p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways

TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling

(2022) Sushama Sivakumar et al.   Cell Reports

LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint

(2022) Wilson McKerrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death

(2021) Ana Domostegui et al.   BLOOD

Mutation in Eftud2 causes craniofacial defects in mice via mis-splicing of Mdm2 and increased P53

(2021) Marie-Claude Beauchamp et al.   HUMAN MOLECULAR GENETICS

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

(2021) Emiliano Maiani et al.   NATURE

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies

(2021) Gerald C. Tiu et al.   DEVELOPMENTAL CELL

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output

(2021) Dimitris C. Kanellis et al.   Science Advances

RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis

(2021) Pavel Moudry et al.   CELL DEATH AND DIFFERENTIATION

p53 induces a survival transcriptional response after nucleolar stress

(2021) Han Liao et al.   MOLECULAR BIOLOGY OF THE CELL

The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation

(2021) Ilaria Volpi et al.   Open Biology

Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication

(2020) Daniel Ardeljan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint

(2020) Ines Oršolić et al.   ONCOGENE

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors

(2020) Sona Hubackova et al.   Cell Death & Disease

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

(2020) Rita Ferreira et al.   Cells

Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage

(2020) Joffrey Pelletier et al.   EMBO JOURNAL

Nucleolar RNA polymerase II drives ribosome biogenesis

(2020) Karan J. Abraham et al.   NATURE

p53 activation during ribosome biogenesis regulates normal erythroid differentiation.

(2020) Salomé Le Goff et al.   BLOOD

Telomere replication—When the going gets tough

(2020) Susanna Stroik et al.   DNA REPAIR

p53 directly represses human LINE1 transposons

(2020) Bhavana Tiwari et al.   GENES & DEVELOPMENT

Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy

(2019) Annika Krüger et al.   NUCLEIC ACIDS RESEARCH

Exploiting DNA Replication Stress for Cancer Treatment

(2019) Tajinder Ubhi et al.   CANCER RESEARCH

Common motifs in ETAA1 and TOPBP1 required for ATR kinase activation

(2019) Vaughn Thada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic MYC Induces the Impaired Ribosome Biogenesis Checkpoint and Stabilizes p53, Independent of Increased Ribosome Content.

(2019) Carmen Morcelle et al.   CANCER RESEARCH

The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity

(2019) Jaime A. Espinoza et al.   CELL DEATH AND DIFFERENTIATION

Regulation of replication fork speed: Mechanisms and impact on genomic stability

(2019) Joanna Maria Merchut-Maya et al.   DNA REPAIR

Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21

(2019) Dae-Seok Kim et al.   MOLECULAR CELL

R Loops: From Physiological to Pathological Roles

(2019) Tatiana García-Muse et al.   CELL

The Initial Response of a Eukaryotic Replisome to DNA Damage

(2018) Martin R.G. Taylor et al.   MOLECULAR CELL

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

(2018) Hana Hanzlikova et al.   MOLECULAR CELL

Targeting the replication stress response in cancer

(2018) Josep V. Forment et al.   PHARMACOLOGY & THERAPEUTICS

TAp73 contributes to the oxidative stress response by regulating protein synthesis

(2018) Alberto Marini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

(2018) Sunetra Roy et al.   eLife

High speed of fork progression induces DNA replication stress and genomic instability

(2018) Apolinar Maya-Mendoza et al.   NATURE

Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders

(2018) Eliezer Calo et al.   NATURE

Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells

(2018) Bente Benedict et al.   eLife

The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1

(2017) Arthur Fischbach et al.   NUCLEIC ACIDS RESEARCH

The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types

(2017) Laura Fancello et al.   Oncotarget

Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway

(2016) Stephanie A. Yazinski et al.   Annual Review of Genetics

RPL5 on 1p22.1 is recurrently deleted in multiple myeloma and its expression is linked to bortezomib response

(2016) I J F Hofman et al.   LEUKEMIA

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

(2016) Panagiotis Galanos et al.   NATURE CELL BIOLOGY

Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress

(2016) Emilien Nicolas et al.   Nature Communications

p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication

(2016) Constance Qiao Xin Yeo et al.   Cell Reports

The Evolution of the Ribosomal Protein–MDM2–p53 Pathway

(2016) Chad Deisenroth et al.   Cold Spring Harbor Perspectives in Medicine

Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly

(2016) Hanqian Mao et al.   PLoS Genetics

Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion

(2015) J. K. Meena et al.   EMBO JOURNAL

Alu element-containing RNAs maintain nucleolar structure and function

(2015) M. Caudron-Herger et al.   EMBO JOURNAL

Chaperoning 5S RNA assembly

(2015) Clément Madru et al.   GENES & DEVELOPMENT

High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation

(2015) Miiko Sokka et al.   NUCLEIC ACIDS RESEARCH

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function

(2015) Claire Breslin et al.   NUCLEIC ACIDS RESEARCH

Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

(2015) Kazuho Nishimura et al.   Cell Reports

Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis

(2015) Lucia Morgado-Palacin et al.   Cell Reports

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells

(2015) Lukas Badertscher et al.   Cell Reports

Long Interspersed Element-1 Protein Expression Is a Hallmark of Many Human Cancers

(2014) Nemanja Rodić et al.   AMERICAN JOURNAL OF PATHOLOGY

mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels

(2014) Kaveh M Goudarzi et al.   CANCER BIOLOGY & THERAPY

Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition

(2014) X Zhou et al.   CELL DEATH AND DIFFERENTIATION

Poly(ADP-Ribosyl) Glycohydrolase Prevents the Accumulation of Unusual Replication Structures during Unperturbed S Phase

(2014) Arnab Ray Chaudhuri et al.   MOLECULAR AND CELLULAR BIOLOGY

RNA helicase DDX21 coordinates transcription and ribosomal RNA processing

(2014) Eliezer Calo et al.   NATURE

Nucleolar stress with and without p53

(2014) Allison James et al.   Nucleus

A Noncoding Expansion in EIF4A3 Causes Richieri-Costa-Pereira Syndrome, a Craniofacial Disorder Associated with Limb Defects

(2013) Francine P. Favaro et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loss of Tumor Suppressor RPL5/RPL11 Does Not Induce Cell Cycle Arrest but Impedes Proliferation Due to Reduced Ribosome Content and Translation Capacity

(2013) T. Teng et al.   MOLECULAR AND CELLULAR BIOLOGY

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Identification of a Heteromeric Complex That Promotes DNA Replication Origin Firing in Human Cells

(2013) D. Boos et al.   SCIENCE

5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint

(2013) Giulio Donati et al.   Cell Reports

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

(2013) Katherine E. Sloan et al.   Cell Reports

Stepwise Activation of the ATR Signaling Pathway upon Increasing Replication Stress Impacts Fragile Site Integrity

(2013) Stéphane Koundrioukoff et al.   PLoS Genetics

Incidence of neoplasia in Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry

(2012) A. Vlachos et al.   BLOOD

mTORC1 and p53

(2012) Paul Hasty et al.   CELL CYCLE

ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres

(2012) Maria Thanasoula et al.   EMBO JOURNAL

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells

(2011) G Donati et al.   ONCOGENE

Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation

(2010) Wojciech Strzalka et al.   ANNALS OF BOTANY

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

(2010) Everardo Macias et al.   CANCER CELL

p53 Prevents Entry into Mitosis with Uncapped Telomeres

(2010) Maria Thanasoula et al.   CURRENT BIOLOGY

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

C-terminal binding protein and poly(ADP)ribose polymerase 1 contribute to repression of the p21waf1/cip1 promoter

(2010) D L Madison et al.   ONCOGENE

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

(2009) Stefano Fumagalli et al.   NATURE CELL BIOLOGY

The Isoforms of the p53 Protein

(2009) M. P. Khoury et al.   Cold Spring Harbor Perspectives in Biology

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

ATR and Chk1 Suppress a Caspase-3–Dependent Apoptotic Response Following DNA Replication Stress

(2009) Katie Myers et al.   PLoS Genetics

Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation

(2008) Amit Kulkarni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Replication fork arrest, recombination and the maintenance of ribosomal DNA stability

(2008) E TSANG et al.   DNA REPAIR

Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks

(2008) N. Nitani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA