Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection

Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin

(2019) Ida Hafstrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural aspects of chaperone-mediated peptide loading in the MHC-I antigen presentation pathway

(2019) Kannan Natarajan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

(2019) Robert Busch et al.   Nature Reviews Rheumatology

Rethinking Thymic Tolerance: Lessons from Mice

(2019) Sarah Inglesfield et al.   TRENDS IN IMMUNOLOGY

Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B*27 subtype

(2019) Ronja Driller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered Cytotoxicity Profile of CD8+ T cells in Ankylosing Spondylitis

(2019) Eric Gracey et al.   Arthritis & Rheumatology

Previously Hidden Dynamics at the TCR–Peptide–MHC Interface Revealed

(2018) James Fodor et al.   JOURNAL OF IMMUNOLOGY

Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle

(2018) Andrew C. McShan et al.   Nature Chemical Biology

The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling

(2018) Kannan Natarajan et al.   Frontiers in Immunology

The role of HLA-B*27 in spondyloarthritis

(2018) Robert A. Colbert et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy

(2018) Guo Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrating Experiment and Theory to Understand TCR-pMHC Dynamics

(2018) Ashley M. Buckle et al.   Frontiers in Immunology

Update on Aire and thymic negative selection

(2017) Geraldo A. Passos et al.   IMMUNOLOGY

Computational characterization of residue couplings and micropolymorphism-induced changes in the dynamics of two differentially disease-associated human MHC class-I alleles

(2017) Onur Serçinoğlu et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

The Mechanisms of T Cell Selection in the Thymus

(2017) Hiroyuki Takaba et al.   TRENDS IN IMMUNOLOGY

HLA-B27

(2015) Paul Bowness   Annual Review of Immunology

F pocket flexibility influences the tapasin dependence of two differentially disease-associated MHC Class I proteins

(2015) Esam T. Abualrous et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Increased conformational flexibility characterizes HLA-B*27 subtypes associated with ankylosing spondylitis

(2015) Bernhard Loll et al.   Arthritis & Rheumatology

X-ray refinement significantly underestimates the level of microscopic heterogeneity in biomolecular crystals

(2014) Antonija Kuzmanic et al.   Nature Communications

Novel HLA-B27-restricted Epitopes fromChlamydia trachomatisGenerated upon Endogenous Processing of Bacterial Proteins Suggest a Role of Molecular Mimicry in Reactive Arthritis

(2013) Carlos Alvarez-Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional mosaic nature of MHC class I molecules in their peptide-free form

(2013) Eiji Kurimoto et al.   MOLECULAR IMMUNOLOGY

Recognition of self and altered self by T cells in autoimmunity and allergy

(2013) Lei Yin et al.   Protein & Cell

Interaction Pattern of Arg 62 in the A-Pocket of Differentially Disease-Associated HLA-B27 Subtypes Suggests Distinct TCR Binding Modes

(2012) Elisa Nurzia et al.   PLoS One

HLA class I-associated diseases with a suspected autoimmune etiology: HLA-B27 subtypes as a model system

(2011) Barbara Uchanska-Ziegler et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Influence of inflammation-related changes on conformational characteristics of HLA-B27 subtypes as detected by IR spectroscopy

(2011) Heinz Fabian et al.   FEBS Journal

Dynamical Characterization of Two Differentially Disease Associated MHC Class I Proteins in Complex with Viral and Self-Peptides

(2011) Daniele Narzi et al.   JOURNAL OF MOLECULAR BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

HLA-B27 heavy chains distinguished by a micropolymorphism exhibit differential flexibility

(2010) Heinz Fabian et al.   ARTHRITIS AND RHEUMATISM

CD8+ T-cell mediated self-reactivity in HLA-B27 context as a consequence of dual peptide conformation

(2010) Elisa Nurzia et al.   CLINICAL IMMUNOLOGY

Conformational changes and flexibility in T-cell receptor recognition of peptide–MHC complexes

(2008) Kathryn M. Armstrong et al.   BIOCHEMICAL JOURNAL

Citrullination-dependent Differential Presentation of a Self-peptide by HLA-B27 Subtypes

(2008) Alessandra Beltrami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HLA-B27 Subtypes Differentially Associated with Disease Exhibit Conformational Differences in Solution

(2007) Heinz Fabian et al.   JOURNAL OF MOLECULAR BIOLOGY