Article
Cell Biology
Chin-Man Wang, Ming-Kun Liu, Yeong-Jian Jan Wu, Jing-Chi Lin, Jian-Wen Zheng, Jianming Wu, Ji-Yih Chen
Summary: The study examined the impact of ERAP1 allelic variants and their interaction with HLA-B27 on ankylosing spondylitis susceptibility. It discovered multiple ERAP1 SNVs and allelic variants in Taiwanese individuals, and found that ERAP1 variants significantly contribute to the development of AS in a HLA-B27-dependent manner.
Article
Biochemistry & Molecular Biology
Javier Fernandez-Torres, Yessica Zamudio-Cuevas, Nathalie Montano-Armendariz, Ivan Alejandro Lujan-Juarez, Roberto Sanchez-Sanchez, Karina Martinez-Flores
Summary: The study found that variants of the ERAP1 gene may interact with smoking to increase the risk of AS in patients, especially those carrying the B27 allele.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell Biology
Hongyun Liu, Bin Wang, Qiliang Zhang
Summary: This study found that the COX-2 polymorphism rs5275 may contribute to an increased risk of developing ankylosing spondylitis among Chinese Han people, while the polymorphisms rs20417 and rs2745557 may offer protection against disease incidence.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Rheumatology
Marta Arevalo Salaet, Clementina Lopez-Medina, Mireia Moreno, Victoria Navarro-Compan, Joan Calvet Fontova, Maria Llop, Maxime Dougados, Jordi Gratacos
Summary: This study analyzed the influence of HLA-B27 in the phenotypical expression of pSpA. The results showed that HLA-B27-positive patients had an earlier disease onset and higher axial involvement, tarsitis, and uveitis, but no association with other EMM, fibromyalgia, or peripheral structural damage was observed.
Article
Multidisciplinary Sciences
Zachary Maben, Richa Arya, Dimitris Georgiadis, Efstratios Stratikos, Lawrence J. J. Stern
Summary: This study investigates the conformational states of ERAP1 in solution, shedding light on the molecular mechanisms behind ERAP1 substrate-length dependent catalytic activity and regulation, including the impact of autoimmune disease-associated polymorphism.
NATURE COMMUNICATIONS
(2021)
Article
Rheumatology
Xabier Michelena, Clementina Lopez-Medina, Alba Erra, Xavier Juanola, Pilar Font-Ugalde, Eduardo Collantes, Helena Marzo-Ortega
Summary: This study compared the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) with ankylosing spondylitis (AS) with psoriasis. It found that axial PsA is predominantly HLA-B27 negative and has different manifestations compared to AS with psoriasis. There is great heterogeneity in the definition of axial PsA from a clinical and imaging perspective.
Article
Rheumatology
Haseeb Chaudhary, Clementina Lopez-Medina, Muhammad Asim Khan, Maxime Dougados, Marina Magrey
Summary: In a global axSpA cohort, HLA-B*27 (-) patients had a longer delay in diagnosis, more frequently had peripheral arthritis, enthesitis, IBD, and psoriasis, and were more often treated with csDMARDs compared to the HLA-B*27 (+) subgroup.
Article
Biochemical Research Methods
Xin Wu, Hao Zheng, Zuochao Dou, Feng Chen, Jieren Deng, Xiang Chen, Shengqian Xu, Guanmin Gao, Mengmeng Li, Zhen Wang, Yuhui Xiao, Kang Xie, Shuang Wang, Huji Xu
Summary: Genome-wide association studies (GWAS) are used to identify potential risk variants in diseases, but typically require cross-institutional partnerships to overcome sample size limitations and increase statistical power. However, data privacy remains a major challenge in such partnerships.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Rheumatology
Elena Nikiphorou, Pedro D. Carvalho, Annelies Boonen, Bruno Fautrel, Pascal Richette, Pedro M. Machado, Desiree van der Heijde, Robert Landewe, Sofia Ramiro
Summary: This study investigated sick leave occurrence in early axSpA patients, finding that male gender and higher education were associated with lower risk of SL, while higher disease activity, older age, smoking, and use of TNF inhibitors were associated with higher risk of SL.
Article
Rheumatology
Michael Nissen, Benedicte Delcoigne, Daniela Di Giuseppe, Lennart Jacobsson, Merete Lund Hetland, Adrian Ciurea, Lucie Nekvindova, Florenzo Iannone, Nurullah Akkoc, Tuulikki Sokka-Isler, Karen Minde Fagerli, Maria Jose Santos, Catalin Codreanu, Manuel Pombo-Suarez, Ziga Rotar, Bjorn Gudbjornsson, Irene Van der Horst-Bruinsma, Anne Gitte Loft, Burkhard Moeller, Herman Mann, Fabrizio Conti, Gozde Yildirim Cetin, Heikki Relas, Brigitte Michelsen, Pedro Avila Ribeiro, Ruxandra Ionescu, Carlos Sanchez-Piedra, Matija Tomsic, Arni Jon Geirsson, Johan Askling, Bente Glintborg, Ulf Lindstroem
Summary: This multicenter study of axSpA patients found similar one-year treatment outcomes between TNFi monotherapy and csDMARD co-therapy. Heterogeneity across countries limited the identification of specific subgroups, such as peripheral arthritis, that may benefit from co-therapy.
Article
Multidisciplinary Sciences
Yaoyao Liu, Zhong Wang, Mingyong Liu, Xiang Yin, Jiming Liu, Jianhua Zhao, Peng Liu
Summary: The study found that longer fixation segments and combined fixation approaches provided better stability and reduced maximal stress. The rate of motion change decreased more significantly with an increase in fixation length from 1 to 3 levels than from 3 to 5 levels. Combined approaches are recommended for surgery to provide optimal stability, and long skipped-screwing posterior fixation is suggested as an alternative technique for ASCF patients.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Yubo Ma, Dazhi Fan, Shanshan Xu, Jixiang Deng, Xing Gao, Shiyang Guan, Xu Zhang, Faming Pan
Summary: Our study found that ERAP1 gene is significantly hypermethylated and mRNA levels of EARP1 decreased in AS patients. The differential methylated CpG loci of ERAP1 showed high sensitivity, specificity, and area under curve for AS diagnosis. Furthermore, the methylation levels of ERAP1 were associated with family history, NSAID use, X-ray classification, and clinical manifestations in AS patients.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Biology
Haige Han, Beatrice A. McGivney, Lucy Allen, Dongyi Bai, Leanne R. Corduff, Gantulga Davaakhuu, Jargalsaikhan Davaasambuu, Dulguun Dorjgotov, Thomas J. Hall, Andrew J. Hemmings, Amy R. Holtby, Tuyatsetseg Jambal, Badarch Jargalsaikhan, Uyasakh Jargalsaikhan, Naveen K. Kadri, David E. MacHugh, Hubert Pausch, Carol Readhead, David Warburton, Manglai Dugarjaviin, Emmeline W. Hill
Summary: Genetic variants in key genes related to muscle, metabolism, and neurobiology are identified in racehorse breeds, suggesting their important roles in shaping the athletic phenotype of horses bred for racing.
COMMUNICATIONS BIOLOGY
(2022)
Article
Rheumatology
Robert D. Inman, Denis Choquette, Majed Khraishi, Dafna D. Gladman, Shamiza Hussein, Drew Neish, Patrick Leclerc
Summary: This study aimed to describe the real-world use of Secukinumab (SEC) in Canadian patients with axSpA. The results showed that SEC was effective in treating axSpA, with improvements in disease activity observed in patients after 12 months of treatment.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Immunology
Farhad Babaie, Hamed Mohammadi, Sorayya Salimi, Alireza Ghanavatinegad, Mitra Abbasifard, Mehdi Yousefi, Mehrzad Hajaliloo, Younes Khalili, Sajjad Zamanlou, Roghaiyeh Safari, Maryam Hemmatzadeh, Alireza Rezaiemanesh, Reza Salimi, Behzad Baradaran, Zohreh Babaloo
Summary: This study aimed to evaluate the impact of Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms on the expression of Human leukocyte antigen (HLA)-B27-free heavy chains (FHCs) on macrophages and subsequent NK cell activation in Ankylosing spondylitis (AS) patients. Results showed reduced expression of HLA-B27-FHCs on M1 and M2 macrophages in patients with protective ERAP1 genotype. Co-culturing ERAP1-inhibited M1 macrophages with NK cells from patients with protective genotype resulted in downregulation of CD69 and CD107a markers on NK cells and decreased number of IFN-gamma+ NK cells. Inhibiting ERAP1 activity to reduce NK cell activation may have therapeutic potential in treating AS patients.
CLINICAL IMMUNOLOGY
(2023)
Article
Rheumatology
Johannes Nossent, Warren Raymond, Helen Isobel Keen, David Preen, Charles Inderjeeth
Summary: The study found that mortality rate in patients with IgA vasculitis was significantly higher than in the control group and the general population, with a lower survival rate. The accrual of premorbid comorbidities was higher in hospitalized patients with IgAV and may predict premature death.
Article
Rheumatology
Joanna Tieu, Susan Lester, Warren Raymond, Helen Keen, Catherine L. Hill, Johannes Nossent
Summary: Survival rate is reduced and mortality is higher in AAV/PAN patients in Western Australia compared with controls. Older age at diagnosis is associated with higher mortality. The study also identifies the main causes of death in different time periods.
Article
Rheumatology
Khalid Almutairi, Johannes Nossent, David B. Preen, Helen Keen, Charles Inderjeeth
Summary: The Australian Pharmaceutical Benefits Scheme has subsidized biological therapy since 2003. A study was conducted to investigate the association between biological therapy and hospitalization rates and healthcare costs for rheumatoid arthritis. The study found that the use of conventional therapy for RA has led to a decline in hospital admissions, while the introduction of biological therapy has further reduced hospitalization rates, but it is not as cost-effective as conventional therapy in terms of RA hospital admission costs.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Rheumatology
Johannes Nossent, Charles Inderjeeth, Helen Keen, David Preen, Ian Li, Erin Kelty
Summary: In Western Australia, the uptake of TNFi reached 0.45 DDD per 1000 population per day, costing AU$17.7 million annually in 2020. Although some costs increased, the introduction of subsidized TNFi therapy did not result in changes in all-cause hospital admission or ED visit rates for existing AS patients.
RHEUMATOLOGY AND THERAPY
(2022)
Article
Rheumatology
Owen Taylor-Williams, Charles A. Inderjeeth, Khalid B. Almutairi, Helen Keen, David B. Preen, Johannes C. Nossent
Summary: Over the last 30 years, the incidence of total hip replacement (THR) and mechanical complications have significantly decreased in patients with rheumatoid arthritis (RA), while medical complications such as infection have not changed significantly.
RHEUMATOLOGY AND THERAPY
(2022)
Article
Rheumatology
Erin Kelty, Milica Ognjenovic, Warren D. Raymond, Charles A. Inderjeeth, Helen Keen, David B. Preen, Johannes C. Nossent
Summary: This retrospective cohort study found that hospitalized patients with ankylosing spondylitis (AS) had significantly higher mortality rates compared to a matched comparison group. The excess mortality in AS patients was associated with cardiovascular disease, cancer, external causes, and infectious diseases. Furthermore, comorbidities, extraarticular manifestations (EAMs), and smoking were found to increase the risk of mortality in AS patients.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Johannes C. Nossent, Helen I. Keen, David B. Preen, Charles A. Inderjeeth
Summary: This study investigated the impact of immune-modulating therapy on hospitalization rates with opportunistic infections in patients with inflammatory joint diseases. It found that while hospitalization rates for tuberculosis and pneumocystosis decreased, rates for fungal and viral infections increased over time, highlighting the need for improved infection prevention in the management of these patients.
