Article
Multidisciplinary Sciences
James T. Rosenbaum, Michael H. Weisman, Hedley Hamilton, Cassie Shafer, Elin Aslanyan, Richard A. Howard, Kimberly Ogle, John D. Reveille, Kevin L. Winthrop, Dongseok Choi
Summary: HLA-B27 positive patients with axial spondyloarthritis (AxSpA) tend to have lower disease activity compared to HLA-B27 negative patients, as indicated by higher BASDAI scores. HLA-B27 positive patients with mild back pain are more likely to be diagnosed with AxSpA, suggesting a cognitive bias introduced by the HLA-B27 test.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Javier Fernandez-Torres, Yessica Zamudio-Cuevas, Nathalie Montano-Armendariz, Ivan Alejandro Lujan-Juarez, Roberto Sanchez-Sanchez, Karina Martinez-Flores
Summary: The study found that variants of the ERAP1 gene may interact with smoking to increase the risk of AS in patients, especially those carrying the B27 allele.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cell Biology
Chin-Man Wang, Ming-Kun Liu, Yeong-Jian Jan Wu, Jing-Chi Lin, Jian-Wen Zheng, Jianming Wu, Ji-Yih Chen
Summary: The study examined the impact of ERAP1 allelic variants and their interaction with HLA-B27 on ankylosing spondylitis susceptibility. It discovered multiple ERAP1 SNVs and allelic variants in Taiwanese individuals, and found that ERAP1 variants significantly contribute to the development of AS in a HLA-B27-dependent manner.
Review
Clinical Neurology
Naiwen Hu, Dongxia Liu, Na Zhao, Xia Wang, Yanyan Bai, Hongsheng Sun
Summary: The study found significant associations between TNF-238, -308, -857, -1031, and -863 minor alleles and AS susceptibility in the HLA-B27 positive population. However, no association was found between TNF polymorphisms and AS in the HLA-B27-positive patients group and the HLA-B27-positive healthy controls group. Other gene SNPs may play a role in AS susceptibility in the HLA-B27-positive population.
EUROPEAN SPINE JOURNAL
(2021)
Article
Rheumatology
Rodrigo Garcia-Salinas, Santiago Ruta, Jessica Torres Chichande, Sebastian Magri
Summary: This study aimed to evaluate the frequency of HLA-B27 in Argentinean patients with axial spondyloarthritis and analyze its performance as a diagnostic biomarker. The results showed that HLA-B27-positive patients had an earlier age of onset, higher BASFI, and more extra-articular SpA features. However, HLA-B27 had low sensitivity but good specificity for the diagnosis of SpA.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Xinbo Yang, Lee I. I. Garner, Ivan V. V. Zvyagin, Michael A. A. Paley, Ekaterina A. A. Komech, Kevin M. M. Jude, Xiang Zhao, Ricardo A. A. Fernandes, Lynn M. M. Hassman, Grace L. L. Paley, Christina S. S. Savvides, Simon Brackenridge, Max N. N. Quastel, M. M. Chudakov, Paul Bowness, Wayne M. M. Yokoyama, Andrew J. J. McMichael, Geraldine M. M. Gillespie, K. Christopher Garcia
Summary: The human leucocyte antigen B*27 (HLA-B*27) is strongly associated with inflammatory diseases of the spine and pelvis and the eye. The mechanism by which HLA-B*27 facilitates disease remains unknown, but it may involve the presentation of pathogenic peptides to CD8(+) T cells. In this study, orphan T cell receptors (TCRs) expressing a disease-associated public beta-chain variable region-complementary-determining region 3 beta (BV9-CDR3 beta) motif were isolated from blood and synovial fluid T cells from individuals with ankylosing spondylitis (AS) and from the eye in individuals with acute anterior uveitis (AAU). These TCRs showed consistent alpha-chain variable region (AV21) chain pairing and were clonally expanded in the joint and eye. Using peptide libraries, self-peptides and microbial peptides that activated the AS- and AAU-derived TCRs were identified. Structural analysis revealed that TCR cross-reactivity for peptide-MHC was rooted in a shared binding motif present in both self-antigens and microbial antigens that engages the BV9-CDR3 beta TCRs. These findings suggest that both microbial antigens and self-antigens could play a pathogenic role in HLA-B*27-associated disease.
Review
Immunology
Zi-Yi Song, Duo Yuan, Sheng-Xiao Zhang
Summary: Ankylosing spondylitis is a chronic condition that affects the spine and sacroiliac joints, with multifactorial etiology and pathogenesis that remain elusive. Gut microbiota as an environmental factor plays a critical role in the pathogenesis of AS through various mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Adelmo Segota, Tea Schnurrer-Luke-Vrbanic, Viviana Avancini-Dobrovic, Filip Miric
Summary: The aim of this study was to compare four forms of axial spondyloarthritis (axSpA): non-radiographic axial spondyloarthritis (nr-axSpA), ankylosing spondylitis (AS), non-radiographic axial psoriatic arthritis (nr-axPsA) and radiographic axial psoriatic arthritis (r-axPsA). The study analyzed gender differences, human leukocyte antigen (HLA) typing, laboratory values, radiographic and magnetic resonance scans of 137 patients. The key findings included newly detected HLA typing beyond HLA-27 positivity, which could serve as possible biomarkers for early detection of axSpA.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Immunology
Nan Sheng, Yingying Gao, Hui Li, Wenwen Wang, Linyu Geng, Bo Zhang, Qiang Huang, Xueqin Wang, Lingyun Sun
Summary: This study explored the associations between several single nucleotide polymorphisms (SNPs) in the coding gene of tumor necrosis factor alpha (TNFa) and ankylosing spondylitis (AS) risk. The results showed that the T allele of rs1799724 was associated with increased AS risk, while the A allele of rs361525 was associated with decreased AS risk. Moreover, the contributions of rs1799724 and rs361525 to AS risk were dependent on HLA-B27 status.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Tri M. M. Tran, Tejpal Gill, Joshua Bennett, Sohee Hong, Vance Holt, Anders J. J. Lindstedt, Sufia Bakshi, Keith Sikora, Joel D. D. Taurog, Maxime Breban, Fatemeh Navid, Robert A. A. Colbert
Summary: This study aimed to investigate the functional basis for the epistasis between endoplasmic reticulum aminopeptidase 1 (ERAP1) and HLA-B27 in experimental spondyloarthritis (SpA). The results showed that ERAP1 deficiency increased the folded to unfolded ratio of HLA-B27 heavy chains and reduced HLA-B27 misfolding. Additionally, ERAP1 deficiency led to a reduction in endoplasmic reticulum stress and decreased the prevalence of arthritis in HLA-B27-Tg rats.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
M. L. Stoll, H. Sawhney, P. M. Wells, P. R. Sternes, J. D. Reveille, C. D. Morrow, C. J. Steves, M. A. Brown, L. S. Gensler
Summary: Objective: The objective of this study was to evaluate the contents of the faecal microbiota in HLA-B27+ AS patients and healthy adults, and to assess the impact of HLA-B27 on the microbiota.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi, Tetsuya Tomita, Hironori Nakagami
Summary: This study aimed to assess the efficacy of an IL17A peptide-based vaccine on SpA manifestations in model rats. The results showed that the IL17A peptide-based vaccine successfully induced antibody production and suppressed the arthritis score and joint thickness. It also inhibited enthesitis, bone destruction, and new bone formation. The study suggests that the IL17A peptide-based vaccine may be a therapeutic option for SpA treatment.
Article
Ophthalmology
Douglas A. Jabs, Nisha R. Acharya, Soon-Phaik Chee, Debra Goldstein, Peter McCluskey, Philip Murray, Neal Oden, Alan G. Palestine, James T. Rosenbaum, Jennifer E. Thorne, Brett E. Trusko
Summary: This study aimed to establish classification criteria for spondyloarthritis/HLA-B27-associated anterior uveitis using machine learning, achieving high accuracy in both training and validation sets. Key criteria for this condition were identified, with a low misclassification rate, indicating their potential utility in clinical and translational research.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Rheumatology
Juergen Braun, Joachim Sieper
Summary: The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex. It is associated with ankylosing spondylitis (AS) and plays a role in the immune system's defense against microbes. HLA B27 accounts for less than 30% of the genetic load and can be found in 60-90% of axSpA patients worldwide. Its prevalence in the population is linked to the prevalence of the disease.
Article
Clinical Neurology
Ennio Lubrano, Pablo Fanlo Mazas, Jurgen Freiwald, Karsten Kruger, Ignazio Grattagliano, Erich Mur, Ruben Queiro Silva, Guillermo Rodriguez Maruri, Luis Sequeira de Medeiros
Summary: This Delphi consensus recognizes the role of heat therapy mostly in chronic musculoskeletal pain and highlights the need for stronger scientific evidence to regulate the use of this therapy in clinical practice.
Review
Rheumatology
Ennio Lubrano, Jon Chan, Ruben Queiro-Silva, Alberto Cauli, Niti Goel, Denis Poddubnyy, Peter Nash, Dafna D. Gladman
Summary: Objective. The objective of this study was to identify and evaluate the efficacy of therapeutic interventions for treatment of axial disease in PsA. Methods. This systematic review updated the treatment recommendations for axial PsA. Results. The literature review revealed that new biologic and targeted synthetic disease-modifying antirheumatic drug classes could be considered for the treatment of axial PsA. Conclusion. Further studies are needed for a better understanding of the treatment of axial PsA.
JOURNAL OF RHEUMATOLOGY
(2023)
Letter
Rheumatology
Ruben Queiro-Silva
Article
Oncology
Oscar Rapado-Gonzalez, Jenifer Brea-Iglesias, Aitor Rodriguez-Casanova, Aida Bao-Caamano, Jose-Luis Lopez-Cedrun, Gabriel Triana-Martinez, Roberto Diaz-Pena, Maria Arminda Santos, Rafael Lopez-Lopez, Laura Muinelo-Romay, Monica Martinez-Fernandez, Angel Diaz-Lagares, Maria Mercedes Suarez-Cunqueiro
Summary: This study examines the use of the TST170 panel for detecting somatic mutations in tumor and cfDNA of HNSCC patients. The results demonstrate the potential of a single assay for consistent detection of mutations in both tissue and plasma.
Article
Medicine, General & Internal
Ruben Queiro, Daniel Seoane-Mato, Ana Laiz, Eva Galindez Agirregoikoa, Carlos Montilla, Hye S. Park, Jose A. Pinto Tasende, Juan J. Bethencourt Baute, Beatriz Joven Ibanez, Elide Toniolo, Julio Ramirez, Nuria Montero, Cristina Pruenza Garcia-Hinojosa, Ana Serrano Garcia
Summary: This study aimed to identify characteristics predicting moderate-to-high disease activity in recent-onset psoriatic arthritis (PsA). They conducted a multicenter observational prospective study and found that PsAID score, tender joint count, level of physical activity, and sex were predictors of moderate-to-high activity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ignacio Brana, Estefania Pardo, Stefanie Burger, Pablo Gonzalez del Pozo, Mercedes Alperi, Ruben Queiro
Summary: This study aimed to analyze the retention rate and safety of IXE in patients with PsA in routine clinical practice. The results showed that the retention rate of IXE was high in PsA patients and was consistently good regardless of age, gender, metabolic comorbidities, smoking status, or prior number of biologic therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Agriculture, Dairy & Animal Science
Ruben X. G. Silva, Diana Madeira, Paulo Cartaxana, Ricardo Calado
Summary: Climate change-induced bleaching events have become increasingly common in coral reefs. While direct impacts have received attention, the indirect impacts, such as trophic interactions, have been largely overlooked. To address this research gap, the model predator-prey pair of Berghia stephanieae and Exaiptasia diaphana is advocated for studying the trophic effects of bleaching. These organisms are already used in other research fields, allowing for the utilization of existing knowledge on their physiology and culture protocols. The use of this model pair can help unravel the long-term prevalence of trophic effects in coral reef communities.
Article
Rheumatology
Stefan Siebert, Frank Behrens, Ennio Lubrano, Nicolas Martin, Mohamed Sharaf, Christine Contre, Elke Theander, Ruben Queiro, Miriam Zimmermann, Laure Gossec
Summary: This study aims to collect data on the long-term clinical practice of using guselkumab or interleukin-17 inhibitors for the treatment of PsA to understand drug persistence, effectiveness, and long-term safety. Data will be collected through electronic patient-reported outcomes and physician-completed assessments, along with safety data. The study will last for 36 months with an additional 24-week observation period.
RHEUMATOLOGY AND THERAPY
(2023)
Article
Rheumatology
Alen Zabotti, Gabriele De Marco, Laure Gossec, Xenofon Baraliakos, Daniel Aletaha, Annamaria Iagnocco, Paolo Gisondi, Peter Balint, Heidi Bertheussen, Wolf-Henning Boehncke, Nemanja S. Damjanov, Maarten de Wit, Enzo Errichetti, Helena Marzo-Ortega, Mikhail Protopopov, Lluis Puig, Ruben Queiro, Piero Ruscitti, Laura Savage, Georg Schett, Stefan Siebert, Tanja A. Stamm, Paul Studenic, Ilaria Tinazzi, Filip E. Van den Bosch, Annette van der Helm-van Mil, Abdulla Watad, Josef S. Smolen, Dennis G. McGonagle
Summary: This study proposes EULAR guidelines for the early diagnosis of psoriatic arthritis (PsA) by conducting research on multiple patients. It also establishes standardized operating procedures for clinical practice and trials, providing guidance and consensus in the field of prevention and interception of PsA for psoriasis patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Pathology
Patricia Mondelo-Macia, Ramon Manuel Lago-Leston, Aitor Rodriguez-Casanova, Alicia Abalo, Angel Diaz-Lagares, Jorge Garcia-Gonzalez, Luis Leon-Mateos, Roberto Diaz-Pena, Laura Muinelo-Romay
Article
Rheumatology
Sara Alonso, Isla Morante, Ignacio Brana, Ruben Queiro
Summary: This study compared the factors associated with sleep problems in psoriatic arthritis (PsA) and axial SpA (axSpA). The results showed that a considerable proportion of patients in both populations reported sleep problems. Additionally, sleep quality was associated with factors such as disease activity and inflammation severity in both populations.
REUMATOLOGIA CLINICA
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Marta Loredo, Ignacio Brana, Ruben Queiro
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Review
Immunology
Ruben Queiro, Marta Loredo, Ignacio Brana, Estefania Pardo, Sara Alonso, Mercedes Alperi
Summary: Psoriatic arthritis (PsA), a chronic immune-mediated disease, significantly impairs patients' physical function and quality of life. Managing PsA is challenging due to its complex clinical features and comorbidities. This article reviews the current understanding of PsA and available pharmacological options, providing expert opinion on treatment strategies considering the disease domain and comorbidities.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Immunology
Patricia Castro-Santos, Angel Carracedo, Roberto Diaz-Pena
Summary: The recent study in Nature by Augusto et al. reveals a strong association between HLA-B*15:01 and asymptomatic COVID-19, making an important contribution to genetics in COVID-19 research.
TRENDS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Patricia Castro-Santos, Augusto Rojas-Martinez, Jose A. Riancho, Pablo Lapunzina, Carlos Flores, Angel Carracedo, Roberto Diaz-Pena, Scourge Cohort Group
Summary: We investigated the relationship between HLA polymorphisms and susceptibility to SARS-CoV-2 infection and disease severity. Genotyping data from 9373 COVID-19-positive cases and 5943 population controls were analyzed. The study found associations between HLA-B*14:02 and HLA-C*08:02 alleles with a lower risk of COVID-19 infection, and HLA-A*11:01 and HLA-C*04:01 alleles with disease severity.
