Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice

Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway

(2020) Shihao Xiang et al.   Drug Design Development and Therapy

FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway

(2020) Xue Wang et al.   Frontiers in Pharmacology

Direct inhibition of TLR4/MyD88 pathway by geniposide suppresses HIF1α‐independent VEGF expression and hepatocellular carcinoma angiogenesis

(2020) Cheng Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Matrine alleviates neurobehavioral alterations via modulation of JNK-mediated caspase-3 and BDNF/VEGF signaling in a mouse model of burn injury

(2020) Adnan Khan et al.   PSYCHOPHARMACOLOGY

Major depression accompanied with inflammation and multiple cytokines alterations: Evidences from clinical patients to macaca fascicularis and LPS-induced depressive mice model

(2020) Yong He et al.   JOURNAL OF AFFECTIVE DISORDERS

EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice

(2020) Wei Wang et al.   JOURNAL OF AFFECTIVE DISORDERS

Phenol glycosides extract of Fructus Ligustri Lucidi attenuated depressive‐like behaviors by suppressing neuroinflammation in hypothalamus of mice

(2020) Rui Feng et al.   PHYTOTHERAPY RESEARCH

Antidepressant-like effect of a selenopropargylic benzamide in mice: involvement of the serotonergic system

(2020) Evelyn Mianes Besckow et al.   PSYCHOPHARMACOLOGY

ZYBT1, a potent, irreversible Bruton’s Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer

(2020) Krishnarup Ghoshdastidar et al.   Pharmacology Research & Perspectives

hUC-MSCs ameliorated CUMS-induced depression by modulating complement C3 signaling-mediated microglial polarization during astrocyte-microglia crosstalk

(2020) Jing Li et al.   BRAIN RESEARCH BULLETIN

Mechanism of TREM2/DAP12 complex affecting β-amyloid plaque deposition in Alzheimer's disease modeled mice through mediating inflammatory response

(2020) Xin Cui et al.   BRAIN RESEARCH BULLETIN

Differential serum exosome microRNA profile in a stress-induced depression rat model

(2020) Ke Fang et al.   JOURNAL OF AFFECTIVE DISORDERS

The role of CCR5 in the protective effect of Esculin on lipopolysaccharide-induced depressive symptom in mice

(2020) Tong Chen et al.   JOURNAL OF AFFECTIVE DISORDERS

Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats

(2020) Fatma Z. Sakhri et al.   PHYTOTHERAPY RESEARCH

Inhibition of Bruton’s Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer’s Disease

(2019) James Keaney et al.   Journal of Neuroimmune Pharmacology

Design, synthesis and evaluation of novel 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as potent, selective and reversible Bruton's tyrosine kinase (BTK) inhibitors for the treatment of rheumatoid arthritis

(2019) Chufeng Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Geniposide protects against hypoxia/reperfusion-induced blood-brain barrier impairment by increasing tight junction protein expression and decreasing inflammation, oxidative stress, and apoptosis in an in vitro system

(2019) Changxiang Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hyperbaric oxygen preconditioning attenuates brain injury after intracerebral hemorrhage by regulating microglia polarization in rats

(2019) Ming Wang et al.   CNS Neuroscience & Therapeutics

Combination of Geniposide and Eleutheroside B Exerts Antidepressant-like Effect on Lipopolysaccharide-Induced Depression Mice Model

(2019) Bo Zhang et al.   Chinese Journal of Integrative Medicine

Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats

(2019) Hong Fan et al.   Journal of Neuroinflammation

Tau deposition is associated with functional isolation of the hippocampus in aging

(2019) Theresa M. Harrison et al.   Nature Communications

Effect and Mechanism of the Bruton Tyrosine Kinase (Btk) Inhibitor Ibrutinib on Rat Model of Diabetic Foot Ulcers

(2019) Xuedong Yang et al.   MEDICAL SCIENCE MONITOR

Hippocampal metabolic alteration in rat exhibited susceptibility to prenatal stress

(2019) Huifang Zhang et al.   JOURNAL OF AFFECTIVE DISORDERS

Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1/M2 Polarization through NF-κB Pathway

(2019) Rui Zhao et al.   NEUROSCIENCE

The protective effect of Geniposide on diabetic cognitive impairment through BTK/TLR4/NF-κB pathway

(2019) Shengnan Liu et al.   PSYCHOPHARMACOLOGY

Therapeutic Strategies for Treatment of Inflammation-related Depression

(2018) Miroslav Adzic et al.   Current Neuropharmacology

Effects of microRNA-10a on synapse remodeling in hippocampal neurons and neuronal cell proliferation and apoptosis through the BDNF-TrkB signaling pathway in a rat model of Alzheimer's disease

(2018) Bo-Wen Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease

(2018) Ean-Jeong Seo et al.   PHARMACOLOGICAL RESEARCH

B-cell receptor-mediated NFATc1 activation induces IL-10/STAT3/PD-L1 signaling in diffuse large B-cell lymphoma

(2018) Li Li et al.   BLOOD

Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice

(2018) Hye Yeon Nam et al.   Journal of Neuroinflammation

TLR Signaling Is Activated in Lymph Node–Resident CLL Cells and Is Only Partially Inhibited by Ibrutinib

(2018) Eman L. Dadashian et al.   CANCER RESEARCH

Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity

(2017) Alexander N. R. Weber et al.   Frontiers in Immunology

Targeted therapies for CLL: Practical issues with the changing treatment paradigm

(2016) Nitin Jain et al.   BLOOD REVIEWS

Geniposide alleviates depression-like behavior via enhancing BDNF expression in hippocampus of streptozotocin-evoked mice

(2016) Junming Wang et al.   METABOLIC BRAIN DISEASE

The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression

(2016) Yong-Ku Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Antidepressant-like effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus–pituitary–adrenal axis

(2015) Li Cai et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Genipin attenuates lipopolysaccharide-induced persistent changes of emotional behaviors and neural activation in the hypothalamic paraventricular nucleus and the central amygdala nucleus

(2014) Ryota Araki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Btk Regulates Macrophage Polarization in Response to Lipopolysaccharide

(2014) Joan Ní Gabhann et al.   PLoS One