Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases

Inhibition of TRIM8 restrains ischaemia-reperfusion-mediated cerebral injury by regulation of NF-κB activation associated inflammation and apoptosis

(2020) Xue Bai et al.   EXPERIMENTAL CELL RESEARCH

Geniposide effectively reverses cognitive impairment and inhibits pathological cerebral damage by regulating the mTOR Signal pathway in APP∕PS1 mice

(2020) Zhihua Zhang et al.   NEUROSCIENCE LETTERS

Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids

(2020) Jinxin Liu et al.   PHARMACOLOGICAL RESEARCH

miR-221-3p Drives the Shift of M2-Macrophages to a Pro-Inflammatory Function by Suppressing JAK3/STAT3 Activation

(2020) Lilian Quero et al.   Frontiers in Immunology

Geniposide Balances the Redox Signaling to Mediate Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells

(2020) Chunyan Liu et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Geniposide alleviates atherosclerosis by regulating macrophage polarization via the FOS/MAPK signaling pathway

(2020) Zheng Jin et al.   BIOMEDICINE & PHARMACOTHERAPY

Dual Targeting of Monomeric Tau and α-Synuclein Aggregation: A New Multitarget Therapeutic Strategy for Neurodegeneration

(2020) Moustafa T. Gabr et al.   ACS Chemical Neuroscience

3-Hydroxyisobutyrate, a Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism

(2020) Mona S. Nilsen et al.   DIABETES

Inhibition of Rheumatoid Arthritis Using Bark, Leaf, and Male Flower Extracts of Eucommia ulmoides

(2020) Yun-Yun Xing et al.   Evidence-based Complementary and Alternative Medicine

Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/GSK-3β

(2020) Haixiao Liu et al.   EXPERIMENTAL NEUROLOGY

Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen–glucose deprivation/reoxygenation

(2020) Chen Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of autophagy by geniposide protects against myocardial ischemia/reperfusion injury

(2020) Xuexiu Luo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

(–)-Epicatechin Modulates Mitochondrial Redox in Vascular Cell Models of Oxidative Stress

(2020) Amy Keller et al.   Oxidative Medicine and Cellular Longevity

Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

(2020) Karpagam Srinivasan et al.   Cell Reports

Sphingosine kinase 1/sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 pathway: A novel target of geniposide to inhibit angiogenesis

(2020) Minghui Sun et al.   LIFE SCIENCES

Immunity and Inflammation in Atherosclerosis

(2019) Dennis Wolf et al.   CIRCULATION RESEARCH

Comparative Analysis of Sixteen Active Compounds and Antioxidant and Anti-influenza Properties of Gardenia jasminoides Fruits at Different Times and Application to the Determination of the Appropriate Harvest Period with Hierarchical Cluster Analysis

(2019) Ming-Qiu Shan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Attenuation of Myocardial ischemia reperfusion injury by Geniposide preconditioning in diabetic rats

(2019) Jia wang et al.   Current Research in Translational Medicine

Vital Signs: Epidemiology and Recent Trends in Methicillin-Resistant and in Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections — United States

(2019) Athena P. Kourtis et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Gardenia Decoction Prevent Intestinal Mucosal Injury by Inhibiting Pro-inflammatory Cytokines and NF-κB Signaling

(2019) Yizhe Cui et al.   Frontiers in Pharmacology

Genipin enhances the therapeutic effects of oxaliplatin by upregulating BIM in colorectal cancer

(2019) Bo Ram Kim et al.   MOLECULAR CANCER THERAPEUTICS

UHPLC–MS/MS analysis of sphingosine 1‐phosphate in joint cavity dialysate and hemodialysis solution of adjuvant arthritis rats: Application to geniposide pharmacodynamic study

(2019) Dai Xuejing et al.   BIOMEDICAL CHROMATOGRAPHY

Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease

(2019) Zhihua Zhang et al.   Aging-US

Comparative pharmacokinetic study of four major bioactive components after oral administration of Zhi‐Zi‐Hou‐Po decoction in normal and corticosterone‐induced depressive rats

(2019) Yongtao Bai et al.   BIOMEDICAL CHROMATOGRAPHY

Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle

(2019) Yan Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Penta-acetyl geniposide induces apoptosis of fibroblast-like synoviocytes from adjuvant-induced arthritis rats in vitro, associated with inhibition of NF-κB activation

(2019) Li Cai et al.   Pharmacological Reports

Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis

(2019) Javier Rodríguez-Ubreva et al.   ANNALS OF THE RHEUMATIC DISEASES

Unfolded protein response is involved in geniposide-regulating glucose-stimulated insulin secretion in INS-1 cells

(2019) Yanan Hao et al.   CELL BIOCHEMISTRY AND FUNCTION

Geniposide protects against hypoxia/reperfusion-induced blood-brain barrier impairment by increasing tight junction protein expression and decreasing inflammation, oxidative stress, and apoptosis in an in vitro system

(2019) Changxiang Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroinflammation and functional connectivity in Alzheimer's disease: interactive influences on cognitive performance

(2019) L. Passamonti et al.   JOURNAL OF NEUROSCIENCE

Topical ocular administration of the GLP-1 receptor agonist liraglutide arrests hyperphosphorylated tau-triggered diabetic retinal neurodegeneration via activation of GLP-1R/Akt/GSK3β signaling

(2019) Xingsheng Shu et al.   NEUROPHARMACOLOGY

Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades

(2019) Michelle K. Y. Siu et al.   Cancers

Three percent annually on systemic glucocorticoids: facts, worries and perspectives

(2019) Onno C. Meijer et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Gardenia jasminoides extract without crocin improved atopic dermatitis-like skin lesions via suppression of Th2-related cytokines in Dfe-induced NC/Nga mice

(2019) Sun Haeng Park et al.   JOURNAL OF ETHNOPHARMACOLOGY

Regulatory innate lymphoid cells suppress innate immunity and reduce renal ischemia/reperfusion injury

(2019) Qi Cao et al.   KIDNEY INTERNATIONAL

Role of intestinal microbiota-mediated genipin dialdehyde intermediate formation in geniposide-induced hepatotoxicity in rats

(2019) Yi Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Aβ43 in human Alzheimer’s disease: effects of active Aβ42 immunization

(2019) Lieke Jäkel et al.   Acta Neuropathologica Communications

Apolipoprotein AI) Promotes Atherosclerosis Regression in Diabetic Mice by Suppressing Myelopoiesis and Plaque Inflammation

(2019) Tessa J. Barrett et al.   CIRCULATION

NF‐E2‐related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin‐1 mutated Alzheimer's disease astrocytes

(2019) Minna Oksanen et al.   GLIA

MicroRNAs as Potential Biomarkers in Atherosclerosis

(2019) Alexey Churov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Maresin1 Decreased Microglial Chemotaxis and Ameliorated Inflammation Induced by Amyloid-β42 in Neuron-Microglia Co-Culture Models

(2019) Ping Yin et al.   JOURNAL OF ALZHEIMERS DISEASE

Proteomic Investigations of Transcription Factors Critical in Geniposide-Mediated Suppression of Alcoholic Steatosis and in Overdose-Induced Hepatotoxicity on Liver in Rats

(2019) Junying Wei et al.   JOURNAL OF PROTEOME RESEARCH

Nrf2 Activation Protects Mouse Beta Cells from Glucolipotoxicity by Restoring Mitochondrial Function and Physiological Redox Balance

(2019) Johanna Schultheis et al.   Oxidative Medicine and Cellular Longevity

Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats

(2019) Songyan Yu et al.   Stem Cell Research & Therapy

Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages

(2019) Hongrui Guo et al.   Aging-US

Geniposide against atherosclerosis by inhibiting the formation of foam cell and lowering reverse lipid transport via p38/MAPK signaling pathways

(2019) Di Shen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Linking APOE-ε4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology

(2019) Joost M. Riphagen et al.   NEUROBIOLOGY OF AGING

The protective effect of Geniposide on diabetic cognitive impairment through BTK/TLR4/NF-κB pathway

(2019) Shengnan Liu et al.   PSYCHOPHARMACOLOGY

Schisandrin A protects intestinal epithelial cells from deoxynivalenol-induced cytotoxicity, oxidative damage and inflammation

(2019) Murphy L. Y. Wan et al.   Scientific Reports

Short-term and low-dose IL-2 therapy restores the Th17/Treg balance in the peripheral blood of patients with primary Sjögren’s syndrome

(2018) Miao Miao et al.   ANNALS OF THE RHEUMATIC DISEASES

Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells

(2018) Ennian Leng et al.   BMC Complementary and Alternative Medicine

Low-level shear stress promotes migration of liver cancer stem cells via the FAK-ERK1/2 signalling pathway

(2018) Jinghui Sun et al.   CANCER LETTERS

Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1

(2018) Di Ye et al.   Epigenetics

Geniposide improves hepatic inflammation in diabetic db/db mice

(2018) Xiaolei Hu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Fecal Metabolomics of Type 2 Diabetic Rats and Treatment with Gardenia jasminoides Ellis Based on Mass Spectrometry Technique

(2018) Yuan Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oral chronic toxicity study of geniposide in rats

(2018) Jingzhuo Tian et al.   JOURNAL OF ETHNOPHARMACOLOGY

Microglia-Mediated Synapse Loss in Alzheimer's Disease

(2018) Lawrence Rajendran et al.   JOURNAL OF NEUROSCIENCE

Taming Immune and Inflammatory Responses to Treat Atherosclerosis ∗

(2018) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Microdialysis in Adjuvant Arthritic Rats for Pharmacokinetics–Pharmacodynamics Modeling Study of Geniposide with Determination of Drug Concentration and Efficacy Levels in Dialysate

(2018) Ran Deng et al.   MOLECULES

Immunosuppressive Effect of Geniposide on Mitogen-Activated Protein Kinase Signalling Pathway and Their Cross-Talk in Fibroblast-Like Synoviocytes of Adjuvant Arthritis Rats

(2018) Feng Li et al.   MOLECULES

Geniposide Increases Unfolded Protein Response-Mediating HRD1 Expression to Accelerate APP Degradation in Primary Cortical Neurons

(2018) Huaqing Cui et al.   NEUROCHEMICAL RESEARCH

Geniposide improves repeated restraint stress-induced depression-like behavior in mice by ameliorating neuronal apoptosis via regulating GLP-1R/AKT signaling pathway

(2018) Yinghua Zhao et al.   NEUROSCIENCE LETTERS

Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation End-Products in Diabetic Mice Kidney

(2018) Moon Do et al.   Nutrients

Obesity and Insulin Resistance Promote Atherosclerosis through an IFNγ-Regulated Macrophage Protein Network

(2018) Catherine A. Reardon et al.   Cell Reports

Anti-inflammatory Mechanism of Geniposide: Inhibiting the Hyperpermeability of Fibroblast-Like Synoviocytes via the RhoA/p38MAPK/NF-κB/F-Actin Signal Pathway

(2018) Ran Deng et al.   Frontiers in Pharmacology

Therapeutic Effect of Penta-acetyl Geniposide on Adjuvant-Induced Arthritis in Rats: Involvement of Inducing Synovial Apoptosis and Inhibiting NF-κB Signal Pathway

(2018) Li Cai et al.   INFLAMMATION

Comparative anti-arthritic investigation of iridoid glycosides and crocetin derivatives from Gardenia jasminoides Ellis in Freund's complete adjuvant-induced arthritis in rats

(2018) Yaya Hu et al.   PHYTOMEDICINE

Pro-inflammatory cytokines: The link between obesity and osteoarthritis

(2018) Tiantian Wang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Geniposide regulates the miR-101/MKP-1/p38 pathway and alleviates atherosclerosis inflammatory injury in ApoE-/- mice

(2018) Saibo Cheng et al.   IMMUNOBIOLOGY

Novel anti-inflammatory target of geniposide: Inhibiting Itgβ1/Ras-Erk1/2 signal pathway via the miRNA-124a in rheumatoid arthritis synovial fibroblasts

(2018) Yan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Crocin Ameliorates Atopic Dermatitis Symptoms by down Regulation of Th2 Response via Blocking of NF-κB/STAT6 Signaling Pathways in Mice

(2018) Yoon-Young Sung et al.   Nutrients

Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling

(2017) Saowanee Jeayeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Preventive effect of Eucommia leaf extract on aortic media hypertrophy in Wistar-Kyoto rats fed a high-fat diet

(2017) Shingo Hosoo et al.   HYPERTENSION RESEARCH

Geniposide Suppresses Interleukin-1β-Induced Inflammation and Apoptosis in Rat Chondrocytes via the PI3K/Akt/NF-κB Signaling Pathway

(2017) Tianlong Pan et al.   INFLAMMATION

Administration of geniposide ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of inflammation and mucosal damage

(2017) Zecai Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats

(2017) Lingling Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Online microdialysis-ultra performance liquid chromatography–mass spectrometry method for comparative pharmacokinetic investigation on iridoids from Gardenia jasminoides Ellis in rats with different progressions of type 2 diabetic complications

(2017) Xueju Zhang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

Geniposide promotes autophagy to inhibit insulin resistance in HepG2 cells via P62/NF-κB/GLUT-4

(2017) Hongwei Jiang et al.   Molecular Medicine Reports

Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease

(2017) Ruohe Zhao et al.   Molecular Neurodegeneration

A Review on the Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Geniposide, a Natural Product

(2017) Mingqiu Shan et al.   MOLECULES

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Geniposide ameliorates cognitive deficits by attenuating the cholinergic defect and amyloidosis in middle-aged Alzheimer model mice

(2017) Chunhui Zhao et al.   NEUROPHARMACOLOGY

Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen-Induced Arthritis

(2017) Rong Wang et al.   PHYTOTHERAPY RESEARCH

Immune Tolerance Effect in Mesenteric Lymph Node Lymphocytes of Geniposide on Adjuvant Arthritis Rats

(2017) Zheng-Rong Zhang et al.   PHYTOTHERAPY RESEARCH

Protective Effects of Geniposide on Hepatic Ischemia/Reperfusion Injury

(2017) Y.-P. Rong et al.   TRANSPLANTATION PROCEEDINGS

Geniposide Alleviates Amyloid-Induced Synaptic Injury by Protecting Axonal Mitochondrial Trafficking

(2017) Haijing Zhang et al.   Frontiers in Cellular Neuroscience

Dissect new mechanistic insights for geniposide efficacy on the hepatoprotection using multiomics approach

(2017) Shi Qiu et al.   Oncotarget

Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation

(2017) Jingzhuo Tian et al.   Scientific Reports

Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation

(2016) Judith Miklossy et al.   Aging-US

Formoterol decreases muscle wasting as well as inflammation in the rat model of rheumatoid arthritis

(2016) Ana Belén Gómez-SanMiguel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Geniposide Suppresses Hepatic Glucose Production via AMPK in HepG2 Cells

(2016) Lixia Guo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Geniposide Prevents Hypoxia/Reoxygenation-Induced Apoptosis in H9c2 Cells: Improvement of Mitochondrial Dysfunction and Activation of GLP-1R and the PI3K/AKT Signaling Pathway

(2016) You-Qin Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MicroRNA Regulation of Atherosclerosis

(2016) Mark W. Feinberg et al.   CIRCULATION RESEARCH

Geniposide reduces development of streptozotocin-induced diabetic nephropathy via regulating nuclear factor-kappa B signaling pathways

(2016) Xiaolei Hu et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Comparative investigation on the pharmacokinetics of geniposide in type 2 diabetic and normal rats after oral administration of Fructus Gradeniae extract

(2016) Li-Hua He et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Extract from Eucommia ulmoides Oliv. ameliorates arthritis via regulation of inflammation, synoviocyte proliferation and osteoclastogenesis in vitro and in vivo

(2016) Jian-Ying Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Geniposide alleviates depression-like behavior via enhancing BDNF expression in hippocampus of streptozotocin-evoked mice

(2016) Junming Wang et al.   METABOLIC BRAIN DISEASE

Evaluation of the Antidepressant Activity, Hepatotoxicity and Blood Brain Barrier Permeability of Methyl Genipin

