Microfluidic Organs-on-a-Chip for Modeling Human Infectious Diseases

Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication

(2021) Nathalie Picollet-D’hahan et al.   TRENDS IN BIOTECHNOLOGY

3D human liver organoids: An in vitro platform to investigate HBV infection, replication and liver tumorigenesis

(2021) Shringar Rao et al.   CANCER LETTERS

Developing therapeutic approaches for twenty-first-century emerging infectious viral diseases

(2021) Rita M. Meganck et al.   NATURE MEDICINE

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

(2021) Longlong Si et al.   Nature Biomedical Engineering

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection

(2020) Lu Lin et al.   GUT

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

(2020) Wanchao Yin et al.   SCIENCE

and Animal Models for SARS-CoV-2 research

(2020) Kazuo Takayama   TRENDS IN PHARMACOLOGICAL SCIENCES

Assessment of Air Pollutant PM2.5 Pulmonary Exposure Using a 3D Lung-on-Chip Model

(2020) Cong Xu et al.   ACS Biomaterials-Science & Engineering

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

(2020) Liuliu Yang et al.   Cell Stem Cell

Animal Models to Study Emerging Technologies Against SARS-CoV-2

(2020) Jhinuk Basu Mullick et al.   Cellular and Molecular Bioengineering

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Extrapulmonary manifestations of COVID-19

(2020) Aakriti Gupta et al.   NATURE MEDICINE

Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

(2020) Wei Deng et al.   SCIENCE

Microengineered hiPSC-Derived 3D Amnion Tissue Model to Probe Amniotic Inflammatory Responses under Bacterial Exposure

(2020) Fangchao Yin et al.   ACS Biomaterials-Science & Engineering

Biomimetic Human Disease Model of SARS‐CoV‐2 Induced Lung Injury and Immune Responses on Organ Chip System

(2020) Min Zhang et al.   Advanced Science

SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip

(2020) Yaqiong Guo et al.   Science Bulletin

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

(2019) Haitao Liu et al.   ADVANCED MATERIALS

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue

(2019) Marta Lemme et al.   CARDIOVASCULAR RESEARCH

Multifunctional 3D electrode platform for real-time in situ monitoring and stimulation of cardiac tissues

(2018) Ning Zhang et al.   BIOSENSORS & BIOELECTRONICS

Urinary tract infection during pregnancy: current concepts on a common multifaceted problem

(2018) Kallirhoe Kalinderi et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Human brain organoid-on-a-chip to model prenatal nicotine exposure

(2018) Yaqing Wang et al.   LAB ON A CHIP

3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

(2018) A. M. Ortega-Prieto et al.   Nature Communications

Placental barrier-on-a-chip: modeling placental inflammatory responses to bacterial infection

(2018) Jianhua Qin et al.   ACS Biomaterials-Science & Engineering

Access to Treatment for Hepatitis B Virus Infection — Worldwide, 2016

(2018) Yvan Hutin et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Placental barrier-on-a-chip: modeling placental inflammatory responses to bacterial infection

(2018) Jianhua Qin et al.   ACS Biomaterials Science & Engineering

A 3D human lung-on-a-chip model for nanotoxicity testing

(2018) Min Zhang et al.   Toxicology Research

Back to the Future: Lessons Learned From the 1918 Influenza Pandemic

(2018) Kirsty R. Short et al.   Frontiers in Cellular and Infection Microbiology

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche

(2016) Yue Shao et al.   NATURE MATERIALS

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Emerging and re-emerging infectious diseases: a continuous challenge for Europe

(2012) GianLuca Quaglio et al.   EUROPEAN RESPIRATORY JOURNAL

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Epithelial Cell Coculture Models for Studying Infectious Diseases: Benefits and Limitations

(2011) Benjamin L. Duell et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE