Article
Cell Biology
Melissa G. Lechner, Zikang Zhou, Aline T. Hoang, Nicole Huang, Jessica Ortega, Lauren N. Scott, Ho -Chung Chen, Anushi Y. Patel, Rana Yakhshi-Tafti, Kristy Kim, Willy Hugo, Pouyan Famini, Alexandra Drakaki, Antoni Ribas, Trevor E. Angell, Maureen A. Su
Summary: Autoimmune toxicity is an increasing challenge in using immune checkpoint inhibitors for cancer treatment. This study investigated the immune infiltrates in ICI-thyroiditis patients and identified a dominant population of cytotoxic CD8+ T cells. The researchers also found that interleukin-21 played a crucial role in the formation of these thyrotoxic CD8+ T cells and validated the findings in a mouse model. These findings provide insights into the mechanisms and potential therapeutic targets for individuals with IRAEs.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biology
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Summary: In this study, it was identified that Tregs limit the availability of IL-2, thereby suppressing the formation of a previously uncharacterized subset of antigen-stimulated KILR CD8(+) effector T cells. These KILR CD8(+) T cells exhibit superior cell-killing abilities and can be induced by the administration of agonistic IL-2 immunocomplexes. This research has potential implications for immunotherapy targeting these cells in humans.
Article
Immunology
Shannon M. Kahan, Rakesh K. Bakshi, Jennifer T. Ingram, R. Curtis Hendrickson, Elliot J. Lefkowitz, David K. Crossman, Laurie E. Harrington, Casey T. Weaver, Allan J. Zajac
Summary: The ability to produce IL-2 identifies constituents of the expanded CD8 T cell effector pool with stem-like features, which exhibit superior protective powers. The production of IL-2 by cells attenuates the ability to receive IL-2 signals, limiting terminal effector formation and conferring superior protection. Non-producing effector cells, on the other hand, gain effector traits at the expense of memory formation. Despite distinct properties during the effector phase, IL-2-producing and non-producing CD8 T cells converge transcriptionally as memory matures, forming populations with equal recall abilities.
SCIENCE IMMUNOLOGY
(2022)
Review
Food Science & Technology
Astri Dewayani, Kartika Afrida Fauzia, Ricky Indra Alfaray, Langgeng Agung Waskito, Dalla Doohan, Yudith Annisa Ayu Rezkitha, Abdurachman Abdurachman, Takashi Kobayashi, Reny I'tishom, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: The development of Helicobacter pylori-related diseases is closely linked to chronic inflammation, which is significantly impacted by immune responses. Key cytokines such as IL-17, IL-21, and IL-23 play crucial roles in antimicrobial activity and pathogenic immune response, maintaining Th17 cells and accommodating humoral immune cells in the gut environment.
Article
Cell Biology
Victor Tkachev, James Kaminski, E. Lake Potter, Scott N. Furlan, Alison Yu, Daniel J. Hunt, Connor McGuckin, Hengqi Zheng, Lucrezia Colonna, Ulrike Gerdemann, Judith Carlson, Michelle Hoffman, Joe Olvera, Chris English, Audrey Baldessari, Angela Panoskaltsis-Mortari, Benjamin Watkins, Muna Qayed, Yvonne Suessmuth, Kayla Betz, Brandi Bratrude, Amelia Langston, John T. Horan, Jose Ordovas-Montanes, Alex K. Shalek, Bruce R. Blazar, Mario Roederer, Leslie S. Kean
Summary: The study reveals the processes by which donor CD8(+) T cells infiltrate tissues and establish pathogenic tissue residency in acute graft-versus-host disease (aGVHD). By combining intravascular staining with single-cell RNA sequencing, researchers created a map of transcriptional programs controlling donor T cell infiltration into the primary aGVHD target organ, the gastrointestinal tract. The gene expression signature associated with tissue invasion was able to distinguish CD8(+) T cell transcriptome in patients with GI aGVHD from GVHD-free patients.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Yihe Chen, Chunyi Shao, Nai-Wen Fan, Takeshi Nakao, Afsaneh Amouzegar, Sunil K. Chauhan, Reza Dana
Summary: In a murine model of dry eye disease (DED), a linear transition from effector to memory Th17 cells was detected during the abatement phase of acute inflammation, with persistently high levels of IL-23 and diminished levels of IL-2. Additionally, in vitro culture of effector Th17 cells with IL-23 but not IL-2 led to significant generation of memory Th17 cells. The data demonstrate a new dichotomy between IL-23 and IL-2 in driving effector Th17 cells into the memory pool in autoimmune-mediated ocular surface inflammation.
