Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice

Alzheimer’s Disease and Diabetes: Insulin Signaling as the Bridge Linking Two Pathologies

(2020) Jonathan Chang-Cheng Shieh et al.   MOLECULAR NEUROBIOLOGY

Metformin and cognition from the perspectives of sex, age, and disease

(2020) Kiran Chaudhari et al.   GeroScience

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

Ethyl acetate fraction from Hibiscus sabdariffa L. attenuates diabetes-associated cognitive impairment in mice

(2018) Tae Wan Seung et al.   FOOD RESEARCH INTERNATIONAL

Targeting Insulin for Alzheimer’s Disease: Mechanisms, Status and Potential Directions

(2018) Jung Hyun Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals

(2018) Hsin-Yi Wu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mitochondrial dysfunction contribute to diabetic neurotoxicity induced by streptozocin in mice: protective effect of Urtica dioica and pioglitazone

(2018) Mohammad Shokrzadeh et al.   TOXICOLOGY MECHANISMS AND METHODS

Mitochondrial dysfunction contribute to diabetic neurotoxicity induced by streptozocin in mice: protective effect of Urtica dioica and pioglitazone

(2018) Mohammad Shokrzadeh et al.   TOXICOLOGY MECHANISMS AND METHODS

Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCs

(2017) Ming-Min Chung et al.   EXPERIMENTAL CELL RESEARCH

Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation

(2017) Judith M. van der Harg et al.   NEUROBIOLOGY OF DISEASE

The role of astrocytes in amyloid production and Alzheimer's disease

(2017) Georgia R. Frost et al.   Open Biology

Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice

(2016) Joanne S. Allard et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice

(2016) Wilma Helena Oliveira et al.   BRAIN RESEARCH

Activation of the cAMP-PKA pathway Antagonizes Metformin Suppression of Hepatic Glucose Production

(2016) Ling He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons

(2016) Yunhua Peng et al.   JOURNAL OF NEUROCHEMISTRY

The rise and fall of insulin signaling in Alzheimer’s disease

(2016) B. Chami et al.   METABOLIC BRAIN DISEASE

Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

(2016) E Haroon et al.   MOLECULAR PSYCHIATRY

Differential metformin dose-dependent effects on cognition in rats: role of Akt

(2016) Dalia K. Mostafa et al.   PSYCHOPHARMACOLOGY

Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system

(2016) Afrah A.K. Ismaiel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice

(2016) Wenjun Zhou et al.   PLoS One

Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect

(2015) Pasquale Picone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

(2015) Amy M Pooler et al.   Acta Neuropathologica Communications

Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis

(2014) Chin Cheng et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Diethylcarbamazine Reduces Chronic Inflammation and Fibrosis in Carbon Tetrachloride- (CCl4-) Induced Liver Injury in Mice

(2014) Sura Wanessa Santos Rocha et al.   MEDIATORS OF INFLAMMATION

Astrocytic and microglial response in experimentally induced diabetic rat brain

(2014) Aarti Nagayach et al.   METABOLIC BRAIN DISEASE

Resveratrol and Endothelial Nitric Oxide

(2014) Ning Xia et al.   MOLECULES

Reversal of neurobehavioral and neurochemical alterations in STZ-induced diabetic rats by FeTMPyP, a peroxynitrite decomposition catalyst and 1,5-Isoquinolinediol a poly(ADP-ribose) polymerase inhibitor

(2014) Ashok Jangra et al.   NEUROLOGICAL RESEARCH

The dual role of astrocyte activation and reactive gliosis

(2014) Milos Pekny et al.   NEUROSCIENCE LETTERS

Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures

(2014) Krzysztof Łabuzek et al.   Pharmacological Reports

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

(2014) Enrique Blázquez et al.   Frontiers in Endocrinology

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease

(2014) Hwan-Ching Tai et al.   Acta Neuropathologica Communications

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Neurodegeneration in Streptozotocin-Induced Diabetic Rats Is Attenuated by Treatment with Resveratrol

(2013) Yu-Hong Jing et al.   NEUROENDOCRINOLOGY

Role of the eNOS-NO System in Regulating the Antiproteinuric Effects of VEGF Receptor 2 Inhibition in Diabetes

(2013) Andrew Advani et al.   Biomed Research International

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation

(2012) Jing Wang et al.   Cell Stem Cell

NMDA and AMPA receptor mediated excitotoxicity in cerebral cortex of streptozotocin induced diabetic rat: Ameliorating effects of curcumin

(2012) S. Jayanarayanan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

(2012) Latha Devi et al.   PLoS One

Signaling Mechanism of Poly(ADP-Ribose) Polymerase-1 (PARP-1) in Inflammatory Diseases

(2011) Xueqing Ba et al.   AMERICAN JOURNAL OF PATHOLOGY

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030

(2011) David R. Whiting et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

PARP inhibitors: New tools to protect from inflammation

(2010) Vincenzo Giansanti et al.   BIOCHEMICAL PHARMACOLOGY

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

(2010) Elena Alberdi et al.   CELL CALCIUM

Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats

(2010) Cheng-Xi Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

(2010) Xu Wang et al.   Molecular Neurodegeneration

Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network

(2010) Julie A. Harris et al.   NEURON

Endothelial dysfunction and vascular disease

(2009) P. M. Vanhoutte et al.   Acta Physiologica

Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice

(2009) Corinne G. Jolivalt et al.   EXPERIMENTAL NEUROLOGY

Ambivalent effects of compound C (dorsomorphin) on inflammatory response in LPS-stimulated rat primary microglial cultures

(2009) Krzysztof Łabuzek et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cognitive dysfunction and hippocampal changes in experimental type 1 diabetes

(2008) Edgardo O. Alvarez et al.   BEHAVIOURAL BRAIN RESEARCH

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

(2008) C.G. Jolivalt et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mechanisms of Action of Metformin in Type 2 Diabetes and Associated Complications: An Overview

(2008) Sonia Correia et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Tyrosine phosphorylation of ionotropic glutamate receptors by Fyn or Src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and PSD-95

(2003) Yongqi Rong et al.   JOURNAL OF NEUROCHEMISTRY