How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins
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Title
How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-10-30
DOI
10.3389/fimmu.2018.02463
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Note: Only part of the references are listed.- ERAP1-dependent antigen cross-presentation determines efficacy of adoptive T cell therapy in mice
- (2018) Karin Schmidt et al. CANCER RESEARCH
- The association of ERAP1 and ERAP2 single nucleotide polymorphisms and their haplotypes with psoriasis vulgaris is dependent on the presence or absence of the HLA-C*06:02 allele and age at disease onset
- (2018) Andrzej Wiśniewski et al. HUMAN IMMUNOLOGY
- Allele-specific alterations in the peptidome underlie the joint association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy
- (2018) Alejandro Sanz-Bravo et al. MOLECULAR & CELLULAR PROTEOMICS
- Ranking the Contribution of Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphisms to Shaping the HLA-B*27 Peptidome
- (2018) Alejandro Sanz-Bravo et al. MOLECULAR & CELLULAR PROTEOMICS
- Molecular pathways for antigenic peptide generation by ER aminopeptidase 1
- (2018) Anastasia Mpakali et al. MOLECULAR IMMUNOLOGY
- The Peptide Repertoire of HLA-B27 may include Ligands with Lysine at P2 Anchor Position
- (2018) Shira Yair-Sabag et al. PROTEOMICS
- Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women
- (2018) Robert Y. L. Zee et al. International Journal of Genomics
- The role of polymorphic ERAP1 in autoinflammatory disease
- (2018) Emma Reeves et al. BIOSCIENCE REPORTS
- Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis
- (2018) Jonas J W Kuiper, Jessica van Setten, Matthew Devall, Mircea Cretu-Stancu, Sanne Hiddingh, Roel A Ophoff, Tom O A R Missotten, Mirjam van Velthoven et al. HUMAN MOLECULAR GENETICS
- An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes
- (2018) Fabiana Paladini et al. Scientific Reports
- Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia
- (2018) Nandor Gabor Than et al. Frontiers in Immunology
- Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction
- (2017) Jennifer G. Abelin et al. IMMUNITY
- Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality
- (2017) David P W Rastall et al. INTERNATIONAL IMMUNOLOGY
- Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome
- (2017) Adrian Martín-Esteban et al. JOURNAL OF AUTOIMMUNITY
- The molecular basis for peptide repertoire selection in the human leukocyte antigen (HLA) C*06:02 molecule
- (2017) Jesse I. Mobbs et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Behçet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing
- (2017) Pablo Guasp et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Human Leukocyte Antigen (HLA)-B27 Peptidomein Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion
- (2017) Eilon Barnea et al. MOLECULAR & CELLULAR PROTEOMICS
- Heterozygosity of the 721.221-B*51:01 Cell Line Used in the Study by Guasp et (Arthritis Rheumatol, February 2016)
- (2017) Arthritis & Rheumatology
- Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile
- (2017) Aimee L. Hanson et al. Arthritis & Rheumatology
- A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behçet's disease in HLA-B*51 carriers
- (2016) Masaki Takeuchi et al. ANNALS OF THE RHEUMATIC DISEASES
- Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view
- (2016) José A. López de Castro et al. MOLECULAR IMMUNOLOGY
- Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1
- (2016) Athanasios Stamogiannos et al. ACS Medicinal Chemistry Letters
- ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing
- (2016) Hanna Chen et al. Scientific Reports
- Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA-B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis
- (2016) Anna Ridley et al. Arthritis & Rheumatology
- Functional Interaction of the Ankylosing Spondylitis-Associated Endoplasmic Reticulum Aminopeptidase 2 With the HLA-B*27 Peptidome in Human Cells
