Ion channel regulation by β-secretase BACE1 – enzymatic and non-enzymatic effects beyond Alzheimer's disease

Amyloid-β as a Modulator of Synaptic Plasticity

(2017) Mordhwaj S. Parihar et al.   JOURNAL OF ALZHEIMERS DISEASE

The Voltage Activation of Cortical KCNQ Channels Depends on Global PIP2 Levels

(2016) Kwang S. Kim et al.   BIOPHYSICAL JOURNAL

KCNE1 and KCNE3: The yin and yang of voltage-gated K+ channel regulation

(2016) Geoffrey W. Abbott   GENE

Meta-analysis of BACE1 gene rs638405 polymorphism and the risk of Alzheimer’s disease in Caucasion and Asian population

(2016) Minhua Yu et al.   NEUROSCIENCE LETTERS

Short-term trends in dementia prevalence in Germany between the years 2007 and 2009

(2015) Gabriele Doblhammer et al.   Alzheimers & Dementia

2015 Alzheimer's disease facts and figures

(2015)   Alzheimers & Dementia

Sodium Channel β Subunits: Emerging Targets in Channelopathies

(2015) Heather A. O'Malley et al.   Annual Review of Physiology

Physiological, pathological, and structural implications of non-enzymatic protein–protein interactions of the multifunctional human transglutaminase 2

(2015) Kajal Kanchan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs)

(2015) Marianne Agsten et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

 -Secretase BACE1 Regulates Hippocampal and Reconstituted M-Currents in a  -Subunit-Like Fashion

(2015) S. Hessler et al.   JOURNAL OF NEUROSCIENCE

Navβ4 Regulates Fast Resurgent Sodium Currents and Excitability in Sensory Neurons

(2015) Cindy Barbosa et al.   Molecular Pain

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

The Alzheimer disease market

(2015) XiaoXiao Qian et al.   NATURE REVIEWS DRUG DISCOVERY

Seizures in Alzheimer’s disease

(2015) H.A. Born   NEUROSCIENCE

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

KCNQ5 K+ channels control hippocampal synaptic inhibition and fast network oscillations

(2015) Pawel Fidzinski et al.   Nature Communications

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

(2015) Zhentao Zhang et al.   Nature Communications

Amyloid accumulation is a late event in sporadic Alzheimer’s disease-like pathology in nontransgenic rats

(2015) Natalia A. Stefanova et al.   Oncotarget

A new look at sodium channel   subunits

(2015) S. Namadurai et al.   Open Biology

Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime

(2015) MaryKate McBrayer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein

(2014) Janice A. Maloney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Alzheimer Disease Protective Mutation A2T Modulates Kinetic and Thermodynamic Properties of Amyloid-β (Aβ) Aggregation

(2014) Iryna Benilova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kv7.2 regulates the function of peripheral sensory neurons

(2014) Chih H. King et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Kv7 channels regulate pairwise spiking covariability in health and disease

(2014) Gabriel Koch Ocker et al.   JOURNAL OF NEUROPHYSIOLOGY

Conditional Deletions of Epilepsy-Associated KCNQ2 and KCNQ3 Channels from Cerebral Cortex Cause Differential Effects on Neuronal Excitability

(2014) H. Soh et al.   JOURNAL OF NEUROSCIENCE

Heteromeric Kv7.2/7.3 Channels Differentially Regulate Action Potential Initiation and Conduction in Neocortical Myelinated Axons

(2014) A. Battefeld et al.   JOURNAL OF NEUROSCIENCE

Resurgent current of voltage-gated Na+channels

(2014) Amanda H. Lewis et al.   JOURNAL OF PHYSIOLOGY-LONDON

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

(2014) David J Marchant et al.   NATURE MEDICINE

Postsynaptic Target Specific Synaptic Dysfunctions in the CA3 Area of BACE1 Knockout Mice

(2014) Hui Wang et al.   PLoS One

Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits

(2014) L. D. Plant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seizures and Epileptiform Activity in Early Alzheimer Disease: How Hard Should We Be Looking?

(2014) David Spencer   Epilepsy Currents

High Activities of BACE1 in Brains with Mild Cognitive Impairment

(2013) Xin Cheng et al.   AMERICAN JOURNAL OF PATHOLOGY

Allosteric inhibition of BACE1 by an exosite-binding antibody

(2013) Weiru Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

(2013) Cyril Cheret et al.   EMBO JOURNAL

BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels

(2013) Carolyn C. Sachse et al.   FASEB JOURNAL

Differential Protein Kinase C-dependent Modulation of Kv7.4 and Kv7.5 Subunits of Vascular Kv7 Channels

(2013) Lioubov I. Brueggemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vestibular Role of KCNQ4 and KCNQ5 K+Channels Revealed by Mouse Models

(2013) Guillermo Spitzmaul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium Channel Cleavage Is Associated with Aberrant Neuronal Activity and Cognitive Deficits in a Mouse Model of Alzheimer's Disease

(2013) B. F. Corbett et al.   JOURNAL OF NEUROSCIENCE

Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels

(2013) P. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

(2013) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Voltage-Dependent Na+ Channels as Targets of BACE1 - Implications for Neuronal Firing and Beyond

(2012) Tobias Huth et al.   Current Alzheimer Research

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

(2012) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Activity-Dependent Transcriptional Regulation of M-Type (Kv7) K+ Channels by AKAP79/150-Mediated NFAT Actions

(2012) Jie Zhang et al.   NEURON

A Peptide Binding to the β-Site of APP Improves Spatial Memory and Attenuates Aβ Burden in Alzheimer’s Disease Transgenic Mice

(2012) Shi-gao Yang et al.   PLoS One

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nav1.1 dysfunction in genetic epilepsy with febrile seizures-plus or Dravet syndrome

(2011) Linda Volkers et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Kv7.5 is the primary Kv7 subunit expressed in C-fibers

(2011) Chih H. King et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Contributions of Kv7-mediated potassium current to sub- and suprathreshold responses of rat layer II/III neocortical pyramidal neurons

(2011) D. Guan et al.   JOURNAL OF NEUROPHYSIOLOGY

Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit

(2011) Manuel T Gersbacher et al.   Molecular Neurodegeneration

β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current

(2011) Tobias Huth et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity

(2011) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for dimeric BACE-mediated APP processing

(2010) Shaobo Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nonenzymatic Rapid Control of GIRK Channel Function by a G Protein-Coupled Receptor Kinase

(2010) Adi Raveh et al.   CELL

Reduced Sodium Channel Nav1.1 Levels in BACE1-null Mice

(2010) Doo Yeon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus

(2010) Verena C. Wimmer et al.   JOURNAL OF CLINICAL INVESTIGATION

BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration

(2010) X. Hu et al.   JOURNAL OF NEUROSCIENCE

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

(2010) Brian D. Hitt et al.   Molecular Neurodegeneration

Alzheimer's secretases regulate voltage-gated sodium channels

(2010) Dora M. Kovacs et al.   NEUROSCIENCE LETTERS

KV7 channelopathies

(2010) Snezana Maljevic et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels

(2010) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stoichiometry of the KCNQ1 - KCNE1 ion channel complex

(2010) K. Nakajo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural KCNQ (Kv7) channels

(2009) David A Brown et al.   BRITISH JOURNAL OF PHARMACOLOGY

The therapeutic potential of neuronal KV7 (KCNQ) channel modulators: an update

(2008) Valentin K Gribkoff   EXPERT OPINION ON THERAPEUTIC TARGETS

Homomeric and Heteromeric Assembly of KCNQ (Kv7) K+Channels Assayed by Total Internal Reflection Fluorescence/Fluorescence Resonance Energy Transfer and Patch Clamp Analysis

(2008) Manjot Bal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BACE1 Knock-Outs Display Deficits in Activity-Dependent Potentiation of Synaptic Transmission at Mossy Fiber to CA3 Synapses in the Hippocampus

(2008) H. Wang et al.   JOURNAL OF NEUROSCIENCE

Non-proteolytic effect of β-site APP-cleaving enzyme 1 (BACE1) on sodium channel function

(2008) Tobias Huth et al.   NEUROBIOLOGY OF DISEASE

Localization and Targeting of Voltage-Dependent Ion Channels in Mammalian Central Neurons

(2008) Helene Vacher et al.   PHYSIOLOGICAL REVIEWS

Counting membrane-embedded KCNE  -subunits in functioning K+ channel complexes

(2008) T. J. Morin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA