Crocin alleviates the inflammation and oxidative stress responses associated with diabetic nephropathy in rats via NLRP3 inflammasomes

NADPH Oxidase Inhibition in Fibrotic Pathologies

(2020) Karen Bernard et al.   ANTIOXIDANTS & REDOX SIGNALING

Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2020) Boris Bikbov et al.   LANCET

ErHuang Formula Improves Renal Fibrosis in Diabetic Nephropathy Rats by Inhibiting CXCL6/JAK/STAT3 Signaling Pathway

(2020) Yu-Li Shen et al.   Frontiers in Pharmacology

Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes

(2020) Xueling Li et al.   Frontiers in Physiology

Protective Effects of Chromium Picolinate Against Diabetic-Induced Renal Dysfunction and Renal Fibrosis in Streptozotocin-Induced Diabetic Rats

(2020) Shan Shan Qi et al.   Biomolecules

Reactive oxygen species in renal vascular function

(2020) Nan Xu et al.   Acta Physiologica

Crocin inhibits the migration, invasion, and epithelial-mesenchymal transition of gastric cancer cells via miR-320/KLF5/HIF-1α signaling

(2019) Ying Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation

(2019) CongXiao Zhang et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

NLRP3 inflammasome negatively regulates podocyte autophagy in diabetic nephropathy

(2019) Yun Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crocin ameliorates chronic obstructive pulmonary disease-induced depression via PI3K/Akt mediated suppression of inflammation

(2019) Yupeng Xie et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress

(2019) Chandraiah Godugu et al.   PHYTOTHERAPY RESEARCH

Diosmin and crocin alleviate nephropathy in metabolic syndrome rat model: Effect on oxidative stress and low grade inflammation

(2018) Rania El-Fawal et al.   BIOMEDICINE & PHARMACOTHERAPY

Apocynin inhibited NLRP3/XIAP signalling to alleviate renal fibrotic injury in rat diabetic nephropathy

(2018) Rui Xin et al.   BIOMEDICINE & PHARMACOTHERAPY

Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes

(2018) Yochai Birnbaum et al.   CARDIOVASCULAR DRUGS AND THERAPY

Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats

(2018) Hadeer O. Abou-Hany et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Diabetic nephropathy: Is there a role for oxidative stress?

(2018) Manpreet K. Sagoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Crocin alleviates coronary atherosclerosis via inhibiting lipid synthesis and inducing M2 macrophage polarization

(2018) Jing Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Angiotensin II receptor blocker valsartan ameliorates cardiac fibrosis partly by inhibiting miR-21 expression in diabetic nephropathy mice

(2018) Jinyang Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Treatment with crocin improves cardiac dysfunction by normalizing autophagy and inhibiting apoptosis in STZ-induced diabetic cardiomyopathy

(2018) K. Feidantsis et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Cellular death, reactive oxygen species (ROS) and diabetic complications

(2018) Caroline Maria Oliveira Volpe et al.   Cell Death & Disease

Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis

(2018) Yachun Han et al.   Redox Biology

Crocin, a natural product attenuates lipopolysaccharide-induced anxiety and depressive-like behaviors through suppressing NF-kB and NLRP3 signaling pathway

(2018) Lang Zhang et al.   BRAIN RESEARCH BULLETIN

Effects of antidiabetic drugs on NLRP3 inflammasome activity, with a focus on diabetic kidneys

(2018) Habib Yaribeygi et al.   DRUG DISCOVERY TODAY

Crocin synergistically enhances the antiproliferative activity of 5-flurouracil through Wnt/PI3K pathway in a mouse model of colitis-associated colorectal cancer

(2018) Forouzan Amerizadeh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice

(2018) Ming Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Crocin Inhibits Apoptosis and Astrogliosis of Hippocampus Neurons Against Methamphetamine Neurotoxicity via Antioxidant and Anti-inflammatory Mechanisms

(2018) Monire Shafahi et al.   NEUROCHEMICAL RESEARCH

Optineurin inhibits NLRP3 inflammasome activation by enhancing mitophagy of renal tubular cells in diabetic nephropathy

(2018) Kehong Chen et al.   FASEB JOURNAL

Crocin Ameliorates Atopic Dermatitis Symptoms by down Regulation of Th2 Response via Blocking of NF-κB/STAT6 Signaling Pathways in Mice

(2018) Yoon-Young Sung et al.   Nutrients

Function of NLRP3 in the Pathogenesis and Development of Diabetic Nephropathy

(2017) Ying Fu et al.   MEDICAL SCIENCE MONITOR

Crocin attenuate Tumor Necrosis Factor-alpha (TNF-α) and interleukin-6 (IL-6) in streptozotocin-induced diabetic rat aorta

(2016) Saeed Samarghandian et al.   CYTOKINE

Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy

(2016) Yuan-ye Qiu et al.   PHARMACOLOGICAL RESEARCH

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

(2015) Jay C. Jha et al.   DIABETOLOGIA

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease

(2015) Merlin C. Thomas et al.   Nature Reviews Nephrology

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

Diabetic nephropathy: diagnosis and treatment

(2013) Daniel Fineberg et al.   Nature Reviews Endocrinology

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes

(2012) Mona Sedeek et al.   CLINICAL SCIENCE

Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

(2011) Juan F. Navarro-González et al.   Nature Reviews Nephrology

Crocin attenuates cisplatin-induced renal oxidative stress in rats

(2010) Bahareh Naghizadeh et al.   FOOD AND CHEMICAL TOXICOLOGY