immunity through CD103+ dendritic cell–NK cell axis in murine hepatocellular carcinoma model

(2022) Shuai Wang et al.   JOURNAL OF HEPATOLOGY

Aberrant activation of p53/p66Shc-mInsc axis increases asymmetric divisions and attenuates proliferation of aged mammary stem cells

(2022) Chiara Priami et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy

(2022) Shijun Ma et al.   Nature Communications

Effective low-dose Anlotinib induces long-term tumor vascular normalization and improves anti-PD-1 therapy

(2022) Peng Fan et al.   Frontiers in Immunology

Hypoxia and the phenomenon of immune exclusion

(2021) Violena Pietrobon et al.   Journal of Translational Medicine

Rapid Depletion of Intratumoral Regulatory T cells Induces Synchronized CD8 T and NK Cell Activation and IFN-γ-dependent Tumor Vessel Regression

(2021) Yutaka Kurebayashi et al.   CANCER RESEARCH

Metabolic adaptation to hypoxia: do worms and cancer cells share common metabolic responses to hypoxic stress?

(2021) Ralf Baumeister et al.   CELL DEATH AND DIFFERENTIATION

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors

(2021) Jang Hyun Park et al.   NATURE IMMUNOLOGY

PD-L1 as a biomarker of response to immune-checkpoint inhibitors

(2021) Deborah Blythe Doroshow et al.   Nature Reviews Clinical Oncology

β-arrestin 2 stimulates degradation of HIF-1α and modulates tumor progression of glioblastoma

(2021) Woom-Yee Bae et al.   CELL DEATH AND DIFFERENTIATION

Global mapping of cancers: The Cancer Genome Atlas and beyond

(2021) Carlo Ganini et al.   Molecular Oncology

Therapeutic targeting of the hypoxic tumour microenvironment

(2021) Dean C. Singleton et al.   Nature Reviews Clinical Oncology

DLL1 orchestrates CD8+ T cells to induce long-term vascular normalization and tumor regression

(2021) Naidong Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy

(2021) Yi Sun et al.   Science Translational Medicine

Hypoxia as a driver of resistance to immunotherapy

(2021) Joanna Kopecka et al.   DRUG RESISTANCE UPDATES

Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

(2021) Shuangli Zhu et al.   Experimental Hematology & Oncology

HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α

(2020) Peizhan Chen et al.   ONCOGENE

BMP9 signaling promotes the normalization of tumor blood vessels

(2020) Claire Viallard et al.   ONCOGENE

The CD47-SIRPα Immune Checkpoint

(2020) Meike E.W. Logtenberg et al.   IMMUNITY

The adenosine pathway in immuno-oncology

(2020) Bertrand Allard et al.   Nature Reviews Clinical Oncology

The role of hypoxia‐inducible factor 1 in tumor immune evasion

(2020) Li You et al.   MEDICINAL RESEARCH REVIEWS

CSN8 is a key regulator in hypoxia-induced epithelial–mesenchymal transition and dormancy of colorectal cancer cells

(2020) Songwen Ju et al.   Molecular Cancer

Tumor-associated macrophages enhance tumor hypoxia and aerobic glycolysis

(2019) Hoibin Jeong et al.   CANCER RESEARCH

Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia

(2019) Yuanyuan Wang et al.   Nature Communications

Collagen density regulates the activity of tumor-infiltrating T cells

(2019) Dorota E. Kuczek et al.   Journal for ImmunoTherapy of Cancer

Tumor infiltrating mast cells determine oncogenic HIF-2α-conferred immune evasion in clear cell renal cell carcinoma

(2019) Ying Xiong et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Metformin enhances gefitinib efficacy by interfering with interactions between tumor-associated macrophages and head and neck squamous cell carcinoma cells

(2019) Xiteng Yin et al.   CELLULAR ONCOLOGY

Hypoxia-induced VISTA promotes the suppressive function of myeloid- derived suppressor cells in the tumor microenvironment

(2019) Jie Deng et al.   Cancer Immunology Research

The role of collagen in cancer: from bench to bedside

(2019) Shuaishuai Xu et al.   Journal of Translational Medicine

VISTA is an acidic pH-selective ligand for PSGL-1

(2019) Robert J. Johnston et al.   NATURE

Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance

(2019) Xiaohu Zheng et al.   NATURE IMMUNOLOGY

A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

(2019) Hee Chan Yoo et al.   Cell Metabolism

CTLA4 blockade promotes vessel normalization in breast tumors via the accumulation of eosinophils

(2019) Xichen Zheng et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models

(2018) Robert D. Leone et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Increased vessel perfusion predicts the efficacy of immune checkpoint blockade

(2018) Xichen Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

(2018) Noemi Gioelli et al.   Science Translational Medicine

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer

(2018) Marie Ouarné et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tumor-associated Macrophage-derived Interleukin-23 Interlinks Kidney Cancer Glutamine Addiction with Immune Evasion

(2018) Qiang Fu et al.   EUROPEAN UROLOGY

Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

(2018) Priyamvada Jayaprakash et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered cancer metabolism in mechanisms of immunotherapy resistance

(2018) Rishab Ramapriyan et al.   PHARMACOLOGY & THERAPEUTICS

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

(2018) Monica Parodi et al.   Frontiers in Immunology

The use of immunotherapy in the treatment of melanoma

(2017) Tala Achkar et al.   Journal of Hematology & Oncology

Effect of angiotensin system inhibitors on survival in newly diagnosed glioma patients and recurrent glioblastoma patients receiving chemotherapy and/or bevacizumab

(2017) Victor A. Levin et al.   JOURNAL OF NEURO-ONCOLOGY

Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

(2017) Si-Rui Ma et al.   Molecular Cancer

Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming

(2017) Lin Tian et al.   NATURE

Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells

(2017) Nicole Colwell et al.   NEURO-ONCOLOGY

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

(2017) Martina Schmittnaegel et al.   Science Translational Medicine

Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

(2017) David Kung-Chun Chiu et al.   Nature Communications

HIF1/2α mediates hypoxia-induced LDHA expression in human pancreatic cancer cells

(2017) Xin-gang Cui et al.   Oncotarget

Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells

(2017) Marica Garziera et al.   Journal of Immunology Research

Integration of pro- and anti-angiogenic signals by endothelial cells

(2017) Shideh Kazerounian et al.   Journal of Cell Communication and Signaling

Programmed cell death ligands expression in phaeochromocytomas and paragangliomas: Relationship with the hypoxic response, immune evasion and malignant behavior

(2017) David J. Pinato et al.   OncoImmunology

Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells

(2017) Shalini Sethumadhavan et al.   PLoS One

The Multifaceted Role of Perivascular Macrophages in Tumors

(2016) Claire E. Lewis et al.   CANCER CELL

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

(2016) Jin-Sung Park et al.   CANCER CELL

Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers

(2016) Florence T.H. Wu et al.   CANCER RESEARCH

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis

(2016) L.-Y. Ye et al.   CANCER RESEARCH

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

(2016) Jianjun Gao et al.   CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer

(2016) Stephen M Hatfield et al.   CURRENT OPINION IN PHARMACOLOGY

BMP signaling in vascular biology and dysfunction

(2016) Amaya García de Vinuesa et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

(2016) Gregg L Semenza   EMBO JOURNAL

Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma

(2016) Alan Ka-Lun Kai et al.   HEPATOLOGY

The impact of hypoxia on tumor-associated macrophages

(2016) Anne-Theres Henze et al.   JOURNAL OF CLINICAL INVESTIGATION

The ever-expanding role of HIF in tumour and stromal biology

(2016) Edward L. LaGory et al.   NATURE CELL BIOLOGY

Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

(2016) Teresa E. Peterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

(2016) Jonas Kloepper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion

(2016) Balint Otvos et al.   STEM CELLS

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

(2016) Hiroaki Semba et al.   Nature Communications

Regulation of Cellular Metabolism and Hypoxia by p53

(2016) Timothy J. Humpton et al.   Cold Spring Harbor Perspectives in Medicine

Angiopoietin-2 as a Biomarker and Target for Immune Checkpoint Therapy

(2016) Xinqi Wu et al.   Cancer Immunology Research

Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210

(2015) Muhammad Zaeem Noman et al.   CANCER RESEARCH

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells

(2015) Rafael Carretero et al.   NATURE IMMUNOLOGY

The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression

(2015) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism

(2015) Sara Labiano et al.   OncoImmunology

Effect of NKG2D ligand expression on host immune responses

(2015) Marine Champsaur et al.   IMMUNOLOGICAL REVIEWS

HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer

(2015) Wenjing Zhang et al.   PLoS One

The Thrombospondin-1 Mimetic ABT-510 Increases the Uptake and Effectiveness of Cisplatin and Paclitaxel in a Mouse Model of Epithelial Ovarian Cancer

(2015) Nicole E. Campbell et al.   NEOPLASIA

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age

(2014) G Kenneth Gray et al.   Expert Review of Neurotherapeutics

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration

(2014) Z Wen et al.   ONCOGENE

Eosinophils and Cancer

(2014) B. P. Davis et al.   Cancer Immunology Research

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

CTLA-4 and PD-1/PD-L1 Blockade: New Immunotherapeutic Modalities with Durable Clinical Benefit in Melanoma Patients

(2013) P. A. Ott et al.   CLINICAL CANCER RESEARCH

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia

(2012) Sensen Lin et al.   CANCER SCIENCE

Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1α-dependent manner

(2012) NAOKO YAMADA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

(2012) Federica Maione et al.   JOURNAL OF CLINICAL INVESTIGATION

Continuous daily sunitinib for recurrent glioblastoma

(2012) Teri Nguyen Kreisl et al.   JOURNAL OF NEURO-ONCOLOGY

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

(2012) Asís Palazón et al.   Cancer Discovery

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Origin-specific epigenetic program correlates with vascular bed-specific differences in Rgs5 expression

(2011) Hangjun Zhang et al.   FASEB JOURNAL

Relation between bevacizumab dose intensity and high-grade glioma survival: a retrospective study in two large cohorts

(2011) Veronique Lorgis et al.   JOURNAL OF NEURO-ONCOLOGY

Mouse Snail Is a Target Gene for HIF

(2011) D. Luo et al.   MOLECULAR CANCER RESEARCH

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)

(2010) M. Reck et al.   ANNALS OF ONCOLOGY

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Gemcitabine Plus Bevacizumab Compared With Gemcitabine Plus Placebo in Patients With Advanced Pancreatic Cancer: Phase III Trial of the Cancer and Leukemia Group B (CALGB 80303)

(2010) Hedy Lee Kindler et al.   JOURNAL OF CLINICAL ONCOLOGY

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

(2010) Ming Zhou et al.   Molecular Cancer

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia

(2009) Ruth Schietke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleic Acid Binding of the RTN1-C C-Terminal Region: Toward the Functional Role of a Reticulon Protein†

(2008) Sonia Melino et al.   BIOCHEMISTRY

HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak

(2008) J. C. Morote-Garcia et al.   BLOOD

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Thrombospondins: from structure to therapeutics

(2008) S. Kazerounian et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH

Bevacizumab in Combination With Oxaliplatin-Based Chemotherapy As First-Line Therapy in Metastatic Colorectal Cancer: A Randomized Phase III Study

(2008) Leonard B. Saltz et al.   JOURNAL OF CLINICAL ONCOLOGY

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

(2008) Juliana Hamzah et al.   NATURE

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY