Immune response in COVID-19: what is next?

Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

(2022) Pengcheng Han et al.   CELL

Novel SARS-CoV-2 therapeutic targets: RNA proofreading complex and virus-induced senescence

(2022) Liangyu Lin et al.   CELL DEATH AND DIFFERENTIATION

T cell apoptosis characterizes severe Covid-19 disease

(2022) Sonia André et al.   CELL DEATH AND DIFFERENTIATION

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study

(2022) Nicole Wolter et al.   LANCET

Omicron’s feeble attack on the lungs could make it less dangerous

(2022) Max Kozlov   NATURE

Scientists deliberately gave people COVID — here’s what they learnt

(2022) Ewen Callaway   NATURE

Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

(2022) Chansavath Phetsouphanh et al.   NATURE IMMUNOLOGY

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

(2022) Matteo Stravalaci et al.   NATURE IMMUNOLOGY

Cocirculation of two SARS-CoV-2 variant strains within imported pet hamsters in Hong Kong

(2022) Kin-Hang Kok et al.   Emerging Microbes & Infections

Disulfiram inhibits neutrophil extracellular trap formation protecting rodents from acute lung injury and SARS-CoV-2 infection

(2022) Jose M. Adrover et al.   JCI Insight

Antibody evasion properties of SARS-CoV-2 Omicron sublineages

(2022) Sho Iketani et al.   NATURE

Inflammasome activation in infected macrophages drives COVID-19 pathology

(2022) Esen Sefik et al.   NATURE

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

(2022) Caroline Junqueira et al.   NATURE

Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses

(2022) Jeffrey A. Tomalka et al.   NATURE IMMUNOLOGY

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant

(2022) Fanglei Zuo et al.   Nature Communications

The Interplay Between Coronavirus and Type I IFN Response

(2022) Wenxiang Xue et al.   Frontiers in Microbiology

Cell-in-cell structure mediates in-cell killing suppressed by CD44

(2022) Yan Su et al.   Cell Discovery

Evolution of resistance to COVID-19 vaccination with dynamic social distancing

(2022) Gabriela Lobinska et al.   Nature Human Behaviour

COVID-19 vaccines: where we stand and challenges ahead

(2021) Guido Forni et al.   CELL DEATH AND DIFFERENTIATION

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

(2021) Rogan A. Grant et al.   NATURE

Lessons from the host defences of bats, a unique viral reservoir

(2021) Aaron T. Irving et al.   NATURE

No higher infectivity but immune escape of SARS-CoV-2 501Y.V2 variants

(2021) Qianqian Li et al.   CELL

COVID-19 and the human innate immune system

(2021) Joachim L. Schultze et al.   CELL

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

(2021) Christoph Muus et al.   NATURE MEDICINE

Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

(2021) Ben M. Flude et al.   Viruses-Basel

Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

(2021) Daniel Butler et al.   Nature Communications

Time course of the sensitivity and specificity of anti-SARS-CoV-2 IgM and IgG antibodies for symptomatic COVID-19 in Japan

(2021) Yuki Nakano et al.   Scientific Reports

SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination

(2021) Zhengrong Zhang et al.   CELL DEATH AND DIFFERENTIATION

Syncytia formation during SARS-CoV-2 lung infection: a disastrous unity to eliminate lymphocytes

(2021) Liangyu Lin et al.   CELL DEATH AND DIFFERENTIATION

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2

(2021) Qiao Lu et al.   IMMUNITY

The Potential Future of the COVID-19 Pandemic

(2021) Christopher J. L. Murray et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

(2021) Toni M. Delorey et al.   NATURE

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

(2021) Luca Braga et al.   NATURE

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

(2021) Min Zheng et al.   NATURE IMMUNOLOGY

Delayed production of neutralizing antibodies correlates with fatal COVID-19

(2021) Carolina Lucas et al.   NATURE MEDICINE

A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection

(2021) Fiachra Humphries et al.   Science Immunology

Pharmacological activation of STING blocks SARS-CoV-2 infection

(2021) Minghua Li et al.   Science Immunology

Patients with COVID-19: in the dark-NETs of neutrophils

(2021) Maximilian Ackermann et al.   CELL DEATH AND DIFFERENTIATION

SARS-CoV-2 N501Y variants of concern and their potential transmission by mouse

(2021) Hongyan Huang et al.   CELL DEATH AND DIFFERENTIATION

Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis

(2021) Anne-Gaëlle Goubet et al.   CELL DEATH AND DIFFERENTIATION

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

(2021) Benjamin Krämer et al.   IMMUNITY

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

(2021) Frauke Muecksch et al.   IMMUNITY

Siltuximab downregulates interleukin-8 and pentraxin 3 to improve ventilatory status and survival in severe COVID-19

