Microphysiological Neurovascular Barriers to Model the Inner Retinal Microvasculature

Engineered human blood–brain barrier microfluidic model for vascular permeability analyses

(2022) Cynthia Hajal et al.   Nature Protocols

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate

(2021) Tyler M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterocellular spheroids of the neurovascular blood-brain barrier as a platform for personalized nanoneuromedicine

(2021) Murali Kumarasamy et al.   iScience

Microheart: A microfluidic pump for functional vascular culture in microphysiological systems

(2021) Giovanni S. Offeddu et al.   JOURNAL OF BIOMECHANICS

Stem cell-based vascularization of microphysiological systems

(2021) Shane Browne et al.   Stem Cell Reports

A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties

(2021) Christoph Eilenberger et al.   Advanced Science

Interplay between Brain Pericytes and Endothelial Cells in Dementia

(2021) Tessa V. Procter et al.   AMERICAN JOURNAL OF PATHOLOGY

Biology and Models of the Blood–Brain Barrier

(2021) Cynthia Hajal et al.   Annual Review of Biomedical Engineering

Organs-on-a-chip models for biological research

(2021) Gordana Vunjak-Novakovic et al.   CELL

Advancing models of neural development with biomaterials

(2021) Julien G. Roth et al.   NATURE REVIEWS NEUROSCIENCE

Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease

(2021) Dong Wang et al.   Frontiers in Cellular Neuroscience

Blood–Brain Barrier Breakdown: An Emerging Biomarker of Cognitive Impairment in Normal Aging and Dementia

(2021) Basharat Hussain et al.   Frontiers in Neuroscience

The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain

(2021) Cynthia Hajal et al.   Science Advances

Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays

(2021) Claire Simonneau et al.   Fluids and Barriers of the CNS

Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline

(2021) Karis Little et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease

(2020) Jaydeep Sidhaye et al.   CELL DEATH AND DIFFERENTIATION

In vitro modeling of the neurovascular unit: advances in the field

(2020) Aditya Bhalerao et al.   Fluids and Barriers of the CNS

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

(2020) Joel W. Blanchard et al.   NATURE MEDICINE

Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells

(2020) Filip Roudnicky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation

(2020) Thomas L. Maurissen et al.   Nature Communications

Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction

(2020) Goodwell Nzou et al.   Scientific Reports

Transcriptomic comparison of human and mouse brain microvessels

(2020) Hannah W. Song et al.   Scientific Reports

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

(2020) Cameron S. Cowan et al.   CELL

Models of the blood-brain barrier using iPSC-derived cells

(2020) Louise Delsing et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

Transport of ultrasmall gold nanoparticles (2 nm) across the blood–brain barrier in a six-cell brain spheroid model

(2020) Viktoriya Sokolova et al.   Scientific Reports

Human Retinal Microvasculature‐on‐a‐Chip for Drug Discovery

(2020) Héloïse Ragelle et al.   Advanced Healthcare Materials

Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier

(2020) Zhongxiao Wang et al.   Science Advances

Advances in microphysiological blood-brain barrier (BBB) models towards drug delivery

(2020) Caleb S Lee et al.   CURRENT OPINION IN BIOTECHNOLOGY

Retinal organoids: a window into human retinal development

(2020) Michelle O'Hara-Wright et al.   DEVELOPMENT

A human retinal microvascular endothelial-pericyte co-culture model to study diabetic retinopathy in vitro

(2020) Jessica J. Eyre et al.   EXPERIMENTAL EYE RESEARCH

Rethinking organoid technology through bioengineering

(2020) Elena Garreta et al.   NATURE MATERIALS

Human mini-brain models

(2020) Hsih-Yin Tan et al.   Nature Biomedical Engineering

Human blood vessel organoids as a model of diabetic vasculopathy

(2019) Reiner A. Wimmer et al.   NATURE

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Human pluripotent stem cell–derived brain pericyte–like cells induce blood-brain barrier properties

(2019) Matthew J. Stebbins et al.   Science Advances

Unraveling the role of genetics in the pathogenesis of diabetic retinopathy

(2019) Ashok Sharma et al.   EYE

Targeting pericytes for neurovascular regeneration

(2019) Mohammad Hossein Geranmayeh et al.   Cell Communication and Signaling

Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression

(2019) Yu Yamazaki et al.   BRAIN

Organ-On-A-Chip Technologies for Advanced Blood–Retinal Barrier Models

(2019) Héloïse Ragelle et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Microfabricated blood vessels for modeling the vascular transport barrier

(2019) William J. Polacheck et al.   Nature Protocols

Advances in Microfluidic Blood–Brain Barrier (BBB) Models

(2019) Arianna Oddo et al.   TRENDS IN BIOTECHNOLOGY

Development and Cell Biology of the Blood-Brain Barrier

(2019) Urs H. Langen et al.   Annual Review of Cell and Developmental Biology

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

(2019) Gad D. Vatine et al.   Cell Stem Cell

A Novel Transwell Blood Brain Barrier Model Using Primary Human Cells

(2019) Nicole L. Stone et al.   Frontiers in Cellular Neuroscience

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

(2019) Tae-Eun Park et al.   Nature Communications

An on-chip model of protein paracellular and transcellular permeability in the microcirculation

