Article
Medicine, General & Internal
Ruben Queiro, Sara Alonso, Isla Morante, Mercedes Alperi
Summary: The psychosocial health of patients with axial spondyloarthritis and psoriatic arthritis has a significant impact on quality of life. Disease activity and severity are associated with alterations in psychosocial health, with a greater impact observed in psoriatic arthritis patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Dermatology
Alice B. Gottlieb, Joseph F. Merola
Summary: Psoriasis is a chronic inflammatory disorder that can lead to psoriatic arthritis, a heterogeneous musculoskeletal disease causing joint damage. Early detection and intervention by dermatologists is crucial in preventing permanent joint damage from psoriatic arthritis, which often manifests after skin symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Rheumatology
Celia A. J. Michielsens, Nathan den Broeder, Michelle L. M. Mulder, Frank H. J. van den Hoogen, Lise M. Verhoef, Alfons A. den Broeder
Summary: This study demonstrates that disease activity-guided dose optimization (DAGDO) of TNF inhibitor (TNFi) has no negative effects on disease activity in PsA and axSpA patients and reduces drug exposure.
Article
Rheumatology
Adrian Ciurea, Andrea Gotschi, Seraphina Kissling, Alexander Bernatschek, Kristina Burki, Pascale Exer, Michael J. Nissen, Burkhard Moller, Almut Scherer, Raphael Micheroli
Summary: This study compared the characteristics of patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and found differences in demographic and clinical features between the two groups, but a similar disease burden.
Article
Rheumatology
Manouk de Hooge, Alla Ishchenko, Ann-Sophie De Craemer, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Kurt de Vlam, Filip van den Bosch
Summary: This study aimed to examine radiographic axial damage of the sacroiliac joints and spine in patients with psoriatic arthritis (PsA) and spondyloarthritis (SpA) in private and academic Belgian practices. The data comparison between the two patient groups found that patients with SpA tend to have more severe spinal damage compared to those with PsA. In patients with PsA, the cervical spine is more often affected, while in patients with SpA, the location of syndesmophytes is more evenly distributed.
Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Venice Liu, Warren Fong, Yu Heng Kwan, Ying Ying Leung
Summary: The study evaluated the residual burden in patients with axSpA and PsA who achieved low disease activity, finding that despite being in LDA, patients still experienced substantial burden in pain, poorer physical function, and mental well-being.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Carina Goetestam Skorpen, Stian Lydersen, Kjell Asmund Salvesen, Hege Suorza Svean Koksvik, Bente Jakobsen, Marianne Wallenius
Summary: This study analyzed the pregnancy outcomes of women with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). The results showed that active inflammation increased the risk of cesarean section, which delayed recovery from inflammatory pain and stiffness.
Review
Genetics & Heredity
Alberto Floris, Mattia Congia, Elisabetta Chessa, Maria Maddalena Angioni, Matteo Piga, Alberto Cauli
Summary: Specific and high-quality evidence on the efficacy of current targeted therapies for axial disease in psoriatic arthritis (axPsA) is lacking. More studies specifically designed for axPsA and based on validated definition and outcome measures are urgently needed to provide reliable evidence.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Arthur Kavanaugh, Xenofon Baraliakos, Sheng Gao, Warner Chen, Kristen Sweet, Soumya D. Chakravarty, Qingxuan Song, May Shawi, Proton Rahman
Summary: This study suggests that psoriatic arthritis with axial involvement (axPsA) and radiographic axial spondyloarthritis (r-axSpA) may be distinct disorders with different clinical manifestations and genetic associations. Additionally, these disorders may respond differently to therapies. The findings contribute to our understanding of the potential genetic and molecular differences between axPsA and r-axSpA.
ADVANCES IN THERAPY
(2023)
Article
Rheumatology
Stefan Kleinert, Florian Schuch, Praxedis Rapp, Monika Ronneberger, Joerg Wendler, Patrizia Sternad, Florian Popp, Peter Bartz-Bazzanella, Cay von der Decken, Kirsten Karberg, Georg Gauler, Patrick Wurth, Susanna Spaethling-Mestekemper, Christoph Kuhn, Matthias Englbrecht, Wolfgang Vorbrueggen, Georg Adler, Martin Welcker
Summary: This study compares cognitive abilities in patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) and finds that patients with both conditions have significant impairments in selective attention compared to matched reference subjects, while the differences in episodic working memory are not significant. These findings suggest that axSpA and PsA may affect cognitive abilities, particularly in selective attention.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Rheumatology
Victoria Navarro-Compan, Diego Benavent, Dafne Capelusnik, Desiree van der Heijde, Robert B. M. Landewe, Denis Poddubnyy, Astrid van Tubergen, Xenofon Baraliakos, Filip E. van den Bosch, Floris A. van Gaalen, Lianne Gensler, Clementina Lopez-Medina, Helena Marzo-Ortega, Anna Molto, Rodolfo Perez-Alamino, Martin Rudwaleit, Marleen van de Sande, Raj Sengupta, Ulrich Weber, Sofia Ramiro
Summary: This study developed a consensual definition for 'early axial spondyloarthritis-axSpA' and 'early peripheral spondyloarthritis-pSpA' through a systematic literature review and Delphi survey. The results indicated that early axSpA should be based on symptom duration only, without considering the presence of radiographic damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Pedro M. Machado, Martin Schaefer, Satveer K. Mahil, Jean Liew, Laure Gossec, Nick Dand, Alexander Pfeil, Anja Strangfeld, Anne Constanze Regierer, Bruno Fautrel, Carla Gimena Alonso, Carla G. S. Saad, Christopher E. M. Griffiths, Claudia Lomater, Corinne Miceli-Richard, Daniel Wendling, Deshire Alpizar Rodriguez, Dieter Wiek, Elsa F. Mateus, Emily Sirotich, Enrique R. Soriano, Francinne Machado Ribeiro, Felipe Omura, Frederico Rajao Martins, Helena Santos, Jonathan Dau, Jonathan N. Barker, Jonathan Hausmann, Kimme L. Hyrich, Lianne Gensler, Ligia Silva, Lindsay Jacobsohn, Loreto Carmona, Marcelo M. Pinheiro, Marcos David Zelaya, Maria de los Angeles Severina, Mark Yates, Maureen Dubreuil, Monique Gore-Massy, Nicoletta Romeo, Nigil Haroon, Paul Sufka, Rebecca Grainger, Rebecca Hasseli, Saskia Lawson-Tovey, Suleman Bhana, Thao Pham, Tor Olofsson, Wilson Bautista-Molano, Zachary S. Wallace, Zenas Z. N. Yiu, Jinoos Yazdany, Philip C. Robinson, Catherine H. Smith
Summary: This study investigated factors associated with severe COVID-19 in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis. The study found that age, sex, comorbidities, disease activity, and glucocorticoid use were associated with the severity of COVID-19. Additionally, later pandemic time periods, psoriasis, and the use of TNFi, IL17i, and IL-23i/IL-12+23i were associated with a reduced risk of severe COVID-19.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Natalie Frede, Eva Rieger, Raquel Lorenzetti, Alexandra Nieters, Ana C. Venhoff, Carolin Hentze, Marcus von Deimling, Nora Bartholomae, Jens Thiel, Reinhard E. Voll, Nils Venhoff
Summary: The study evaluated the occurrence of respiratory tract infections in patients with spondyloarthritis, finding a high prevalence of upper and lower respiratory tract infections, with factors such as chronic lung disease, glucocorticoid therapy, and previous history of severe airway infections associated with increased risk. Female patients reported more LRTIs, and antibiotic therapy was linked to smoking, biological therapy, sleep quality, and age.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Dafna D. Gladman
Summary: The prevalence of axial psoriatic arthritis (axPsA) is estimated at 40-50%, and recent studies suggest it has distinct features from ankylosing spondylitis. Due to the lack of a widely accepted definition of axPsA, designing therapeutic trials for this type of PsA has been challenging, but some recent trials indicate that treatments effective for peripheral arthritis may also be effective for axPsA.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Article
Rheumatology
Katharina Ziegeler, Sevtap Tugce Ulas, Denis Poddubnyy, Fabian Proft, Valeria Rios Rodriguez, Judith Rademacher, Kay Geert A. Hermann, Torsten Diekhoff
Summary: Joint shape variations are associated with inflammatory lesions on SI joint MRIs in axSpA patients. This should be taken into consideration in future research on the interplay of mechanical strain and inflammation in axSpA.
Article
Rheumatology
Victoria Navarro-Compan, Anne Boel, Annelies Boonen, Philip J. Mease, Maxime Dougados, Uta Kiltz, Robert B. M. Landewe, Xenofon Baraliakos, Wilson Bautista-Molano, Praveena Chiowchanwisawakit, Hanne Dagfinrud, Lara Fallon, Marco Garrido-Cumbrera, Lianne Gensler, Bassel Kamal ElZorkany, Nigil Haroon, Yu Heng Kwan, Pedro M. Machado, Walter Maksymowych, Anna Molto, Natasha de Peyrecave, Denis Poddubnyy, Mikhail Protopopov, Sofia Ramiro, In-Ho Song, Salima van Weely, Desiree van der Heijde
Summary: This study aims to define the instruments for the Assessment of SpondyloArthritis international Society-Outcomes Measures in Rheumatology core domain set for axial spondyloarthritis (axSpA). The study selected core outcome instruments through a systematic literature review and assessment of the instruments' psychometric properties. Additionally, the study endorsed additional instruments to enhance the evaluation of axSpA trials.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Mikhail Protopopov, Fabian Proft, Stephanie Wichuk, Pedro M. Machado, Robert G. Lambert, Ulrich Weber, Susanne Juhl Pedersen, Mikkel Ostergaard, Joachim Sieper, Martin Rudwaleit, Xenofon Baraliakos, Walter P. Maksymowych, Denis Poddubnyy
Summary: This study compares the ability of MRI and conventional radiography to detect structural lesions indicative of axSpA.
Article
Rheumatology
Judith Rademacher, Hanna Mullner, Torsten Diekhoff, Hildrun Haibel, Sabrina Igel, Dominika Pohlmann, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Murat Torgutalp, Uwe Pleyer, Denis Poddubnyy
Summary: This study aims to analyze the prevalence of spondyloarthritis (SpA) in patients with acute anterior uveitis (AAU), identify parameters associated with SpA, and evaluate referral algorithms for identifying patients with a high probability of having SpA. The study found a high prevalence of SpA in AAU patients, with the majority having predominantly axial SpA. Psoriasis, HLA-B27 positivity, elevated C-reactive protein level, and male sex were associated with the presence of SpA. The Dublin Uveitis Evaluation Tool (DUET) showed higher specificity than the Assessment of SpondyloArthritis international Society (ASAS) tool, but both strategies missed over 20% of AAU patients with SpA.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Sofia Ramiro, Elena Nikiphorou, Alexandre Sepriano, Augusta Ortolan, Casper Webers, Xenofon Baraliakos, Robert B. M. Landewe, Filip E. Van den Bosch, Boryana Boteva, Ann Bremander, Philippe Carron, Adrian Ciurea, Floris A. van Gaalen, Pal Geher, Lianne Gensler, Josef Hermann, Manouk de Hooge, Marketa Husakova, Uta Kiltz, Clementina Lopez-Medina, Pedro M. Machado, Helena Marzo-Ortega, Anna Molto, Victoria Navarro-Compan, Michael J. Nissen, Fernando M. Pimentel-Santos, Denis Poddubnyy, Fabian Proft, Martin Rudwaleit, Mark Telkman, Sizheng Steven Zhao, Nelly Ziade, Desiree van der Heijde
Summary: The ASAS-EULAR recommendations provide updated guidance on the management of axial spondyloarthritis, including treatment targets, non-pharmacological interventions, and the use of non-steroidal anti-inflammatory drugs (NSAIDs) as the first-line pharmacological treatment. For patients with comorbidities, the use of biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) is recommended. The recommendations also cover the management of extramusculoskeletal manifestations, tapering of bDMARDs, and surgical interventions.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Robert B. M. Landewe, Denis Poddubnyy, Proton Rahman, Filip E. Van den Bosch, Rebecca Bolce, Soyi Liu Leage, Jeffrey R. Lisse, So Young Park, Lianne Gensler
Summary: In patients with axial spondyloarthritis who flared after withdrawal of IXE therapy, retreatment with open-label IXE can recapture a certain proportion of patients achieving low disease activity (LDA) or inactive disease (ID).
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Ennio Lubrano, Jon Chan, Ruben Queiro-Silva, Alberto Cauli, Niti Goel, Denis Poddubnyy, Peter Nash, Dafna D. Gladman
Summary: Objective. The objective of this study was to identify and evaluate the efficacy of therapeutic interventions for treatment of axial disease in PsA. Methods. This systematic review updated the treatment recommendations for axial PsA. Results. The literature review revealed that new biologic and targeted synthetic disease-modifying antirheumatic drug classes could be considered for the treatment of axial PsA. Conclusion. Further studies are needed for a better understanding of the treatment of axial PsA.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
Dafne Capelusnik, Diego Benavent, Desiree van der Heijde, Robert Landewe, Denis Poddubnyy, Astrid van Tubergen, Louise Falzon, Victoria Navarro-Compan, Sofia Ramiro
Summary: This study conducted a systematic literature review to summarize the relationship between early treatment and treatment clinical response in patients with SpA. It found that early treatment was associated with better outcomes in patients with non-radiographic axSpA and symptom duration of less than 5 years, but no differences in response to treatment were found in radiographic axSpA or in patients with longer symptom duration.
Article
Rheumatology
Hisashi Yamanaka, Mitsumasa Kishimoto, Nobuo Nishijima, Katsuhisa Yamashita, Junnosuke Matsushima, Jacqueline O'Brien, Taylor Blachley, Melissa Eliot, Zachary Margolin, Swapna S. Dave, Yoshiya Tanaka
Summary: This study evaluates the socioeconomic impact of biological and targeted synthetic disease-modifying antirheumatic drugs in Japanese patients with rheumatoid arthritis. The analysis shows high medication persistence, improved treatment outcomes, and reduced outpatient visits. Although direct costs increased, there was a decrease in indirect (loss of productivity) costs, partially offsetting the socioeconomic burden.
MODERN RHEUMATOLOGY
(2023)
Article
Rheumatology
Victoria Navarro-Compan, Diego Benavent, Dafne Capelusnik, Desiree van der Heijde, Robert B. M. Landewe, Denis Poddubnyy, Astrid van Tubergen, Xenofon Baraliakos, Filip E. van den Bosch, Floris A. van Gaalen, Lianne Gensler, Clementina Lopez-Medina, Helena Marzo-Ortega, Anna Molto, Rodolfo Perez-Alamino, Martin Rudwaleit, Marleen van de Sande, Raj Sengupta, Ulrich Weber, Sofia Ramiro
Summary: This study developed a consensual definition for 'early axial spondyloarthritis-axSpA' and 'early peripheral spondyloarthritis-pSpA' through a systematic literature review and Delphi survey. The results indicated that early axSpA should be based on symptom duration only, without considering the presence of radiographic damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Pharmacology & Pharmacy
Denis Poddubnyy
Summary: A significant number of PsA patients exhibit symptoms of inflammatory axial involvement, requiring clinical and laboratory evaluation as well as axial imaging. Treatment for confirmed axial PsA includes non-pharmacologic and pharmacologic methods such as non-steroidal anti-inflammatory drugs, tumor necrosis factor, interleukin 17, and Janus kinase inhibitors.
Review
Rheumatology
Diego Benavent, Dafne Capelusnik, Sofia Ramiro, Victoria Navarro-Compan
Summary: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that affects the spine and sacroiliac joints, potentially leading to irreversible structural damage. Early detection and intervention are crucial for preventing long-term damage and improving outcomes. However, it is unclear if the concept of a window of opportunity applies to axSpA. Recent advances in management, including diagnostic techniques and advanced therapies, show promise in improving outcomes.
Article
Rheumatology
Labinsky Hannah, Rohr von Sophie, Raimondo Maria Gabriella, Bohr Daniela, Morf Harriet, Horstmann Britta, Seese Felix, Proft Fabian, Muehlensiepen Felix, Boy Katharina, Kuhn Sebastian, Schmalzing Marc, Vuillerme Nicolas, Schett Georg, Ramming Andreas, Knitza Johannes
Summary: Patients with suspected axSpA can benefit from a stepwise asynchronous telemedicine-based diagnostic approach, which can potentially reduce the diagnostic delay and improve accuracy. Sufficient information, especially imaging results, is essential for correct diagnosis.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Walter P. Maksymowych, Nele Herregods, Nisha Varma, Arthur B. Meyers, Jennifer Stimec, Andrea S. Doria, Nikolay Tzaribachev, Tarimobo M. Otobo, Marion A. van Rossum, Joel Paschke, Stephanie Wichuk, Robert G. Lambert
Summary: This study aimed to investigate whether systematic calibration improves the scoring proficiency of JAMRIS-SIJ and whether contrast-enhancement enhances its performance. The results showed that calibrated readers achieved greater reliability in scoring specific inflammatory and structural lesions. Sensitivity and reliability for scoring inflammatory lesions were higher on fluid-sensitive sequences compared to contrast-enhanced sequences. Therefore, systematic calibration should be implemented before using JAMRIS-SIJ in clinical trials, and it is unlikely that contrast-enhanced MRI will improve the performance of this method.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
L. van Ouwerkerk, S. A. Bergstra, T. D. Maarseveen, T. W. J. Huizinga, R. Knevel, C. F. Allaart
Summary: This study evaluated whether the initial use of glucocorticoid (GC) bridging in RA patients leads to a higher probability of long-term GC and bDMARD use. The results showed that patients who initially started GC had a higher risk of later GC use, but the risk of bDMARD use was not significantly increased.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu
Summary: This study assessed the cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis. The results showed that in women with primary osteoporosis, zoledronic acid may increase the risk of atrial fibrillation and arrhythmias, but the cardiovascular risk in men with osteoporosis is uncertain.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
