Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties

Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation

(2020) John Liddle et al.   JOURNAL OF MEDICINAL CHEMISTRY

ERAP1: a potential therapeutic target for a myriad of diseases

(2020) Emma Reeves et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Cytokine storm induced by SARS-CoV-2

(2020) Peipei Song et al.   CLINICA CHIMICA ACTA

High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor

(2019) Petros Giastas et al.   ACS Medicinal Chemistry Letters

ERAP1 shapes just part of the immunopeptidome

(2019) Arie Admon   HUMAN IMMUNOLOGY

HPV Epitope Processing Differences Correlate with ERAP1 Allotype and Extent of CD8+ T-cell Tumor Infiltration in OPSCC

(2019) Emma Reeves et al.   Cancer Immunology Research

Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility

(2019) Cory M. Ayres et al.   Frontiers in Immunology

Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1

(2019) Petros Giastas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Surface MHC Class I Expression Is Limited by the Availability of Peptide-Receptive “Empty” Molecules Rather than by the Supply of Peptide Ligands

(2018) Liran Komov et al.   PROTEOMICS

Intracellular antigen processing by ERAP2: Molecular mechanism and roles in health and disease

(2018) José A. López de Castro et al.   HUMAN IMMUNOLOGY

Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration

(2018) Yoong Wearn Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins

(2018) José A. López de Castro   Frontiers in Immunology

Structure of the human MHC-I peptide-loading complex

(2017) Andreas Blees et al.   NATURE

Reply to Reeves et al.: No evidence for rareERAP1haplotypes and haplotype combinations in ankylosing spondylitis

(2017) Bryon Paul Wordsworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERAP1association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations

(2017) Amity R. Roberts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile

(2017) Aimee L. Hanson et al.   Arthritis & Rheumatology

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases

(2017) Athanasios Papakyriakou et al.   Frontiers in Immunology

Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view

(2016) José A. López de Castro et al.   MOLECULAR IMMUNOLOGY

The Peptidome of Behçet's Disease-Associated HLA-B*51:01 Includes Two Subpeptidomes Differentially Shaped by Endoplasmic Reticulum Aminopeptidase 1

(2016) Pablo Guasp et al.   Arthritis & Rheumatology

Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease

(2015) Michael J. Ombrello et al.   CURRENT OPINION IN RHEUMATOLOGY

Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2

(2015) Anastasia Mpakali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1

(2015) Athanasios Stamogiannos et al.   MOLECULAR IMMUNOLOGY

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

(2015) Adrian Cortes et al.   Nature Communications

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Dominant Role of the ERAP1 Polymorphism R528K in Shaping the HLA-B27 Peptidome Through Differential Processing Determined by Multiple Peptide Residues

(2015) Alejandro Sanz-Bravo et al.   Arthritis & Rheumatology

ERAP1Gene Expression Is Influenced by Nonsynonymous Polymorphisms Associated With Predisposition to Spondyloarthritis

(2015) Félicie Costantino et al.   Arthritis & Rheumatology

Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases

(2014) N Agrawal et al.   GENES AND IMMUNITY

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy

(2014) Jonas J.W. Kuiper et al.   HUMAN MOLECULAR GENETICS

Functionally distinctERAP1allotype combinations distinguish individuals with Ankylosing Spondylitis

(2014) Emma Reeves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating antigen processing for cancer immunotherapy

(2014) Efstratios Stratikos   OncoImmunology

Combined Effects of Ankylosing Spondylitis-associated ERAP1 Polymorphisms Outside the Catalytic and Peptide-binding Sites on the Processing of Natural HLA-B27 Ligands

(2013) Adrian Martín-Esteban et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naturally Occurring ERAP1 Haplotypes Encode Functionally Distinct Alleles with Fine Substrate Specificity

(2013) E. Reeves et al.   JOURNAL OF IMMUNOLOGY

ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases

(2013) Carlos Alvarez-Navarro et al.   MOLECULAR IMMUNOLOGY

Concerted In Vitro Trimming of Viral HLA-B27-Restricted Ligands by Human ERAP1 and ERAP2 Aminopeptidases

(2013) Elena Lorente et al.   PLoS One

Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

(2013) E. Zervoudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA-B27

(2013) Liye Chen et al.   Arthritis & Rheumatology

Peptidases trimming MHC class I ligands

(2012) Mirjana Weimershaus et al.   CURRENT OPINION IN IMMUNOLOGY

A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing

(2012) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides

(2011) Efthalia Zervoudi et al.   BIOCHEMICAL JOURNAL

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

(2011) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

ggplot2: Elegant Graphics for Data Analysis

(2011) Cedric Ginestet   JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

(2011) Tina T Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection

(2010) R. Cagliani et al.   HUMAN MOLECULAR GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation

(2010) Aida M. Andrés et al.   PLoS Genetics