Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17+ cell frequency

(2016) Simone Punt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma

(2016) Alexander W. Eckert et al.   Journal of Translational Medicine

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

Oral Cavity Carcinoma: Current Management, Controversies, and Future Directions

(2015) Steven B. Chinn et al.   JOURNAL OF CLINICAL ONCOLOGY

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

CD39: A complementary target to immune checkpoints to counteract tumor-mediated immunosuppression

(2015) Nathalie Bonnefoy et al.   OncoImmunology

Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators

(2015) Stephen M Hatfield et al.   OncoImmunology

Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma

(2015) Simona Partlová et al.   OncoImmunology

Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment

(2014) C. Cekic et al.   CANCER RESEARCH

Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor

(2014) D. Mittal et al.   CANCER RESEARCH

Targeting Cancer-Derived Adenosine:New Therapeutic Approaches

(2014) A. Young et al.   Cancer Discovery

Hostile, Hypoxia-A2-Adenosinergic Tumor Biology as the Next Barrier to Overcome for Tumor Immunologists

(2014) M. V. Sitkovsky et al.   Cancer Immunology Research

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

(2013) B. Allard et al.   CLINICAL CANCER RESEARCH

The immune system and head and neck squamous cell carcinoma: from carcinogenesis to new therapeutic opportunities

(2013) Monika E. Freiser et al.   IMMUNOLOGIC RESEARCH

Blockade of A2Areceptors potently suppresses the metastasis of CD73+tumors

(2013) Paul A. Beavis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy

(2013) Christel Devaud et al.   OncoImmunology

The adenosinergic system in cancer

(2013) Rosalinda Sorrentino et al.   OncoImmunology

Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically Defined Head and Neck Squamous Cell Carcinoma Mouse Model

(2012) Z.-J. Sun et al.   CLINICAL CANCER RESEARCH

Randomized Phase III Trial of Induction Chemotherapy With Docetaxel, Cisplatin, and Fluorouracil Followed by Surgery Versus Up-Front Surgery in Locally Advanced Resectable Oral Squamous Cell Carcinoma

(2012) Lai-ping Zhong et al.   JOURNAL OF CLINICAL ONCOLOGY

The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

(2012) Akio Ohta et al.   Frontiers in Immunology

CD73 promotes tumor growth and metastasis

(2012) Bin Zhang   OncoImmunology

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms

(2011) Jingjing Quan et al.   CANCER AND METASTASIS REVIEWS

Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor

(2011) Adam T. Waickman et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hypoxia-inducible factors in OSCC

(2011) Mario Pérez-Sayáns et al.   CANCER LETTERS

CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis

(2011) J. Stagg et al.   CANCER RESEARCH

Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation

(2011) Y Bian et al.   ONCOGENE

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer

(2011) Beat M. Künzli et al.   Purinergic Signalling

Extracellular adenosine triphosphate and adenosine in cancer

(2010) J Stagg et al.   ONCOGENE

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

(2010) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral tongue cancer gene expression profiling: Identification of novel potential prognosticators by oligonucleotide microarray analysis

(2009) Cherry L Estilo et al.   BMC CANCER

Progressive Tumor Formation in Mice with Conditional Deletion of TGF-  Signaling in Head and Neck Epithelia Is Associated with Activation of the PI3K/Akt Pathway

(2009) Y. Bian et al.   CANCER RESEARCH

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

Head and Neck Cancer: Changing Epidemiology, Diagnosis, and Treatment

(2009) Shanthi Marur et al.   MAYO CLINIC PROCEEDINGS

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

(2009) Michail V. Sitkovsky   TRENDS IN IMMUNOLOGY

HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak

(2008) J. C. Morote-Garcia et al.   BLOOD

T Regulatory Type 1 Cells in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Suppression and Expansion in Advanced Disease

(2008) C. Bergmann et al.   CLINICAL CANCER RESEARCH

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

Dysregulated molecular networks in head and neck carcinogenesis

(2008) Alfredo A. Molinolo et al.   ORAL ONCOLOGY

Clinicopathologic significance of tumor cell-lined vessel and microenvironment in oral squamous cell carcinoma

(2007) Shyun-Yeu Liu et al.   ORAL ONCOLOGY