(2021) Giuseppe Gritti et al.   LEUKEMIA

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

(2021) Florian A. Lempp et al.   NATURE

A STING in the tail for SARS-CoV-2

(2021) Nicholas J. Bernard   NATURE IMMUNOLOGY

The virological impacts of SARS-CoV-2 D614G mutation

(2021) Chenxi Wang et al.   Journal of Molecular Cell Biology

Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia

(2021) Alessandro Mauriello et al.   Cell Death & Disease

SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care

(2021) Clemens Gutmann et al.   Nature Communications

Assessment of avidity related to IgG subclasses in SARS-CoV-2 Brazilian infected patients

(2021) Andrew D. Moura et al.   Scientific Reports

Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity

(2021) Susan Westfall et al.   Frontiers in Immunology

CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2

(2021) Razie Amraei et al.   ACS Central Science

Neutrophil Extracellular Trap-Driven Occlusive Diseases

(2021) Kursat Oguz Yaykasli et al.   Cells

Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cells

(2021) Huabin Ma et al.   Cell Discovery

SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8

(2021) Valentina Salvi et al.   JCI Insight

Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection

(2021) He Ren et al.   Biology Direct

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

(2021) Philipp Georg et al.   CELL

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

(2021) Daniel Wendisch et al.   CELL

Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19

(2021) Toshifumi Matsuyama et al.   CELL DEATH AND DIFFERENTIATION

Differential Internalization of Thrombin-Derived Host Defense Peptides into Monocytes and Macrophages

(2021) Finja C. Hansen et al.   Journal of Innate Immunity

Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic

(2021) Salim S Abdool Karim et al.   LANCET

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

(2021) Mario Witkowski et al.   NATURE

Where did ‘weird’ Omicron come from?

(2021) Kai Kupferschmidt   SCIENCE

Organ-specific genome diversity of replication-competent SARS-CoV-2

(2021) Jolien Van Cleemput et al.   Nature Communications

Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

(2021) Claudia A. Jette et al.   Cell Reports

Omicron variant and booster COVID-19 vaccines

(2021) Talha Khan Burki   Lancet Respiratory Medicine

Emerging SARS-CoV-2 variants expand species tropism to murines

(2021) Huiping Shuai et al.   EBioMedicine

COVID-19 Infection Among Women in Iran Exposed vs Unexposed to Children Who Received Attenuated Poliovirus Used in Oral Polio Vaccine

(2021) Farrokh Habibzadeh et al.   JAMA Network Open

PAD Inhibitors as a Potential Treatment for SARS-CoV-2 Immunothrombosis

(2021) Willie Elliott et al.   Biomedicines

WHO international standard for SARS-CoV-2 antibodies to determine markers of protection

(2021) Feng Zhu et al.   Lancet Microbe

COVID-19 infection: the perspectives on immune responses

(2020) Yufang Shi et al.   CELL DEATH AND DIFFERENTIATION

Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients

(2020) Hong-Yi Zheng et al.   Cellular & Molecular Immunology

Antibody responses to SARS-CoV-2 in patients with COVID-19

(2020) Quan-Xin Long et al.   NATURE MEDICINE

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Increased CD95 (Fas) and PD‐1 expression in peripheral blood T lymphocytes in COVID‐19 patients

(2020) Silvia Bellesi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

(2020) Jonas Schulte-Schrepping et al.   CELL

Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

(2020) Chiara Agrati et al.   CELL DEATH AND DIFFERENTIATION

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

(2020) Sara Mastaglio et al.   CLINICAL IMMUNOLOGY

Endothelial Injury and Thrombotic Microangiopathy in COVID-19: Treatment with the Lectin-Pathway Inhibitor Narsoplimab

(2020) Alessandro Rambaldi et al.   IMMUNOBIOLOGY

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19)

(2020) W. Joost Wiersinga et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

(2020) Alessio Mazzoni et al.   JOURNAL OF CLINICAL INVESTIGATION

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

(2020) Lihong Liu et al.   NATURE

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

(2020) David Ellinghaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and safety of aerosolized intra-tracheal dornase alfa administration in patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS): a structured summary of a study protocol for a randomised controlled trial

