Three-Dimensional Regeneration of Patient-Derived Intestinal Organoid Epithelium in a Physiodynamic Mucosal Interface-on-a-Chip

Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

(2020) Magdalena Kasendra et al.   eLife

Recapitulation of the accessible interface of biopsy-derived canine intestinal organoids to study epithelial-luminal interactions

(2020) Yoko M. Ambrosini et al.   PLoS One

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

(2019) Sasan Jalili-Firoozinezhad et al.   Nature Biomedical Engineering

The NIH microphysiological systems program: developing in vitro tools for safety and efficacy in drug development

(2019) Danilo A Tagle   CURRENT OPINION IN PHARMACOLOGY

3D bioengineered tissue model of the large intestine to study inflammatory bowel disease

(2019) Terrence T. Roh et al.   BIOMATERIALS

Mechanical Stimuli Affect Escherichia coli Heat-Stable Enterotoxin-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Model

(2019) Laxmi Sunuwar et al.   INFECTION AND IMMUNITY

Gut Movements: A Review of the Physiology of Gastrointestinal Transit

(2018) Dennis Kumral et al.   DIGESTIVE DISEASES AND SCIENCES

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

Intestinal barrier dysfunction orchestrates the onset of inflammatory host–microbiome cross-talk in a human gut inflammation-on-a-chip

(2018) Woojung Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary Cell-Derived Intestinal Models: Recapitulating Physiology

(2018) Johanna S. Dutton et al.   TRENDS IN BIOTECHNOLOGY

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)

(2017) Christian Maass et al.   Integrative Biology

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

(2017) Miguel Crespo et al.   NATURE MEDICINE

Effect of water flow and chemical environment on microbiota growth and composition in the human colon

(2017) Jonas Cremer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel

(2016) Jonas Cremer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

(2016) Hyun Jung Kim et al.   Jove-Journal of Visualized Experiments

Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells

(2015) Jessica L. Forbester et al.   INFECTION AND IMMUNITY

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices

(2012) Mandy Brigitte Esch et al.   BIOMEDICAL MICRODEVICES

Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications

(2012) Fredrik Bäckhed et al.   Cell Host & Microbe

Investigating the relationships between peristaltic contraction and fluid transport in the human colon using Smoothed Particle Hydrodynamics

(2012) M.D. Sinnott et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Flow Behavior of Digesta and the Absorption of Nutrients in the Gastrointestine

(2011) Toru TAKAHASHI   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Transport phenomena of microbial flora in the small intestine with peristalsis

(2011) T. Ishikawa et al.   JOURNAL OF THEORETICAL BIOLOGY

Systems biology of the gut: the interplay of food, microbiota and host at the mucosal interface

(2010) Vítor Martins dos Santos et al.   CURRENT OPINION IN BIOTECHNOLOGY

The effects of mechanical forces on intestinal physiology and pathology

(2009) Christopher P. Gayer et al.   CELLULAR SIGNALLING

Physical characteristics of digesta and their influence on flow and mixing in the mammalian intestine: a review

(2008) R. G. Lentle et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY