Collagen density regulates the activity of tumor-infiltrating T cells

αβ T Cell Receptor Mechanosensing Forces out Serial Engagement

(2018) Yinnian Feng et al.   TRENDS IN IMMUNOLOGY

Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers

(2018) Muhammad Umair Mushtaq et al.   Journal for ImmunoTherapy of Cancer

Cancer cells’ ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential

(2018) Lena Wullkopf et al.   MOLECULAR BIOLOGY OF THE CELL

The immune contexture in cancer prognosis and treatment

(2017) Wolf H. Fridman et al.   Nature Reviews Clinical Oncology

Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model

(2017) Henrik Jespersen et al.   Nature Communications

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

(2017) Daniel Hargbøl Madsen et al.   Cell Reports

Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction

(2017) Manja Idorn et al.   OncoImmunology

Immune suppressive mechanisms in the tumor microenvironment

(2016) David H Munn et al.   CURRENT OPINION IN IMMUNOLOGY

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

(2016) K. Sadtler et al.   SCIENCE

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

ADAMTS5 Is a Critical Regulator of Virus-Specific T Cell Immunity

(2016) Meagan McMahon et al.   PLOS BIOLOGY

CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection

(2016) Christophe Côme et al.   PLoS One

Tenascin-C Protects Cancer Stem-like Cells from Immune Surveillance by Arresting T-cell Activation

(2015) E. Jachetti et al.   CANCER RESEARCH

The source of matrix-degrading enzymes in human cancer: Problems of research reproducibility and possible solutions

(2015) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer

(2014) N. Hartmann et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Connecting Fibrosis and Solid Tumor Metastasis

(2014) T. R. Cox et al.   CLINICAL CANCER RESEARCH

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs

(2014) P. J. Balwierz et al.   GENOME RESEARCH

Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β–dependent cancer metastasis

(2014) Jianfei Xue et al.   JOURNAL OF CLINICAL INVESTIGATION

Matrix Stiffening and β 1 Integrin Drive Subtype-Specific Fibroblast Accumulation in Lung Cancer

(2014) Marta Puig et al.   MOLECULAR CANCER RESEARCH

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

(2014) Alexandra Naba et al.   eLife

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

(2013) T. R. Cox et al.   CANCER RESEARCH

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Expression of αvβ6 integrin and collagen fibre in oral squamous cell carcinoma: association with clinical outcomes and prognostic implications

(2013) Hai-Xia Li et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Control of cell cycle transcription during G1 and S phases

(2013) Cosetta Bertoli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Substrate Rigidity Regulates Human T Cell Activation and Proliferation

(2012) R. S. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

An MEK-cofilin signalling module controls migration of human T cells in 3D but not 2D environments

(2010) Martin Klemke et al.   EMBO JOURNAL

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

(2010) Weiming Ouyang et al.   NATURE IMMUNOLOGY

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression

(2010) P. Schedin et al.   Cold Spring Harbor Perspectives in Biology

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine