Article
Rheumatology
Philip J. Mease, Mei Liu, Sabrina Rebello, Robert R. McLean, Blessing Dube, Meghan Glynn, Peter Hur, Alexis Ogdie
Summary: Patients with PsA who have nail psoriasis demonstrated worse disease activity, quality of life, and work productivity compared to those without nail involvement, highlighting the importance of identifying and managing nail disease in PsA patients.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Immunology
Weize Gao, Zhan Wang, Wenshuai Li, Yongxin Li, Mingjun Liu
Summary: This review systematically demonstrates the research progress of psoriasis-related biomarkers and elaborates their related mechanisms in the pathological development of psoriasis and psoriatic arthritis. In addition, we summarize the development of biologic therapies for psoriasis and psoriatic arthritis in order to drive the broader discussion of psoriasis as an autoimmune-mediated inflammatory skin disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Fei Qi, Yaqi Tan, Amin Yao, Xutong Yang, Yanling He
Summary: Psoriatic disease is a spectrum of diseases affecting both skin and musculoskeletal features, with a considerable number of patients progressing from cutaneous psoriasis to psoriatic arthritis. The use of proteomics technologies provides a unique opportunity to explore potential biomarkers for psoriatic arthritis.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Piero Ruscitti, Maria Esposito, Ilenia Di Cola, Cristina Pellegrini, Andrea De Berardinis, Mirco Mastrangelo, Camilla Gianneramo, Antonio Barile, Maria Concetta Fargnoli, Paola Cipriani
Summary: This study aimed to evaluate biomolecules in naive patients with psoriasis (PSO), psoriatic arthritis (PSA) with PSO, and PSA sine PSO. The results showed that these patients have a similar cytokine profile, suggesting the concept of a psoriatic disease continuum. However, differences were also found, indicating possible pathogenic differences and contributing to the clinical heterogeneity of these patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Guillaume Larid, Adriana Delwail, Thomas Dalle, Philippe Vasseur, Christine Silvain, Jean-Francois Jegou, Franck Morel, Jean-Claude Lecron, Elisabeth Gervais
Summary: Psoriatic arthritis (PsA) and cutaneous psoriasis (PsO) exhibit distinct cytokine production profiles, which are influenced by clinical phenotype and metabolic syndrome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Telma Thrastardottir, Elana Meer, Arna Hauksdottir, Bjorn Gudbjornsson, Sigurdur Yngvi Kristinsson, Alexis Ogdie, Thorvardur Jon Love
Summary: This study found a strong site-specific association between pharyngeal culture samples and an increased risk of PsA and psoriasis, regardless of the pathogen.
Article
Medicine, General & Internal
Jie Zhu, Zhicheng Wang, Lu Tao, Ling Han, Qiong Huang, Xu Fang, Ke Yang, Guiqin Huang, Zhizhong Zheng, Nikhil Yawalkar, Zhenghua Zhang, Kexiang Yan
Summary: This study provides evidence for an association between MTHFR polymorphism and the risk of PsA, as well as the efficacy and hepatotoxicity of low-dose MTX in the Chinese population.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Daniel Pereira, Richard J. Cook, Vinod Chandran, Nigil Haroon, Robert D. Inman, Dafna D. Gladman
Summary: Isolated axial PsA and AS with psoriasis are relatively uncommon. HLA-B*27 positivity is associated with isolated axial PsA and may predict the development of peripheral disease. Isolated axial PsA is associated with better functional status. Isolated axial PsA appears clinically distinct from isolated axial AS with psoriasis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Irmina Olejniczak-Staruch, Magdalena Ciazynska, Dorota Sobolewska-Sztychny, Joanna Narbutt, Malgorzata Skibinska, Aleksandra Lesiak
Summary: Numerous scientific studies have shown significant skin and gut dysbiosis in patients with psoriasis, with changes in abundance of specific bacterial taxa. Treatments for psoriasis have been found to significantly influence skin and gut microbiome, with orally administered probiotics having a positive impact on the course of the disease. Further research is needed to understand the influence of microbiome on the development of inflammatory skin diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Keith Colaco, Ker-Ai Lee, Shadi Akhtari, Raz Winer, Paul Welsh, Naveed Sattar, Iain B. McInnes, Vinod Chandran, Paula Harvey, Richard J. Cook, Dafna D. Gladman, Vincent Piguet, Lihi Eder
Summary: In patients with psoriatic disease, cardiac troponin I may reflect the burden of atherosclerosis independent of traditional cardiovascular risk factors. Cardiac troponin I and NT-proBNP are associated with incident cardiovascular events independent of the Framingham Risk Score, but further study of their role in cardiovascular risk stratification is warranted.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Ran Cui, Hua Zhang, Miao Chen, Qian Wang, Qiang Tong, Zhiyong Chen, Ke-Xiang Yan, Yang-Feng Ding, Sheng-Ming Dai
Summary: Nail disease is associated with psoriatic arthritis (PsA), and onycholysis and hyperkeratosis are independently associated with PsA. Onycholysis has higher accuracy and sensitivity for diagnosing PsA compared to pitting and hyperkeratosis.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Maria Laura Acosta Felquer, Luciano LoGiudice, Maria Laura Galimberti, Javier Rosa, Luis Mazzuoccolo, Enrique R. Soriano
Summary: The study found that using biologics in patients with psoriasis can reduce the risk of developing psoriatic arthritis (PsA).
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi-Tong Chen, Rong-Fen Chen, Xiao-Long Li, Qiao Wang, Wei-Wei Ren, Dan-Dan Shan, Yu-Jing Zhao, Li-Ping Sun, Hui-Xiong Xu, Yu-Ling Shi, Le-Hang Guo
Summary: Objective is to identify patients in the subclinical psoriatic arthritis (Sub-PsA) phase by ultrasound (US) and provide a solution to screen them.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alessandra Bettiol, Filippo Fagni, Irene Mattioli, Giacomo Bagni, Gianfranco Vitiello, Alessia Grassi, Chiara Della Bella, Marisa Benagiano, Arianna Troilo, Katarzyna Stella Holownia, David Simon, Flavia Rita Argento, Jurgen Sota, Claudia Fabiani, Matteo Becatti, Claudia Fiorillo, Georg Schett, Giuseppe Lopalco, Luca Cantarini, Domenico Prisco, Elena Silvestri, Giacomo Emmi, Mario Milco D'Elios
Summary: In this study, the ability of serum interleukin (IL)-36a concentration to differentiate Behcet's syndrome (BS) from psoriatic arthritis (PsA) was investigated. The results showed significantly lower IL-36a concentrations in BS patients compared to PsA patients, although both groups had significantly higher IL-36a levels compared to healthy controls. A cut-off of 420.6 pg/mL displayed good specificity and sensitivity in discriminating PsA from BS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Holly R. Harris, Karen Moreno Nascimento Korkes, Tricia Li, Marina Kvaskoff, Eunyoung Cho, Luiz Fernando Carvalho, Abrar A. Qureshi, Mauricio Abrao, Stacey A. Missmer
Summary: A bidirectional association between endometriosis and psoriasis with PsA was found in this study. Psoriasis with concomitant PsA was associated with a higher risk of laparoscopically confirmed endometriosis, while the diagnosis of endometriosis was suggestive of subsequent risk of psoriasis with PsA.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jihye Song, Yong Cheol Lim, Inseok Ko, Jong-Yeup Kim, Dong-Kyu Kim
Summary: This study found that the prevalence of IA in patients with AD was four times higher than the general population, with hypertension being a major risk factor. Early screening for IA is recommended among patients with AD for appropriate management.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Chemistry, Multidisciplinary
Hyunah Shin, Jaehun Cha, Chungchun Lee, Hyejin Song, Hyuntae Jeong, Jong-Yeup Kim, Suehyun Lee
Summary: Pharmacovigilance, the science of drug safety, relies heavily on medical informatics and interpretation. Trends in pharmacovigilance systems, particularly in data collection, detection, assessment, and monitoring processes, were investigated and analyzed. The study highlighted challenges in standardizing data and terminology, establishing an ADR evaluation system, and the ongoing need for appropriate methods and guidelines in active pharmacovigilance using medical big data.
APPLIED SCIENCES-BASEL
(2021)
Article
Public, Environmental & Occupational Health
Seunghee Lee, Jeongwon Shin, Hyeon Seong Kim, Min Je Lee, Jung Min Yoon, Sohee Lee, Yongsuk Kim, Jong-Yeup Kim, Suehyun Lee
Summary: This study focused on prescription errors in pediatric patients, utilizing real medical data to supplement the current Drug Utilization Review (DUR)-based rules. A novel hybrid method called Advanced Rule-based Deep Neural Network (ARDNN) was developed for prescription error prediction, showing promising performance and reducing alert fatigue for doctors. This approach can enhance medical efficiency and service quality by improving prescription error detection using deep learning.
Article
Health Care Sciences & Services
Suehyun Lee, Jeong Hoon Lee, Grace Juyun Kim, Jong-Yeup Kim, Hyunah Shin, Inseok Ko, Seon Choe, Ju Han Kim
Summary: This study aimed to develop a reference standard for adverse drug reactions (RS-ADR) to facilitate the detection, assessment, and understanding of drug-ADR associations suggested by real-world data (RWD) analyses. By integrating various reference sets and utilizing a pharmacovigilance dictionary and analytic algorithms, the RS-ADR can effectively validate computationally detected adverse drug reaction signals.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Medicine, General & Internal
Kyung-Do Han, Sang-Hyun Park, Sumin Son, Seung-Ho Kim, Ikhee Kim, Jong-Yeup Kim, Seung-Min In, Yeon-Soo Kim, Ki-Il Lee
Summary: This study analyzed the association between chronic rhinosinusitis (CRS) and the incidence of head and neck cancers (HNCs) in a Korean adult population. The results showed that patients with CRS had a significantly higher risk of developing nasal cavity/paranasal sinus cancer, hypopharynx/larynx cancer, and thyroid cancer compared to the control group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Ae Ra Han, Suehyun Lee, Jaehun Cha, Jong-Yeup Kim, Dong-Kyu Kim, Jae Won Han, Chul Jung Kim, Sung Ki Lee
Summary: Endometriosis is a multifactorial disease with inflammation as a core pathology. This study found that women with recent history of genital tract infection, pelvic surgery, or both had a higher incidence of endometriosis.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Seunghee Lee, Hyekyung Woo, Chung Chun Lee, Gyeongmin Kim, Jong-Yeup Kim, Suehyun Lee
Summary: As society ages, it is crucial to monitor drug use in the elderly. This study explores the usefulness of social network studies (SNS) in providing drug side effects information. By analyzing social media data, the researchers were able to obtain well-known side effects and propose a pharmacovigilance pipeline for unknown side effects. The proposed Drug_SNSMiner analysis pipeline proved effective in monitoring side effects and served as a drug prescription platform for the elderly.
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Sungjung Kwak, Jieun Shin, Jong-Yeup Kim
Summary: The purpose of this study was to explore the impact of self-perceived health and physical activity on the mental health of cancer survivors. Data from the 2014, 2016, 2018, and 2020 National Health and Nutrition Examination Survey (NHANES) were analyzed. The results showed that cancer survivors with good self-perceived health had significantly lower levels of stress and depression, and engaging in walking exercise was associated with lower levels of stress and depression.
Review
Nutrition & Dietetics
Mijoo Choi, Jong-Yeup Kim, Hyun-Hi Kang, Eunju Park, Sung Ryul Shim
Summary: This systematic review and meta-analysis found that oral nutritional supplements (ONSs) can significantly reduce body weight loss after gastrectomy in patients with gastric cancer, and they are more effective in patients with lower nutritional intake.
Review
Computer Science, Information Systems
Seunghee Lee, Seonyoung Kim, Jieun Lee, Jong-Yeup Kim, Mi-Hwa Song, Suehyun Lee
Summary: Explainable AI (XAI) is a methodology that provides an explanation for artificial intelligence, and there is growing recognition of its importance in various fields. This study aims to identify the use of XAI in pharmacovigilance research. Among 781 papers, only 25 met the selection criteria. The study provides an intuitive review of the potential of XAI in pharmacovigilance and identifies key challenges in its implementation.
Article
Computer Science, Information Systems
Seunghee Lee, Gyun-Ho Roh, Jong-Yeup Kim, Young Ho Lee, Hyekyung Woo, Suehyun Lee
Summary: The objective of this study is to develop a medical data quality management system that standardizes data extraction and quality control methods to increase the utilization of medical data.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Immunology
Ki-Il Lee, Younghwan Han, Jae-Sung Ryu, Seung Min In, Jong-Yeup Kim, Joong Su Park, Jong-Seok Kim, Juhye Kim, Jubin Youn, Seok-Rae Park
Summary: Tobacco smoking has been found to contribute to the alteration of immunological response in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), leading to the deterioration of the disease. The study revealed that smoking upregulated the expression of epithelial-derived cytokines and Th2 cytokines, resulting in epithelial-mesenchymal transition and increased serum IgE levels.
Article
Computer Science, Information Systems
Seongbin Lee, Seunghee Lee, Duhyeuk Chang, Mi-Hwa Song, Jong-Yeup Kim, Suehyun Lee
Summary: A machine learning model was developed to predict the need for blood transfusions in ICU patients using the MIMIC-III database, achieving a high accuracy. The study is expected to provide basic data for improving patient recovery and reducing excessive consumption of blood products.
JOURNAL OF INFORMATION PROCESSING SYSTEMS
(2022)
Article
Health Care Sciences & Services
Jong-Yeup Kim, Inseok Ko, Dong-Kyu Kim
Summary: The study suggests a potential relationship between sudden sensorineural hearing loss (SSNHL) and retinal vein occlusion (RVO), with SSNHL patients having a higher risk of developing RVO, especially among elderly male patients.