Gardenia ( Gardenia jasminoides Ellis) fruit: a critical review of its functional nutrients, processing methods, health-promoting effects, comprehensive application and future tendencies

Health oil preparation from gardenia seeds by aqueous enzymatic extraction combined with puffing pre-treatment and its properties analysis

(2023) Chengyu Jin et al.   FOOD SCIENCE AND BIOTECHNOLOGY

High efficiency biosynthesis of gardenia blue and red pigment by lactic acid bacteria: A great potential for natural color pigments

(2023) Ling Li et al.   Food Chemistry

Crocin induces ROS-mediated papillary thyroid cancer cell apoptosis by modulating the miR-34a-5p/PTPN4 axis in vitro

(2022) Yan Tang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

High-Purity Preparation of Enzyme Transformed Trans-Crocetin Reclaimed from Gardenia Fruit Waste

(2022) Charng-Cherng Chyau et al.   Plants-Basel

Integrated natural deep eutectic solvent and pulse-ultrasonication for efficient extraction of crocins from gardenia fruits (Gardenia jasminoides Ellis) and its bioactivities

(2022) Hao Huang et al.   FOOD CHEMISTRY

Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4/NF-κB signaling pathway

(2022) Su Fang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A review of the ethnopharmacology, phytochemistry, pharmacology and toxicology of Fructus Gardeniae (Zhi-zi)

(2022) Jingzhuo Tian et al.   JOURNAL OF ETHNOPHARMACOLOGY

The structural characterization, physicochemical properties, and stability of gardenia yellow pigment microcapsules

(2022) Liqin Tang et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Ultrasound assisted aqueous two-phase extraction of polysaccharides from Cornus officinalis fruit: Modeling, optimization, purification, and characterization

(2022) Jiaqi Tan et al.   ULTRASONICS SONOCHEMISTRY

The physicochemical properties and immunomodulatory activities of gardenia yellow pigment from gardenia fruit

(2022) Liqin Tang et al.   Journal of Functional Foods

Assessment of oil extracted from Gardenia fruits by different commercial extraction methods for potential industrial applications

(2022) Haocheng Liu et al.   INDUSTRIAL CROPS AND PRODUCTS

Ultrasound-assisted aqueous enzymatic extraction of gardenia fruits (Gardenia jasminoides Ellis) oil: Optimization and quality evaluation

(2022) Danli Wang et al.   INDUSTRIAL CROPS AND PRODUCTS

Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice

(2021) Menglin Zheng et al.   BRAIN RESEARCH BULLETIN

Avocado oil: Production and market demand, bioactive components, implications in health, and tendencies and potential uses

(2021) Braulio Cervantes‐Paz et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases

(2021) Deng Ran et al.   JOURNAL OF ETHNOPHARMACOLOGY

Crocin alleviates the inflammation and oxidative stress responses associated with diabetic nephropathy in rats via NLRP3 inflammasomes

(2021) Linjuan Zhang et al.   LIFE SCIENCES

Expression of heat-resistant β-glucosidase in Escherichia coli and its application in the production of gardenia blue

(2021) Wenxi Li et al.   Synthetic and Systems Biotechnology

Treatment with crocin suppresses diabetic nephropathy progression via modulating TGF-β1 and oxidative stress in an experimental model of pinealectomized diabetic rats

(2021) Rihab Mudhafar Ali Hammood Keelo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Study on ultrahigh-pressure extraction technology on properties of yellow extract from gardenia fruit

(2021) Tang Liqin et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

The composition, extraction, analysis, bioactivities, bioavailability and applications in food system of flaxseed (Linum usitatissimum L.) oil: A review

(2021) Jing Yang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Preparation and Characterization of Water-Insoluble Gardenia Blue Pigment

(2021) Yakun Gao et al.   Materials

Stability evaluation of gardenia yellow pigment in presence of different phenolic compounds

(2021) Jun Wu et al.   FOOD CHEMISTRY

Preparation of multiresponsive hydrophilic molecularly imprinted microspheres for rapid separation of gardenia yellow and geniposide from gardenia fruit

(2021) Jinshuang Wang et al.   FOOD CHEMISTRY

Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model

(2021) Zijin Xu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids

(2020) Jinxin Liu et al.   PHARMACOLOGICAL RESEARCH

Geniposide alleviates atherosclerosis by regulating macrophage polarization via the FOS/MAPK signaling pathway

