Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation

Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3

(2020) József Jászai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myristoylation, an Ancient Protein Modification Mirroring Eukaryogenesis and Evolution

(2020) Thierry Meinnel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis

(2019) Johnathan Cooper-Knock et al.   Cell Reports

USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells

(2019) Zhengxin Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

The antibiotic clofoctol suppresses glioma stem cell proliferation by activating KLF13

(2019) Yan Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells

(2018) Jianghong Man et al.   Cell Stem Cell

Monoubiquitination of Cancer Stem Cell Marker CD133 at Lysine 848 Regulates Its Secretion and Promotes Cell Migration

(2018) Fan Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

VDAC2 interacts with PFKP to regulate glucose metabolism and phenotypic reprogramming of glioma stem cells

(2018) Kai Zhou et al.   Cell Death & Disease

Prominin‐1 controls stem cell activation by orchestrating ciliary dynamics

(2018) Donald Singer et al.   EMBO JOURNAL

Prominin‐1 (CD133) modulates the architecture and dynamics of microvilli

(2018) Kristina Thamm et al.   TRAFFIC

The HDAC6 Inhibitor Tubacin Induces Release of CD133+ Extracellular Vesicles From Cancer Cells

(2017) Olivia S. Chao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Prominin-1/CD133: Lipid Raft Association, Detergent Resistance, and Immunodetection

(2017) Jana Karbanová et al.   Stem Cells Translational Medicine

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

Differential effects of enalapril–felodipine versus enalapril–lercanidipine combination drug treatment on sympathetic nerve traffic and metabolic profile in obesity-related hypertension

(2016) Gino Seravalle et al.   Journal of the American Society of Hypertension

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

(2015) Jeanette E. Eckel-Passow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutation of N-linked glycosylation at Asn548 in CD133 decreases its ability to promote hepatoma cell growth

(2015) Ying Liu et al.   Oncotarget

Commentary: “Prom1 Function in Development, Intestinal Inflammation, and Intestinal Tumorigenesis”

(2015) Christine A. Fargeas et al.   Frontiers in Oncology

Current approaches to the treatment of metastatic brain tumours

(2014) Taofeek K. Owonikoko et al.   Nature Reviews Clinical Oncology

Bevacizumab in Glioblastoma — Still Much to Learn

(2014) Howard A. Fine   NEW ENGLAND JOURNAL OF MEDICINE

Human Prominin-1 (CD133) Is Detected in Both Neoplastic and Non-Neoplastic Salivary Gland Diseases and Released into Saliva in a Ubiquitinated Form

(2014) Jana Karbanová et al.   PLoS One

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas

(2013) Sungjae Hwang et al.   CANCER

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner

(2013) Ying Yang et al.   EMBO REPORTS

CD133 glycosylation is enhanced by hypoxia in cultured glioma stem cells

(2013) KRISTINA S. LEHNUS et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

ITIH3 polymorphism may confer susceptibility to psychiatric disorders by altering the expression levels of GLT8D1

(2013) Daimei Sasayama et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Reciprocal Regulation of HIF-1α and LincRNA-p21 Modulates the Warburg Effect

(2013) Fan Yang et al.   MOLECULAR CELL

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells

(2013) Y. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges

(2012) Philipp Grosse-Gehling et al.   JOURNAL OF PATHOLOGY

FOXM1 Induces a Global Methylation Signature That Mimics the Cancer Epigenome in Head and Neck Squamous Cell Carcinoma

(2012) Muy-Teck Teh et al.   PLoS One

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation

(2012) Anthony B. Mak et al.   Cell Reports

HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia

(2011) Pablo A. Robador et al.   CARDIOVASCULAR RESEARCH

Haematopoietic stem cell differentiation promotes the release of prominin-1/CD133-containing membrane vesicles-a role of the endocytic-exocytic pathway

(2011) Nicola Bauer et al.   EMBO Molecular Medicine

CD133 ProteinN-Glycosylation Processing Contributes to Cell Surface Recognition of the Primitive Cell Marker AC133 Epitope

(2011) Anthony B. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatio-temporal transcriptome of the human brain

(2011) Hyo Jung Kang et al.   NATURE

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2010) R. Stupp et al.   ANNALS OF ONCOLOGY

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

(2010) Sascha Seidel et al.   BRAIN

The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

(2010) K. Kemper et al.   CANCER RESEARCH

MGMT-Independent Temozolomide Resistance in Pediatric Glioblastoma Cells Associated with a PI3-Kinase-Mediated HOX/Stem Cell Gene Signature

(2010) N. Gaspar et al.   CANCER RESEARCH

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Targeting CD133 antigen in cancer

(2009) Gabriella Ferrandina et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Loss of the Cholesterol-Binding Protein Prominin-1/CD133 Causes Disk Dysmorphogenesis and Photoreceptor Degeneration

(2009) S. Zacchigna et al.   JOURNAL OF NEUROSCIENCE

Glycoproteomics Analysis of Human Liver Tissue by Combination of Multiple Enzyme Digestion and Hydrazide Chemistry

(2009) Rui Chen et al.   JOURNAL OF PROTEOME RESEARCH

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

The stem cell marker CD133 meets the endosomal compartment – New insights into the cell division of hematopoietic stem cells

(2008) A.-V. Fonseca et al.   BLOOD CELLS MOLECULES AND DISEASES

Temozolomide Preferentially Depletes Cancer Stem Cells in Glioblastoma

(2008) D. Beier et al.   CANCER RESEARCH

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE