Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Daniel Pereira, Richard J. Cook, Vinod Chandran, Nigil Haroon, Robert D. Inman, Dafna D. Gladman
Summary: Isolated axial PsA and AS with psoriasis are relatively uncommon. HLA-B*27 positivity is associated with isolated axial PsA and may predict the development of peripheral disease. Isolated axial PsA is associated with better functional status. Isolated axial PsA appears clinically distinct from isolated axial AS with psoriasis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Xabier Michelena, Clementina Lopez-Medina, Alba Erra, Xavier Juanola, Pilar Font-Ugalde, Eduardo Collantes, Helena Marzo-Ortega
Summary: This study compared the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) with ankylosing spondylitis (AS) with psoriasis. It found that axial PsA is predominantly HLA-B27 negative and has different manifestations compared to AS with psoriasis. There is great heterogeneity in the definition of axial PsA from a clinical and imaging perspective.
Article
Biochemistry & Molecular Biology
Krzysztof Bonek, Ewa Kuca Warnawin, Anna Kornatka, Magdalena Plebanczyk, Tomasz Burakowski, Wlodzimierz Maslinski, Malgorzata Wislowska, Piotr Gluszko, Marzena Ciechomska
Summary: This study investigates the associations between miR signatures and cytokines, serum lipids, and disease activity in patients with PsA, AS, and RA. The results show the superiority of miR expressions in distinguishing between RA, PsA, and AS, and a unique regulatory pathway in PsA.
Article
Biochemistry & Molecular Biology
Chia-Jung Tsai, Yu-Chih Lin, Chung-Yu Chen, Chih-Hsing Hung, Yi-Ching Lin
Summary: This retrospective study analyzed the impact of biologics and non-biologics treatment on the development of hematologic malignancies in patients with AS, psoriasis, and PsA. The results showed that biologics significantly increased the risk of hematologic malignancies, specifically non-Hodgkin's lymphoma. Different treatment patterns, types of biologics, cumulative defined daily doses, comorbidities, and comedications did not have a significant effect on hematologic malignancy development.
Article
Rheumatology
Fataneh Tavasolian, Starlee Lively, Chiara Pastrello, Michael Tang, Melissa Lim, Addison Pacheco, Zoya Qaiyum, Enoch Yau, Zeynep Baskurt, Igor Jurisica, Mohit Kapoor, Robert D. Inman
Summary: Advances in genomics and proteomics have provided new insights into the biology of ankylosing spondylitis (AS), offering opportunities for improved diagnosis and management. Altered gene, microRNA, and protein expression have been implicated in immune dysregulation and inflammation in AS. This study demonstrates that exosomes from AS patients inhibit the proliferation of regulatory T cells, potentially contributing to the chronically activated T cells seen in this disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Clementina Lopez-Medina, Anna Molto, Joachim Sieper, Tuncay Duruoz, Uta Kiltz, Bassel Elzorkany, Najia Hajjaj-Hassouni, Ruben Burgos-Vargas, Jose Maldonado-Cocco, Nelly Ziade, Meghna Gavali, Victoria Navarro-Compan, Shue-Fen Luo, Sara Monti, Kim Tae-Jong, Mitsumasa Kishimoto, F. M. Pimentel-Santos, Jieruo Gu, Ruxandra Schiotis, Floris A. van Gaalen, Pal Geher, Marina Magrey, Sebastian E. Ibanez Vodnizza, Wilson Bautista-Molano, Walter Maksymowych, Pedro M. Machado, Robert Landew, Desiree van der Heijde, Maxime Dougados
Summary: This study included 4465 patients with SpA from 24 countries around the world, showing quantitative differences in peripheral manifestations among different subtypes but no significant qualitative differences. It was found that a high proportion of patients with SpA had both axial and peripheral manifestations coinciding.
Article
Rheumatology
Adrian Ciurea, Andrea Gotschi, Seraphina Kissling, Alexander Bernatschek, Kristina Burki, Pascale Exer, Michael J. Nissen, Burkhard Moller, Almut Scherer, Raphael Micheroli
Summary: This study compared the characteristics of patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and found differences in demographic and clinical features between the two groups, but a similar disease burden.
Review
Rheumatology
Monica Schwartzman, Joerg Ermann, Kristine A. Kuhn, Sergio Schwartzman, Michael H. Weisman
Summary: This systematic literature review critically appraises study designs evaluating spondyloarthritis (SpA) phenotypes in patients with inflammatory bowel disease (IBD). The review finds that the characterization of SpA phenotypes in IBD patients remains incomplete and suggests the need for standardization of variables and definitions in order to advance clinical and research purposes.
Article
Rheumatology
Siwen Chen, Zihao Li, Dongying Chen, Haowen Cui, Jianru Wang, Zemin Li, Xiang Li, Zhaomin Zheng, Zhongping Zhan, Hui Liu
Summary: The aim of this study was to identify the role of Piezo1-mediated mechanotransduction in entheseal pathological new bone formation and explore the underlying molecular mechanism. It was found that Piezo1 was aberrantly upregulated in ligaments and entheseal tissues from patients with ankylosing spondylitis (AS) and animal models. Pharmacological and genetic inhibition of Piezo1 attenuated while its activation promoted pathological new bone formation. Mechanistically, activation of CaMKII signalling was found essential for Piezo1-mediated mechanotransduction. Additionally, Piezo1 was upregulated by AS-associated inflammatory cytokines.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Ana De Vicente Delmas, Lara Sanchez-Bilbao, Vanesa Calvo-Rio, David Martinez-Lopez, Alba Herrero-Morant, Eva Galindez-Agirregoikoa, Inigo Gonzalez-Mazon, Nuria Barroso-Garcia, Natalia Palmou-Fontana, Miguel A. Gonzalez-Gay, Jose L. Hernandez, Ricardo Blanco
Summary: This study aimed to assess the frequency and clinical features of uveitis in psoriatic arthritis (PsA) patients, as well as its association with disease activity, functional disability, and biological treatment. The prevalence of uveitis in PsA patients was about 5%, and it was associated with a worse quality of life and greater functional disability. The incidence rate of uveitis varied depending on the type of biological treatment used.
Article
Rheumatology
Christina Charles-Schoeman, Ernest Choy, Iain B. McInnes, Eduardo Mysler, Peter Nash, Kunihiro Yamaoka, Ralph Lippe, Nasser Khan, Anna K. Shmagel, Hannah Palac, Jessica Suboticki, Jeffrey R. Curtis
Summary: This study provides an integrated analysis of major adverse cardiovascular events (MACEs) and venous thromboembolism (VTE) events in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) patients treated with upadacitinib. The results show that the rates of MACEs and VTE events with upadacitinib are similar to those reported for conventional synthetic and biologic disease-modifying drugs, and comparable to adalimumab and methotrexate.
Article
Rheumatology
Xenofon Baraliakos, Effie Pournara, Laure Gossec, Philip J. Mease, Roisin White, Eamonn O'Brien, Barbara Schulz, Helena Marzo-Ortega, Laura C. Coates
Summary: This study investigated patient characteristics predictive of response to secukinumab in patients with psoriatic arthritis with axial manifestations. Nail dystrophy was identified as a predictor of response to secukinumab in these patients.
Article
Rheumatology
Hao-Guang Li, Dan-Min Wang, Feng-Cai Shen, Shu-Xin Huang, Zhi-Duo Hou, Ling Lin, Zheng-Yu Xiao
Summary: Peripheral involvement is common in juvenile-onset non-radiographic axial spondyloarthritis, and risk factors associated with progression to juvenile-onset ankylosing spondylitis include inflammatory back pain, buttock pain, enthesitis, elevated baseline CRP levels, and sacroiliac joint-MRI positivity.
Article
Rheumatology
Anton Jonatan Landgren, Mats Dehlin, Lennart Jacobsson, Ulrika Bergsten, Eva Klingberg
Summary: The study aimed to compare traditional cardiovascular risk factors among patients with different rheumatic diseases, and found that hypertension was the most common comorbidity, with patients with gout having the highest prevalence of traditional CVRFs. Significant differences in occurrence of CVRFs by sex were also observed among patients with PsA, RA and AS.