(2020) Zheng Jin et al.   BIOMEDICINE & PHARMACOTHERAPY

CREB-mediated Generation and Neuronal Growth Regulates the Behavioral Improvement of Geniposide in Diabetes-Associated Depression Mouse Model

(2020) Bo Sun et al.   NEUROSCIENCE RESEARCH

Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: more friend than foe

(2020) Xiaofei Fan et al.   PHARMACOLOGICAL RESEARCH

Cytosolic and mitochondrial ROS production resulted in apoptosis induction in breast cancer cells treated with Crocin: The role of FOXO3a, PTEN and AKT signaling

(2020) Ahmad Nasimian et al.   BIOCHEMICAL PHARMACOLOGY

Geniposide alleviates diabetic nephropathy of mice through AMPK/SIRT1/NF-κB pathway

(2020) Fengtao Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gardenia jasminoides Ellis: Ethnopharmacology, phytochemistry, and pharmacological and industrial applications of an important traditional Chinese medicine

(2020) Liping Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti‐diabetic effects of fermented milk contained with Gardenia jasminoides water extracts on streptozotocin‐induced mice

(2020) Ziyang Ye et al.   JOURNAL OF FOOD PROCESSING AND PRESERVATION

Carvacrol methyl ether, a compound from the essential oil of Gardenia jasminoides fruits, exhibits antioxidant effects in the deep-frying of Chinese Youmotou using sunflower oil

(2020) Dongying Wang et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Preparation of gardenia red pigment and its antineoplastic activity in multiple tumor cells

(2020) Shuai Hao et al.   Food Bioscience

Lactobacillus plantarum KFY02 enhances the prevention of CCl4-induced liver injury by transforming geniposide into genipin to increase the antioxidant capacity of mice

(2020) Yanni Pan et al.   Journal of Functional Foods

Dietary fibers fractionated from gardenia ( Gardenia jasminoides Ellis) husk: structure and in vitro hypoglycemic effect

(2020) Xianghe Meng et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Extraction of Natural Pigments from Gardenia Jasminoides J.Ellis Fruit Pulp Using CO2-Expanded Liquids and Direct Sonication

(2020) Hiroki Sakai et al.   Separations

Crocetin ameliorates chronic restraint stress-induced depression-like behaviors in mice by regulating MEK/ERK pathways and gut microbiota

(2020) Susu Lin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Evaluation of inhibitory effects of geniposide on a tumor model of human breast cancer based on 3D printed Cs/Gel hybrid scaffold

(2020) Kena Lv et al.   Materials Science & Engineering C-Materials for Biological Applications

Comparative Analysis of Sixteen Active Compounds and Antioxidant and Anti-influenza Properties of Gardenia jasminoides Fruits at Different Times and Application to the Determination of the Appropriate Harvest Period with Hierarchical Cluster Analysis

(2019) Ming-Qiu Shan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-depressant effects of oil from fructus gardeniae via PKA-CREB-BDNF signaling

(2019) Jie Ruan et al.   BIOSCIENCE REPORTS

Genipin protects rats against lipopolysaccharide-induced acute lung injury by reinforcing autophagy

(2019) Zhijie Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Geniposide protected hepatocytes from acetaminophen hepatotoxicity by down-regulating CYP 2E1 expression and inhibiting TLR 4/NF-κB signaling pathway

(2019) Sen Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Crocin ameliorates chronic obstructive pulmonary disease-induced depression via PI3K/Akt mediated suppression of inflammation

(2019) Yupeng Xie et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury

(2019) Xu Luo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Geniposide against atherosclerosis by inhibiting the formation of foam cell and lowering reverse lipid transport via p38/MAPK signaling pathways

(2019) Di Shen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice

(2019) Qingfeng Xiao et al.   PHYSIOLOGY & BEHAVIOR

Postharvest physiology of cut Gardenia jasminoides flowers

(2019) Fisun G. Çelikel et al.   SCIENTIA HORTICULTURAE

Stability assessment of crocetin and crocetin derivatives in Gardenia yellow pigment and Gardenia fruit pomace in presence of different cooking methods

(2019) Na Li et al.   FOOD CHEMISTRY

Crocin potentiates antioxidant defense system and improves oxidative damage in liver tissue in diabetic rats

(2018) Habib Yaribeygi et al.   BIOMEDICINE & PHARMACOTHERAPY

Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats

(2018) Hadeer O. Abou-Hany et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Genipin inhibits the invasion and migration of colon cancer cells by the suppression of HIF-1α accumulation and VEGF expression

