Metformin a Potential Pharmacological Strategy in Late Onset Alzheimer’s Disease Treatment

Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus

(2021) Maheedhar Kodali et al.   AGING CELL

Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities and Cognitive Dysfunction

(2021) Thomas M. Barber et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin restores hippocampal neurogenesis and learning and memory via regulating gut microbiota in the obese mouse model

(2021) Xiaoyi Ma et al.   BRAIN BEHAVIOR AND IMMUNITY

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice

(2021) Yanxing Chen et al.   Alzheimers Research & Therapy

TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer’s Disease: Lessons Learned from Transcriptomics

(2021) Feng Xue et al.   Cells

Alzheimer’s Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models

(2021) Maria Jose Carranza-Naval et al.   Biomolecules

TREM2, microglia, and Alzheimer’s disease

(2021) Qi Qin et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Interplay Between Microglia and Alzheimer’s Disease—Focus on the Most Relevant Risks: APOE Genotype, Sex and Age

(2021) Yanting Chen et al.   Frontiers in Aging Neuroscience

Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer’s Disease

(2021) Angeles Vinuesa et al.   Frontiers in Neuroscience

Alzheimer disease

(2021) David S. Knopman et al.   Nature Reviews Disease Primers

Brain Glucose Metabolism in Health, Obesity, and Cognitive Decline—Does Insulin Have Anything to Do with It? A Narrative Review

(2021) Eleni Rebelos et al.   Journal of Clinical Medicine

Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease

(2021) Jesús Burillo et al.   Cells

Some Candidate Drugs for Pharmacotherapy of Alzheimer’s Disease

(2021) Barbara Miziak et al.   Pharmaceuticals

Alzheimer’s Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment

(2021) Tsuyoshi Nakai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Promise of metformin for preventing age-related cognitive dysfunction

(2021) AshokK Shetty et al.   Neural Regeneration Research

Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer’s Disease: Targeting Mitochondria for Diagnosis and Prevention

(2020) Yunhua Peng et al.   ANTIOXIDANTS & REDOX SIGNALING

Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease

(2020) Yanan Sun et al.   Journal of Diabetes Research

Metformin and cognition from the perspectives of sex, age, and disease

(2020) Kiran Chaudhari et al.   GeroScience

Diabetes Mellitus Increases Risk of Incident Dementia in APOE ɛ4 Carriers: A Meta-Analysis

(2020) Lily Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Diabetes-Induced H3K9 Hyperacetylation Promotes Development of Alzheimer’s Disease Through CDK5

(2020) Hong-Bin Cai et al.   JOURNAL OF ALZHEIMERS DISEASE

A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Ab oligomers from Alzheimer brain

(2020) Shaomin Li et al.   JOURNAL OF NEUROCHEMISTRY

Metformin loaded phosphatidylserine nanoliposomes improve memory deficit and reduce neuroinflammation in streptozotocin-induced Alzheimer's disease model

(2020) Partow Mirzaee Saffari et al.   LIFE SCIENCES

Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function

(2020) Zoe Arvanitakis et al.   ANNALS OF NEUROLOGY

Activation of AMPK/aPKCζ/CREB pathway by metformin is associated with upregulation of GDNF and dopamine

(2020) Nikita Katila et al.   BIOCHEMICAL PHARMACOLOGY

Neuroprotective potential of antihyperglycemic drug metformin in streptozocin-induced rat model of sporadic Alzheimer's disease

(2020) Vladimirs Pilipenko et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Upregulation of AMPK Ameliorates Alzheimer’s Disease-Like Tau Pathology and Memory Impairment

(2020) Lin Wang et al.   MOLECULAR NEUROBIOLOGY

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

Metformin Ameliorates Synaptic Defects in a Mouse Model of AD by Inhibiting Cdk5 Activity

(2020) YaLi Wang et al.   Frontiers in Cellular Neuroscience

Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis

(2020) Xiaoqi Zhu et al.   Aging-US

Metformin: A Growing Journey from Glycemic Control to the Treatment of Alzheimer’s Disease and Depression

(2020) Mohamed El Massry et al.   CURRENT MEDICINAL CHEMISTRY

Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study

(2020) Katherine Samaras et al.   DIABETES CARE

Metformin as a Potential Agent in the Treatment of Multiple Sclerosis

(2020) Angela Dziedzic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders

(2020) Sonja K. Soo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Drug repositioning and repurposing for Alzheimer disease

