Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena

Impaired glucose tolerance is associated with enhanced postprandial pancreatic polypeptide secretion

(2022) Yanyun Zhao et al.   Journal of Diabetes

Acute effects on glucose tolerance by neprilysin inhibition in patients with type 2 diabetes

(2022) Nicolai J. Wewer Albrechtsen et al.   DIABETES OBESITY & METABOLISM

Statins Use in Alzheimer Disease: Bane or Boon from Frantic Search and Narrative Review

(2022) Nawal Alsubaie et al.   Brain Sciences

Montelukast and Acute Coronary Syndrome: The Endowed Drug

(2022) Basil Mohammed Alomair et al.   Pharmaceuticals

Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes

(2021) Danilo Milardi et al.   CHEMICAL REVIEWS

Do neprilysin inhibitors walk the line? Heart ameliorative but brain threatening!

(2021) Elnaz Poorgolizadeh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

COVID-19 in Relation to Hyperglycemia and Diabetes Mellitus

(2021) Hayder M. Al-kuraishy et al.   Frontiers in Cardiovascular Medicine

Bradykinin Protects Human Endothelial Progenitor Cells from High-Glucose-Induced Senescence through B2 Receptor-Mediated Activation of the Akt/eNOS Signalling Pathway

(2021) Yuehuan Wu et al.   Journal of Diabetes Research

Efficacy and tolerability of tirzepatide, a dual glucose‐dependent insulinotropic peptide and glucagon‐like peptide‐1 receptor agonist in patients with type 2 diabetes: A 12‐week, randomized, double‐blind, placebo‐controlled study to evaluate different dose‐escalation regimens

(2020) Juan Pablo Frias et al.   DIABETES OBESITY & METABOLISM

Neprilysin inhibition, endorphin dynamics, and early symptomatic improvement in heart failure: a pilot study

(2020) Elena Revuelta‐López et al.   ESC Heart Failure

Type 3 Diabetes and Its Role Implications in Alzheimer’s Disease

(2020) Thuy Trang Nguyen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bradykinin B2 Receptor Signaling Increases Glucose Uptake and Oxidation: Evidence and Open Questions

(2020) Marcos Fernandes Gregnani et al.   Frontiers in Pharmacology

The plasma levels of atrial natriuretic peptide and brain natriuretic peptide in type 2 diabetes treated with sodium-glucose cotransporter-2 inhibitor

(2020) Xiu Feng et al.   ANNALES D ENDOCRINOLOGIE

Neprilysin expression and functions in development, ageing and disease

(2020) NN Nalivaeva et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Neprilysin inhibition: a new therapeutic option for type 2 diabetes?

(2019) Nathalie Esser et al.   DIABETOLOGIA

Effects of the Angiotensin‐Receptor Neprilysin Inhibitor on Cardiac Reverse Remodeling: Meta‐Analysis

(2019) Yiwen Wang et al.   Journal of the American Heart Association

Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction

(2019) Scott D. Solomon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Does Neprilysin Inhibition Potentiate or Minimize the Adverse Effects of Glucagon-Like Peptide-1 Receptor Agonists in Chronic Heart Failure?

(2018) Milton Packer   JOURNAL OF CARDIAC FAILURE

Neprilysin Deficiency Is Associated With Expansion of Islet β-Cell Mass in High Fat-Fed Mice

(2018) Jacqueline H. Parilla et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Natriuretic peptides promote glucose uptake in a cGMP-dependent manner in human adipocytes

(2018) Marine Coué et al.   Scientific Reports

Effect of neprilysin inhibition on renal function in patients with type 2 diabetes and chronic heart failure who are receiving target doses of inhibitors of the renin-angiotensin system: a secondary analysis of the PARADIGM-HF trial

(2018) Milton Packer et al.   Lancet Diabetes & Endocrinology

Neprilysin inhibition in mouse islets enhances insulin secretion in a GLP-1 receptor dependent manner

(2018) Nathalie Esser et al.   Islets

Effects of sacubitril/valsartan on neprilysin targets and the metabolism of natriuretic peptides in chronic heart failure: a mechanistic clinical study

