DLL1 orchestrates CD8+ T cells to induce long-term vascular normalization and tumor regression

Inactivation of endothelial ZEB1 impedes tumor progression and sensitizes tumors to conventional therapies

(2020) Rong Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Combining microenvironment normalization strategies to improve cancer immunotherapy

(2020) Fotios Mpekris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

(2020) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy

(2020) Stephen M. Hatfield et al.   JOURNAL OF CLINICAL INVESTIGATION

Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T cell immunity

(2019) Elena E. Tchekneva et al.   Journal for ImmunoTherapy of Cancer

Diversity, Mechanisms, and Significance of Macrophage Plasticity

(2019) Massimo Locati et al.   Annual Review of Pathology-Mechanisms of Disease

Vascular regulation of antitumor immunity

(2019) Lance L. Munn et al.   SCIENCE

CTLA4 blockade promotes vessel normalization in breast tumors via the accumulation of eosinophils

(2019) Xichen Zheng et al.   INTERNATIONAL JOURNAL OF CANCER

Increased vessel perfusion predicts the efficacy of immune checkpoint blockade

(2018) Xichen Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial Tie1–mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis

(2018) Silvia La Porta et al.   JOURNAL OF CLINICAL INVESTIGATION

Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC

(2018) Mark A. Socinski et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunomodulation of Tumor Vessels: It Takes Two to Tango

(2018) Anna Johansson-Percival et al.   TRENDS IN IMMUNOLOGY

Complementary actions of dopamine D2 receptor agonist and anti-vegf therapy on tumoral vessel normalization in a transgenic mouse model

(2017) Norbert Chauvet et al.   INTERNATIONAL JOURNAL OF CANCER

Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming

(2017) Lin Tian et al.   NATURE

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression

(2017) Thomas Kammertoens et al.   NATURE

Monitoring immune-checkpoint blockade: response evaluation and biomarker development

(2017) Mizuki Nishino et al.   Nature Reviews Clinical Oncology

Remodeling Tumor Vasculature to Enhance Delivery of Intermediate-Sized Nanoparticles

(2015) Wen Jiang et al.   ACS Nano

Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients

(2015) Emanuela Romano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

Inhibition of Tumor Angiogenesis and Tumor Growth by the DSL Domain of Human Delta-Like 1 Targeted to Vascular Endothelial Cells

(2015) Xing-Cheng Zhao et al.   NEOPLASIA

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection

(2014) Stephen M. Hatfield et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy

(2013) Y. Huang et al.   CANCER RESEARCH

Benefits of Vascular Normalization Are Dose and Time Dependent--Letter

(2013) Y. Huang et al.   CANCER RESEARCH

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

(2013) Tyler R. Simpson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Notch ligand Dll1 in B16 melanoma cells leads to reduced tumor growth due to attenuated vascularization

(2011) Jian-Ping Zhang et al.   CANCER LETTERS

Resuscitating Cancer Immunosurveillance: Selective Stimulation of DLL1-Notch Signaling in T cells Rescues T-cell Function and Inhibits Tumor Growth

(2011) Y. Huang et al.   CANCER RESEARCH

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

(2011) A. G. Sorensen et al.   CANCER RESEARCH

Notch regulation of tumor angiogenesis

(2011) Esther Bridges et al.   Future Oncology

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Chronic DLL4 blockade induces vascular neoplasms

(2010) Minhong Yan et al.   NATURE

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

(2009) Michail V. Sitkovsky   TRENDS IN IMMUNOLOGY

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

(2008) Juliana Hamzah et al.   NATURE