- (2016) Adrian Martín-Esteban et al. Arthritis & Rheumatology
- The Peptidome of Behçet's Disease-Associated HLA-B*51:01 Includes Two Subpeptidomes Differentially Shaped by Endoplasmic Reticulum Aminopeptidase 1
- (2016) Pablo Guasp et al. Arthritis & Rheumatology
- ERAP2is associated with ankylosing spondylitis inHLA-B27-positive andHLA-B27-negative patients
- (2015) Philip C Robinson et al. ANNALS OF THE RHEUMATIC DISEASES
- ERAP1 Regulates Natural Killer Cell Function by Controlling the Engagement of Inhibitory Receptors
- (2015) L. Cifaldi et al. CANCER RESEARCH
- MHC Genes Linked to Autoimmune Disease
- (2015) Philip Deitiker et al. CRITICAL REVIEWS IN IMMUNOLOGY
- Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease
- (2015) Michael J. Ombrello et al. CURRENT OPINION IN RHEUMATOLOGY
- Association of single nucleotide polymorphisms in the 3′UTR of ERAP1 gene with essential hypertension in the Northeastern Han Chinese
- (2015) Sibao Yang et al. GENE
- Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages
- (2015) Y. Goto et al. JOURNAL OF BIOCHEMISTRY
- Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2
- (2015) Anastasia Mpakali et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autoimmune Disease-Associated Variants of Extracellular Endoplasmic Reticulum Aminopeptidase 1 Induce Altered Innate Immune Responses by Human Immune Cells
- (2015) Yasser A. Aldhamen et al. Journal of Innate Immunity
- Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen
- (2015) Carlos Alvarez-Navarro et al. MOLECULAR & CELLULAR PROTEOMICS
- ERp44 Exerts Redox-Dependent Control of Blood Pressure at the ER
- (2015) Chihiro Hisatsune et al. MOLECULAR CELL
- Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1
- (2015) Athanasios Stamogiannos et al. MOLECULAR IMMUNOLOGY
- 'MHC-I-opathy'—unified concept for spondyloarthritis and Behçet disease
- (2015) Dennis McGonagle et al. Nature Reviews Rheumatology
- The immunopathogenesis of birdshot chorioretinopathy; a bird of many feathers
- (2015) Jonas Kuiper et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility
- (2015) Xianyong Yin et al. Nature Communications
- Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
- (2015) Adrian Cortes et al. Nature Communications
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- (2015) Martijn van de Bunt et al. PLoS Genetics
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- ERAP1Gene Expression Is Influenced by Nonsynonymous Polymorphisms Associated With Predisposition to Spondyloarthritis
- (2015) Félicie Costantino et al. Arthritis & Rheumatology
- Revisiting the Arthritogenic Peptide Theory: Quantitative Not Qualitative Changes in the Peptide Repertoire of HLA-B27 Allotypes
- (2015) Ralf B. Schittenhelm et al. Arthritis & Rheumatology
- A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy
- (2014) Jonas J.W. Kuiper et al. HUMAN MOLECULAR GENETICS
- TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages
- (2014) Y. Goto et al. JOURNAL OF IMMUNOLOGY
- ERAP1–ERAP2 Dimerization Increases Peptide-Trimming Efficiency
- (2014) Irini Evnouchidou et al. JOURNAL OF IMMUNOLOGY
- Peptide Handling by HLA-B27 Subtypes Influences Their Biological Behavior, Association with Ankylosing Spondylitis and Susceptibility to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)
- (2014) Noel García-Medel et al. MOLECULAR & CELLULAR PROTEOMICS
- Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides
- (2014) Diana Paola Granados et al. Nature Communications
- A Role for Naturally Occurring Alleles of Endoplasmic Reticulum Aminopeptidases in Tumor Immunity and Cancer Pre-Disposition
- (2014) Efstratios Stratikos et al. Frontiers in Oncology
- Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens
- (2013) Sergey S. Seregin et al. AUTOIMMUNITY
- Combined Effects of Ankylosing Spondylitis-associated ERAP1 Polymorphisms Outside the Catalytic and Peptide-binding Sites on the Processing of Natural HLA-B27 Ligands
- (2013) Adrian Martín-Esteban et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Naturally Occurring ERAP1 Haplotypes Encode Functionally Distinct Alleles with Fine Substrate Specificity
- (2013) E. Reeves et al. JOURNAL OF IMMUNOLOGY
- Antigenic peptide trimming by ER aminopeptidases—Insights from structural studies
- (2013) Efstratios Stratikos et al. MOLECULAR IMMUNOLOGY
- The biochemistry and immunology of non-canonical forms of HLA-B27
- (2013) Jacqueline Shaw et al. MOLECULAR IMMUNOLOGY
- ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases
- (2013) Carlos Alvarez-Navarro et al. MOLECULAR IMMUNOLOGY
- HLA-B27 misfolding and ankylosing spondylitis
- (2013) Robert A. Colbert et al. MOLECULAR IMMUNOLOGY
- Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1
- (2013) Yohei Kirino et al. NATURE GENETICS
- Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
- (2013) Adrian Cortes et al. NATURE GENETICS
- Endoplasmic Reticulum Aminopeptidase-1 Functions Regulate Key Aspects of the Innate Immune Response
- (2013) Yasser A. Aldhamen et al. PLoS One
- Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA-B27
- (2013) Liye Chen et al. Arthritis & Rheumatology
- A novelERAP2haplotype structure in a Chilean population: implications for ERAP2 protein expression and preeclampsia risk
- (2013) Derek L. Vanhille et al. Molecular Genetics & Genomic Medicine
- Peptidases trimming MHC class I ligands
- (2012) Mirjana Weimershaus et al. CURRENT OPINION IN IMMUNOLOGY
- A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing
- (2012) I. Evnouchidou et al. JOURNAL OF IMMUNOLOGY
- Genetic Association with ERAP1 in Psoriasis Is Confined to Disease Onset after Puberty and Not Dependent on HLA-C*06
- (2012) Josefin Lysell et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Functional Interaction of the Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 Polymorphism and HLA-B27in Vivo
- (2012) Noel García-Medel et al. MOLECULAR & CELLULAR PROTEOMICS
- Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
- (2012) Lam C Tsoi et al. NATURE GENETICS
- The Crystal Structure of Human Endoplasmic Reticulum Aminopeptidase 2 Reveals the Atomic Basis for Distinct Roles in Antigen Processing
- (2011) James R. Birtley et al. BIOCHEMISTRY
- Nitric oxide synthases: regulation and function
- (2011) U. Forstermann et al. EUROPEAN HEART JOURNAL
- Secretion of Endoplasmic Reticulum Aminopeptidase 1 Is Involved in the Activation of Macrophages Induced by Lipopolysaccharide and Interferon-γ
- (2011) Yoshikuni Goto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme
- (2011) I. Evnouchidou et al. JOURNAL OF IMMUNOLOGY
- Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
- (2011) David M Evans et al. NATURE GENETICS
- Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1
- (2011) Tina T Nguyen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- HLA-B*51 and Behçet Disease
- (2011) Ahmet Gul et al. OCULAR IMMUNOLOGY AND INFLAMMATION
- Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming
- (2011) G. Kochan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The HLA-B2705 peptidome
- (2010) Lilach Halevi et al. ARTHRITIS AND RHEUMATISM
- A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
- (2010) Amy Strange et al. NATURE GENETICS
- Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation
- (2010) Aida M. Andrés et al. PLoS Genetics
- HLA-B51/B5and the risk of Behçet's disease: A systematic review and meta-analysis of case-control genetic association studies
- (2009) Mathilde de Menthon et al. ARTHRITIS AND RHEUMATISM
- Investigating the genetic association between ERAP1 and ankylosing spondylitis
- (2009) David Harvey et al. HUMAN MOLECULAR GENETICS
- From HLA-B27 to spondyloarthritis: a journey through the ER
- (2009) Robert A. Colbert et al. IMMUNOLOGICAL REVIEWS
- The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum
- (2009) A. Hearn et al. JOURNAL OF IMMUNOLOGY
- Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non‐lymphoid human tissues
- (2008) Doriana Fruci et al. JOURNAL OF CELLULAR PHYSIOLOGY
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