Article
Rheumatology
Andrew Ostor, Filip Van den Bosch, Kim Papp, Cecilia Asnal, Ricardo Blanco, Jacob Aelion, Gabriela Alperovich, Wenjing Lu, Zailong Wang, Ahmed M. Soliman, Ann Eldred, Lisa Barcomb, Alan Kivitz
Summary: The study found that treatment with risankizumab resulted in significant improvements in key disease outcomes for patients with PsA who were Bio-IR and/or csDMARD-IR, and was well tolerated.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Lars Erik Kristensen, Mauro Keiserman, Kim Papp, Leslie McCasland, Douglas White, Wenjing Lu, Ahmed M. Soliman, Ann Eldred, Lisa Barcomb, Frank Behrens
Summary: This follow-up analysis evaluated the 52-week efficacy and safety of risankizumab 150 mg in patients with active PsA who had previous inadequate response/intolerance to one or more conventional synthetic DMARDs. The results showed that continuous treatment with risankizumab achieved robust long-term efficacy and was well tolerated through 52 weeks of treatment.
Article
Rheumatology
Andrew Ostor, Filip van den Bosch, Kim Papp, Cecilia Asnal, Ricardo Blanco, Jacob Aelion, Wenjing Lu, Zailong Wang, Ahmed M. Soliman, Ann Eldred, Byron Padilla, Alan Kivitz
Summary: This study evaluated the efficacy and safety of risankizumab 150 mg in patients with active PsA for 52 weeks. The results showed that risankizumab was effective in improving symptoms and had a good safety profile.
Article
Rheumatology
Lars Erik Kristensen, Ahmed M. Soliman, Kim Papp, Douglas White, Lisa Barcomb, Wenjing Lu, Ann Eldred, Frank Behrens
Summary: Treatment with risankizumab leads to significant improvements in health-related quality of life, fatigue, pain, and work productivity in patients with active PsA who have inadequate response or intolerance to conventional synthetic DMARD.
Article
Rheumatology
Xiaomei Leng, Wei Lin, Shixue Liu, Keith Kanik, Cunshan Wang, Weiguo Wan, Zhenyu Jiang, Yi Liu, Shengyun Liu, Zhuoli Zhang, Zhiyi Zhang, Jian Xu, Wenfeng Tan, Jiankang Hu, Jingyang Li, Ju Liu, Levent M. Gunay, Oluwaseyi Dina, Cassandra Kinch, Xiaofeng Zeng
Summary: The efficacy and safety of tofacitinib were evaluated in Chinese patients with active Psoriatic Arthritis who had inadequate response to conventional synthetic disease-modifying antirheumatic drug. Tofacitinib showed greater efficacy compared to placebo at both primary and secondary endpoints. The drug was well tolerated with a consistent safety profile.
Article
Rheumatology
Andrew J. K. Ostor, Ahmed M. Soliman, Kim A. Papp, Byron Padilla, Zailong Wang, Ann Eldred, Kurt de Vlam, Alan Kivitz
Summary: The study found that treatment with risankizumab resulted in significant improvements in pain, fatigue, health-related quality of life, and work ability in patients with psoriatic arthritis who had inadequate response to one or two biologics and/or one or more conventional synthetic disease-modifying antirheumatic drugs.
Article
Rheumatology
Christopher T. Ritchlin, Laura C. Coates, Iain B. Mcinnes, Philip J. Mease, Joseph F. Merola, Yoshiya Tanaka, Akihiko Asahina, Laure Gossec, Alice B. Gottlieb, Richard B. Warren, Barbara Ink, Rajan Bajracharya, Vishvesh Shende, Jason Coarse, Robert B. M. Landewe
Summary: The long-term efficacy and safety of Bimekizumab (BKZ) in patients with psoriatic arthritis (PsA) was evaluated. The results showed that the efficacy of BKZ was sustained from Week 16 to Week 52, and patients who switched to BKZ treatment demonstrated similar efficacy to those who received BKZ continuously. BKZ treatment was well tolerated without any new safety signals.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Philip J. Mease, Saima Chohan, Ferran J. Garcia Fructuoso, Michael E. Luggen, Proton Rahman, Siba P. Raychaudhuri, Richard C. Chou, Alan M. Mendelsohn, Stephen J. Rozzo, Alice Gottlieb
Summary: Tildrakizumab treatment significantly improved joint and skin manifestations of PsA, with good tolerability through Week 52. However, the effectiveness on dactylitis and enthesitis was not significant.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Gastroenterology & Hepatology
Siew C. Ng, Zhilu Xu, Joyce Wing Yan Mak, Keli Yang, Qin Liu, Tao Zuo, Whitney Tang, Louis Lau, Rashid N. Lui, Sunny H. Wong, Yee Kit Tse, Amy Y. L. Li, Kitty Cheung, Jessica Y. L. Ching, Vincent W. S. Wong, Alice P. S. Kong, Ronald C. W. Ma, Elaine Y. K. Chow, Simon K. H. Wong, Ivan Chak Hang Ho, Paul K. S. Chan, Francis K. L. Chan
Summary: Repeated FMTs enhance microbiota engraftment in obese patients with T2DM, leading to more favorable changes in recipients' microbiota and improvement in lipid profile and liver stiffness when combined with lifestyle intervention.
Article
Medicine, General & Internal
Marc Ferrante, Remo Panaccione, Filip Baert, Peter Bossuyt, Jean-Frederic Colombel, Silvio Danese, Marla Dubinsky, Brian G. Feagan, Tadakazu Hisamatsu, Allen Lim, James O. Lindsay, Edward V. Loftus, Julian Panes, Laurent Peyrin-Biroulet, Zhihua Ran, David T. Rubin, William J. Sandborn, Stefan Schreiber, Ezequiel Neimark, Alexandra Song, Kristina Kligys, Yinuo Pang, Valerie Pivorunas, Sofie Berg, W. Rachel Duan, Bidan Huang, Jasmina Kalabic, Xiaomei Liao, Anne Robinson, Kori Wallace, Geert D'Haens
Summary: Subcutaneous risankizumab is a safe and effective treatment for maintenance of remission in patients with moderately to severely active Crohn's disease and offers a new therapeutic option that might change the future course of the disease.
Article
Rheumatology
Xenofon Baraliakos, Laure Gossec, Effie Pournara, Slawomir Jeka, Antonio Mera-Varela, Salvatore D'Angelo, Barbara Schulz, Michael Rissler, Kriti Nagar, Chiara Perella, Laura C. Coates
Summary: The MAXIMISE trial demonstrated that secukinumab significantly improved axial disease symptoms in patients with PsA, particularly those with inadequate response to NSAIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Hermine Brunner, Ivan Foeldvari, Ekaterina Alexeeva, Nuray Aktay Ayaz, Inmaculada Calvo Penades, Ozgur Kasapcopur, Vyacheslav G. Chasnyk, Markus Hufnagel, Zbigniew Zuber, Grant Schulert, Seza Ozen, Adelina Rakhimyanova, Athimalaipet Ramanan, Christiaan Scott, Betul Sozeri, Elena Zholobova, Ruvie Martin, Xuan Zhu, Sarah Whelan, Luminita Pricop, Alberto Martini, Daniel Lovell, Nicolino Ruperto
Summary: This study demonstrates that secukinumab has a significant effect in prolonging the time to disease flare in children with ERA and JPsA, with a consistent safety profile to the adult indications.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Takamitsu Makino, Hironobu Ihn, Motoo Nakagawa, Misugi Urano, Ryuhei Okuyama, Norito Katoh, Chiharu Tateishi, Koji Masuda, Eisaku Ogawa, Emi Nishida, Shohei Nishimoto, Kenzo Muramoto, Daisuke Tsuruta, Akimichi Morita
Summary: This study examined axial involvement in PsA patients using MRI and evaluated the efficacy of 24-week adalimumab treatment in improving spondylitis and sacroiliitis. The results showed that spondylitis and sacroiliitis were common in PsA patients, and treatment with adalimumab for 24 weeks resulted in improvement in these conditions.
Article
Rheumatology
Philip J. Mease, Herbert Kellner, Akimichi Morita, Alan J. Kivitz, Stella Aslanyan, Steven J. Padula, Andrew S. Topp, Ann Eldred, Frank Behrens, Kim A. Papp
Summary: This study assessed the efficacy and safety of risankizumab in psoriatic arthritis (PsA) patients over 76 weeks. The results showed that risankizumab significantly improved joint and skin symptoms in PsA patients compared to placebo, and these improvements were sustained long term. Risankizumab was well tolerated with no new safety findings over the 76-week period.
RHEUMATOLOGY AND THERAPY
(2022)
Article
Medicine, General & Internal
Michelle Petri, Ian N. Bruce, Thomas Doerner, Yoshiya Tanaka, Eric F. Morand, Kenneth C. Kalunian, Mario H. Cardiel, Maria E. Silk, Christina L. Dickson, Gabriella Meszaros, Lu Zhang, Bochao Jia, Youna Zhao, Conor J. McVeigh, Marta Mosca
Summary: Baricitinib, an oral inhibitor of Janus kinase 1 and 2, was evaluated as a treatment for patients with systemic lupus erythematosus (SLE) in a 52-week phase 3 study. The study found that baricitinib did not significantly improve SLE disease activity compared with placebo, and there were no new safety concerns.
Article
Dermatology
Andrew Blauvelt, Kenneth B. Gordon, Patricia Lee, Jerry Bagel, Howard Sofen, Benjamin Lockshin, Ahmed M. Soliman, Ziqian Geng, Tianyu Zhan, Gabriela Alperovich, Linda Stein Gold
Summary: The study showed that the single self-administered injection of 150 mg/mL risankizumab is effective and safe for patients with moderate to severe plaque psoriasis, and patients have high acceptance of this form of treatment.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
April W. Armstrong, Ahmed M. Soliman, Keith A. Betts, Yan Wang, Yawen Gao, Vassilis Stakias, Luis Puig
Summary: Through network meta-analysis, risankizumab was found to have the most favorable long-term benefit-risk profile for the treatment of moderate-to-severe plaque psoriasis, while ixekizumab and bimekizumab showed good efficacy but lower rankings for safety outcomes.
DERMATOLOGY AND THERAPY
(2022)
Article
Dermatology
Mark G. Lebwohl, Ahmed M. Soliman, Hongbo Yang, Jessie Wang, Kaitlin Hagan, Byron Padilla, Andreas Pinter
Summary: This study used data from four phase 3 randomized clinical trials of risankizumab to estimate the duration of PASI 90 and DLQI 0/1 among patients with moderate-to-severe psoriasis receiving risankizumab and other treatments during a one-year period. The results showed that patients treated with risankizumab had longer durations of PASI 90 and DLQI 0/1 compared to patients treated with other therapies.
DERMATOLOGY AND THERAPY
(2022)
Article
Multidisciplinary Sciences
Amr A. Hassanain, Mohamed A. A. Eldosoky, Ahmed M. Soliman
Summary: Designing healthcare facilities is crucial for providing high-quality care, as it directly impacts productivity, economic performance, clinical outcomes, and patient/staff satisfaction. Redesigning healthcare facilities can create a serene healing environment, improving patient healing rates, reducing time spent in facilities, and increasing satisfaction levels. Evaluation methodologies, including weighting standards and using algorithms to measure layout scores, help assess performance and determine the need for redesign.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Lars Erik Kristensen, Ahmed M. Soliman, Kim Papp, Douglas White, Lisa Barcomb, Wenjing Lu, Ann Eldred, Frank Behrens
Summary: Treatment with risankizumab leads to significant improvements in health-related quality of life, fatigue, pain, and work productivity in patients with active PsA who have inadequate response or intolerance to conventional synthetic DMARD.
Article
Engineering, Electrical & Electronic
Amal Ibrahim Mahmood, Sadik Kamel Gharghan, Mohamed A. Eldosoky, Ahmed M. Soliman
Summary: Biomedical implants (BMI) and biomedical sensors (BMS) are important in improving quality of life by detecting diseases and ensuring the proper functioning of organs. This research focuses on developing a wireless charging system specifically for cardiac pacemakers. The study investigates the impact of different parameters such as air gap, source voltage, coil size, and operating frequency on the performance of the system. Results show that the system achieves high power transfer efficiency at an operating frequency of 1.78 MHz.
INTERNATIONAL JOURNAL OF CIRCUIT THEORY AND APPLICATIONS
(2023)
Article
Rheumatology
Andrew Ostor, Filip van den Bosch, Kim Papp, Cecilia Asnal, Ricardo Blanco, Jacob Aelion, Wenjing Lu, Zailong Wang, Ahmed M. Soliman, Ann Eldred, Byron Padilla, Alan Kivitz
Summary: This study evaluated the efficacy and safety of risankizumab 150 mg in patients with active PsA for 52 weeks. The results showed that risankizumab was effective in improving symptoms and had a good safety profile.
Article
Rheumatology
Lars Erik Kristensen, Mauro Keiserman, Kim Papp, Leslie McCasland, Douglas White, Wenjing Lu, Ahmed M. Soliman, Ann Eldred, Lisa Barcomb, Frank Behrens
Summary: This follow-up analysis evaluated the 52-week efficacy and safety of risankizumab 150 mg in patients with active PsA who had previous inadequate response/intolerance to one or more conventional synthetic DMARDs. The results showed that continuous treatment with risankizumab achieved robust long-term efficacy and was well tolerated through 52 weeks of treatment.
Article
Obstetrics & Gynecology
Bhuchitra Singh, Julia Berry, Michelle Volovsky, Yanqing Xu, Ahmed M. Soliman, Carol B. Thompson, James H. Segars
Summary: The objective of this study was to evaluate the utility and impact of the Painful Periods Screening Tool (PPST) to improve healthcare delivery for people with symptoms of pelvic pain. The results showed that most participants reported severe pain during menstruation, and using the PPST helped them discuss their symptoms more easily with healthcare providers.
REPRODUCTIVE SCIENCES
(2023)
Article
Engineering, Electrical & Electronic
Amal Ibrahim Mahmood, Sadik Kamel Gharghan, Mohamed A. A. Eldosoky, Ahmed M. Soliman
Summary: Implantable biomedical devices and biomedical sensors enhance patients' quality of life by monitoring vital signs, detecting diseases, and replacing malfunctioning organs. However, these devices require battery power and have limited battery life. Wireless power transfer (WPT) is a practical solution to address this limitation.
IET POWER ELECTRONICS
(2023)
Article
Polymer Science
Manar Fathy Al-Sayed, Mohamed Tarek El-Wakad, Mohammed A. Hassan, Ahmed M. Soliman, Amal S. Eldesoky
Summary: This study prepared silver nitrate sol-gel with different concentrations and pH values, and evaluated its antimicrobial activity and biocompatibility. The results showed that a concentration of 0.03496% exhibited the highest effectiveness in inhibiting bacterial colonization, indicating that silver nitrate sol-gel may be a potential preventive measure against VAP.
Article
Plant Sciences
Marwa A. Hamada, Ahmed M. Soliman, Hoda H. El-Hendawy
Summary: This study evaluated the level of bacterial contamination in minced meat samples treated with essential oils or untreated. The results showed that untreated samples had higher counts of various types of bacteria compared to treated samples. The total bacterial contamination was greater in samples collected in summer compared to samples collected in winter. Adding marjoram or thyme essential oils significantly extended the shelf life of minced meat at 2oC without affecting its quality and sensory properties.
EGYPTIAN JOURNAL OF BOTANY
(2023)