(2016) Xin Che et al.   MOLECULES

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Simultaneous Determination of Catalpol, Aucubin, and Geniposidic Acid in Different Developmental Stages ofRehmannia glutinosaLeaves by High Performance Liquid Chromatography

(2016) Yanjie Wang et al.   Journal of Analytical Methods in Chemistry

Geniposide accelerates proteasome degradation of Txnip to inhibit insulin secretion in pancreatic β-cells

(2016) C. Y. Liu et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Geniposide Attenuates the Phosphorylation of Tau Protein in Cellular and Insulin-deficient APP/PS1 Transgenic Mouse Model of Alzheimer's Disease

(2015) Yonglan Zhang et al.   Chemical Biology & Drug Design

Cell Signaling Mechanisms by which Geniposide Regulates Insulin- Degrading Enzyme Expression in Primary Cortical Neurons

(2015) Yonglan Zhang et al.   CNS & Neurological Disorders-Drug Targets

Antidepressant-like effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus–pituitary–adrenal axis

(2015) Li Cai et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Apoptotic Effect of Geniposide on Fibroblast-Like Synoviocytes in Rats with Adjuvant-Induced Arthritis via Inhibiting ERK Signal Pathway In Vitro

(2015) Rong Li et al.   INFLAMMATION

Anti-inflammatory effects and pharmacokinetics study of geniposide on rats with adjuvant arthritis

(2015) Jin-Yun Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Determination of geniposide in adjuvant arthritis rat plasma by ultra-high performance liquid chromatography tandem mass spectrometry method and its application to oral bioavailability and plasma protein binding ability studies

(2015) Jian Chen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Geniposide prevents rotenone-induced apoptosis in primary cultured neurons

(2015) Yue-ze Liu et al.   Neural Regeneration Research

Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS1 transgenic model of Alzheimer’s disease

(2015) Yonglan Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model

(2015) Cui Lv et al.   NEUROPHARMACOLOGY

New Insights for Oxidative Stress and Diabetes Mellitus

(2015) Kenneth Maiese   Oxidative Medicine and Cellular Longevity

Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and AβAccumulation

(2015) Maja Jazvinšćak Jembrek et al.   Oxidative Medicine and Cellular Longevity

Obesity, insulin resistance, and type 1 diabetes mellitus

(2015) Sarit Polsky et al.   Current Opinion in Endocrinology Diabetes and Obesity

Geniposide promotes beta-cell regeneration and survival through regulating β-catenin/TCF7L2 pathway

(2015) D D Yao et al.   Cell Death & Disease

Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice

(2014) Seung-Hwan Kwon et al.   Biomolecules & Therapeutics

Geniposide protects pancreatic INS-1E β cells from hIAPP-induced cell damage: Potential involvement of insulin degrading-enzyme

(2014) Yonglan Zhang et al.   CELL BIOLOGY INTERNATIONAL

Geniposide Attenuates Oligomeric Aβ1-42-Induced Inflammatory Response by Targeting RAGE-Dependent Signaling in BV2 Cells

(2014) Cui Lv et al.   Current Alzheimer Research

Geniposide Attenuates Mitochondrial Dysfunction and Memory Deficits in APP/PS1 Transgenic Mice

(2014) Cui Lv et al.   Current Alzheimer Research

Baicalin and geniposide attenuate atherosclerosis involving lipids regulation and immunoregulation in ApoE−/− mice

(2014) Pingping Liao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification and distribution of four metabolites of geniposide in rats with adjuvant arthritis

(2014) Jian Chen et al.   FITOTERAPIA

Effects and mechanisms of Geniposide on rats with adjuvant arthritis

(2014) Miao-Miao Dai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The effect of stroke and other components in Xing-Nao-Jing on the pharmacokinetics of geniposide

(2014) Pan Xu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Proteomic Investigation of Signatures for Geniposide-Induced Hepatotoxicity

(2014) Junying Wei et al.   JOURNAL OF PROTEOME RESEARCH

Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat

(2014) Yan Huo et al.   MOLECULES

Simultaneous determination of bioactive marker compounds from Gardeniae fructus by high performance liquid chromatography

(2013) Eun Ju Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Protective Effects of Geniposide and Genipin against Hepatic Ischemia/Reperfusion Injury in Mice

(2013) Joonki Kim et al.   Biomolecules & Therapeutics

Pharmacokinetics, bioavailability and tissue distribution of geniposide following intravenous and peroral administration to rats

(2013) Fugang Wang et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Geniposide Ameliorates Learning Memory Deficits, Reduces Tau Phosphorylation and Decreases Apoptosis via GSK3β Pathway in Streptozotocin-Induced Alzheimer Rat Model

(2013) Chong Gao et al.   BRAIN PATHOLOGY

Effects of borneol on the pharmacokinetics of geniposide in cortex, hippocampus, hypothalamus and striatum of conscious rat by simultaneous brain microdialysis coupled with UPLC–MS

(2013) Bin Yu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Eucommia ulmoides Oliver Extract, Aucubin, and Geniposide Enhance Lysosomal Activity to Regulate ER Stress and Hepatic Lipid Accumulation

(2013) Hwa-Young Lee et al.   PLoS One

Rehmannia glutinosa Suppresses Inflammatory Responses Elicited by Advanced Glycation End Products

(2012) Gui-Hyun Baek et al.   INFLAMMATION

The effects of notoginsenoside R1 on the intestinal absorption of geniposide by the everted rat gut sac model

(2012) Sa Chula et al.   JOURNAL OF ETHNOPHARMACOLOGY

Potential hepatotoxicity of geniposide, the major iridoid glycoside in dried ripe fruits ofGardenia jasminoides(Zhi-zi)

(2012) Yue Ding et al.   NATURAL PRODUCT RESEARCH

Geniposide Reduces Inflammatory Responses of Oxygen-Glucose Deprived Rat Microglial Cells via Inhibition of the TLR4 Signaling Pathway

(2012) Jun Wang et al.   NEUROCHEMICAL RESEARCH

Antithrombotic activities of aqueous extract fromGardenia jasminoidesand its main constituent

(2012) Hai-yan Zhang et al.   PHARMACEUTICAL BIOLOGY

Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicity-induced β-cell apoptosis

(2012) Jianhui Liu et al.   TOXICOLOGY IN VITRO

Glucagon-like peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells

(2011) Li-xia Guo et al.   ACTA PHARMACOLOGICA SINICA

Preventive Effect of Geniposide on Metabolic Disease Status in Spontaneously Obese Type 2 Diabetic Mice and Free Fatty Acid-Treated HepG2 Cells

(2011) Kazuko Kojima et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Role of reactive oxygen and nitrogen species in the vascular responses to inflammation

(2011) Peter R. Kvietys et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis

(2011) Taotao Ma et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Geniposide inhibits high glucose-induced cell adhesion through the NF-κB signaling pathway in human umbilical vein endothelial cells

(2010) Guang-fa Wang et al.   ACTA PHARMACOLOGICA SINICA

Ameliorative effect of Eucommia ulmoides Oliv. leaves extract (ELE) on insulin resistance and abnormal perivascular innervation in fructose-drinking rats

(2010) Xin Jin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Characterization and identification of saponins in Achyranthes bidentata by rapid-resolution liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry

(2010) Yan-Jing Li et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway

(2009) Jian-hui Liu et al.   ACTA PHARMACOLOGICA SINICA

Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin

(2009) Shao-yu Wu et al.   ACTA PHARMACOLOGICA SINICA

Inhibitory effect of penta-acetyl geniposide on C6 glioma cells metastasis by inhibiting matrix metalloproteinase-2 expression involved in both the PI3K and ERK signaling pathways

(2009) Hui-Pei Huang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Studies on the antioxidant activity and phenolic compounds of enzyme-assisted water extracts from Du-zhong (Eucommia ulmoidesOliv.) leaves

(2009) Jiyang Luo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Interleukin-6 Receptor Gene, Plasma C-Reactive Protein, and Diabetes Risk in Women

(2008) L. Qi et al.   DIABETES

Genetic Relationships amongRehmannia glutinosaCultivars and Varieties

(2008) Jianjun Qi et al.   PLANTA MEDICA