Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer’s disease

Stem Cell-Derived Neurons as Cellular Models of Sporadic Alzheimer’s Disease

(2019) Bénédicte Foveau et al.   JOURNAL OF ALZHEIMERS DISEASE

Mucin-type glycosylation as a regulatory factor of amyloid precursor protein processing

(2019) Naosuke Nakamura et al.   JOURNAL OF BIOCHEMISTRY

Regulation of AβPP Glycosylation Modification and Roles of Glycosylation on AβPP Cleavage in Alzheimer’s Disease

(2019) Peng-Fei Tao et al.   ACS Chemical Neuroscience

O-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease

(2019) Philip Ryan et al.   ACS Chemical Neuroscience

The Role of Insulin Resistance and Protein O-GlcNAcylation in Neurodegeneration

(2019) Suraiya A. Ansari et al.   Frontiers in Neuroscience

O-GlcNAcylation of Amyloid-β Protein Precursor by Insulin Signaling Reduces Amyloid-β Production

(2019) Oh Hoon Kwon et al.   JOURNAL OF ALZHEIMERS DISEASE

C99 selectively accumulates in vulnerable neurons in Alzheimer's disease

(2019) Maria V. Pulina et al.   Alzheimers & Dementia

Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies

(2019) Hazal Haytural et al.   Frontiers in Aging Neuroscience

Glycan biomarkers for Alzheimer disease correlate with T‐tau and P‐tau in cerebrospinal fluid in subjective cognitive impairment

(2019) Sophia Schedin‐Weiss et al.   FEBS Journal

Measurement of Altered AβPP Isoform Expression in Frontal Cortex of Patients with Alzheimer's Disease by Absolute Quantification Real-Time PCR

(2018) William G. Tharp et al.   JOURNAL OF ALZHEIMERS DISEASE

Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing

(2018) Caroline Evrard et al.   Frontiers in Cellular Neuroscience

Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway

(2017) Alexis E. González et al.   FASEB JOURNAL

Alterations in the Balance of Amyloid-β Protein Precursor Species in the Cerebrospinal Fluid of Alzheimer’s Disease Patients

(2017) Inmaculada Lopez-Font et al.   JOURNAL OF ALZHEIMERS DISEASE

The small molecule luteolin inhibitsN-acetyl-α-galactosaminyltransferases and reduces mucin-typeO-glycosylation of amyloid precursor protein

(2017) Feng Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1

(2017) Aitana Sogorb-Esteve et al.   MOLECULAR NEUROBIOLOGY

Bidirectional regulation of Aβ levels by Presenilin 1

(2017) Victor Bustos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

(2017) Anna Ochalek et al.   Alzheimers Research & Therapy

The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

(2017) Gabriele Siegel et al.   Cell Reports

Post-transcriptional regulation across human tissues

(2017) Alexander Franks et al.   PLoS Computational Biology

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease

(2017) Xin Wang et al.   Frontiers in Molecular Neuroscience

Gene Expression of Quaking in Sporadic Alzheimer’s Disease Patients is Both Upregulated and Related to Expression Levels of Genes Involved in Amyloid Plaque and Neurofibrillary Tangle Formation

(2016) Bryn Farnsworth et al.   JOURNAL OF ALZHEIMERS DISEASE

Excess APPO-glycosylation by GalNAc-T6 decreases Aβ production

(2016) Keiko Akasaka-Manya et al.   JOURNAL OF BIOCHEMISTRY

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

(2016) Robert J. Andrew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Decrease in APP and CP mRNA expression supports impairment of iron export in Alzheimer's disease patients

(2015) Cláudia Guerreiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Heteromers of amyloid precursor protein in cerebrospinal fluid

(2015) Inmaculada Cuchillo-Ibañez et al.   Molecular Neurodegeneration

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

(2014) Hoang S. Nhan et al.   ACTA NEUROPATHOLOGICA

Amyloid precursor protein expression is enhanced in human platelets from subjects with Alzheimer's disease and frontotemporal lobar degeneration: A Real-time PCR study

(2013) Arianna Vignini et al.   EXPERIMENTAL GERONTOLOGY

The role of protein glycosylation in Alzheimer disease

(2013) Sophia Schedin-Weiss et al.   FEBS Journal

Soluble amyloid precursor proteins and secretases as Alzheimer's disease biomarkers

(2013) Robert Perneczky et al.   TRENDS IN MOLECULAR MEDICINE

Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease

(2012) Marta Pera et al.   ACTA NEUROPATHOLOGICA

γ-Secretase Substrates and their Implications for Drug Development in Alzheimer's Disease

(2011) Alberto Lleo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Functions of Aβ, sAPPα and sAPPβ : similarities and differences

(2011) Stéphanie Chasseigneaux et al.   JOURNAL OF NEUROCHEMISTRY

Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex

(2011) Guoxin Wu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid  -peptides in human cerebrospinal fluid

(2011) A. Halim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP)

(2010) Kristin T. Jacobsen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cross-platform comparison of SYBR Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study

(2008) Emi Arikawa et al.   BMC GENOMICS