Review
Chemistry, Multidisciplinary
Faezeh Dangkoub, Mojtaba Sankian, Mohsen Tafaghodi, Mahmoud Reza Jaafari, Ali Badiee
Summary: This paper reviews the application of nanocarriers in inducing immunotolerance, with a focus on targeted delivery to APCs and direct targeting of autoreactive lymphocytes. The physicochemical properties and composition of NCs play essential roles in achieving the desired immunological outcome, making them a promising approach for treating autoimmune diseases in humans.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Immunology
Andrea Kristina Horst, Kingsley Gideon Kumashie, Katrin Neumann, Linda Diehl, Gisa Tiegs
Summary: The liver is a crucial immunological organ responsible for maintaining immune balance through interactions between different cells within the liver. Disruption of this balance in response to pathogens or autoantigens may lead to autoimmune liver diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Cell Biology
Irina A. Ishina, Maria Y. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov, Alexey A. A. Belogurov Jr, Alexander G. G. Gabibov
Summary: Antigen presentation by MHC-II is crucial for immune response and self-antigen tolerance. Certain MHC-II alleles are associated with autoimmune diseases. The process of MHC-II-mediated presentation plays a significant role in understanding the mechanisms of autoimmune diseases and the protective effect of certain MHC-II alleles.
Article
Immunology
Xueting Yu, Yaping Mai, Yaya Wei, Na Yu, Ting Gao, Jianhong Yang
Summary: Autoimmune diseases result from dysregulation of the body's immune system, leading to the recognition and destruction of self-tissues by immune cells such as T and B cells. These diseases affect 5-10% of the global population. Current treatments only provide symptomatic relief and come with significant side effects. Antigen-specific therapies, particularly vaccines carrying autoantigenic peptides, have gained attention in recent years for their potential to induce immune tolerance and effectively treat autoimmune diseases. This article reviews the latest progress on the use of autoantigen peptide vaccines, including their delivery systems, mechanisms of immune tolerance induction, and applications.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
He Li, Yong-Guang Yang, Tianmeng Sun
Summary: Autoimmune diseases are chronic inflammatory diseases caused by immune regulation disorders. Nanoparticles, as drug delivery systems, can improve the efficiency of inducing antigen-specific immune tolerance in the body.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nasrin Aktar, Tingting Chen, Ahmed Moudud, Suowen Xu, Xiaohui Zhou
Summary: Autoimmunity arises from reduced tolerance to self-antigens by the immune system, with antigen-specific immunotherapy showing better effects but facing challenges due to inadequate antigen delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Laura Passeri, Fortunato Marta, Virginia Bassi, Silvia Gregori
Summary: Dendritic cells play a crucial role in autoimmune diseases by instructing T cells to respond to antigens, leading to organ damage or promoting immune tolerance. Research on different subsets of human DCs and the regulatory mechanisms associated with tolDC functions is ongoing, along with exploring tolDC-based therapies for treating autoimmune diseases. Continued expansion of research in the area of tolDCs will enhance understanding of the role of DCs in the development and treatment of autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ian Mantel, Barzan A. A. Sadiq, J. Magarian Blander
Summary: This article discusses the importance of the transporter associated with antigen processing (TAP) protein in cellular immune responses, particularly in cross-presentation. TAP plays a crucial role in transporting peptides to the endoplasmic reticulum as well as in phagosomes and endosomes, and its expression and function are often compromised by cancer and viruses.
MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Maria Maslinska, Joanna Dmowska-Chalaba, Michal Jakubaszek
Summary: The role of IgG4 in IgG4-RD and other autoimmune diseases has attracted attention. IgG4, as a unique subclass of immunoglobulins, is generally considered non-inflammatory and tolerance inducing, but in IgG4-RD, it may play a pathogenic role in fibrogenesis and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Peng Wang, Qian Wu, Zong-Wen Shuai
Summary: Ficolins are pattern-recognition molecules that can trigger complement activation and play a crucial role in various autoimmune diseases. Studies have elucidated the immunological regulations of ficolins and discussed their potential diagnostic and therapeutic applications in autoimmune diseases.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Klaudia Dopytalska, Anna Czaplicka, Elzbieta Szymanska, Irena Walecka
Summary: The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood. Epigenetic factors, particularly microRNAs, play an important role in the development of these diseases. Research on microRNAs has provided new insights into the pathogenesis and potential therapeutic targets of inflammatory and autoimmune skin diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Karolina D. Witt
Summary: MHC class I antigen processing is a less recognized area in nonviral host-pathogen interactions, involving immunology and cell biology. This review focuses on the MHC-I antigen processing pathway and alternative sources of antigens, particularly in the context of Mycobacterium tuberculosis (Mtb) as an intracellular pathogen. It explores how Mtb manipulates host immunity for survival and proposes directions for MHC-I-focused approaches in developing vaccines against tuberculosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Immunology
Rossella Fasano, Eleonora Malerba, Marcella Prete, Antonio Giovanni Solimando, Alessio Buonavoglia, Nicola Silvestris, Patrizia Leone, Vito Racanelli
Summary: The liver is a tolerogenic organ that can induce immune tolerance against self-antigens. However, autoimmune liver diseases can disrupt this tolerance due to genetic predisposition, environmental factors, and imbalance in regulatory mechanisms. Liver cells, including conventional and unconventional antigen presenting cells (APCs), present self-antigens to T cells, leading to altered immune responses, liver injury, and inflammation. Understanding the impact of antigen presentation and the role of immune cells in liver inflammation could aid in the development of novel therapeutic strategies for autoimmune liver diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Dermatology
Ke Chai, Ruixuan Zhu, Fujian Luo, Yaqian Shi, Minghui Liu, Yangfan Xiao, Rong Xiao
Summary: This article summarizes the characteristics of high-frequency ultrasound imaging in common autoimmune skin diseases and provides new ideas and strategies for dermatologists to diagnose and track the prognosis of these diseases.
ACTA DERMATO-VENEREOLOGICA
(2022)
Letter
Dermatology
Stefan Haskamp, Joseph Simon Horowitz, Vinzenz Oji, Sandra Philipp, Michael Sticherling, Knut Schaekel, Sarah Schuhmann, Jorg C. Prinz, Harald Burkhardt, Frank Behrens, Beate Boehm, Michaela Koehm, Jurgen Rech, David Simon, Georg Schett, Kirsten Morrison, Sascha Gerdes, Gunter Assmann, Ali Nimeh, Volker Schuster, Arnd Jacobi, Ansgar Weyergraf, Andre Reis, Steffen Uebe, Dagmar Wilsmann-Theis, Rotraut Moessner, Ulrike Hueffmeier
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Immunology
Akiko Arakawa, Emma Reeves, Sigrid Vollmer, Yukiyasu Arakawa, Mengwen He, Adrian Galinski, Julia Stoehr, Klaus Dornmair, Edward James, Joerg C. Prinz
Summary: In psoriasis, ERAP1 trims peptide precursors to generate melanocyte autoantigen, with the risk haplotype producing it more efficiently. This increases HLA-C expression and TCR stimulation, leading to activation of autoreactive T cells and autoimmune disease. ERAP1 function emerges as a central checkpoint and potential therapeutic target in psoriasis and other HLA class I-associated diseases.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Dermatology
Jorg C. Prinz, Siew Eng Choon, Christopher E. M. Griffiths, Joseph F. Merola, Akimichi Morita, Darren M. Ashcroft, Manuelle Viguier
Summary: Generalized pustular psoriasis (GPP) is a rare auto-inflammatory skin disease with acute episodes of pustule formation. Understanding the epidemiology and clinical data of GPP is challenging due to its rarity. This review article provides an overview of GPP prevalence estimates in key demographics, genetic mutations associated with the disease, incidence of comorbidities, mortality rate, and causes of death.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
