Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse

Defective Autophagy and Mitophagy in Aging and Alzheimer’s Disease

(2021) Michael Tran et al.   Frontiers in Neuroscience

Anti-brain Aging Effects of Small Molecule Inhibitor DDQ

(2021) Murali Vijayan et al.   MOLECULAR NEUROBIOLOGY

Mendelian neurodegenerative disease genes involved in autophagy

(2020) Eleanna Stamatakou et al.   Cell Discovery

Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance

(2020) Sinsuk Han et al.   EMBO REPORTS

Defective mitophagy in Alzheimer’s disease

(2020) Jangampalli Adi Pradeepkiran et al.   AGEING RESEARCH REVIEWS

Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria

(2020) Albin John et al.   AGEING RESEARCH REVIEWS

Mitochondrial DNA copy number is associated with cognitive impairment

(2020) Shea J Andrews et al.   Alzheimers & Dementia

Structure Based Design and Molecular Docking Studies for Phosphorylated Tau Inhibitors in Alzheimer’s Disease

(2019) Jangampalli Pradeepkiran et al.   Cells

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Molecular Basis of Alzheimer’s Disease: Focus on Mitochondria

(2019) Darryll M.A. Oliver et al.   JOURNAL OF ALZHEIMERS DISEASE

The Effectiveness of Vitamin E Treatment in Alzheimer’s Disease

(2019) Ana Lloret et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Does intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein trigger early neurotoxicity in Alzheimer’s disease?

(2019) I. Lauritzen et al.   Current Alzheimer Research

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

(2019) P. Hemachandra Reddy et al.   Cells

Current Status of Healthy Aging and Dementia Research: A Symposium Summary

(2019) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

Synapse loss and progress of Alzheimer’s disease -A network model

(2019) G. Kashyap et al.   Scientific Reports

Targeting Mitochondria in Alzheimer Disease: Rationale and Perspectives

(2019) Chiara Lanzillotta et al.   CNS DRUGS

A mitochondrial delicacy: dynamin-related protein 1 and mitochondrial dynamics

(2018) Mason T. Breitzig et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer’s disease

(2018) P Hemachandra Reddy et al.   HUMAN MOLECULAR GENETICS

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer’s Disease

(2018) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

(2018) Xiongwei Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Redox Proteomics and Amyloid β-Peptide: Insights into Alzheimer Disease

(2018) D Allan Butterfield et al.   JOURNAL OF NEUROCHEMISTRY

Pharmacophore-based models for therapeutic drugs against phosphorylated tau in Alzheimer’s disease

(2018) Jangampalli Adi Pradeepkiran et al.   DRUG DISCOVERY TODAY

Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer’s disease

(2017) P. Hemachandra Reddy et al.   HUMAN MOLECULAR GENETICS

Mitochondria-Division Inhibitor 1 Protects Against Amyloid-β induced Mitochondrial Fragmentation and Synaptic Damage in Alzheimer’s Disease

(2017) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons

(2017) Ravi Rajmohan et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

(2017) Stefania Forner et al.   TRENDS IN NEUROSCIENCES

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target

(2017) Amadou K. S. Camara et al.   Frontiers in Physiology

Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline

(2017) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Why Women Have More Alzheimer's Disease Than Men: Gender and Mitochondrial Toxicity of Amyloid-β Peptide

(2017) Jose Viña et al.   JOURNAL OF ALZHEIMERS DISEASE

MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff

(2017) Rong Yu et al.   Scientific Reports

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

(2016) Ramesh Kandimalla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alzheimer's disease, menopause and the impact of the estrogenic environment

(2016) A. Pines   CLIMACTERIC

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease

(2016) Xiangling Yin et al.   HUMAN MOLECULAR GENETICS

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease

(2015) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)

(2014) Teresa Valero   CURRENT PHARMACEUTICAL DESIGN

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

(2013) D. F. Silva et al.   HUMAN MOLECULAR GENETICS

Sugar for the brain: the role of glucose in physiological and pathological brain function

(2013) Philipp Mergenthaler et al.   TRENDS IN NEUROSCIENCES

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?

(2012) P. Hemachandra Reddy   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: Implications for impaired mitochondrial biogenesis and synaptic damage

(2011) Marcus J. Calkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

(2011) Marcus J. Calkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

(2011) P. Hemachandra Reddy   BRAIN RESEARCH

Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases

(2011) P. H. Reddy et al.   Current Alzheimer Research

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

(2011) U. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Alzheimer's Disease: Diagnosis and Treatment Across the Spectrum of Disease Severity

(2011) Judith Neugroschl et al.   MOUNT SINAI JOURNAL OF MEDICINE

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

(2010) P. Hemachandra Reddy et al.   BRAIN RESEARCH REVIEWS

Treatment of Alzheimer’s Disease with a Cholinesterase Inhibitor Combined with Antioxidants

(2010) Umberto Cornelli   Neurodegenerative Diseases

Characteristics and Performance of a Modified Version of the ADCS-CGIC CIBIC+ for Mild Cognitive Impairment Clinical Trials

(2009) Lon S. Schneider et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

(2009) P. Hemachandra Reddy   EXPERIMENTAL NEUROLOGY

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Donepezil delays progression to AD in MCI subjects with depressive symptoms

(2009) P. H. Lu et al.   NEUROLOGY

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Mitochondrial Medicine for Aging and Neurodegenerative Diseases

(2008) P. Hemachandra Reddy   NEUROMOLECULAR MEDICINE

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE

Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging

(2007) Grégoria Kalpouzos et al.   NEUROBIOLOGY OF AGING