Gut-on-a-chip for disease models

Implementing organ-on-chip in a next-generation risk assessment of chemicals: a review

(2022) Katharina S. Nitsche et al.   ARCHIVES OF TOXICOLOGY

3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert

(2022) Woojung Shin et al.   Nature Protocols

Gut-on-chip for ecological and causal human gut microbiome research

(2022) Shirin Moossavi et al.   TRENDS IN MICROBIOLOGY

Fecal Microbiota Transplants for Inflammatory Bowel Disease Treatment: Synthetic- and Engineered Communities-Based Microbiota Transplants Are the Future

(2022) Raees Khan et al.   Gastroenterology Research and Practice

In vitro Models of the Small Intestine for Studying Intestinal Diseases

(2022) Sang-Myung Jung et al.   Frontiers in Microbiology

Current Perspectives on Gastrointestinal Models to Assess Probiotic-Pathogen Interactions

(2022) Mehreen Anjum et al.   Frontiers in Microbiology

Contributions of the microbiome to intestinal inflammation in a gut-on-a-chip

(2022) Min Seo Jeon et al.   Nano Convergence

The microbiota‐gut‐brain axis and epilepsy from a multidisciplinary perspective: clinical evidence and technological solutions for improvement of in vitro preclinical models

(2022) Federica Fusco et al.   Bioengineering & Translational Medicine

Microphysiological Neurovascular Barriers to Model the Inner Retinal Microvasculature

(2022) Thomas L. Maurissen et al.   Journal of Personalized Medicine

Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine

(2022) Zhen Xiong et al.   IMMUNITY

Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy

(2022) Hyo-Jin Yoon et al.   Bioactive Materials

Advances in Reconstructing Intestinal Functionalities in Vitro: from Two/Three Dimensional-Cell Culture Platforms to Human Intestine-on-a-Chip

(2021) Li Wang et al.   TALANTA

Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota

(2021) Umair Shabbir et al.   Nutrients

Advances in modelling the human microbiome–gut–brain axis in vitro

(2021) Chrysanthi-Maria Moysidou et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Gut-on-a-chip: mimicking and monitoring the human intestine

(2021) Denise Marrero et al.   BIOSENSORS & BIOELECTRONICS

Disorders of the enteric nervous system — a holistic view

(2021) Beate Niesler et al.   Nature Reviews Gastroenterology & Hepatology

Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication

(2021) Nathalie Picollet-D’hahan et al.   TRENDS IN BIOTECHNOLOGY

A Review on the Role of Food-Derived Bioactive Molecules and the Microbiota–Gut–Brain Axis in Satiety Regulation

(2021) Nuria A. Pizarroso et al.   Nutrients

A versatile, compartmentalised gut-on-a-chip system for pharmacological and toxicological analyses

(2021) Pim de Haan et al.   Scientific Reports

COVID-19 Crisis Creates Opportunity towards Global Monitoring & Surveillance

(2021) Ahmed Donia et al.   Pathogens

Technological tools and strategies for culturing human gut microbiota in engineered in vitro models

(2021) Lorenzo Sardelli et al.   BIOTECHNOLOGY AND BIOENGINEERING

3D Cell Culture Models: Drug Pharmacokinetics, Safety Assessment, and Regulatory Consideration

(2021) Hongbing Wang et al.   CTS-Clinical and Translational Science

Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip

(2021) M. Tyler Nelson et al.   Nature Communications

Microfluidic Organs-on-a-Chip for Modeling Human Infectious Diseases

(2021) Yaqing Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Bioderived materials that disarm the gut mucosal immune system: Potential lessons from commensal microbiota

(2021) Rian Harriman et al.   Acta Biomaterialia

Organoids and organs-on-chips: Insights into human gut-microbe interactions

(2021) Jens Puschhof et al.   Cell Host & Microbe

Mucosal defense

(2021) Susan J. Hagen   CURRENT OPINION IN GASTROENTEROLOGY

Mechanical Strain-Enabled Reconstitution of Dynamic Environment in Organ-on-a-Chip Platforms: A Review

(2021) Qianbin Zhao et al.   Micromachines

Uncovering the pathophysiology of irritable bowel syndrome by exploring the gut-brain axis: a narrative review

(2021) He-Yong Tang et al.   Annals of Translational Medicine

Organ-on-chip approaches for intestinal 3D in vitro modelling

(2021) Joana Pimenta et al.   Cellular and Molecular Gastroenterology and Hepatology

In vitro models to evaluate ingestible devices: Present status and current trends

(2021) Connor O'Farrell et al.   ADVANCED DRUG DELIVERY REVIEWS

Relevance of organ(s)-on-a-chip systems to the investigation of food-gut microbiota-host interactions

(2021) Enriqueta Garcia-Gutierrez et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Multiorgan microphysiological systems as tools to interrogate interorgan crosstalk and complex diseases

(2021) Martin Trapecar   FEBS LETTERS

Organ-on-a-Chip for Studying Gut-Brain Interaction Mediated by Extracellular Vesicles in the Gut Microenvironment

(2021) Min-Hyeok Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Progress of Intestinal Epithelial Models from Cell Lines to Gut-On-Chip

(2021) Shafaque Rahman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

All layers matter: Innovative three-dimensional epithelium-stroma-endothelium intestinal model for reliable permeability outcomes