RHEUMATOLOGY AND THERAPY
(2023)
Article
Rheumatology
Warren David Raymond, David Brian Preen, Helen Isobel Keen, Charles Anoopkumar Inderjeeth, Johannes Cornelis Nossent
Summary: This study examined the association between systemic lupus erythematosus (SLE) and the risk of cancer development and subsequent 5-year mortality in Western Australia. It found that hospitalized SLE patients had an increased risk of multiple cancer sub-types and an increased risk of 5-year mortality following cancer development.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Pediatrics
Erin Kelty, Ebony Quintrell, David B. B. Preen, Prue Manners, Johannes Nossent
Summary: The treatment strategies for juvenile idiopathic arthritis (JIA) have changed significantly over the past 20 years. This study examined the impact of government-subsidised TNF inhibitor (TNFi) treatment on hospitalisation rates for JIA. The results showed that the hospitalisation rates for JIA remained stable over a 22-year period, and the introduction of TNFi therapy did not lead to a decrease in hospitalisation rates for JIA. Instead, there was an increase in hospitalisation rates for joint injections.
PEDIATRIC RHEUMATOLOGY
(2023)
Article
Rheumatology
Khalid B. Almutairi, Charles A. Inderjeeth, David B. Preen, Helen I. Keen, Johannes C. Nossent
Summary: This study investigated the temporal changes in standardized mortality rates for patients with rheumatoid arthritis (RA) using longitudinal linked population-wide health data. The findings suggest that although the mortality rate in RA patients has decreased, it remains 1.59 times higher than in the general population, indicating room for further improvement. Age and comorbidity were identified as the main risk factors for mortality in RA patients.
RHEUMATOLOGY AND THERAPY
(2023)
Article
Rheumatology
Ai Phuong Tran, D. F. Tassone, N. S. Ding, Johannes Nossent
Summary: The persistence of immunogenicity in patients with immune-mediated inflammatory diseases on disease-modifying antirheumatic therapy has been evaluated in this study. The results show that antibody persistence is longer in the Pfizer vaccine group, and a third mRNA vaccine booster can restore immunity in all groups. The targeted synthetic DMARD group that continued therapy had lower levels of protective antibodies compared to the control group.
Article
Rheumatology
Derrick Lopez, Girish Dwivedi, Johannes Nossent, David B. Preen, Kevin Murray, Warren Raymond, Charles Inderjeeth, Helen I. Keen
Summary: There is an increased risk of major adverse cardiovascular events (MACEs) within 30 days after hospital admission for acute gout, indicating a temporal association between acute inflammation and subsequent MACEs in patients with gout.
ACR OPEN RHEUMATOLOGY
(2023)
Editorial Material
Medicine, General & Internal
David Michael Ng, Kenny Sek, Johannes Nossent
Article
Rheumatology
Johannes C. Nossent, Erin Kelty, Helen Keen, David Preen, Charles Inderjeeth
Summary: Systemic juvenile idiopathic arthritis (S-JIA) is a rare, potentially life-threatening autoinflammatory condition in children. A study investigated the epidemiological characteristics and long-term outcomes of S-JIA in the Australasian region. The annual incidence of S-JIA was 0.61/100,000, with a stable prevalence rate of 7.15/100,000. Disease flares occurred in 24% of patients during a median follow-up of 8 years, with higher rates in boys than girls. No deaths were reported, but there were substantial rates of readmission and emergency department visits for other illnesses.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Johannes Nossent, Helen Keen, David B. Preen, Charles A. Inderjeeth
Summary: In this population-wide study, we determined long-term overall and subgroup-specific incidence rates and associated mortality for idiopathic inflammatory myopathies in Western Australia. The overall incidence of the disease remained stable over 35 years, but there were significant changes in the spectrum of the disease, especially with increases in other inflammatory myopathies and overlap myositis. The prognosis for idiopathic inflammatory myopathies remains poor, with a 10-year survival rate just over 50%.
RHEUMATOLOGY INTERNATIONAL
(2023)
