Farewell to Animal Testing: Innovations on Human Intestinal Microphysiological Systems

Therapeutic Application of Synbiotics, a Fusion of Probiotics and Prebiotics, and Biogenics as a New Concept for Oral Candida Infections: A Mini Review

(2016) Tomoko Ohshima et al.   Frontiers in Microbiology

Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile

(2015) Melinda A. Engevik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Human Clostridium difficile infection: altered mucus production and composition

(2015) Melinda A. Engevik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Engineered In Vitro Disease Models

(2015) Kambez H. Benam et al.   Annual Review of Pathology-Mechanisms of Disease

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Prebiotics, probiotics, synbiotics, and the immune system

(2015) Remo Frei et al.   CURRENT OPINION IN GASTROENTEROLOGY

The functional impact of the intestinal microbiome on mucosal immunity and systemic autoimmunity

(2015) Randy S. Longman et al.   CURRENT OPINION IN RHEUMATOLOGY

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An openable artificial intestinal tract system for the in vitro evaluation of medicines

(2015) Satoshi Konishi et al.   Microsystems & Nanoengineering

Synthetic small intestinal scaffolds for improved studies of intestinal differentiation

(2014) Cait M. Costello et al.   BIOTECHNOLOGY AND BIOENGINEERING

First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans

(2014) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

Human enteroids as an ex-vivo model of host–pathogen interactions in the gastrointestinal tract

(2014) Jennifer Foulke-Abel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Sa1743 EHEC Virulence Factor Espp Cleaves Actin Binding Protein Fodrin to Induce Macropinocytosis of Shiga Toxins

(2014) Julie In et al.   GASTROENTEROLOGY

Microbial Therapy in Liver Disease: Probiotics Probe the Microbiome–Gut–Liver–Brain Axis

(2014) David W. Victor et al.   GASTROENTEROLOGY

Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function

(2014) Jhansi L. Leslie et al.   INFECTION AND IMMUNITY

Artificial sweeteners induce glucose intolerance by altering the gut microbiota

(2014) Jotham Suez et al.   NATURE

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

A polymeric cell stretching device for real-time imaging with optical microscopy

(2013) Yuli Huang et al.   BIOMEDICAL MICRODEVICES

Microfluidic cell culture

(2013) Matthias Mehling et al.   CURRENT OPINION IN BIOTECHNOLOGY

The effect of gut microbiota on drug metabolism

(2013) Mi Jeong Kang et al.   Expert Opinion on Drug Metabolism & Toxicology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Multiarray cell stretching platform for high-magnification real-time imaging

(2013) Yuli Huang et al.   Nanomedicine

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

The gut microbiota — masters of host development and physiology

(2013) Felix Sommer et al.   NATURE REVIEWS MICROBIOLOGY

Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis

(2013) Pamela J. Hornby et al.   PHARMACEUTICAL RESEARCH

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Gut–brain axis: how the microbiome influences anxiety and depression

(2013) Jane A. Foster et al.   TRENDS IN NEUROSCIENCES

Building additional complexity to in vitro-derived intestinal tissues

(2013) Samantha A Brugmann et al.   Stem Cell Research & Therapy

Gut Microbial Flora, Prebiotics, and Probiotics in IBD: Their Current Usage and Utility

(2013) Franco Scaldaferri et al.   Biomed Research International

A nomenclature for intestinal in vitro cultures

(2012) Matthias Stelzner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Micro Total Bioassay System for Oral Drugs: Evaluation of Gastrointestinal Degradation, Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2012) Yuki IMURA et al.   ANALYTICAL SCIENCES

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices

(2012) Mandy Brigitte Esch et al.   BIOMEDICAL MICRODEVICES

In vitro 3D human small intestinal villous model for drug permeability determination

(2012) Jiajie Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Current status of monoclonal antibody therapy for the treatment of inflammatory bowel disease: an update

(2012) Vera Kandror Denmark et al.   Expert Review of Clinical Immunology

Clostridium difficile Infection in the Inflammatory Bowel Disease Patient

(2012) Adam M. Berg et al.   INFLAMMATORY BOWEL DISEASES

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

The role of neutrophils during intestinal inflammation

(2012) B M Fournier et al.   Mucosal Immunology

Reciprocal interactions of the intestinal microbiota and immune system

(2012) Craig L. Maynard et al.   NATURE

Oral exposure to polystyrene nanoparticles affects iron absorption

(2012) Gretchen J. Mahler et al.   Nature Nanotechnology

IBD—what role do Proteobacteria play?

(2012) Indrani Mukhopadhya et al.   Nature Reviews Gastroenterology & Hepatology

Use of Preclinical Models to Assess the Therapeutic Potential of New Drug Candidates for Bladder Cancer

(2012) Doron Amit et al.   SEMINARS IN ONCOLOGY

Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses

(2012) S. R. Finkbeiner et al.   mBio

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Research and development of next generation of antibody-based therapeutics

(2010) Jing Li et al.   ACTA PHARMACOLOGICA SINICA

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

Synergic effects of crypt-like topography and ECM proteins on intestinal cell behavior in collagen based membranes

(2010) Lin Wang et al.   BIOMATERIALS

Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells

(2010) Nick Barker et al.   GASTROENTEROLOGY

How Well Can the Caco-2/Madin−Darby Canine Kidney Models Predict Effective Human Jejunal Permeability?†

(2010) Alex Avdeef et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Inflammation for growth

(2010) Samuel I. Miller   NATURE

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Soft lithography for micro- and nanoscale patterning

(2010) Dong Qin et al.   Nature Protocols

Small intestinal bacterial overgrowth syndrome

(2010) Jan Bures   WORLD JOURNAL OF GASTROENTEROLOGY

A Microfluidic System to Evaluate Intestinal Absorption

(2009) Yuki IMURA et al.   ANALYTICAL SCIENCES

Influence of micro-well biomimetic topography on intestinal epithelial Caco-2 cell phenotype

(2009) Lin Wang et al.   BIOMATERIALS

The effects of mechanical forces on intestinal physiology and pathology

(2009) Christopher P. Gayer et al.   CELLULAR SIGNALLING

Efflux-Mediated Drug Resistance in Bacteria

(2009) Xian-Zhi Li et al.   DRUGS

Preclinical models for pulmonary drug delivery

(2009) Cláudia A Fernandes et al.   Expert Opinion on Drug Delivery

Intestinal barrier function: Molecular regulation and disease pathogenesis

(2009) Katherine R. Groschwitz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Co-culture of epithelial cells and bacteria for investigating host–pathogen interactions

(2009) Jeongyun Kim et al.   LAB ON A CHIP

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability☆

(2008) Gretchen J. Mahler et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models

(2008) Hiroshi Kimura et al.   LAB ON A CHIP