(2018) Hélène Nougué et al.   EUROPEAN JOURNAL OF HEART FAILURE

Sacubitril/valsartan in PARADIGM-HF

(2017) Nicolas Vodovar et al.   Lancet Diabetes & Endocrinology

Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: a post-hoc analysis from the PARADIGM-HF trial

(2017) Jelena P Seferovic et al.   Lancet Diabetes & Endocrinology

Natriuretic peptide control of energy balance and glucose homeostasis

(2016) Marine Coué et al.   BIOCHIMIE

Improved Insulin Sensitivity With Angiotensin Receptor Neprilysin Inhibition in Individuals With Obesity and Hypertension

(2016) J Jordan et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Improved glycaemia in high-fat-fed neprilysin-deficient mice is associated with reduced DPP-4 activity and increased active GLP-1 levels

(2016) Joshua R. Willard et al.   DIABETOLOGIA

Soluble neprilysin does not correlate with outcome in heart failure with preserved ejection fraction

(2016) Georg Goliasch et al.   EUROPEAN JOURNAL OF HEART FAILURE

Targeting cardiac natriuretic peptides in the therapy of diabetes and obesity

(2016) Cedric Moro   EXPERT OPINION ON THERAPEUTIC TARGETS

Soluble neprilysin retains catalytic activity in heart failure

(2016) Antoni Bayes-Genis et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Long-term neprilysin inhibition — implications for ARNIs

(2016) Duncan J. Campbell   Nature Reviews Cardiology

Oxytocin and cardioprotection in diabetes and obesity

(2016) Marek Jankowski et al.   BMC Endocrine Disorders

Alpha-, Delta- and PP-cells

(2015) Melissa F. Brereton et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Comparing LCZ696 With Enalapril According to Baseline Risk Using the MAGGIC and EMPHASIS-HF Risk Scores

(2015) Joanne Simpson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Soluble Neprilysin Is Predictive of Cardiovascular Death and Heart Failure Hospitalization in Heart Failure Patients

(2015) Antoni Bayés-Genís et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Regulation of insulin sensitivity, insulin production, and pancreatic β cell survival by angiotensin-(1-7) in a rat model of streptozotocin-induced diabetes mellitus

(2015) Junhua He et al.   PEPTIDES

Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

(2014) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Angiotensin type 2 receptor in pancreatic islets of adult rats: a novel insulinotropic mediator

(2013) Chunhong Shao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Degradation of islet amyloid polypeptide by neprilysin

(2012) H. Guan et al.   DIABETOLOGIA

Adrenomedullin is Up-regulated in Patients With Pancreatic Cancer and Causes Insulin Resistance in β Cells and Mice

(2012) Gaurav Aggarwal et al.   GASTROENTEROLOGY

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

Effect of inhibition of angiotensin converting enzyme and/or neutral endopeptidase on vascular and neural complications in high fat fed/low dose streptozotocin-diabetic rats

(2011) Eric P. Davidson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3

(2010) E. Law et al.   DIABETOLOGIA

The Roles of Streptozotocin Neurotoxicity and Neutral Endopeptidase in Murine Experimental Diabetic Neuropathy

(2010) Eric Davidson et al.   Experimental Diabetes Research

Increase of Plasma Insulin by Racecadotril, an Inhibitor of Enkephalinase, in Wistar Rats

(2010) H. Wu et al.   HORMONE AND METABOLIC RESEARCH

Neprilysin, obesity and the metabolic syndrome

(2010) K F Standeven et al.   INTERNATIONAL JOURNAL OF OBESITY

Neprilysin Impedes Islet Amyloid Formation by Inhibition of Fibril Formation Rather Than Peptide Degradation

(2010) Sakeneh Zraika et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Function for an Old Enzyme: NEP Deficient Mice Develop Late-Onset Obesity

(2010) Matthias Becker et al.   PLoS One

Inhibition of Neutral Endopeptidase 24.11 does not Potentiate the Improvement in Glycemic Control Obtained with Dipeptidyl Peptidase-4 Inhibition in Diabetic Goto–Kakizaki Rats

(2009) L. Simonsen et al.   HORMONE AND METABOLIC RESEARCH