(2021) Maria Helena Macedo et al.   JOURNAL OF CONTROLLED RELEASE

Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota Interaction

(2021) Fatina Siwczak et al.   Frontiers in Immunology

MUC2 and related bacterial factors: Therapeutic targets for ulcerative colitis

(2021) Dianbo Yao et al.   EBioMedicine

In vitro models of the small intestine: engineering challenges, engineering solutions

(2020) Sarah A Hewes et al.   TISSUE ENGINEERING PART B-REVIEWS

Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model

(2020) Kristen M. Seiler et al.   Scientific Reports

SCFA: mechanisms and functional importance in the gut

(2020) Camille Martin-Gallausiaux et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Intestinal epithelial barrier and neuromuscular compartment in health and disease

(2020) Vanessa D’Antongiovanni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Intestinal Permeability, Inflammation and the Role of Nutrients

(2020) Ricard Farré et al.   Nutrients

Microphysiological Systems: Design, Fabrication, and Applications

(2020) Kai Wang et al.   ACS Biomaterials-Science & Engineering

The role of the microbiota-gut-brain axis in neuropsychiatric disorders

(2020) Jaqueline S. Generoso et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Three-Dimensional Regeneration of Patient-Derived Intestinal Organoid Epithelium in a Physiodynamic Mucosal Interface-on-a-Chip

(2020) Yong Cheol Shin et al.   Micromachines

Gut-on-a-chip: Current progress and future opportunities

(2020) Nureddin Ashammakhi et al.   BIOMATERIALS

Mucus barrier, mucins and gut microbiota: the expected slimy partners?

(2020) Paola Paone et al.   GUT

Biomimetic Human Disease Model of SARS‐CoV‐2 Induced Lung Injury and Immune Responses on Organ Chip System

(2020) Min Zhang et al.   Advanced Science

Gut bioengineering strategies for regenerative medicine

(2020) John D. O’Neill et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Development of a human primary gut-on-a-chip to model inflammatory processes

(2020) Claudia Beaurivage et al.   Scientific Reports

SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip

(2020) Yaqiong Guo et al.   Science Bulletin

Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway

(2019) Xiang-Guang Li et al.   TOXICOLOGY LETTERS

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

(2019) Sasan Jalili-Firoozinezhad et al.   Nature Biomedical Engineering

In vitro colonic fermentation of dietary fibers: Fermentation rate, short-chain fatty acid production and changes in microbiota

(2019) Miaomiao Wang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

“Good Fences Make Good Neighbors”: How does the Human Gut Microchip Unravel Mechanism of Intestinal Inflammation?

(2019) Woojung Shin et al.   Gut Microbes

Development of a Gut-on-a-Chip Model for High Throughput Disease Modeling and Drug Discovery

(2019) Claudia Beaurivage et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Big data and tiny proteins: shining a light on the dark corners of the gut microbiome

(2019) Suzanne Devkota   Nature Reviews Gastroenterology & Hepatology

Models of the Gut for Analyzing the Impact of Food and Drugs

(2019) Chiara Anna Maria Fois et al.   Advanced Healthcare Materials

Pharmacokinetic and pharmacodynamic insights from microfluidic intestine-on-a-chip models

(2019) Seung Hwan Lee et al.   Expert Opinion on Drug Metabolism & Toxicology

Current in vitro digestion systems for understanding food digestion in human upper gastrointestinal tract

(2019) Cheng Li et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

(2018) Kristina Martinez-Guryn et al.   Cell Host & Microbe

LGR5 and BMI1 Increase Pig Intestinal Epithelial Cell Proliferation by Stimulating WNT/β-Catenin Signaling

(2018) Xiang-Guang Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Biomimetic Human Gut-on-a-Chip for Modeling Drug Metabolism in Intestine

(2018) Yaqiong Guo et al.   ARTIFICIAL ORGANS

Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

(2018) Vincent M Isabella et al.   NATURE BIOTECHNOLOGY

Implementation of a dynamic intestinal gut-on-a-chip barrier model for transport studies of lipophilic dioxin congeners

(2018) Kornphimol Kulthong et al.   RSC Advances

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

Recent Advances in Body-on-a-Chip Systems

(2018) Jong Hwan Sung et al.   ANALYTICAL CHEMISTRY

Organ-on-chip models: Implications in drug discovery and clinical applications

(2018) Rahul Mittal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fight them or feed them: how the intestinal mucus layer manages the gut microbiota

(2018) Bjoern O Schroeder   Gastroenterology Report

Gastrointestinal microphysiological systems

(2017) Sarah E Blutt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges

(2017) Ying I. Wang et al.   Advanced Healthcare Materials

Emulation of Colonic Oxygen Gradients in a Microdevice

(2017) David I. Walsh et al.   SLAS Technology

Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro

(2017) Remi Villenave et al.   PLoS One

Farewell to Animal Testing: Innovations on Human Intestinal Microphysiological Systems

(2016) Tae Kang et al.   Micromachines

Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems

(2015) Mathieu Odijk et al.   LAB ON A CHIP

The in ovo administration of l-trans pyrrolidine-2,4-dicarboxylic acid regulates small intestinal growth in chicks

(2014) X.-G. Li et al.   Animal

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

The intestinal microbiota and host immune interactions in the critically ill

(2013) Tim J. Schuijt et al.   TRENDS IN MICROBIOLOGY

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA