EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders

Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor

(2022) Changrong Ge et al.   ANNALS OF THE RHEUMATIC DISEASES

Spondyloarthritis in inflammatory bowel disease cohorts: systematic literature review and critical appraisal of study designs

(2022) Monica Schwartzman et al.   RMD Open

Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers

(2022) Amber Barton et al.   INFECTION AND IMMUNITY

Impact of HLA-B27 and Disease Status on the Gut Microbiome of the Offspring of Ankylosing Spondylitis Patients

(2022) Matthew L. Stoll et al.   Children-Basel

Behçet’s disease risk-variant HLA-B51/ERAP1-Hap10 alters human CD8 T cell immunity

(2022) Ann Cavers et al.   ANNALS OF THE RHEUMATIC DISEASES

Both disease activity and HLA‐B27 determine gut microbiome dysbiosis in spondyloarthritis

(2022) Magali Berland et al.   Arthritis & Rheumatology

The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease

(2022) Thomas K. Pedersen et al.   IMMUNITY

T cell Repertoire Profiling and the Mechanism by which HLA-B27 Causes Ankylosing Spondylitis

(2022) Jose Garrido-Mesa et al.   Current Rheumatology Reports

Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides

(2022) Xinbo Yang et al.   NATURE

Lessons on SpA pathogenesis from animal models

(2021) Maxime Breban et al.   Seminars in Immunopathology

Putative Pathobionts in HLA-B27-Associated Spondyloarthropathy

(2021) Tejpal Gill et al.   Frontiers in Immunology

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties

(2021) Jonathan P. Hutchinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRAPPA Treatment Recommendations: An Update From the 2020 GRAPPA Annual Meeting

(2021) Laura C. Coates et al.   JOURNAL OF RHEUMATOLOGY

Association of Behçet disease with psoriasis and psoriatic arthritis

(2021) Hyung Jin Hahn et al.   Scientific Reports

ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29

(2021) Wouter J. Venema et al.   Frontiers in Immunology

PD-1 Expression Defines Epidermal CD8+CD103+ T Cells Preferentially Producing IL-17A and Using Skewed TCR Repertoire in Psoriasis

(2021) Pawit Phadungsaksawasdi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Unveiling axial involvement in psoriatic arthritis: an ancillary analysis of the ASAS-perSpA study

(2021) D Benavent et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Why Inhibition of IL-23 Lacked Efficacy in Ankylosing Spondylitis

(2021) Dennis McGonagle et al.   Frontiers in Immunology

Behçet‘s Syndrome Apart From the Triple Symptom Complex: Vascular, Neurologic, Gastrointestinal, and Musculoskeletal Manifestations. A Mini Review

(2021) Ina Kötter et al.   Frontiers in Medicine

Lesional activation of T c 17 cells in Behçet disease and psoriasis supports HLA class I‐mediated autoimmune responses

(2021) S. Vural et al.   BRITISH JOURNAL OF DERMATOLOGY

Antigen Processing, Presentation, and Tolerance: Role in Autoimmune Skin Diseases

(2021) Jörg Christoph Prinz   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Ankylosing spondylitis: an autoimmune or autoinflammatory disease?

(2021) Daniele Mauro et al.   Nature Reviews Rheumatology

Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases

(2021) Zoltán Szekanecz et al.   Nature Reviews Rheumatology

Absolute quantification of tumor antigens using embedded MHC-I isotopologue calibrants

(2021) Lauren E. Stopfer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axial involvement in psoriatic arthritis: An update for rheumatologists

(2021) Denis Poddubnyy et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

The discriminatory power of the T cell receptor

(2021) Johannes Pettmann et al.   eLife

Quantifying the Impact of Human Leukocyte Antigen on the Human Gut Microbiota

(2021) Stijn P. Andeweg et al.   mSphere

Efficacy and safety of risankizumab for active psoriatic arthritis: 24-week results from the randomised, double-blind, phase 3 KEEPsAKE 1 trial

(2021) Lars Erik Kristensen et al.   ANNALS OF THE RHEUMATIC DISEASES

ERAP1 Controls the Autoimmune Response against Melanocytes in Psoriasis by Generating the Melanocyte Autoantigen and Regulating Its Amount for HLA-C*06:02 Presentation

(2021) Akiko Arakawa et al.   JOURNAL OF IMMUNOLOGY

A cross-population atlas of genetic associations for 220 human phenotypes

(2021) Saori Sakaue et al.   NATURE GENETICS

High-throughput and high-dimensional single-cell analysis of antigen-specific CD8+ T cells

(2021) Ke-Yue Ma et al.   NATURE IMMUNOLOGY

The spectrum of inflammatory responses

(2021) Ruslan Medzhitov   SCIENCE

Identification of Novel Risk Loci for Behçet's Disease–Related Uveitis in a Chinese Population in a Genome‐Wide Association Study

(2021) Guannan Su et al.   Arthritis & Rheumatology

ERAP1 Controls the Interaction of the Inhibitory Receptor KIR3DL1 With HLA-B51:01 by Affecting Natural Killer Cell Function

(2021) Silvia D’Amico et al.   Frontiers in Immunology

Protection against autoimmunity is driven by thymic epithelial cell–mediated regulation of T reg development

(2021) Claudia Haftmann et al.   Science Immunology

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection

(2020) Bernhard Loll et al.   Frontiers in Immunology

The microbiome in rheumatology: Where are we and where should we go?

(2020) Julia Manasson et al.   ANNALS OF THE RHEUMATIC DISEASES

Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants

(2020) Yael Korem Kohanim et al.   IMMUNITY

The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective

(2020) Farhad Babaie et al.   MOLECULAR IMMUNOLOGY

Efficacy and Safety of Continuous Risankizumab Therapy vs Treatment Withdrawal in Patients With Moderate to Severe Plaque Psoriasis

(2020) Andrew Blauvelt et al.   JAMA Dermatology

T‐cell receptor immunosequencing reveals altered repertoire diversity and disease‐associated clonal expansions in ankylosing spondylitis patients

(2020) Aimee L. Hanson et al.   Arthritis & Rheumatology

EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update

(2020) Laure Gossec et al.   ANNALS OF THE RHEUMATIC DISEASES

DRiPs get molecular

(2020) Jonathan W Yewdell et al.   CURRENT OPINION IN IMMUNOLOGY

Cross‐sectional study reveals that HLA ‐C*07:02 is a potential biomarker of early onset/lesion severity of psoriasis

(2020) Junqin Li et al.   EXPERIMENTAL DERMATOLOGY

Psoriasis and Risk of Uveitis: A Systematic Review and Meta-Analysis

(2020) Chayada Chaiyabutr et al.   Biomed Research International

Retinoic acid-responsive CD8 effector T-cells are selectively increased in IL-23-rich tissue in gastrointestinal GvHD

(2020) Jennifer A Ball et al.   BLOOD

HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis

(2020) Jian Wang et al.   CELL

Risk of autoimmune diseases in recurrent aphthous ulcer patients: A nationwide population study

(2020) Young Chan Lee et al.   ORAL DISEASES

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

(2020) Frank Penkava et al.   Nature Communications

Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis

(2020) Aimee L. Hanson et al.   PLoS Genetics

The Impact of the ‘Mis-Peptidome’ on HLA Class I-Mediated Diseases: Contribution of ERAP1 and ERAP2 and Effects on the Immune Response

(2020) Valentina Tedeschi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8+ T cells in autoimmunity and cancer

(2020) Jared Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A phenome-wide association study of 26 mendelian genes reveals phenotypic expressivity of common and rare variants within the general population

(2020) Catherine Tcheandjieu et al.   PLoS Genetics

Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients

(2020) Shangzhu Zhang et al.   Frontiers in Medicine

Modulators of hERAP2 discovered by high-throughput screening

(2020) Medve Laura et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ERAP1 allotypes impact the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection

(2019) Janine Kemming et al.   JOURNAL OF HEPATOLOGY

ERAP1 shapes just part of the immunopeptidome

(2019) Arie Admon   HUMAN IMMUNOLOGY

HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome

(2019) Mark Asquith et al.   Arthritis & Rheumatology

Autoreactive T-Lymphocytes in Inflammatory Skin Diseases

(2019) Wolf-Henning Boehncke et al.   Frontiers in Immunology

Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes

(2019) Berenice Mbiribindi et al.   Frontiers in Immunology

Synovial IL‐17A+ CD8+ T cells display a polyfunctional, pro‐inflammatory and tissue‐resident memory phenotype and function in psoriatic arthritis

(2019) Kathryn J.A. Steel et al.   Arthritis & Rheumatology

Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

(2019) Zachary Maben et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular pathways for antigenic peptide generation by ER aminopeptidase 1

(2018) Anastasia Mpakali et al.   MOLECULAR IMMUNOLOGY

Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in Psoriasis Pathogenesis

(2018) Jörg Christoph Prinz   Frontiers in Immunology

Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study

(2018) Dominique Baeten et al.   ANNALS OF THE RHEUMATIC DISEASES

Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis

(2018) Jonas J W Kuiper, Jessica van Setten, Matthew Devall, Mircea Cretu-Stancu, Sanne Hiddingh, Roel A Ophoff, Tom O A R Missotten, Mirjam van Velthoven et al.   HUMAN MOLECULAR GENETICS

Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules

(2018) F. Tudor Ilca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three Multicenter, Randomized, Double-Blind, Placebo-Controlled Studies Evaluating the Efficacy and Safety of Ustekinumab in Axial Spondyloarthritis

(2018) Atul Deodhar et al.   Arthritis & Rheumatology

Intracellular antigen processing by ERAP2: Molecular mechanism and roles in health and disease

(2018) José A. López de Castro et al.   HUMAN IMMUNOLOGY

The link between ankylosing spondylitis and oral health conditions: two nested case-control studies using data of the UK Biobank

(2018) Hadeel Mohammed Abbood et al.   Journal of Applied Oral Science

Comorbidity profiles among patients with recurrent aphthous stomatitis: A case–control study

(2018) Kuan-Chou Lin et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins

(2018) José A. López de Castro   Frontiers in Immunology

Characterization of Autoantigen Presentation by HLA-C*06:02 in Psoriasis

(2017) Pengcheng Wei et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Structure of the human MHC-I peptide-loading complex

(2017) Andreas Blees et al.   NATURE

Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility

(2017) Masaki Takeuchi et al.   NATURE GENETICS

Classification of common human diseases derived from shared genetic and environmental determinants

(2017) Kanix Wang et al.   NATURE GENETICS

ERAP1association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations

(2017) Amity R. Roberts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile

(2017) Aimee L. Hanson et al.   Arthritis & Rheumatology

Implications of the diversity of class I HLA associations in psoriatic arthritis

(2016) Robert Winchester et al.   CLINICAL IMMUNOLOGY

Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view

(2016) José A. López de Castro et al.   MOLECULAR IMMUNOLOGY

The influence of ERAP1 gene variants on clinical phenotype in ankylosing spondylitis

(2016) JC Nossent et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Present Yourself! By MHC Class I and MHC Class II Molecules

(2016) Kenneth L. Rock et al.   TRENDS IN IMMUNOLOGY

Genetic Analysis with the Immunochip Platform in Behçet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci

(2016) Lourdes Ortiz-Fernández et al.   PLoS One

Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture

(2015) Philip E. Stuart et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ERAP2functional knockout in humans does not alter surface heavy chains or HLA-B27, inflammatory cytokines or endoplasmic reticulum stress markers

(2015) Philip C Robinson et al.   ANNALS OF THE RHEUMATIC DISEASES

ERAP2is associated with ankylosing spondylitis inHLA-B27-positive andHLA-B27-negative patients

(2015) Philip C Robinson et al.   ANNALS OF THE RHEUMATIC DISEASES

ERAP1 Regulates Natural Killer Cell Function by Controlling the Engagement of Inhibitory Receptors

(2015) L. Cifaldi et al.   CANCER RESEARCH

Activating killer immunoglobulin-like receptors genes are associated with increased susceptibility to ankylosing spondylitis

(2015) R. Díaz-Peña et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease

(2015) Michael J. Ombrello et al.   CURRENT OPINION IN RHEUMATOLOGY

F pocket flexibility influences the tapasin dependence of two differentially disease-associated MHC Class I proteins

(2015) Esam T. Abualrous et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes

(2015) Wong Yu et al.   IMMUNITY

Melanocyte antigen triggers autoimmunity in human psoriasis

(2015) Akiko Arakawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Contained Self-Reactive Peripheral T Cell Repertoire: Size, Diversity, and Cellular Composition

(2015) David M. Richards et al.   JOURNAL OF IMMUNOLOGY

Association with Genetic Variants in the IL-23 and NF-κB Pathways Discriminates between Mild and Severe Psoriasis Skin Disease

(2015) Pernilla Nikamo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

'MHC-I-opathy'—unified concept for spondyloarthritis and Behçet disease

(2015) Dennis McGonagle et al.   Nature Reviews Rheumatology

The immunopathogenesis of birdshot chorioretinopathy; a bird of many feathers

(2015) Jonas Kuiper et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Gastrointestinal Behçet's disease: A review

(2015) Wasseem Skef   WORLD JOURNAL OF GASTROENTEROLOGY

Proteasome inhibitors as experimental therapeutics of autoimmune diseases

(2015) Sue Verbrugge et al.   ARTHRITIS RESEARCH & THERAPY

Concepts of pathogenesis in psoriatic arthritis: genotype determines clinical phenotype

(2015) Oliver FitzGerald et al.   ARTHRITIS RESEARCH & THERAPY

Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility

(2015) Xianyong Yin et al.   Nature Communications

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

(2015) Adrian Cortes et al.   Nature Communications

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

(2015) John Bowes et al.   Nature Communications

ERAP1Gene Expression Is Influenced by Nonsynonymous Polymorphisms Associated With Predisposition to Spondyloarthritis

(2015) Félicie Costantino et al.   Arthritis & Rheumatology

Fine Mapping Major Histocompatibility Complex Associations in Psoriasis and Its Clinical Subtypes

(2014) Yukinori Okada et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A novel evidence-based detection of undiagnosed spondyloarthritis in patients presenting with acute anterior uveitis: the DUET (Dublin Uveitis Evaluation Tool)

(2014) Muhammad Haroon et al.   ANNALS OF THE RHEUMATIC DISEASES

Secretion of interleukin-17 by CD8+ T cells expressing CD146 (MCAM)

(2014) Pradeep K. Dagur et al.   CLINICAL IMMUNOLOGY

Regulating adaptive immune responses using small molecule modulators of aminopeptidases that process antigenic peptides

(2014) Efstratios Stratikos   CURRENT OPINION IN CHEMICAL BIOLOGY

Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis

(2014) T J Kenna et al.   GENES AND IMMUNITY

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy

(2014) Jonas J.W. Kuiper et al.   HUMAN MOLECULAR GENETICS

Peptide-independent stabilization of MHC class I molecules breaches cellular quality control

(2014) Z. Hein et al.   JOURNAL OF CELL SCIENCE

Behcet disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated cytotoxicity

(2014) M. J. Ombrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionally distinctERAP1allotype combinations distinguish individuals with Ankylosing Spondylitis

(2014) Emma Reeves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt

(2014) Hao Li et al.   Nature Communications

The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

(2014) Roberto Lande et al.   Nature Communications

Genetic Dissection of Acute Anterior Uveitis Reveals Similarities and Differences in Associations Observed With Ankylosing Spondylitis

(2014) Philip C. Robinson et al.   Arthritis & Rheumatology

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

A large-scale screen for coding variants predisposing to psoriasis

(2013) Huayang Tang et al.   NATURE GENETICS

The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09

(2013) A. Cauli et al.   RHEUMATOLOGY

Peptidases trimming MHC class I ligands

(2012) Mirjana Weimershaus et al.   CURRENT OPINION IN IMMUNOLOGY

Histological findings of birdshot chorioretinopathy in an eye with ciliochoroidal melanoma

(2012) J S Pulido et al.   EYE

Deep phenotyping for precision medicine

(2012) Peter N. Robinson   HUMAN MUTATION

Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2

(2012) Margit H. Lampen et al.   MOLECULAR IMMUNOLOGY

Analysis of the Paired TCR α- and β-chains of Single Human T Cells

(2012) Song-Min Kim et al.   PLoS One

Relationships of HLA-B51 or B5 genotype with Behçet's disease clinical characteristics: systematic review and meta-analyses of observational studies

(2012) Carla Maldini et al.   RHEUMATOLOGY

Natural Killer Cells Efficiently Reject Lymphoma Silenced for the Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing

(2011) L. Cifaldi et al.   CANCER RESEARCH

Expression of MHC class I dimers and ERAP1 in an ankylosing spondylitis patient cohort

(2011) Elaine C. Campbell et al.   IMMUNOLOGY

The Human Immunopeptidome Project, a Suggestion for yet another Postgenome Next Big Thing

(2011) Arie Admon et al.   MOLECULAR & CELLULAR PROTEOMICS

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Association analyses identify six new psoriasis susceptibility loci in the Chinese population

(2010) Liang-Dan Sun et al.   NATURE GENETICS

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

(2010) John D Reveille et al.   NATURE GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Endoplasmic reticulum aminopeptidases: biology and pathogenic potential

(2010) Nigil Haroon et al.   Nature Reviews Rheumatology

Extraocular manifestations of birdshot chorioretinopathy in 118 French patients

(2010) Christian Pagnoux et al.   PRESSE MEDICALE

ER stress affects processing of MHC class I-associated peptides

(2009) Diana P Granados et al.   BMC IMMUNOLOGY

HLA-B27 polymorphism at position 116 critically influences the association with TAP/tapasin, intracellular trafficking and conformational homodimers formation

(2009) M.A. Blanco-Gelaz et al.   MOLECULAR IMMUNOLOGY