(2018) Suk-young Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin

(2018) Cheryl A. Hobbs et al.   FOOD AND CHEMICAL TOXICOLOGY

Crocins pattern in saffron detected by UHPLC-MS/MS as marker of quality, process and traceability

(2018) R. Rocchi et al.   FOOD CHEMISTRY

Crocin alleviates coronary atherosclerosis via inhibiting lipid synthesis and inducing M2 macrophage polarization

(2018) Jing Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Preparation of five high-purity iridoid glycosides from Gardenia jasminoides Eills by molecularly imprinted solid-phase extraction integrated with preparative liquid chromatography

(2018) Lizong Chen et al.   JOURNAL OF SEPARATION SCIENCE

Geniposide improves repeated restraint stress-induced depression-like behavior in mice by ameliorating neuronal apoptosis via regulating GLP-1R/AKT signaling pathway

(2018) Yinghua Zhao et al.   NEUROSCIENCE LETTERS

Potential role of genipin in cancer therapy

(2018) Muthu K. Shanmugam et al.   PHARMACOLOGICAL RESEARCH

Repellency, toxicity, and anti-oviposition of essential oil of Gardenia jasminoides and its four major chemical components against whiteflies and mites

(2018) Tufail Ahmed Wagan et al.   Scientific Reports

Influence of crocetin on high-cholesterol diet induced atherosclerosis in rats via anti-oxidant activity together with inhibition of inflammatory response and p38 MAPK signaling pathway

(2018) Shu-Ling Diao et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Comparative anti-arthritic investigation of iridoid glycosides and crocetin derivatives from Gardenia jasminoides Ellis in Freund's complete adjuvant-induced arthritis in rats

(2018) Yaya Hu et al.   PHYTOMEDICINE

Geniposide regulates the miR-101/MKP-1/p38 pathway and alleviates atherosclerosis inflammatory injury in ApoE-/- mice

(2018) Saibo Cheng et al.   IMMUNOBIOLOGY

Novel anti-inflammatory target of geniposide: Inhibiting Itgβ1/Ras-Erk1/2 signal pathway via the miRNA-124a in rheumatoid arthritis synovial fibroblasts

(2018) Yan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Genipin protects d -galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the necroptosis-mediated inflammasome signaling

(2017) Min-Jong Seo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats

(2017) Lingling Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chemistry and bioactivity of Gardenia jasminoides

(2017) Wenping Xiao et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Instant and Persistent Antidepressant Response of Gardenia Yellow Pigment Is Associated with Acute Protein Synthesis and Delayed Upregulation of BDNF Expression in the Hippocampus

(2016) Ruyan Wu et al.   ACS Chemical Neuroscience

Geniposidic acid protected against ANIT-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2

(2016) Hao Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Selective Extraction of Gardenia Yellow and Geniposide from Gardenia jasminoides by Mechanochemistry

(2016) Wenhao Xu et al.   MOLECULES

Antidepressant-like effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus–pituitary–adrenal axis

(2015) Li Cai et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Geniposide alleviates inflammation by suppressing MeCP2 in mice with carbon tetrachloride-induced acute liver injury and LPS-treated THP-1 cells

(2015) Tao-tao Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: A randomized, double-blind, placebo-controlled, pilot clinical trial

(2015) Ali Talaei et al.   JOURNAL OF AFFECTIVE DISORDERS

Isolation and purification of six iridoid glycosides fromgardenia jasminoidesfruit by medium-pressure liquid chromatography combined with macroporous resin chromatography

(2015) Yun Wang et al.   JOURNAL OF SEPARATION SCIENCE

Systematic Separation and Purification of Iridoid Glycosides and Crocetin Derivatives fromGardenia jasminoidesEllis by High-speed Counter-current Chromatography

(2015) Yarong Wang et al.   PHYTOCHEMICAL ANALYSIS

Selective separation of geniposide and gardenia yellow from gardenia fruit by isopropanol/salt aqueous two-phase system

(2015) Hong-Ping Zhang et al.   SEPARATION SCIENCE AND TECHNOLOGY

Optimization of ultrasound-assisted extraction of gardenia fruit oil with bioactive components and their identification and quantification by HPLC-DAD/ESI-MS2

(2015) Xiaoshuang Cai et al.   Food & Function

Effects and mechanisms of Geniposide on rats with adjuvant arthritis

(2014) Miao-Miao Dai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-κB, MAPK and AP-1 signaling pathways in macrophages

(2014) Qinghai Shi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Evaluation of gardenia yellow using crocetin from alkaline hydrolysis based on ultra high performance liquid chromatography and high-speed countercurrent chromatography

(2014) Koichi Inoue et al.   JOURNAL OF SEPARATION SCIENCE

Optimization of Supercritical Fluid Extraction of Oil from the Fruit of Gardenia jasminoides and Its Antidepressant Activity

(2014) Weiwei Tao et al.   MOLECULES

Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction

(2013) Lili Guan et al.   EXPERIMENTAL GERONTOLOGY

P38 MAP Kinase Mediates Apoptosis After Genipin Treatment in Non^|^ndash;Small-Cell Lung Cancer H1299 Cells via a Mitochondrial Apoptotic Cascade

(2013) Xue Yang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Preparative separation of crocins and geniposide simultaneously from gardenia fruits using macroporous resin and reversed-phase chromatography

(2013) Jianyong Feng et al.   JOURNAL OF SEPARATION SCIENCE

A dietary colorant crocin mitigates arthritis and associated secondary complications by modulating cartilage deteriorating enzymes, inflammatory mediators and antioxidant status

(2012) M. Hemshekhar et al.   BIOCHIMIE

Simple and effective large-scale preparation of geniposide from fruit of Gardenia jasminoides Ellis using a liquid–liquid two-phase extraction

(2012) Min Zhou et al.   FITOTERAPIA

Genipin inhibits lipopolysaccharide-induced acute systemic inflammation in mice as evidenced by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis

(2012) Chia-Cheng Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models

(2012) Yunhe Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Fructus Gardenia (Gardenia jasminoidesJ. Ellis) phytochemistry, pharmacology of cardiovascular, and safety with the perspective of new drugs development

(2012) Hao Liu et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Enrichment and purification of gardenia yellow from Gardenia jasminoides var. radicans Makino by column chromatography technique

(2012) Jian-Fang Chen et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Homogenate extraction of gardenia yellow pigment from Gardenia Jasminoides Ellis fruit using response surface methodology

(2012) Xingyi Zhu et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Potential hepatotoxicity of geniposide, the major iridoid glycoside in dried ripe fruits ofGardenia jasminoides(Zhi-zi)

(2012) Yue Ding et al.   NATURAL PRODUCT RESEARCH

Cost-efficient and process-efficient separation of geniposide from Gardenia jasminoides Ellis by high-performance counter-current chromatography

(2012) Min Zhang et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Ultrasound-assisted extraction of geniposide from Gardenia jasminoides

(2012) Xin-Sheng Wang et al.   ULTRASONICS SONOCHEMISTRY

In vitro Sortagging of an Antibody Fab Fragment: Overcoming Unproductive Reactions of Sortase with Water and Lysine Side Chains

(2011) Sina Möhlmann et al.   CHEMBIOCHEM

Suppression of NF-κB pathway by crocetin contributes to attenuation of lipopolysaccharide-induced acute lung injury in mice

(2011) Ruhui Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A new method research for determination of natural pigment crocin yellow in foods by solid-phase extraction ultrahigh pressure liquid chromatography

(2011) Wenhan Yang et al.   JOURNAL OF CHROMATOGRAPHY A

Genipin, a constituent of Gardenia jasminoides Ellis, induces apoptosis and inhibits invasion in MDA-MB-231 breast cancer cells

(2011) Aree Moon   ONCOLOGY REPORTS

Genipin protects lipopolysaccharide-induced apoptotic liver damage in d-galactosamine-sensitized mice

(2010) Seok-Joo Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells

(2010) Kyong Nyon Nam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Crocin attenuates cisplatin-induced renal oxidative stress in rats

(2010) Bahareh Naghizadeh et al.   FOOD AND CHEMICAL TOXICOLOGY

Optimization of Supercritical Carbon Dioxide Extraction of Gardenia Fruit Oil and the Analysis of Functional Components

(2010) Wenhao He et al.   JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY

Crocin and geniposide profiles and radical scavenging activity of gardenia fruits (Gardenia jasminoides Ellis) from different cultivars and at the various stages of maturation

(2009) Yang Chen et al.   FITOTERAPIA

Extraction optimization of bioactive compounds (crocin, geniposide and total phenolic compounds) from Gardenia (Gardenia jasminoides Ellis) fruits with response surface methodology

(2009) Bin Yang et al.   Innovative Food Science & Emerging Technologies