Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion

Macrophage Migration Inhibitory Factor Secretion Is Induced by Ionizing Radiation and Oxidative Stress in Cancer Cells

(2016) Yashi Gupta et al.   PLoS One

Increase in Both CD14-Positive and CD15-Positive Myeloid-Derived Suppressor Cell Subpopulations in the Blood of Patients With Glioma But Predominance of CD15-Positive Myeloid-Derived Suppressor Cells in Glioma Tissue

(2015) Paul R. Gielen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation

(2015) Yanhua Zheng et al.   NATURE CELL BIOLOGY

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

The intersection of cancer, cancer stem cells, and the immune system: therapeutic opportunities

(2015) Daniel J. Silver et al.   NEURO-ONCOLOGY

Differential Connexin Function Enhances Self-Renewal in Glioblastoma

(2015) Masahiro Hitomi et al.   Cell Reports

MIF Is Necessary for Late-Stage Melanoma Patient MDSC Immune Suppression and Differentiation

(2015) K. Yaddanapudi et al.   Cancer Immunology Research

Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

(2014) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

(2014) Evgeniy B. Eruslanov et al.   JOURNAL OF CLINICAL INVESTIGATION

Glioma virus therapies between bench and bedside

(2014) J. K. Kaufmann et al.   NEURO-ONCOLOGY

High-Throughput Flow Cytometry Screening Reveals a Role for Junctional Adhesion Molecule A as a Cancer Stem Cell Maintenance Factor

(2014) Justin D. Lathia et al.   Cell Reports

CXCR2-Expressing Myeloid-Derived Suppressor Cells Are Essential to Promote Colitis-Associated Tumorigenesis

(2013) Hiroshi Katoh et al.   CANCER CELL

GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor- 

(2013) G. Kohanbash et al.   CANCER RESEARCH

Cytokine patterns in patients with cancer: a systematic review

(2013) Bodo E Lippitz   LANCET ONCOLOGY

Human Anti-Macrophage Migration Inhibitory Factor Antibodies Inhibit Growth of Human Prostate Cancer Cells In Vitro and In Vivo

(2013) F. Hussain et al.   MOLECULAR CANCER THERAPEUTICS

Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner

(2013) Jelena Põlajeva et al.   Molecular Oncology

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells

(2013) Susobhan Sarkar et al.   NATURE NEUROSCIENCE

Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

(2012) Ramona Schulz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage Migration Inhibitory Factor Promotes Tumor Growth and Metastasis by Inducing Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2012) K. D. Simpson et al.   JOURNAL OF IMMUNOLOGY

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Macrophage migration inhibitory factor (MIF) expression in human malignant gliomas contributes to immune escape and tumour progression

(2011) Michel Mittelbronn et al.   ACTA NEUROPATHOLOGICA

Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2

(2011) Christine E. Eyler et al.   CELL

Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

(2011) Je-In Youn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma

(2011) B. Raychaudhuri et al.   NEURO-ONCOLOGY

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

(2010) Suzanne Ostrand-Rosenberg   CANCER IMMUNOLOGY IMMUNOTHERAPY

5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell-Dependent Antitumor Immunity

(2010) J. Vincent et al.   CANCER RESEARCH

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

(2010) Justin D. Lathia et al.   Cell Stem Cell

Microglia/macrophages promote glioma progression

(2010) Haiyan Zhai et al.   GLIA

CD133+ niches and single cells in glioblastoma have different phenotypes

(2010) Karina Christensen et al.   JOURNAL OF NEURO-ONCOLOGY

Glioblastoma Cancer-Initiating Cells Inhibit T-Cell Proliferation and Effector Responses by the Signal Transducers and Activators of Transcription 3 Pathway

(2010) J. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

TGF-β Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma

(2009) Silvia Peñuelas et al.   CANCER CELL

The Novel Role of Tyrosine Kinase Inhibitor in the Reversal of Immune Suppression and Modulation of Tumor Microenvironment for Immune-Based Cancer Therapies

(2009) J. Ozao-Choy et al.   CANCER RESEARCH

Sunitinib Mediates Reversal of Myeloid-Derived Suppressor Cell Accumulation in Renal Cell Carcinoma Patients

(2009) J. S. Ko et al.   CLINICAL CANCER RESEARCH

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Persistence of CD133+ Cells in Human and Mouse Glioma Cell Lines: Detailed Characterization of GL261 Glioma Cells with Cancer Stem Cell-Like Properties

(2008) Anhua Wu et al.   STEM CELLS AND DEVELOPMENT