(2019) Giovanni S. Offeddu et al.   BIOMATERIALS

Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution

(2019) Giovanni S. Offeddu et al.   Small

Blood–Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease

(2019) Yoojin Shin et al.   Advanced Science

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

3D brain angiogenesis model to reconstitute functional human blood–brain barrier in vitro

(2019) Somin Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

(2018) Marco Campisi et al.   BIOMATERIALS

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering

(2018) Tatsuya Osaki et al.   CURRENT OPINION IN BIOTECHNOLOGY

Neurovascular Communication during CNS Development

(2018) Isidora Paredes et al.   DEVELOPMENTAL CELL

A compartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood–retinal barrier

(2018) Jose Yeste et al.   LAB ON A CHIP

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling

(2018) Goodwell Nzou et al.   Scientific Reports

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

Barrier properties and transcriptome expression in human iPSC-derived models of the blood-brain barrier

(2018) Louise Delsing et al.   STEM CELLS

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior

(2018) Raleigh M. Linville et al.   BIOMATERIALS

Stem Cells, Genome Editing, and the Path to Translational Medicine

(2018) Frank Soldner et al.   CELL

Intracellular transport and regulation of transcytosis across the blood–brain barrier

(2018) Roberto Villaseñor et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Organ-on-a-chip technologies that can transform ophthalmic drug discovery and disease modeling

(2018) Jasmin C. Haderspeck et al.   Expert Opinion on Drug Discovery

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Region-specific permeability of the blood–brain barrier upon pericyte loss

(2017) Roberto Villaseñor et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier

(2017) Giulia Adriani et al.   LAB ON A CHIP

Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy

(2017) Jiong Hu et al.   NATURE

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation

(2017) Brian Wai Chow et al.   NEURON

Plastic roles of pericytes in the blood–retinal barrier

(2017) Do Young Park et al.   Nature Communications

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

(2017) Choi-Fong Cho et al.   Nature Communications

Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

(2017) Martin Teichert et al.   Nature Communications

Gene Expression Changes in Long-Term In Vitro Human Blood-Brain Barrier Models and Their Dependence on a Transwell Scaffold Material

(2017) Joel D. Gaston et al.   Journal of Healthcare Engineering

A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact between Perfusable Vascular Network and Astrocytes

(2017) Seokyoung Bang et al.   Scientific Reports

Electrospun gelatin biopapers as substrate forin vitrobilayer models of blood−brain barrier tissue

(2016) Lauren L. Bischel et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels

(2016) Xiaolin Wang et al.   LAB ON A CHIP

Genetic factors associated with the development of age-related macular degeneration

(2016) Olga Sergejeva et al.   Medicina-Lithuania

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Induced pluripotent stem cell technology: a decade of progress

(2016) Yanhong Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Brain and Retinal Pericytes: Origin, Function and Role

(2016) Andrea Trost et al.   Frontiers in Cellular Neuroscience

Genetic factors associated with the development of age-related macular degeneration

(2016) Olga Sergejeva et al.   Medicina-Lithuania

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors

(2016) Hui Xu et al.   Scientific Reports

Deletion of Ocular Transforming Growth Factor β Signaling Mimics Essential Characteristics of Diabetic Retinopathy

(2015) Barbara M. Braunger et al.   AMERICAN JOURNAL OF PATHOLOGY

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

TGFβ1 exacerbates blood–brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5

(2015) Matthew A McMillin et al.   LABORATORY INVESTIGATION

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Primary Human Lung Pericytes Support and StabilizeIn VitroPerfusable Microvessels

(2015) Colette A. Bichsel et al.   TISSUE ENGINEERING PART A

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

(2014) Eliah R. Shamir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The development of blood-retinal barrier during the interaction of astrocytes with vascular wall cells

(2014) Jinbo Deng et al.   Neural Regeneration Research

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

(2014) Yao Yao et al.   Nature Communications

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Astrocytes and the evolution of the human brain

(2013) James M. Robertson   MEDICAL HYPOTHESES

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions

(2013) Ingeborg Klaassen et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Control of Perfusable Microvascular Network Morphology Using a Multiculture Microfluidic System

(2013) Jordan A. Whisler et al.   TISSUE ENGINEERING PART C-METHODS

Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier

(2013) Eduard Urich et al.   Scientific Reports

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Eyeing central neurons in vascular growth and reparative angiogenesis

(2012) P. Sapieha   BLOOD

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Connection of pericyte–angiopoietin-Tie-2 system in diabetic retinopathy: friend or foe?

(2012) Jun Cai et al.   Future Medicinal Chemistry

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

(2011) Frank Soldner et al.   CELL

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

A novel co-culture model of the blood-retinal barrier based on primary retinal endothelial cells, pericytes and astrocytes

(2011) Joanna Wisniewska-Kruk et al.   EXPERIMENTAL EYE RESEARCH

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Disruption of central nervous system barriers in multiple sclerosis

(2010) Jorge Ivan Alvarez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

(2009) Konstantin Gaengel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

(2009) Pedro Geraldes et al.   NATURE MEDICINE

Wnt/β-catenin signaling controls development of the blood–brain barrier

(2008) Stefan Liebner et al.   JOURNAL OF CELL BIOLOGY

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE

Water movements in the brain: role of aquaporins

(2007) Matthew J. Tait et al.   TRENDS IN NEUROSCIENCES