Mutant p53: it’s not all one and the same

Mutant p53 suppresses innate immune signaling to promote tumorigenesis

(2021) Monisankar Ghosh et al.   CANCER CELL

p53 and Tumor Suppression: It Takes a Network

(2021) Anthony M. Boutelle et al.   TRENDS IN CELL BIOLOGY

Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy

(2021) Despina Siolas et al.   Cell Reports

p53 partial loss-of-function mutations sensitize to chemotherapy

(2021) Boris Klimovich et al.   ONCOGENE

Pan-cancer analysis of whole genomes

(2020)   NATURE

The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

(2020) Eliran Kadosh et al.   NATURE

The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

(2019) Steffen Boettcher et al.   SCIENCE

A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation

(2018) Eran Kotler et al.   MOLECULAR CELL

Mutational processes shape the landscape of TP53 mutations in human cancer

(2018) Andrew O. Giacomelli et al.   NATURE GENETICS

Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development

(2018) Brandon J. Aubrey et al.   GENES & DEVELOPMENT

Novel targets and interaction partners of mutant p53 Gain-Of-Function

(2016) Lydia Aschauer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Deletions linked to TP53 loss drive cancer through p53-independent mechanisms

(2016) Yu Liu et al.   NATURE

The Inherited p53 Mutation in the Brazilian Population

(2016) Maria Isabel Achatz et al.   Cold Spring Harbor Perspectives in Medicine

Somatic TP53 Mutations in the Era of Genome Sequencing

(2016) Pierre Hainaut et al.   Cold Spring Harbor Perspectives in Medicine

Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53

(2016) Neil T. Pfister et al.   Cold Spring Harbor Perspectives in Medicine

TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions

(2016) Nitin H Shirole et al.   eLife

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulateVEGFR2in breast cancer cells

(2015) Neil T. Pfister et al.   GENES & DEVELOPMENT

Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers

(2015) Gaëlle Bougeard et al.   JOURNAL OF CLINICAL ONCOLOGY

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

(2014) Susann Weissmueller et al.   CELL

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

(2012) P A J Muller et al.   ONCOGENE

Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2

(2012) Milena Wiech et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

Transcriptional Regulation by P53

(2010) R. Beckerman et al.   Cold Spring Harbor Perspectives in Biology

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology