Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment

Elucidation of Tumor-Stromal Heterogeneity and the Ligand-Receptor Interactome by Single-Cell Transcriptomics in Real-world Pancreatic Cancer Biopsies

(2021) Jaewon J. Lee et al.   CLINICAL CANCER RESEARCH

Belzutifan for Renal Cell Carcinoma in von Hippel–Lindau Disease

(2021) Eric Jonasch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity

(2020) Won Suk Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Targeting the HIF2–VEGF axis in renal cell carcinoma

(2020) Toni K. Choueiri et al.   NATURE MEDICINE

HIF-2α is indispensable for regulatory T cell function

(2020) Tzu-Sheng Hsu et al.   Nature Communications

A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression

(2019) Francesca R. Auciello et al.   Cancer Discovery

Fibroblasts in Pancreatic Ductal Adenocarcinoma: biological mechanisms and therapeutic targets

(2019) Martin C. Whittle et al.   GASTROENTEROLOGY

Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer

(2019) Tara N. Fujimoto et al.   CANCER RESEARCH

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Multiomics Prediction of Response Rates to Therapies to Inhibit Programmed Cell Death 1 and Programmed Cell Death 1 Ligand 1

(2019) Joo Sang Lee et al.   JAMA Oncology

Phase 2 study of vismodegib, a hedgehog inhibitor, combined with gemcitabine and nab-paclitaxel in patients with untreated metastatic pancreatic adenocarcinoma

(2019) Ana De Jesus-Acosta et al.   BRITISH JOURNAL OF CANCER

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

(2017) Qi Zhang et al.   Molecular Cancer

Stromal cues regulate the pancreatic cancer epigenome and metabolome

(2017) Mara H. Sherman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-associated fibroblasts promote M2 polarization of macrophages in pancreatic ductal adenocarcinoma

(2017) Aibin Zhang et al.   Cancer Medicine

Targeting renal cell carcinoma with a HIF-2 antagonist

(2016) Wenfang Chen et al.   NATURE

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

(2016) Hyejin Cho et al.   NATURE

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

High Nuclear Hypoxia-Inducible Factor 1 Alpha Expression Is a Predictor of Distant Recurrence in Patients With Resected Pancreatic Adenocarcinoma

(2015) Lauren E. Colbert et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia

(2015) K. E. Lee et al.   Cancer Discovery

Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure

(2014) Vikash P. Chauhan et al.   CANCER CELL

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

(2014) Nina Schönhuber et al.   NATURE MEDICINE

Convergence of Hypoxia and TGFβ Pathways on Cell Cycle Regulation in Human Hematopoietic Stem/Progenitor Cells

(2014) Albertus T. J. Wierenga et al.   PLoS One

PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2

(2014) C. M. Taniguchi et al.   Science Translational Medicine

Hyaluronan, fluid pressure and stromal resistance in pancreas cancer

(2013) P P Provenzano et al.   BRITISH JOURNAL OF CANCER

PanIN-Specific Regulation of Wnt Signaling by HIF2  during Early Pancreatic Tumorigenesis

(2013) A. Criscimanna et al.   CANCER RESEARCH

Hypoxia Triggers Hedgehog-Mediated Tumor-Stromal Interactions in Pancreatic Cancer

(2013) T. R. Spivak-Kroizman et al.   CANCER RESEARCH

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis

(2011) N. P. Young et al.   CANCER RESEARCH

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

(2010) Hongxia Z. Imtiyaz et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

(2009) William Y. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse

(2008) Olivia Wendling et al.   GENESIS