Advances in Reconstructing Intestinal Functionalities in Vitro: from Two/Three Dimensional-Cell Culture Platforms to Human Intestine-on-a-Chip

Liver‐on‐a‐Chip Models of Fatty Liver Disease

(2020) Shabir Hassan et al.   HEPATOLOGY

Development of a human primary gut-on-a-chip to model inflammatory processes

(2020) Claudia Beaurivage et al.   Scientific Reports

Active thrombin produced by the intestinal epithelium controls mucosal biofilms

(2019) Jean-Paul Motta et al.   Nature Communications

Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection

(2019) Alexandre Grassart et al.   Cell Host & Microbe

Combination of probiotics with different functions alleviate DSS-induced colitis by regulating intestinal microbiota, IL-10, and barrier function

(2019) Yanbo Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Intestine‐on‐chip device increases ECM remodeling inducing faster epithelial cell differentiation

(2019) Vincenza De Gregorio et al.   BIOTECHNOLOGY AND BIOENGINEERING

Farnesol contributes to intestinal epithelial barrier function by enhancing tight junctions via the JAK/STAT3 signaling pathway in differentiated Caco-2 cells

(2019) Yangxin Fang et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Attributable causes of colorectal cancer in China

(2018) Meng-Jia Gu et al.   BMC CANCER

Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure

(2018) Seungbum Kim et al.   CLINICAL SCIENCE

Organ/body-on-a-chip based on microfluidic technology for drug discovery

(2018) Hiroshi Kimura et al.   Drug Metabolism and Pharmacokinetics

Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer

(2018) Jin Li et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells

(2018) Huanhuan Joyce Chen et al.   LAB ON A CHIP

A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies

(2018) Hsih-Yin Tan et al.   PLoS One

Effects of high ambient temperature on the community structure and composition of ileal microbiome of broilers

(2018) X J Wang et al.   POULTRY SCIENCE

iPSC-Derived Enterocyte-like Cells for Drug Absorption and Metabolism Studies

(2018) Maria Helena Macedo et al.   TRENDS IN MOLECULAR MEDICINE

Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip

(2018) Sasan Jalili-Firoozinezhad et al.   Cell Death & Disease

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

Primary Cell-Derived Intestinal Models: Recapitulating Physiology

(2018) Johanna S. Dutton et al.   TRENDS IN BIOTECHNOLOGY

An on-chip intestine-liver model for multiple drugs absorption and metabolism behavior simulation

(2017) Mingsha Jie et al.   Science China-Chemistry

The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis

(2017) Dana Elshaer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state

(2017) Angela A.M. Kämpfer et al.   TOXICOLOGY IN VITRO

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

(2017) Sebastiaan J. Trietsch et al.   Nature Communications

Continuous-flow-based microfluidic systems for therapeutic monoclonal antibody production and organ-on-a-chip drug testing

(2017) Laszlo Hajba et al.   Journal of Flow Chemistry

Intestine-on-a-Chip Microfluidic Model for Efficient in Vitro Screening of Oral Chemotherapeutic Uptake

(2017) Kyall Pocock et al.   ACS Biomaterials-Science & Engineering

Intestine-on-a-Chip Microfluidic Model for Efficient in Vitro Screening of Oral Chemotherapeutic Uptake

(2017) Kyall Pocock et al.   ACS Biomaterials Science & Engineering

Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro

(2017) Remi Villenave et al.   PLoS One

In vitro enteroid-derived three-dimensional tissue model of human small intestinal epithelium with innate immune responses

(2017) Ying Chen et al.   PLoS One

A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model

(2016) Hyuna Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Low-temperature bonding process for the fabrication of hybrid glass–membrane organ-on-a-chip devices

(2016) Kyall J. Pocock et al.   Journal of Micro-Nanolithography MEMS and MOEMS

Geometric correction factor for transepithelial electrical resistance measurements in transwell and microfluidic cell cultures

(2016) J Yeste et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Elastomeric free-form blood vessels for interconnecting organs on chip systems

(2016) Weijia Zhang et al.   LAB ON A CHIP

Individualized medicine using intestinal responses to CFTR potentiators and correctors

(2016) Jeffrey M. Beekman   PEDIATRIC PULMONOLOGY

Elucidation of the Intestinal Absorption Mechanism of Celastrol Using the Caco-2 Cell Transwell Model

(2016) Hong Li et al.   PLANTA MEDICA

Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening

(2016) Martijn J. Wilmer et al.   TRENDS IN BIOTECHNOLOGY

Effects of acute intra-abdominal hypertension on multiple intestinal barrier functions in rats

(2016) Yuxin Leng et al.   Scientific Reports

IGF-1 decreases portal vein endotoxin via regulating intestinal tight junctions and plays a role in attenuating portal hypertension of cirrhotic rats

(2015) Tian-Yu Zhao et al.   BMC GASTROENTEROLOGY

Animal models for acute radiation syndrome drug discovery

(2015) Vijay K Singh et al.   Expert Opinion on Drug Discovery

Gut Dysbiosis Is Linked to HypertensionNovelty and Significance

(2015) Tao Yang et al.   HYPERTENSION

Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems

(2015) Mathieu Odijk et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering

(2015) Ana Perestrelo et al.   SENSORS

A simple coculture system shows mutualism between anaerobic faecalibacteria and epithelial Caco-2 cells

(2015) Mehdi Sadaghian Sadabad et al.   Scientific Reports

Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine

(2015) Tatsuya Ozawa et al.   Scientific Reports

Synthetic small intestinal scaffolds for improved studies of intestinal differentiation

(2014) Cait M. Costello et al.   BIOTECHNOLOGY AND BIOENGINEERING

Organs-on-a-chip: a new tool for drug discovery

(2014) Alessandro Polini et al.   Expert Opinion on Drug Discovery

Effects of fabrication on the mechanics, microstructure and micromechanical environment of small intestinal submucosa scaffolds for vascular tissue engineering

(2014) Diana M. Sánchez-Palencia et al.   JOURNAL OF BIOMECHANICS

An in vivo model of human small intestine using pluripotent stem cells

(2014) Carey L Watson et al.   NATURE MEDICINE

Hollow fiber culture accelerates differentiation of Caco-2 cells

(2013) Xudong Deng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Changes of the Intestinal Microbiota, Short Chain Fatty Acids, and Fecal pH in Patients with Colorectal Cancer

(2013) Seiji Ohigashi et al.   DIGESTIVE DISEASES AND SCIENCES

A Gutsy Task: Generating Intestinal Tissue from Human Pluripotent Stem Cells

(2013) Stacy R. Finkbeiner et al.   DIGESTIVE DISEASES AND SCIENCES

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

Liver-cell patterning Lab Chip: mimicking the morphology of liver lobule tissue

(2013) Chen-Ta Ho et al.   LAB ON A CHIP

Human in Vivo Regional Intestinal Permeability: Importance for Pharmaceutical Drug Development

(2013) Hans Lennernäs   MOLECULAR PHARMACEUTICS

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Beauvericin-induced cytotoxicity via ROS production and mitochondrial damage in Caco-2 cells

(2013) A. Prosperini et al.   TOXICOLOGY LETTERS

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices

(2012) Mandy Brigitte Esch et al.   BIOMEDICAL MICRODEVICES

Intestinal Commensal Microbes as Immune Modulators

(2012) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

In vitro cell migration and invasion assays

(2012) Nina Kramer et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Intestinal barrier function in health and gastrointestinal disease

(2012) M. Camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Understanding the role of gut microbes and probiotics in obesity: How far are we?