(2020) Clive Ballard et al.   Nature Reviews Neurology

Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease

(2020) Courtney K. Walker et al.   NEUROSCIENTIST

Metformin Enhances Excitatory Synaptic Transmission onto Hippocampal CA1 Pyramidal Neurons

(2020) Wen-Bing Chen et al.   Brain Sciences

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches

(2020) Alberto Serrano-Pozo et al.   LANCET NEUROLOGY

AMPK: A bridge between diabetes mellitus and Alzheimer's disease

(2020) Meixiang Chen et al.   BEHAVIOURAL BRAIN RESEARCH

A Multilevel View of the Development of Alzheimer’s Disease

(2020) Jesús Avila et al.   NEUROSCIENCE

The Link Between Tau and Insulin Signaling: Implications for Alzheimer’s Disease and Other Tauopathies

(2019) Rafaella Araujo Gonçalves et al.   Frontiers in Cellular Neuroscience

Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways

(2019) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

Taking metformin and cognitive function change in older patients with diabetes

(2019) Bo Kyung Koo et al.   Geriatrics & Gerontology International

The protective effect of metformin in scopolamine-induced learning and memory impairment in rats

(2019) Elif Aksoz et al.   Pharmacological Reports

Association Between Metformin Initiation and Incident Dementia Among African American and White Veterans Health Administration Patients

(2019) Jeffrey F. Scherrer et al.   ANNALS OF FAMILY MEDICINE

Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer’s Disease

(2019) Susan A. Farr et al.   JOURNAL OF ALZHEIMERS DISEASE

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Effect of metformin on neurodegenerative disease among elderly adult US veterans with type 2 diabetes mellitus

(2019) Qian Shi et al.   BMJ Open

Diabetes drugs in the fight against Alzheimer's disease

(2019) Virginia Boccardi et al.   AGEING RESEARCH REVIEWS

Metformin and risk of Alzheimer’s disease among community-dwelling people with diabetes: a national case-control study

(2019) Janet K Sluggett et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inhibition of cyclin-dependent kinase 5 activity alleviates diabetes-related cognitive deficits

(2019) Wei Liu et al.   FASEB JOURNAL

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

The 20-Year Voyage Aboard the Journal of Alzheimer's Disease: Docking at ‘Type 3 Diabetes’, Environmental/Exposure Factors, Pathogenic Mechanisms, and Potential Treatments

(2018) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

Mutual relationship between Tau and central insulin signalling: consequences for AD and Tauopathies ?

(2018) Maud Gratuze et al.   NEUROENDOCRINOLOGY

Metformin treatment ameliorates diabetes-associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1

(2018) Daisuke Tanokashira et al.   FEBS Open Bio

Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis

(2018) Jared M. Campbell et al.   JOURNAL OF ALZHEIMERS DISEASE

Dendritic spine remodeling accompanies Alzheimer’s disease pathology and genetic susceptibility in cognitively normal aging

(2018) Benjamin D. Boros et al.   NEUROBIOLOGY OF AGING

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

(2017) Gisele S. Seixas da Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau deletion promotes brain insulin resistance

(2017) Elodie Marciniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metformin – a Future Therapy for Neurodegenerative Diseases

(2017) Magdalena Markowicz-Piasecka et al.   PHARMACEUTICAL RESEARCH

Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration

(2017) Eduardo Rojas-Gutierrez et al.   SYNAPSE

Sex Differences in the Cognitive and Hippocampal Effects of Streptozotocin in an Animal Model of Sporadic AD

(2017) Jian Bao et al.   Frontiers in Aging Neuroscience

Insulin-Resistant Brain State after Intracerebroventricular Streptozotocin Injection Exacerbates Alzheimer-like Changes in Tg2576 AβPP-Overexpressing Mice

(2017) Konstanze Plaschke et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice

(2016) Wilma Helena Oliveira et al.   BRAIN RESEARCH

Neuroprotective effects of metformin against Aβ-mediated inhibition of long-term potentiation in rats fed a high-fat diet

(2016) Masoumeh Asadbegi et al.   BRAIN RESEARCH BULLETIN

Neuronal human BACE1 knockin induces systemic diabetes in mice

(2016) Kaja Plucińska et al.   DIABETOLOGIA

Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimer's disease

(2016) Therese S Salameh et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

(2016) José A. Luchsinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Differential metformin dose-dependent effects on cognition in rats: role of Akt

(2016) Dalia K. Mostafa et al.   PSYCHOPHARMACOLOGY

The aPKC-CBP Pathway Regulates Adult Hippocampal Neurogenesis in an Age-Dependent Manner

(2016) Ayden Gouveia et al.   Stem Cell Reports

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo

(2016) Manon Domise et al.   Scientific Reports

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependent

(2015) Ming-Min Chung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity

(2015) Claudia A. Grillo et al.   DIABETES

A Key Role of Insulin Receptors in Memory: Figure 1

(2015) Fernanda G. De Felice et al.   DIABETES

Intracerebroventricular Streptozotocin Injections as a Model of Alzheimer’s Disease: in Search of a Relevant Mechanism

(2015) Paweł Grieb   MOLECULAR NEUROBIOLOGY

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease

(2015) Auriel A. Willette et al.   JAMA Neurology

Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation

(2015) Michael Fatt et al.   Stem Cell Reports

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies

(2014) Mark Yarchoan et al.   ACTA NEUROPATHOLOGICA

Metformin and Alzheimer’s Disease Risk

(2014) Jonathan E. Rosenfeld   AMERICAN JOURNAL OF PSYCHIATRY

Is synaptic loss a unique hallmark of Alzheimer's disease?

(2014) Stephen W. Scheff et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy Dysfunction and its Link to Alzheimer’s Disease and Type II Diabetes Mellitus

(2014) Cornelia Wilson et al.   CNS & Neurological Disorders-Drug Targets

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Metformin promotes focal angiogenesis and neurogenesis in mice following middle cerebral artery occlusion

(2014) Yanqun Liu et al.   NEUROSCIENCE LETTERS

The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex

(2014) Moritz M. Hettich et al.   PLoS One

Glutamatergic regulation prevents hippocampal-dependent age-related cognitive decline through dendritic spine clustering

(2014) Ana C. Pereira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Health

(2014) John H. Morrison et al.   JAMA Psychiatry

Connecting Type 2 diabetes to Alzheimer’s disease

(2013) Fernanda G De Felice   Expert Review of Neurotherapeutics

Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies

(2013) Kapil Gudala et al.   Journal of Diabetes Investigation

The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic rats

(2012) Wen-shan Lv et al.   BRAIN RESEARCH

Amyloid-  Induces Hepatic Insulin Resistance by Activating JAK2/STAT3/SOCS-1 Signaling Pathway

(2012) Y. Zhang et al.   DIABETES

Amyloid-  Induces Hepatic Insulin Resistance In Vivo via JAK2

(2012) Y. Zhang et al.   DIABETES

Insulin Resistance, Brain Atrophy, and Cognitive Performance in Late Middle-Aged Adults

(2012) A. A. Willette et al.   DIABETES CARE

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research

(2012) Melita Salkovic-Petrisic et al.   JOURNAL OF NEURAL TRANSMISSION

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

(2012) Jiejie Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain

(2012) Santosh Ramamurthy et al.   Experimental Neurobiology

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

(2011) Amit Gupta et al.   NEUROPHARMACOLOGY

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

AMP-activated protein kinase and its downstream transcriptional pathways

(2010) Carles Cantó et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Selective Changes in Thin Spine Density and Morphology in Monkey Prefrontal Cortex Correlate with Aging-Related Cognitive Impairment

(2010) D. Dumitriu et al.   JOURNAL OF NEUROSCIENCE

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevation of plasma β-amyloid level by glucose loading in Alzheimer mouse models

(2009) Shuko Takeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PGC-1α and PGC-1β Regulate Mitochondrial Density in Neurons

(2009) Przemyslaw Wareski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Enhanced Risk for Alzheimer Disease in Persons With Type 2 Diabetes and APOE ε4

(2008) Fumiko Irie et al.   ARCHIVES OF NEUROLOGY

Metformin Protects the Brain Against the Oxidative Imbalance Promoted by Type 2 Diabetes

(2008) Sonia Correia et al.   Medicinal Chemistry