ERAP1 Controls the Autoimmune Response against Melanocytes in Psoriasis by Generating the Melanocyte Autoantigen and Regulating Its Amount for HLA-C*06:02 Presentation

Lesional activation of T c 17 cells in Behçet disease and psoriasis supports HLA class I‐mediated autoimmune responses

(2021) S. Vural et al.   BRITISH JOURNAL OF DERMATOLOGY

Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System

(2020) Sarah E. Mann et al.   Frontiers in Immunology

HPV Epitope Processing Differences Correlate with ERAP1 Allotype and Extent of CD8+ T-cell Tumor Infiltration in OPSCC

(2019) Emma Reeves et al.   Cancer Immunology Research

IPD-IMGT/HLA Database

(2019) James Robinson et al.   NUCLEIC ACIDS RESEARCH

Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1

(2019) Petros Giastas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unopposed IL-36 Activity Promotes Clonal CD4 + T-Cell Responses with IL-17A Production in Generalized Pustular Psoriasis

(2018) Akiko Arakawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The role of polymorphic ERAP1 in autoinflammatory disease

(2018) Emma Reeves et al.   BIOSCIENCE REPORTS

Autoantigens ADAMTSL5 and LL37 are significantly upregulated in active Psoriasis and localized with keratinocytes, dendritic cells and other leukocytes

(2017) Judilyn Fuentes-Duculan et al.   EXPERIMENTAL DERMATOLOGY

The molecular basis for peptide repertoire selection in the human leukocyte antigen (HLA) C*06:02 molecule

(2017) Jesse I. Mobbs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices

(2017) Moreno Di Marco et al.   JOURNAL OF IMMUNOLOGY

The Human Leukocyte Antigen (HLA)-B27 Peptidomein Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion

(2017) Eilon Barnea et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural and regulatory diversity shape HLA-C protein expression levels

(2017) Gurman Kaur et al.   Nature Communications

Targeting CD8+ T cells prevents psoriasis development

(2016) Paola Di Meglio et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease

(2015) Michael J. Ombrello et al.   CURRENT OPINION IN RHEUMATOLOGY

Melanocyte antigen triggers autoimmunity in human psoriasis

(2015) Akiko Arakawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

'MHC-I-opathy'—unified concept for spondyloarthritis and Behçet disease

(2015) Dennis McGonagle et al.   Nature Reviews Rheumatology

ERAP1Gene Expression Is Influenced by Nonsynonymous Polymorphisms Associated With Predisposition to Spondyloarthritis

(2015) Félicie Costantino et al.   Arthritis & Rheumatology

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

Naturally Occurring ERAP1 Haplotypes Encode Functionally Distinct Alleles with Fine Substrate Specificity

(2013) E. Reeves et al.   JOURNAL OF IMMUNOLOGY

ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases

(2013) Carlos Alvarez-Navarro et al.   MOLECULAR IMMUNOLOGY

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

A large-scale screen for coding variants predisposing to psoriasis

(2013) Huayang Tang et al.   NATURE GENETICS

Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides

(2012) Katherina Siewert et al.   NATURE MEDICINE

Analysis of the Paired TCR α- and β-chains of Single Human T Cells

(2012) Song-Min Kim et al.   PLoS One

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

(2011) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Association analyses identify six new psoriasis susceptibility loci in the Chinese population

(2010) Liang-Dan Sun et al.   NATURE GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C

(2009) Rasmi Thomas et al.   NATURE GENETICS

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

(2009) Rajan P Nair et al.   NATURE GENETICS

T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

(2008) Sarah E Henrickson et al.   NATURE IMMUNOLOGY