HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α

Exosomal miR-1229 derived from colorectal cancer cells promotes angiogenesis by targeting HIPK2

(2019) Hui-Ying Hu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Homeodomain‐interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer

(2019) Yi Qin et al.   CELL PROLIFERATION

MicroRNA-222-3p associated with Helicobacter pylori targets HIPK2 to promote cell proliferation, invasion, and inhibits apoptosis in gastric cancer

(2018) Xiaoyan Tan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MicroRNA-197 induces epithelial–mesenchymal transition and invasion through the downregulation of HIPK2 in lung adenocarcinoma

(2018) Nan Zhang et al.   JOURNAL OF GENETICS

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Role of Angiogenesis in Hepatocellular Carcinoma

(2018) Michael A. Morse et al.   CLINICAL CANCER RESEARCH

BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction

(2017) Qian Ba et al.   Journal of Molecular Cell Biology

p300-mediated acetylation increased the protein stability of HIPK2 and enhanced its tumor suppressor function

(2017) Jong-Ryoul Choi et al.   Scientific Reports

Prognostic Biomarker Identification Through Integrating the Gene Signatures of Hepatocellular Carcinoma Properties

(2017) Jialin Cai et al.   EBioMedicine

Heat shock modulates the subcellular localization, stability, and activity of HIPK2

(2016) Mamta Upadhyay et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation

(2016) Lavinia Nardinocchi et al.   Aging-US

Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma

(2015) Xiaoguang Li et al.   GUT

Verbascoside promotes apoptosis by regulating HIPK2–p53 signaling in human colorectal cancer

(2014) Lihong Zhou et al.   BMC CANCER

Downregulation of Homeodomain-Interacting Protein Kinase-2 Contributes to Bladder Cancer Metastasis by Regulating Wnt Signaling

(2014) Mingyue Tan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Downregulation of HIPK2 Increases Resistance of Bladder Cancer Cell to Cisplatin by Regulating Wip1

(2014) Jun Lin et al.   PLoS One

Prognostic and Predictive Role of JWA and XRCC1 Expressions in Gastric Cancer

(2012) S. Wang et al.   CLINICAL CANCER RESEARCH

Targeting COX-2/PGE2 Pathway in HIPK2 Knockdown Cancer Cells: Impact on Dendritic Cell Maturation

(2012) Alessia Garufi et al.   PLoS One

The Global Epidemiology of Hepatocellular Carcinoma: Present and Future

(2011) Katherine A. McGlynn et al.   Clinics in Liver Disease

MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma

(2011) Shupeng Liu et al.   JOURNAL OF HEPATOLOGY

HCC and angiogenesis: possible targets and future directions

(2011) Andrew X. Zhu et al.   Nature Reviews Clinical Oncology

HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage

(2011) C Lazzari et al.   ONCOGENE

Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation

(2009) Jutta Moehlenbrink et al.   CANCER LETTERS

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2

(2009) Nadja Bitomsky et al.   FEBS Journal

Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis

(2009) Lavinia Nardinocchi et al.   Molecular Cancer

Transcriptional regulation of hypoxia-inducible factor 1α by HIPK2 suggests a novel mechanism to restrain tumor growth

(2008) Lavinia Nardinocchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells

(2008) Rosa Puca et al.   GYNECOLOGIC ONCOLOGY

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response

(2008) Marco A. Calzado et al.   NATURE CELL BIOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE