The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases

(2017) Scott T. Brady et al.   NEUROBIOLOGY OF DISEASE

Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences

(2017) Philip F. Copenhaver et al.   Frontiers in Molecular Neuroscience

Truncating mutations inAPPcause a distinct neurological phenotype

(2016) Steven Klein et al.   ANNALS OF NEUROLOGY

Protein interacting with NIMA (never in mitosis A)-1 regulates axonal growth cone adhesion and spreading through myristoylated alanine-rich C kinase substrate isomerization

(2016) Lucas J. Sosa et al.   JOURNAL OF NEUROCHEMISTRY

Manduca Contactin Regulates Amyloid Precursor Protein-Dependent Neuronal Migration

(2016) Jenna M. Ramaker et al.   JOURNAL OF NEUROSCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

APP Receptor? To Be or Not To Be

(2016) Carole Deyts et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Loss of presenilin function is associated with a selective gain of APP function

(2016) Carole Deyts et al.   eLife

Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation

(2016) Petra Bergström et al.   Scientific Reports

Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

(2015) Rik van der Kant et al.   DEVELOPMENTAL CELL

The structural biology of the amyloid precursor protein APP – a complex puzzle reveals its multi-domain architecture

(2014) Ina Coburger et al.   BIOLOGICAL CHEMISTRY

Mint Proteins Are Required for Synaptic Activity-dependent Amyloid Precursor Protein (APP) Trafficking and Amyloid β Generation

(2014) Sarah E. Sullivan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Analysis Reveals that Amyloid Precursor Protein and Death Receptor 6 Function in the Same Pathway to Control Axonal Pruning Independent of  -Secretase

(2014) O. Olsen et al.   JOURNAL OF NEUROSCIENCE

Extracellular matrix assembly: a multiscale deconstruction

(2014) Janna K. Mouw et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway

(2014) N Milosch et al.   Cell Death & Disease

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

(2014) Hilla Fogel et al.   Cell Reports

Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

(2014) Sascha W Weyer et al.   Acta Neuropathologica Communications

Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome

(2013) Lucas J. Sosa et al.   FASEB JOURNAL

Mechanisms of cell migration in the nervous system

(2013) Jonathan A. Cooper   JOURNAL OF CELL BIOLOGY

Cellular and molecular mechanisms underlying presynapse formation

(2013) Poh Hui Chia et al.   JOURNAL OF CELL BIOLOGY

Soluble amyloid-  precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans

(2013) C. Reinhard et al.   JOURNAL OF CELL SCIENCE

Amyloid Precursor Proteins Interact with the Heterotrimeric G Protein Go in the Control of Neuronal Migration

(2013) J. M. Ramaker et al.   JOURNAL OF NEUROSCIENCE

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

(2013) Karine Poirier et al.   NATURE GENETICS

Amyloid β precursor protein as a molecular target for amyloid β–induced neuronal degeneration in Alzheimer's disease

(2013) Elena Anahi Bignante et al.   NEUROBIOLOGY OF AGING

Amyloid Precursor Protein Is an Autonomous Growth Cone Adhesion Molecule Engaged in Contact Guidance

(2013) Lucas J. Sosa et al.   PLoS One

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

The Drosophila Homologue of the Amyloid Precursor Protein Is a Conserved Modulator of Wnt PCP Signaling

(2013) Alessia Soldano et al.   PLOS BIOLOGY

Sticky situations: recent advances in control of cell adhesion during neuronal migration

(2012) David J Solecki   CURRENT OPINION IN NEUROBIOLOGY

Pancortins interact with amyloid precursor protein and modulate cortical cell migration

(2012) H. C. Rice et al.   DEVELOPMENT

Amyloid Precursor Protein Regulates Netrin-1-mediated Commissural Axon Outgrowth

(2012) Nicolas Rama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain

(2012) Sven O. Dahms et al.   JOURNAL OF MOLECULAR BIOLOGY

Novel G S-Protein Signaling Associated with Membrane-Tethered Amyloid Precursor Protein Intracellular Domain

(2012) C. Deyts et al.   JOURNAL OF NEUROSCIENCE

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Down syndrome: the brain in trisomic mode

(2012) Mara Dierssen   NATURE REVIEWS NEUROSCIENCE

Knockdown of Amyloid Precursor Protein in Zebrafish Causes Defects in Motor Axon Outgrowth

(2012) Ping Song et al.   PLoS One

New spin on an old transition: epithelial parallels in neuronal adhesion control

(2012) Jakub K. Famulski et al.   TRENDS IN NEUROSCIENCES

Synaptic Cell Adhesion

(2012) M. Missler et al.   Cold Spring Harbor Perspectives in Biology

APP physiological and pathophysiological functions: insights from animal models

(2011) Qinxi Guo et al.   CELL RESEARCH

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome

(2011) Stefania Trazzi et al.   HUMAN MOLECULAR GENETICS

Trisomy 21 and early brain development

(2011) Tarik F. Haydar et al.   TRENDS IN NEUROSCIENCES

Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells

(2011) Silke Brunholz et al.   EXPERIMENTAL BRAIN RESEARCH

Structural aspects and physiological consequences of APP/APLP trans-dimerization

(2011) Frederik Baumkötter et al.   EXPERIMENTAL BRAIN RESEARCH

Functions of the APP gene family in the nervous system: insights from mouse models

(2011) Dorothee Aydin et al.   EXPERIMENTAL BRAIN RESEARCH

Neuronal migration mechanisms in development and disease

(2010) Manuel Valiente et al.   CURRENT OPINION IN NEUROBIOLOGY

Biochemical and Functional Interaction of Disrupted-in-Schizophrenia 1 and Amyloid Precursor Protein Regulates Neuronal Migration during Mammalian Cortical Development

(2010) T. L. Young-Pearse et al.   JOURNAL OF NEUROSCIENCE

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rab GTPases-Dependent Endocytic Pathways Regulate Neuronal Migration and Maturation through N-Cadherin Trafficking

(2010) Takeshi Kawauchi et al.   NEURON

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

(2010) K.J. Lee et al.   NEUROSCIENCE

Communication breaks-Down: From neurodevelopment defects to cognitive disabilities in Down syndrome

(2010) Andrea Contestabile et al.   PROGRESS IN NEUROBIOLOGY

Compartmentalization from the outside: the extracellular matrix and functional microdomains in the brain

(2010) Alexander Dityatev et al.   TRENDS IN NEUROSCIENCES

Cellular Strategies of Axonal Pathfinding

(2010) J. Raper et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms and Molecules of Neuronal Wiring: A Primer

(2010) A. L. Kolodkin et al.   Cold Spring Harbor Perspectives in Biology

Guiding Neuronal Cell Migrations

(2010) O. Marin et al.   Cold Spring Harbor Perspectives in Biology

MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex

(2009) J. M. Weimer et al.   DEVELOPMENT

Interactions between the amyloid precursor protein C-terminal domain and G proteins mediate calcium dysregulation and amyloid β toxicity in Alzheimer’s disease

(2009) Gideon M. Shaked et al.   FEBS Journal

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers

(2009) Matthias Gralle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of Mint Proteins Decreases Amyloid Production in Transgenic Mouse Models of Alzheimer's Disease

(2009) A. Ho et al.   JOURNAL OF NEUROSCIENCE

Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth

(2009) H.-S. Hoe et al.   JOURNAL OF NEUROSCIENCE

Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

(2009) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

Axonal Transport Defects in Neurodegenerative Diseases

(2009) G. A. Morfini et al.   JOURNAL OF NEUROSCIENCE

APP Anterograde Transport Requires Rab3A GTPase Activity for Assembly of the Transport Vesicle

(2009) A. Szodorai et al.   JOURNAL OF NEUROSCIENCE

The trip of the tip: understanding the growth cone machinery

(2009) Laura Anne Lowery et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plasma membrane expansion: a neuron's Herculean task

(2009) Karl H. Pfenninger   NATURE REVIEWS NEUROSCIENCE

Microtubule assembly, organization and dynamics in axons and dendrites

(2009) Cecilia Conde et al.   NATURE REVIEWS NEUROSCIENCE

Antibody binding to cell surface amyloid precursor protein induces neuronal injury by deregulating the phosphorylation of focal adhesion signaling related proteins

(2009) Yu-Xia Xu et al.   NEUROSCIENCE LETTERS

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

(2009) G. Pigino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of Norepinephrine-Modulated Contextual Memory in a Mouse Model of Down Syndrome

(2009) A. Salehi et al.   Science Translational Medicine

Multi-level molecular clutches in motile cell processes

(2009) Grégory Giannone et al.   TRENDS IN CELL BIOLOGY

Reduced cell number in the neocortical part of the human fetal brain in Down syndrome

(2008) Karen Bonde Larsen et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system

(2008) M. Osterfield et al.   DEVELOPMENT

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

(2008) Tracy L Young-Pearse et al.   Neural Development

Amyloid-β precursor protein mediates neuronal toxicity of amyloid β through Go protein activation

(2008) Francisco Sola Vigo et al.   NEUROBIOLOGY OF AGING

Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels

(2008) Ana-María Simón et al.   NEUROBIOLOGY OF DISEASE

Abnormal cleavage of APP impairs its functions in cell adhesion and migration

(2008) Baiyang Sheng et al.   NEUROSCIENCE LETTERS

The cell adhesion molecule L1 controls growth cone navigation via ankyrinB-dependent modulation of cyclic AMP

(2008) Noriko Ooashi et al.   NEUROSCIENCE RESEARCH

Neuro-archaeology: pre-symptomatic architecture and signature of neurological disorders

(2008) Yehezkel Ben-Ari   TRENDS IN NEUROSCIENCES