Article
Rheumatology
Pedro M. Machado, Martin Schaefer, Satveer K. Mahil, Jean Liew, Laure Gossec, Nick Dand, Alexander Pfeil, Anja Strangfeld, Anne Constanze Regierer, Bruno Fautrel, Carla Gimena Alonso, Carla G. S. Saad, Christopher E. M. Griffiths, Claudia Lomater, Corinne Miceli-Richard, Daniel Wendling, Deshire Alpizar Rodriguez, Dieter Wiek, Elsa F. Mateus, Emily Sirotich, Enrique R. Soriano, Francinne Machado Ribeiro, Felipe Omura, Frederico Rajao Martins, Helena Santos, Jonathan Dau, Jonathan N. Barker, Jonathan Hausmann, Kimme L. Hyrich, Lianne Gensler, Ligia Silva, Lindsay Jacobsohn, Loreto Carmona, Marcelo M. Pinheiro, Marcos David Zelaya, Maria de los Angeles Severina, Mark Yates, Maureen Dubreuil, Monique Gore-Massy, Nicoletta Romeo, Nigil Haroon, Paul Sufka, Rebecca Grainger, Rebecca Hasseli, Saskia Lawson-Tovey, Suleman Bhana, Thao Pham, Tor Olofsson, Wilson Bautista-Molano, Zachary S. Wallace, Zenas Z. N. Yiu, Jinoos Yazdany, Philip C. Robinson, Catherine H. Smith
Summary: This study investigated factors associated with severe COVID-19 in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis. The study found that age, sex, comorbidities, disease activity, and glucocorticoid use were associated with the severity of COVID-19. Additionally, later pandemic time periods, psoriasis, and the use of TNFi, IL17i, and IL-23i/IL-12+23i were associated with a reduced risk of severe COVID-19.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Neurosciences
Pauline Michel-Flutot, Camille H. Bourcier, Laila Emam, Adeline Gasser, Simon Glatigny, Stephane Vinit, Arnaud Mansart
Summary: Spinal cord injuries can result in permanent loss of function due to primary and secondary injuries. Extracellular traps, composed of chromatin, granular enzymes, and histones, are known to induce tissue damage and may contribute to secondary injury. This study showed, for the first time, that microglia and neutrophils form extracellular traps in the spinal cord following injury. It is important to determine the mechanisms and kinetics of trap formation to develop interventions for mitigating inflammatory processes and improving functional outcomes after spinal cord injury.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Rheumatology
Parikshit Sen, R. Naveen, Nazanin Houshmand, Siamak Moghadam Kia, Mrudula Joshi, Sreoshy Saha, Kshitij Jagtap, Vishwesh Agarwal, Arvind Nune, Elena Nikiphorou, Ai Lyn Tan, Samuel Katsuyuki Shinjo, Nelly Ziade, Tsvetelina Velikova, Marcin Milchert, Ioannis Parodis, Abraham Edgar Gracia-Ramos, Lorenzo Cavagna, Masataka Kuwana, Johannes Knitza, Ashima Makol, Aarat Patel, John D. Pauling, Chris Wincup, Bhupen Barman, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio de la Torre, Iris J. Colunga-Pedraza, Javier Merayo-Chalico, Okwara Celestine Chibuzo, Wanruchada Katchamart, Phonpen Akawatcharangura Goo, Russka Shumnalieva, Yi-Ming Chen, Leonardo Santos Hoff, Lina El Kibbi, Hussein Halabi, Binit Vaidya, Syahrul Sazliyana Shaharir, A. T. M. Tanveer Hasan, Dzifa Dey, Carlos Enrique Toro Gutierrez, Carlo Vinicio Caballero-Uribe, James B. Lilleker, Babur Salim, Tamer Gheita, Tulika Chatterjee, Oliver Distler, Miguel A. Saavedra, Jessica Day, Hector Chinoy, Sinan Kardes, Sinan A. Kardes, Laura Andreoli, Daniele Lini, Karen Screiber, Melinda Nagy Vince, Yogesh Preet Singh, Rajiv Ranjan, Avinash Jain, Sapan C. Pandya, Rakesh Kumar Pilania, Aman Sharma, M. Manesh Manoj, Vikas Gupta, Chengappa G. Kavadichanda, Pradeepta Sekhar Patro, Sajal Ajmani, Sanat Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha Shenoy, Ajay Asranna, Keerthi Talari Bommakanti, Anuj Shukla, Arunkumar R. Pande, Kunal Chandwar, Akanksha Ghodke, Hiya Boro, Zoha Zahid Fazal, Doendue Ueskuedar Cansu, Resit Yildirim, Armen Yuri Gasparyan, Nicoletta Del Papa, Gianluca Sambataro, Atzeni Fabiola, Marcello Govoni, Simone Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico Fusaro, Marco Sebastiani, Luca Quartuccio, Franco Franceschini, Pier Paolo Sainaghi, Giovanni Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo Venerito, Silvia Grignaschi, Alessandro Giollo, Alessia Alluno, Florenzo Ioannone, Marco Fornaro, Lisa S. Traboco, Suryo Anggoro Kusumo Wibowo, Jesus Loarce-Martos, Sergio Prieto-Gonzalez, Raquel Aranega Gonzalez, Akira Yoshida, Ran Nakashima, Shinji Sato, Naoki Kimura, Yuko Kaneko, Takahisa Gono, Stylianos Tomaras, Fabian Nikolai Proft, Marie-Therese Holzer, Margarita Aleksandrovna Gromova, Or Aharonov, Zoltan Griger, Ihsane Hmamouchi, Imane El Bouchti, Zineb Baba, Margherita Giannini, Francois Maurier, Julien Campagne, Alain Meyer, Daman Langguth, Vidya Limaye, Merrilee Needham, Nilesh Srivastav, Marie Hudson, Oceane Landon-Cardinal, Wilmer Gerardo Rojas Zuleta, Alvaro Arbelaez, Javier Cajas, Jose Antonio Pereira Silva, Joao Eurico Fonseca, Olena Zimba, Doskaliuk Bohdana, Uyi Ima-Edomwonyi, Ibukunoluwa Dedeke, Emorinken Airenakho, Nwankwo Henry Madu, Abubakar Yerima, Hakeem Olaosebikan, A. Becky, Oruma Devi Koussougbo, Elisa Palalane, Ho So, Manuel Francisco Ugarte-Gil, Lyn Chinchay, Jose Proano Bernaola, Victorio Pimentel, Hanan Mohammed Fathi, Reem Hamdy A. Mohammed, Ghita Harifi, Yurilis Fuentes-Silva, Karoll Cabriza, Jonathan Losanto, Nelly Colaman, Antonio Cachafeiro-Vilar, Generoso Guerra Bautista, Enrique Julio Giraldo Ho, Raul Gonzalez, Lilith Stange Nunez, M. Cristian Vergara, Jossiell Then Baez, Hugo Alonzo, Carlos Benito Santiago Pastelin, Rodrigo Garcia Salinas, Alejandro Quinonez Obiols, Nilmo Chavez, Andrea Bran Ordonez, Sandra Argueta, Gil Alberto Reyes Llerena, Radames Sierra-Zorita, Dina Arrieta, Eduardo Romero Hidalgo, Ricardo Saenz, M. Idania Escalante, Roberto Morales, Wendy Calapaqui, Ivonne Quezada, Gabriela Arredondo, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
Summary: In this study, hesitancy in patients with autoimmune rheumatic diseases (AIRDs) towards COVID-19 vaccines was investigated. The results showed a decrease in hesitancy, but an increase in concerns over the long-term safety of the vaccine. Patients with idiopathic inflammatory myopathies (IIMs) expressed more skepticism towards vaccine science and had more concerns over long-term safety.
Letter
Rheumatology
Laura Andreoli, Parikshit Sen, Daniele Lini, Melinda Nagy Vincze, Karen Schreiber, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
Article
Immunology
Quentin Jouhault, Bilade Cherqaoui, Aude Jobart-Malfait, Simon Glatigny, Marc Lauraine, Audrey Hulot, Guillaume Morelle, Benjamin Hagege, Ketia Ermoza, Ahmed El Marjou, Brigitte Izac, Benjamin Saintpierre, Franck Letourneur, Severine Remy, Ignacio Anegon, Marie-Christophe Boissier, Gilles Chiocchia, Maxime Breban, Luiza M. Araujo
Summary: The altered function of conventional dendritic cells (cDCs) in B27-rats promotes the production of inflammatory CD4+ T cells. Addition of exogenous IL-27 to the cell culture can reduce the production of inflammatory CD4+ T cells and increase the production of regulatory T cells. In vivo treatment with recombinant IL-27 can inhibit the development of spondylarthritis in B27-rats.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ioannis Temponeras, Martina Samiotaki, Despoina Koumantou, Martha Nikopaschou, Jonas J. W. Kuiper, George Panayotou, Efstratios Stratikos
Summary: ER Aminopeptidase 1 (ERAP1) is an ER-resident aminopeptidase that plays a role in antigen presentation and may be targeted for cancer immunotherapy. In this study, researchers used an inhibitor to explore the effect of targeting ERAP1 on the immunopeptidome of a human cancer cell line. The results showed significant differences in peptide composition and HLA allele utilization between allosterically inhibited and ERAP1 KO cells, suggesting distinct roles for the allosteric regulatory site of ERAP1 in antigenic peptide selection.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Editorial Material
Ophthalmology
Emmett T. T. Cunningham Jr, Mamta Agarwal, Derrick P. Smit, Ilknur Tugal-Tutkun, Jennifer E. Thorne
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Microbiology
Hamadoun Toure, Lee Ann Galindo, Marion Lagune, Simon Glatigny, Robert M. Waterhouse, Isabelle Guenal, Jean-Louis Herrmann, Sebastien Szuplewski, Fabienne Girard-Misguich
Summary: During the progression and exacerbation of mycobacterial infection, the smooth (S) form of M. abscessus transitions into the rough (R) form, which is lethal. The S form demonstrates the ability to resist the host's immune response and multiply within the host.
Review
Medicine, General & Internal
Carl P. Herbort Jr, Masaru Takeuchi, Ioannis Papasavvas, Ilknur Tugal-Tutkun, Alireza Hedayatfar, Yoshihiko Usui, Pinar C. Ozdal, Cristhian A. Urzua
Summary: The availability of dual fluorescein and indocyanine green angiography has enabled global and precise follow-up of uveitis, while additional non-invasive imaging methods, including OCT, EDI-OCT, BAF, and OCT-A, have brought value-added precision to uveitis imaging. This review examines the evidence for the potential replacement of dye angiographic methods by OCT-A and discusses its practical impact.
Article
Rheumatology
Manouk de Hooge, Alla Ischenko, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Filip van den Bosch, Kurt De Vlam
Summary: This study investigates the association between different definitions of axial involvement and syndesmophytes development in patients with Psoriatic Arthritis (PsA). The results show that the probability of developing syndesmophytes is much higher when axial involvement is determined radiographically rather than clinically, particularly in the context of high CRP.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Biology
Russka Shumnalieva, Georgi Kotov, Simeon Monov
Summary: The knee is commonly affected by osteoarthritis, which significantly impacts patients' health and function. Major risk factors include genetics, age, sex, mechanical load, and obesity/metabolic syndrome. Recent studies have revealed the role of obesity and metabolic syndrome not only in increasing mechanical loading but also in causing systemic inflammation, contributing to knee osteoarthritis. The understanding of knee osteoarthritis has evolved to view it as a 'whole joint disease' involving multiple structures. Obesity and metabolic syndrome are associated with increased levels of inflammatory cytokines, adipokines with both protective and destructive effects on cartilage, up-regulation of proteolytic enzymes, and increased levels of free fatty acids and reactive oxygen species. The management of knee osteoarthritis should include optimizing body weight and promoting physical activity. Future therapeutic strategies may consider pharmacological therapy targeting specific molecules involved in obesity-related osteoarthritis, with personalized treatment approaches.
Review
Ophthalmology
Charlotte van Meerwijk, Jonas Kuiper, Joeri van Straalen, Viera Kalinina Ayuso, Roos Wennink, Anne-Mieke Haasnoot, Carlijn Kouwenberg, Joke de Boer
Summary: Juvenile idiopathic arthritis (JIA) is the leading cause of uveitis in children. Early diagnosis and proper treatment are crucial to prevent complications and visual impairment. This review summarizes the screening strategies, clinical management, and molecular markers associated with JIA-U.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Cell & Tissue Engineering
Jeremie Zappia, Qiao Tong, Renee Van der Cruyssen, Frederique M. F. Cornelis, Cecile Lambert, Tiago Pinto Coelho, Juliane Grisart, Erika Kague, Rik J. Lories, Marc Muller, Dirk Elewaut, Chrissy L. Hammond, Christelle Sanchez, Yves Henrotin
Summary: Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis. Osteomodulin (OMD), a proteoglycan, is associated with the sclerotic phenotype. This study found that OMD binds to RANKL and inhibits osteoclastogenesis, thus regulating bone remodeling and contributing to bone and cartilage homeostasis. Targeting OMD may be a promising personalized approach for osteoarthritis.