(2020) J. P. Desilles et al.   Trials

COVID-19 infection: the China and Italy perspectives

(2020) Jun Chen et al.   Cell Death & Disease

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

Neutrophils as Main Players of Immune Response towards Nondegradable Nanoparticles

(2020) Rostyslav Bilyy et al.   Nanomaterials

Vascular occlusion by neutrophil extracellular traps in COVID-19

(2020) Moritz Leppkes et al.   EBioMedicine

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

Severe immunosuppression and not a cytokine storm characterize COVID-19 infections

(2020) Kenneth E. Remy et al.   JCI Insight

Non-infectious status indicated by detectable IgG antibody to SARS-CoV-2

(2020) David W. Denning et al.   BRITISH DENTAL JOURNAL

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

(2020) Naoki Kaneko et al.   CELL

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

(2020) Carolyn Rydyznski Moderbacher et al.   CELL

An aberrant STAT pathway is central to COVID-19

(2020) Toshifumi Matsuyama et al.   CELL DEATH AND DIFFERENTIATION

Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2

(2020) Sandra C.A. Nielsen et al.   Cell Host & Microbe

Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

(2020) Panagiotis Skendros et al.   JOURNAL OF CLINICAL INVESTIGATION

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

(2020) Flavio Protasio Veras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nebulized in-line endotracheal dornase alfa and albuterol administered to mechanically ventilated COVID-19 patients: a case series

(2020) Andrew G. Weber et al.   MOLECULAR MEDICINE

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

Trained Innate Immunity, Epigenetics, and Covid-19

(2020) Alberto Mantovani et al.   NEW ENGLAND JOURNAL OF MEDICINE

ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19

(2020) Donato Zipeto et al.   Frontiers in Immunology

Can COVID-19 pandemic boost the epidemic of neurodegenerative diseases?

(2020) Alexei Verkhratsky et al.   Biology Direct

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

(2020) Joana P. Bernardes et al.   IMMUNITY

Neutrophil more than platelet activation associates with thrombotic complications in COVID-19 patients

(2020) E Petito et al.   JOURNAL OF INFECTIOUS DISEASES

Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19

(2020) Enrico Brunetta et al.   NATURE IMMUNOLOGY

IgA dominates the early neutralizing antibody response to SARS-CoV-2

(2020) Delphine Sterlin et al.   Science Translational Medicine

Dynamic changes in anti-SARS-CoV-2 antibodies during SARS-CoV-2 infection and recovery from COVID-19

(2020) Kening Li et al.   Nature Communications

New Consensus pattern in Spike CoV-2: potential implications in coagulation process and cell–cell fusion

(2020) Silvia Buonvino et al.   Cell Death Discovery

Pentraxin 3: Potential prognostic role in SARS-CoV-2 patients admitted to the emergency department

(2020) Annalisa Schirinzi et al.   JOURNAL OF INFECTION

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

(2019) Adriaan A. van Beek et al.   TRENDS IN IMMUNOLOGY

Diversity, Mechanisms, and Significance of Macrophage Plasticity

(2019) Massimo Locati et al.   Annual Review of Pathology-Mechanisms of Disease

Aggregated NETs Sequester and Detoxify Extracellular Histones

(2019) Jasmin Knopf et al.   Frontiers in Immunology

The advent and rise of monoclonal antibodies

(2019) Klaus Rajewsky   NATURE

The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques

(2018) Mireille Laforge et al.   JOURNAL OF CLINICAL INVESTIGATION

PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer

(2018) Cecilia Garlanda et al.   PHYSIOLOGICAL REVIEWS

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Recent progress in broadly neutralizing antibodies to HIV

(2018) Devin Sok et al.   NATURE IMMUNOLOGY

Competition between human cells by entosis

(2014) Qiang Sun et al.   CELL RESEARCH

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Updated Guidance for Palivizumab Prophylaxis Among Infants and Young Children at Increased Risk of Hospitalization for Respiratory Syncytial Virus Infection

(2014)   PEDIATRICS

Imbalance between Th17 and Treg Cells May Play an Important Role in the Development of Chronic Unpredictable Mild Stress-Induced Depression in Mice

(2012) Min Hong et al.   NEUROIMMUNOMODULATION

An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

(2009) Barbara Bottazzi et al.   Annual Review of Immunology

Immunology in China: the past, present and future

(2008) Xuetao Cao   NATURE IMMUNOLOGY