(2012) Yolanda Sanz et al.   PHARMACOLOGICAL RESEARCH

Preclinical models in radiation oncology

(2012) Jenna Kahn et al.   Radiation Oncology

Long-term monitoring of Caco-2 cell growth process using a QCM-cell system

(2012) Chao-Fa Lee et al.   SENSORS AND ACTUATORS B-CHEMICAL

Recent developments in microfluidic devices for in vitro cell culture for cell-biology research

(2012) Dan Gao et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Priceless GEMMs: genetically engineered mouse models for colorectal cancer drug development

(2012) Jatin Roper et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Suppression of ovalbumin-induced allergic diarrhea by diminished intestinal peristalsis in RAMP1-deficient mice

(2011) Rintaro Yoshikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vitroandin vivosmall intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences

(2011) Hiroshi Komura et al.   DRUG METABOLISM REVIEWS

Release and absorption of carotenes from processed carrots (Daucus carota) using in vitro digestion coupled with a Caco-2 cell trans-well culture model

(2011) Michael Netzel et al.   FOOD RESEARCH INTERNATIONAL

Everted gut sac model as a tool in pharmaceutical research: limitations and applications

(2011) Mohd Aftab Alam et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

NOX1 participates in ROS-dependent cell death of colon epithelial Caco2 cells induced by Entamoeba histolytica

(2011) Kyeong Ah Kim et al.   MICROBES AND INFECTION

Hydrogels and microtechnologies for engineering the cellular microenvironment

(2011) Robert Gauvin et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Lifestyle as risk factor for cancer: Evidence from human studies

(2010) Naghma Khan et al.   CANCER LETTERS

Microfluidic synthesis of pure chitosan microfibers for bio-artificial liver chip

(2010) Kwang Ho Lee et al.   LAB ON A CHIP

A Three-Dimensional Coculture of Enterocytes, Monocytes and Dendritic Cells To Model Inflamed Intestinal Mucosa in Vitro

(2010) Fransisca Leonard et al.   MOLECULAR PHARMACEUTICS

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

(2010) Inge A M de Graaf et al.   Nature Protocols

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Biocompatibility, Biodistribution, and Drug-Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals

(2010) Jie Lu et al.   Small

Regulation of intestinal Cl−/HCO3− exchanger SLC26A3 by intracellular pH

(2009) Hisayoshi Hayashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Broader Implications of Defining Standards for the Pluripotency of iPSCs

(2009) George Q. Daley et al.   Cell Stem Cell

Absorption and Metabolism of Resveratrol Carboxyesters and Methanesulfonate by Explanted Rat Intestinal Segments

(2009) Lucia Biasutto et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Conditioned polarized Caco-2 cell monolayers allow to discriminate for the ability of gut-derived microorganisms to modulate permeability and antigen-induced basophil degranulation

(2009) A.-C. Thierry et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

(2009) Pieter Annaert et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Intestinal barrier function: Molecular regulation and disease pathogenesis

(2009) Katherine R. Groschwitz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The role of the intestinal microbiota in enteric infection

(2009) Inna Sekirov et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tissue-Engineered Small Intestine and Stomach Form from Autologous Tissue in a Preclinical Large Animal Model

(2009) Frédéric G. Sala et al.   JOURNAL OF SURGICAL RESEARCH

Intestinal motor activity, endoluminal motion and transit

(2009) F. De Iorio et al.   NEUROGASTROENTEROLOGY AND MOTILITY

On the mechanisms of biocompatibility

(2008) David F. Williams   BIOMATERIALS

Clinical Pharmacokinetics and Pharmacodynamics of the Oral Direct Thrombin??Inhibitor Dabigatran Etexilate

(2008) Joachim Stangier   CLINICAL PHARMACOKINETICS

Intestinal barrier dysfunction in inflammatory bowel diseases

(2008) Michael A. McGuckin et al.   INFLAMMATORY BOWEL DISEASES

Using Animal Models to Develop New Treatments for Tuberculosis

(2008) Eric Nuermberger   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE