Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel

Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence

(2023) Mohammad Rafi Khezri et al.   Cell Communication and Signaling

The Cytokine CX3CL1 and ADAMs/MMPs in Concerted Cross-Talk Influencing Neurodegenerative Diseases

(2023) Matilda Iemmolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NF‐κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective

(2023) Mohammed Alrouji et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Insights on benzodiazepines' potential in Alzheimer's disease

(2023) Hayder M. Al-Kuraishy et al.   LIFE SCIENCES

The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer’s diseases

(2023) Mohammed Alrouji et al.   Diabetology & Metabolic Syndrome

Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena

(2023) Faisal Holil AlAnazi et al.   Journal of Diabetes

Pros and cons for statins use and risk of Parkinson's disease: An updated perspective

(2023) Hayder M. Al‐kuraishy et al.   Pharmacology Research & Perspectives

The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation

(2023) Haydar M. Al-kuraishy et al.   AGEING RESEARCH REVIEWS

The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways

(2023) Haydar M. Al-kuraishy et al.   AGEING RESEARCH REVIEWS

The beneficial role of autophagy in multiple sclerosis: Yes or No?

(2023) Hayder M. Al-kuraishy et al.   Autophagy

New insights on the potential anti‐epileptic effect of metformin: Mechanistic pathway

(2023) Saud A. Alnaaim et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pathogenic Role of Fibrinogen in the Neuropathology of Multiple Sclerosis: A Tale of Sorrows and Fears

(2023) Mubarak Alruwaili et al.   NEUROCHEMICAL RESEARCH

Amyloid-β: A potential mediator of aging-related vascular pathologies

(2023) Fazlullah Khan et al.   VASCULAR PHARMACOLOGY

Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease

(2023) Shingo Ito et al.   Fluids and Barriers of the CNS

Alpha- and Gamma-Tocopherol Modulates the Amyloidogenic Pathway of Amyloid Precursor Protein in an in vitro Model of Alzheimer’s Disease: A Transcriptional Study

(2022) Aslina Pahrudin Arrozi et al.   Frontiers in Cellular Neuroscience

DYRK1A regulates the bidirectional axonal transport of APP in human-derived neurons

(2022) Iván Fernandez Bessone et al.   JOURNAL OF NEUROSCIENCE

Physiology and pharmacology of amyloid precursor protein

(2022) Yoonsuk Cho et al.   PHARMACOLOGY & THERAPEUTICS

Autophagy activation by Terminalia chebula Retz. reduce Aβ generation by shifting APP processing toward non-amyloidogenic pathway in APPswe transgenic SH-SY5Y cells

(2022) Longhe Zhao et al.   PHYTOMEDICINE

Amyloid β, Lipid Metabolism, Basal Cholinergic System, and Therapeutics in Alzheimer’s Disease

(2022) Victoria Campos-Peña et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Statins Use in Alzheimer Disease: Bane or Boon from Frantic Search and Narrative Review

(2022) Nawal Alsubaie et al.   Brain Sciences

A Potential Link Between Visceral Obesity and Risk of Alzheimer’s Disease

(2022) Hayder M. Al-Kuraishy et al.   NEUROCHEMICAL RESEARCH

Metformin and growth differentiation factor 15 ( GDF15 ) in type 2 diabetes mellitus: A hidden treasure

(2022) Hayder M. Al‐kuraishy et al.   Journal of Diabetes

Targeting of neuroinflammation by glibenclamide in Covid-19: old weapon from arsenal

(2022) Gaber El-Saber Batiha et al.   INFLAMMOPHARMACOLOGY

Benzodiazepines in Alzheimer’s disease: beneficial or detrimental effects

(2022) Hayder M. Al-kuraishy et al.   INFLAMMOPHARMACOLOGY

SIRT1 pathway in Parkinson’s disease: a faraway snapshot but so close

(2022) Gaber El-Saber Batiha et al.   INFLAMMOPHARMACOLOGY

Role of Hypoxia Inducible Factor-1α in Alzheimer’s Disease

(2021) Yang-Yang Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer’s Disease

(2021) Qing Xia et al.   MOLECULAR NEUROBIOLOGY

The Looming Effects of Estrogen in Covid-19: A Rocky Rollout

(2021) Hayder M. Al-kuraishy et al.   Frontiers in Nutrition

Exercise and estrogen: common pathways in Alzheimer's disease pathology

(2021) Ahmed Bagit et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse

(2021) Hallie Morton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antisense Oligonucleotide-Induced Amyloid Precursor Protein Splicing Modulation as a Therapeutic Approach for Dutch-Type Cerebral Amyloid Angiopathy

(2021) Elena Daoutsali et al.   Nucleic Acid Therapeutics

Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice

(2021) Wilma Helena Oliveira et al.   EXPERIMENTAL BRAIN RESEARCH

Metformin a Potential Pharmacological Strategy in Late Onset Alzheimer’s Disease Treatment

(2021) Saghar Rabiei Poor et al.   Pharmaceuticals

Quercetin stimulates the non-amyloidogenic pathway via activation of ADAM10 and ADAM17 gene expression in aluminum chloride-induced Alzheimer's disease rat model

(2021) Asmaa M. Elfiky et al.   LIFE SCIENCES

Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer’s disease

(2020) Balmiki Ray et al.   Translational Psychiatry

Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3

(2020) Martina Pigoni et al.   EMBO JOURNAL

Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer’s disease

(2020) Claudia P. Boix et al.   Alzheimers Research & Therapy

Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release

(2020) Rémi Opsomer et al.   eNeuro

Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria

(2020) Albin John et al.   AGEING RESEARCH REVIEWS

Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease

(2020) Yuanming Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission

(2019) Heather C. Rice et al.   SCIENCE

Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder

(2019) Deborah K. Sokol et al.   Frontiers in Psychiatry

Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology

(2019) Md. Farhad Hossain et al.   MOLECULAR NEUROBIOLOGY

Ganglioside GQ1b ameliorates cognitive impairments in an Alzheimer’s disease mouse model, and causes reduction of amyloid precursor protein

(2019) Min-Kyoo Shin et al.   Scientific Reports

A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease

(2019) Jodi A. Morrissey et al.   NEUROPHARMACOLOGY

Molecular targets and therapeutic interventions for iron induced neurodegeneration

(2019) Siddhi Bagwe-Parab et al.   BRAIN RESEARCH BULLETIN

Effects of progesterone on glucose uptake in neurons of Alzheimer's disease animals and cell models

(2019) Hang Wu et al.   LIFE SCIENCES

Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells

(2018) Ruohan Sun et al.   Aging-US

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroprotective effects of statins against amyloid β-induced neurotoxicity

(2018) Chien-Ning Huang et al.   Neural Regeneration Research

The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease

(2018) Holly M. Brothers et al.   Frontiers in Aging Neuroscience

Impairments in Brain-to-Blood Transport of Amyloid-β and Reabsorption of Cerebrospinal Fluid in an Animal Model of Alzheimer's Disease are Reversed by Antisense Directed Against Amyloid-β Protein Precursor

(2018) William A. Banks et al.   JOURNAL OF ALZHEIMERS DISEASE

In silico evidence of direct interaction between statins and β-amyloid

(2018) Neda Shakour et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Levels of ADAM10 are reduced in Alzheimer’s disease CSF

(2018) Aitana Sogorb-Esteve et al.   Journal of Neuroinflammation

Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET

(2018) Viktoria Zoufal et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer’s Disease

(2017) Patricia R. Manzine et al.   JOURNAL OF ALZHEIMERS DISEASE

Endothelium-specific amyloid precursor protein deficiency causes endothelial dysfunction in cerebral arteries

(2017) Livius V d’Uscio et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system

(2017) Lucas J. Sosa et al.   JOURNAL OF NEUROCHEMISTRY

Ginsenoside Rd promotes non-amyloidogenic pathway of amyloid precursor protein processing by regulating phosphorylation of estrogen receptor alpha

(2017) Xiaodong Yan et al.   LIFE SCIENCES

BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer’s Disease Pathology

(2017) Gerald Koelsch   MOLECULES

APP as a Protective Factor in Acute Neuronal Insults

(2017) Dimitri Hefter et al.   Frontiers in Molecular Neuroscience

Statins and the Squalene Synthase Inhibitor Zaragozic Acid Stimulate the Non-Amyloidogenic Pathway of Amyloid-β Protein Precursor Processing by Suppression of Cholesterol Synthesis

(2017) Elzbieta Kojro et al.   JOURNAL OF ALZHEIMERS DISEASE

Dysregulation of intracellular trafficking and endosomal sorting in Alzheimer's disease: controversies and unanswered questions

(2016) W. H. Toh et al.   BIOCHEMICAL JOURNAL

Ion channel regulation by β-secretase BACE1 – enzymatic and non-enzymatic effects beyond Alzheimer's disease

(2016) Sandra Lehnert et al.   Channels

Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction

(2016) Ming-Chang Chiang et al.   EXPERIMENTAL CELL RESEARCH

Functions of the Alzheimer’s Disease Protease BACE1 at the Synapse in the Central Nervous System

(2016) Kathryn M. Munro et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Alzheimer Mythology: A Time to Think Out of the Box

(2016) John E. Morley et al.   Journal of the American Medical Directors Association

Amyloid β precursor protein regulates neuron survival and maturation in the adult mouse brain

(2016) Shiwei Wang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

APP Receptor? To Be or Not To Be

(2016) Carole Deyts et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ADAM10: a new player in breast cancer progression?