MUCOSAL IMMUNOLOGY
(2021)
Article
Oncology
Florian J. Sulzmaier, Nadja Kern, Sae Jeong Ahn, Anya Polovina, Jason Ho, Abrahim Hussain, Garrett Cyprus, Chelsie Macedo, Rajay Pandit, William Crago, Emily Rowell, John C. Timmer, Brendan P. Eckelman
Summary: INBRX-120 is a CD8 alpha-targeted Cisleukin (TM) molecule that selectively activates and expands the antitumor activity of CD8 T cells and natural killer cells without affecting regulatory T cells. It demonstrates good safety and pharmacodynamic profile.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Mostafa G. G. Aly, Eman H. H. Ibrahim, Hristos Karakizlis, Rolf Weimer, Gerhard Opelz, Christian Morath, Martin Zeier, Naruemol Ekpoom, Volker Daniel
Summary: In this study, the relationship between regulatory cells and immunosuppressive drugs in transplant recipients was investigated. The results showed a negative correlation between CD4+CD25+CD127-Foxp3+ Tregs and CD19+IL-10+ Bregs in early transplant recipients, with Tregs being affected by steroid dose and tacrolimus levels, while Bregs seemed less affected by potent immunosuppression. It was also found that CD4+CD25+CD127-Foxp3+ Tregs were lower in patients treated with certain antibodies compared to end-stage kidney disease patients. Early transplant recipients exhibited different patterns of Tregs and Bregs within the first 3 months post-transplant, indicating a complex relationship between these regulatory cells and immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
David Bastian, Xiaohui Sui, Hee-Jin Choi, Yongxia Wu, Linlu Tian, Kaipo Yang, Chen Liu, Yuejun Liu, Xue-Zhong Yu
Summary: The gastrointestinal tract is commonly affected in acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic cell transplantation (allo-HCT). IL-12 plays a critical role in the development of GVHD, and reducing IL-12R132 expression on host nonhematopoietic cells attenuates aGVHD and preserves intestinal integrity.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Virology
Siva Thirugnanam, Edith M. Walker, Faith Schiro, Pyone P. Aye, Jay Rappaport, Namita Rout
Summary: Previous studies have shown that the loss of CD161-expressing CD4(+) Th17 cells is associated with the progression of chronic HIV infection. These cells are significantly reduced in the peripheral blood and gut mucosa of HIV-infected individuals, leading to inflammation and disruption of the gut barrier. However, the impact of HIV infection on CD161-expressing CD8(+) T cells is still unclear.
Article
Immunology
Dong Hyun Kim, Hee Young Kim, Won-Woo Lee
Summary: IL-1 beta enhances the effector function of CD8(+) T cells expressing IL-21-induced IL-1RI, playing a crucial role in immune responses, which is beneficial for combating viral infections.
Article
Immunology
Israel Parra-Ortega, Noemi Najera-Martinez, Felix Gaytan-Morales, Ivan Castorena-Villa, Briceida Lopez-Martinez, Vianney Ortiz-Navarrete, Irlanda Olvera-Gomez
Summary: During allogeneic Hematopoietic stem cell transplantation (HSCT), chronic graft versus host disease (GVHD) leads to an enrichment of TEM cells in CD4 and CD8 T cells, while viral infections are associated with poor recovery of T cells after HSCT.
TRANSPLANT IMMUNOLOGY
(2023)
