Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication

Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform

(2020) Shiny Amala Priya Rajan et al.   Acta Biomaterialia

On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

(2020) David B. Chou et al.   Nature Biomedical Engineering

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

(2020) Richard Novak et al.   Nature Biomedical Engineering

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

(2020) Anna Herland et al.   Nature Biomedical Engineering

A 3D polydimethylsiloxane microhourglass-shaped channel array made by reflowing photoresist structures for engineering a blood capillary network

(2020) Hoon Suk Rho et al.   METHODS

Efficient Drug Screening and Nephrotoxicity Assessment on Co-culture Microfluidic Kidney Chip

(2020) Lei Yin et al.   Scientific Reports

Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids

(2020) Martin Trapecar et al.   Cell Systems

Model-based wavefront shaping microscopy

(2020) T. Abhilash et al.   OPTICS LETTERS

Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage

(2020) Carlo Alberto Paggi et al.   SENSORS AND ACTUATORS B-CHEMICAL

Cancer-ID: Toward Identification of Cancer by Tumor-Derived Extracellular Vesicles in Blood

(2020) L. G. Rikkert et al.   Frontiers in Oncology

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies?

(2020) Donald E. Ingber   Advanced Science

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Applications of Light-Sheet Microscopy in Microdevices

(2019) Ignacio Albert-Smet et al.   Frontiers in Neuroanatomy

Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations

(2019) Yi Zhao et al.   MOLECULES

Microfluidic bioprinting for organ-on-a-chip models

(2019) Fang Yu et al.   DRUG DISCOVERY TODAY

Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

(2019) DoYeun Park et al.   TRENDS IN BIOTECHNOLOGY

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

(2019) Tae-Eun Park et al.   Nature Communications

Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model

(2019) Paola Occhetta et al.   Nature Biomedical Engineering

Human-gut-microbiome on a chip

(2019) Roberta Poceviciute et al.   Nature Biomedical Engineering

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

(2019) Kevin Achberger et al.   eLife

Imaging the dynamic recruitment of monocytes to the blood–brain barrier and specific brain regions during Toxoplasma gondii infection

(2019) Christine A. Schneider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methods of Delivering Mechanical Stimuli to Organ-on-a-Chip

(2019) Kaarj et al.   Micromachines

Combining additive manufacturing with microfluidics: an emerging method for developing novel organs-on-chips

(2019) Hao Sun et al.   Current Opinion in Chemical Engineering

Microfluidics to Mimic Blood Flow in Health and Disease

(2018) Bernhard Sebastian et al.   Annual Review of Fluid Mechanics

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform

(2018) T. Satoh et al.   LAB ON A CHIP

Powering ex vivo tissue models in microfluidic systems

(2018) Ian C. McLean et al.   LAB ON A CHIP

Use of porous membranes in tissue barrier and co-culture models

(2018) Henry H. Chung et al.   LAB ON A CHIP

A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells

(2018) Huanhuan Joyce Chen et al.   LAB ON A CHIP

A Fluidic Culture Platform for Spatially Patterned Cell Growth, Differentiation, and Cocultures

(2018) Josephine Lembong et al.   TISSUE ENGINEERING PART A

A Guide for Using Mechanical Stimulation to Enhance Tissue-Engineered Articular Cartilage Properties

(2018) Evelia Y. Salinas et al.   TISSUE ENGINEERING PART B-REVIEWS

Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system

(2018) Carlota Oleaga et al.   BIOMATERIALS

Development of a biomimetic liver tumor-on-a-chip model based on decellularized liver matrix for toxicity testing

(2018) Siming Lu et al.   LAB ON A CHIP

A liver-immune coculture array for predicting systemic drug-induced skin sensitization

(2018) Lor Huai Chong et al.   LAB ON A CHIP

Curvature facilitates podocyte culture in a biomimetic platform

(2018) Anastasia Korolj et al.   LAB ON A CHIP

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

Implementation of a dynamic intestinal gut-on-a-chip barrier model for transport studies of lipophilic dioxin congeners

(2018) Kornphimol Kulthong et al.   RSC Advances

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model

(2018) Juliane Hübner et al.   Scientific Reports

Recent Advances in Body-on-a-Chip Systems

(2018) Jong Hwan Sung et al.   ANALYTICAL CHEMISTRY

A multi-site metastasis-on-a-chip microphysiological system for assessing metastatic preference of cancer cells

(2018) Julio Aleman et al.   BIOTECHNOLOGY AND BIOENGINEERING

From organotypic culture to body-on-a-chip: A neuroendocrine perspective

(2018) Luke A. Schwerdtfeger et al.   JOURNAL OF NEUROENDOCRINOLOGY

Current and future perspectives of liquid biopsies in genomics-driven oncology

(2018) Ellen Heitzer et al.   NATURE REVIEWS GENETICS

An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming

(2018) Marcia A. M. M. Ferraz et al.   Nature Communications

Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes

(2017) Sean P Sheehy et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems

(2017) David J Hughes et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device

(2017) Yuji Nashimoto et al.   Integrative Biology

Thermoplastic elastomer with advanced hydrophilization and bonding performances for rapid (30 s) and easy molding of microfluidic devices

(2017) Julie Lachaux et al.   LAB ON A CHIP

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

(2017) Duc T. T. Phan et al.   LAB ON A CHIP

A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control

(2017) J. R. Coppeta et al.   LAB ON A CHIP

Synthesis and characterization of well-defined hydrogel matrices and their application to intestinal stem cell and organoid culture

(2017) Nikolce Gjorevski et al.   Nature Protocols

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progress and Future Prospectives in Skin-on-Chip Development with Emphasis on the use of Different Cell Types and Technical Challenges

(2017) Lenie J. van den Broek et al.   Stem Cell Reviews and Reports

Deciphering Cell Intrinsic Properties: A Key Issue for Robust Organoid Production

(2017) Nathalie Picollet-D’hahan et al.   TRENDS IN BIOTECHNOLOGY

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

(2017) Shuo Xiao et al.   Nature Communications

Progress and Future Prospectives in Skin-on-Chip Development with Emphasis on the use of Different Cell Types and Technical Challenges

(2017) Lenie J. van den Broek et al.   Stem Cell Reviews and Reports

The scaling and allometry of organ size associated with miniaturization in insects: A case study for Coleoptera and Hymenoptera

(2017) Alexey A. Polilov et al.   Scientific Reports

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

(2017) Aleksander Skardal et al.   Scientific Reports

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

(2017) Sophie Bauer et al.   Scientific Reports

Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis

(2016) Zhiyun Xu et al.   ACS Applied Materials & Interfaces

Studying the influence of angiogenesis in in vitro cancer model systems

(2016) Laila C. Roudsari et al.   ADVANCED DRUG DELIVERY REVIEWS

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening

(2016) Aleksander Skardal et al.   BIOTECHNOLOGY AND BIOENGINEERING

Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling

(2016) Huanjun Chen et al.   CANCER LETTERS

Transient microfluidic compartmentalization using actionable microfilaments for biochemical assays, cell culture and organs-on-chip

(2016) Ayako Yamada et al.   LAB ON A CHIP

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

(2016) Mandy B. Esch et al.   LAB ON A CHIP

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

(2016) Johan U. Lind et al.   NATURE MATERIALS

Self-driven jamming in growing microbial populations

(2016) Morgan Delarue et al.   Nature Physics

A 3D Toolbox to Enhance Physiological Relevance of Human Tissue Models

(2016) Nathalie Picollet-D’hahan et al.   TRENDS IN BIOTECHNOLOGY

4D Bioprinting for Biomedical Applications

(2016) Bin Gao et al.   TRENDS IN BIOTECHNOLOGY

A novel microfluidic model can mimic organ-specific metastasis of circulating tumor cells

(2016) Jing Kong et al.   Oncotarget

Cytostretch, an Organ-on-Chip Platform

(2016) Nikolas Gaio et al.   Micromachines

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration ofin vitroliver-kidney microfluidic data and pharmacokinetic-system biology models

(2015) Eric Leclerc et al.   JOURNAL OF APPLIED TOXICOLOGY

A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing

(2015) Eva-Maria Materne et al.   JOURNAL OF BIOTECHNOLOGY

3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis

(2015) Jin-Young Kim et al.   JOURNAL OF BIOTECHNOLOGY

A medium throughput device to study the effects of combinations of surface strains and fluid-flow shear stresses on cells

(2015) R. Sinha et al.   LAB ON A CHIP

Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture

(2015) Edinson Lucumi Moreno et al.   LAB ON A CHIP

Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury

(2015) Qing Zhou et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips

(2015) Peter Loskill et al.   PLoS One

On being the right size: scaling effects in designing a human-on-a-chip

(2013) Christopher Moraes et al.   Integrative Biology

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

(2013) Beren Ataç et al.   LAB ON A CHIP

admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties

(2012) Feixiong Cheng et al.   Journal of Chemical Information and Modeling