BMP9 signaling promotes the normalization of tumor blood vessels

A phase 2, randomized trial evaluating the combination of dalantercept plus axitinib in patients with advanced clear cell renal cell carcinoma

(2019) Martin H. Voss et al.   CANCER

BMP (Bone Morphogenetic Protein) 9/Alk1 (Activin-Like Kinase Receptor Type I) Signaling Prevents Hyperglycemia-Induced Vascular Permeability

(2018) Naoufal Akla et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endoglin interacts with VEGFR2 to promote angiogenesis

(2018) Hongyu Tian et al.   FASEB JOURNAL

BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer

(2018) Marie Ouarné et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1)

(2018) Sunday S. Oladipupo et al.   Scientific Reports

Enhanced antitumor and anti-angiogenic effects of metronomic Vinorelbine combined with Endostar on Lewis lung carcinoma

(2018) Rong-Sheng Qin et al.   BMC CANCER

Isolation of tumor endothelial cells from murine cancer

(2018) Kazuhiro Taguchi et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A Phase Ib, Open‐Label Study of Dalantercept, an Activin Receptor‐Like Kinase 1 Ligand Trap, plus Sorafenib in Advanced Hepatocellular Carcinoma

(2018) Ghassan K. Abou‐Alfa et al.   ONCOLOGIST

Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2

(2017) Claudia-Gabriela Mitrofan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD31, a Valuable Marker to Identify Early and Late Stages of T Cell Differentiation in the Human Thymus

(2017) Marc Douaisi et al.   JOURNAL OF IMMUNOLOGY

Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function

(2016) A. G. de Vinuesa et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

(2016) Jin-Sung Park et al.   CANCER CELL

Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes

(2016) Nicolas Renier et al.   CELL

Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia

(2016) Nicolas Baeyens et al.   JOURNAL OF CELL BIOLOGY

Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium

(2016) Sarah L. Appleby et al.   JOURNAL OF IMMUNOLOGY

Antiangiogenic therapy in oncology: current status and future directions

(2016) Gordon C Jayson et al.   LANCET

Impact of selective anti-BMP9 treatment on tumor cells and tumor angiogenesis

(2016) Verena Brand et al.   Molecular Oncology

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

(2016) M. Oubaha et al.   Science Translational Medicine

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

(2016) Roxana Ola et al.   Nature Communications

Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma

(2016) Xiaoen Wang et al.   Oncotarget

BMP9/ALK1 inhibits neovascularization in mouse models of age-related macular degeneration

(2016) Kalonji Ntumba et al.   Oncotarget

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Lack of adrenomedullin in mouse endothelial cells results in defective angiogenesis, enhanced vascular permeability, less metastasis, and more brain damage

(2016) Laura Ochoa-Callejero et al.   Scientific Reports

Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

(2015) Muhammad Zaeem Noman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1and Thrombospondin-1Significance

(2015) Bahman Rostama et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors

(2015) L. J. A. C. Hawinkels et al.   CLINICAL CANCER RESEARCH

Increased endothelial cell permeability in endoglin-deficient cells

(2015) Mirjana Jerkic et al.   FASEB JOURNAL

VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling

(2015) Andreas Benn et al.   JOURNAL OF CELL SCIENCE

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

(2015) Lu Long et al.   NATURE MEDICINE

Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients

(2015) Sara M. Tolaney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activin Receptor Inhibitors—Dalantercept

(2015) Shilpa Gupta et al.   Current Oncology Reports

Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia

(2015) Archana Varadaraj et al.   NEOPLASIA

Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment

(2014) Vinit Kumar et al.   IMMUNOLOGY

Gr-1+CD11b+ cells facilitate Lewis lung cancer recurrence by enhancing neovasculature after local irradiation

(2014) Tao Liu et al.   Scientific Reports

Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy

(2013) Y. Huang et al.   CANCER RESEARCH

Neuron-Derived Semaphorin 3A Is an Early Inducer of Vascular Permeability in Diabetic Retinopathy via Neuropilin-1

(2013) Agustin Cerani et al.   Cell Metabolism

Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy

(2013) Lukas JAC Hawinkels et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Immunogenicity of Murine Solid Tumor Models as a Defining Feature of In Vivo Behavior and Response to Immunotherapy

(2013) Melissa G. Lechner et al.   JOURNAL OF IMMUNOTHERAPY

Vascular Permeability and Drug Delivery in Cancers

(2013) Sandy Azzi et al.   Frontiers in Oncology

BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II

(2012) Jai-Hyun Kim et al.   ANGIOGENESIS

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling

(2012) N. Ricard et al.   BLOOD

Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades

(2012) Iván M. Moya et al.   DEVELOPMENTAL CELL

ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

(2012) Bruno Larrivée et al.   DEVELOPMENTAL CELL

VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd

(2012) Zuyue Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-driven immunosuppression contributes to the pre-metastatic niche

(2012) Jaclyn Sceneay et al.   OncoImmunology

Targeting Activin Receptor-Like Kinase 1 Inhibits Angiogenesis and Tumorigenesis through a Mechanism of Action Complementary to Anti-VEGF Therapies

(2011) Dana D. Hu-Lowe et al.   CANCER RESEARCH

Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B

(2011) Alexander W. Koch et al.   DEVELOPMENTAL CELL

Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice

(2011) Tangying Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Antiangiogenic therapy: impact on invasion, disease progression and metastasis

(2011) John M. L. Ebos et al.   Nature Reviews Clinical Oncology

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Identification and functional analysis of endothelial tip cell-enriched genes

(2010) R. del Toro et al.   BLOOD

Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer

(2010) R. K. Shrimali et al.   CANCER RESEARCH

CEACAM1: a key regulator of vascular permeability

(2010) A.-L. Nouvion et al.   JOURNAL OF CELL SCIENCE

ALK1-Fc Inhibits Multiple Mediators of Angiogenesis and Suppresses Tumor Growth

(2010) D. Mitchell et al.   MOLECULAR CANCER THERAPEUTICS

VEGF as an inhibitor of tumor vessel maturation: implications for cancer therapy

(2009) Joshua I Greenberg et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Occludin Phosphorylation and Ubiquitination Regulate Tight Junction Trafficking and Vascular Endothelial Growth Factor-induced Permeability

(2009) Tomoaki Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells

(2009) Paul D. Upton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired tumor growth, metastasis, angiogenesis and wound healing in annexin A1-null mice

(2009) M. Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH

Hypoxia-Adenosinergic Immunosuppression: Tumor Protection by T Regulatory Cells and Cancerous Tissue Hypoxia

(2008) M. V. Sitkovsky et al.   CLINICAL CANCER RESEARCH

New Role for the Protein Tyrosine Phosphatase DEP-1 in Akt Activation and Endothelial Cell Survival

(2008) C. Chabot et al.   MOLECULAR AND CELLULAR BIOLOGY

Bone Morphogenetic Protein-9 Induces Apoptosis in Prostate Cancer Cells, the Role of Prostate Apoptosis Response-4

(2008) L. Ye et al.   MOLECULAR CANCER RESEARCH