(2015) Maeve Mullooly et al.   BRITISH JOURNAL OF CANCER

Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference

(2015) John E. Morley et al.   Journal of the American Medical Directors Association

The keystone of Alzheimer pathogenesis might be sought in Aβ physiology

(2015) D. Puzzo et al.   NEUROSCIENCE

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

(2014) Meike Hick et al.   ACTA NEUROPATHOLOGICA

A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease

(2014) Eric Karran et al.   ANNALS OF NEUROLOGY

The role of amyloid-beta in the regulation of memory

(2014) John E. Morley et al.   BIOCHEMICAL PHARMACOLOGY

The evolution of amidine-based brain penetrant BACE1 inhibitors

(2014) Daniel Oehlrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Paths to Alzheimer’s disease prevention: From modifiable risk factors to biomarker enrichment strategies

(2014) Simone Lista et al.   Journal of Nutrition Health & Aging

Increased CSF APPs-  levels in patients with Alzheimer disease treated with acitretin

(2014) K. Endres et al.   NEUROLOGY

The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex

(2014) Moritz M. Hettich et al.   PLoS One

Human Chorionic Gonadotropin Increases β-Cleavage of Amyloid Precursor Protein in SH-SY5Y Cells

(2013) Soheila Saberi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Soluble amyloid precursor proteins and secretases as Alzheimer's disease biomarkers

(2013) Robert Perneczky et al.   TRENDS IN MOLECULAR MEDICINE

Alzheimer’s Disease, Cholesterol, and Statins: The Junctions of Important Metabolic Pathways

(2012) Tiago Silva et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

(2012) Fredrik Jeppsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides

(2012) Britt-Marie Swahn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cerebrospinal Fluid Profiles of Amyloid β-Related Biomarkers in Alzheimer’s Disease

(2012) Christoffer Rosén et al.   NEUROMOLECULAR MEDICINE

Alzheimer’s-Related Peptide Amyloid-β Plays a Conserved Role in Angiogenesis

(2012) D. Joshua Cameron et al.   PLoS One

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

(2012) Demian Obregon et al.   Nature Communications

Statins in Unconventional Secretion of Insulin-Degrading Enzyme and Degradation of the Amyloid-ß Peptide

(2011) Konstantin Glebov et al.   Neurodegenerative Diseases

Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease

(2011) Kaan E. Biron et al.   PLoS One

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-  Production in Vivo

(2011) J. K. Atwal et al.   Science Translational Medicine

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Inhibiting β-Secretase Activity in Alzheimer's Disease Cell Models with Single-Chain Antibodies Specifically Targeting APP

(2010) Shanta Boddapati et al.   JOURNAL OF MOLECULAR BIOLOGY

Memantine Improves Cognition and Reduces Alzheimer’s-Like Neuropathology in Transgenic Mice

(2009) Hilda Martinez-Coria et al.   AMERICAN JOURNAL OF PATHOLOGY

Vascular endothelial growth factor (VEGF) affects processing of amyloid precursor protein and β-amyloidogenesis in brain slice cultures derived from transgenic Tg2576 mouse brain

(2009) Susanne Bürger et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

S100A7, a Novel Alzheimer's Disease Biomarker with Non-Amyloidogenic α-Secretase Activity Acts via Selective Promotion of ADAM-10

(2009) Weiping Qin et al.   PLoS One

p3 peptide, a truncated form of Aβ devoid of synaptotoxic effect, does not assemble into soluble oligomers

(2008) Fabienne Dulin et al.   FEBS LETTERS

Human chorionic gonadotropin (a luteinizing hormone homologue) decreases spatial memory and increases brain amyloid-β levels in female rats

(2008) Anne Berry et al.   HORMONES AND BEHAVIOR

β-Secretase as a therapeutic target for Alzheimer’s disease

(2008) Arun K. Ghosh et al.   Neurotherapeutics

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE