Gastrointestinal microphysiological systems

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening

(2016) Aleksander Skardal et al.   BIOTECHNOLOGY AND BIOENGINEERING

Reverse Engineering Human Pathophysiology with Organs-on-Chips

(2016) Donald E. Ingber   CELL

hPSC-derived lung and intestinal organoids as models of human fetal tissue

(2016) Megan Aurora et al.   DEVELOPMENTAL BIOLOGY

Physiologically relevant human tissue models for infectious diseases

(2016) Melody Mills et al.   DRUG DISCOVERY TODAY

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology

(2016) Jennifer Foulke-Abel et al.   GASTROENTEROLOGY

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Human mini-guts: new insights into intestinal physiology and host–pathogen interactions

(2016) Julie G. In et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals

(2016) Shahab A Shaffiey et al.   Regenerative Medicine

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges

(2016) Courtney M. Sakolish et al.   EBioMedicine

Application of Caco-2 Cell Line in Herb-Drug Interaction Studies: Current Approaches and Challenges

(2016) Charles Awortwe et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

In Vitro Polarization of Colonoids to Create an Intestinal Stem Cell Compartment

(2016) Peter J. Attayek et al.   PLoS One

Engineered In Vitro Disease Models

(2015) Kambez H. Benam et al.   Annual Review of Pathology-Mechanisms of Disease

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology

(2015) Nicholas C. Zachos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A 3-D enteroid-based model to study T-cell and epithelial cell interaction

(2015) Aneta Rogoz et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology

(2015) Kapil Saxena et al.   JOURNAL OF VIROLOGY

Cloning and variation of ground state intestinal stem cells

(2015) Xia Wang et al.   NATURE

Directed differentiation of cholangiocytes from human pluripotent stem cells

(2015) Mina Ogawa et al.   NATURE BIOTECHNOLOGY

A high-throughput platform for stem cell niche co-cultures and downstream gene expression analysis

(2015) Adam D. Gracz et al.   NATURE CELL BIOLOGY

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping

(2015) David J. Cutler et al.   PLoS One

Animal models to study acute and chronic intestinal inflammation in mammals

(2015) Janelle A. Jiminez et al.   Gut Pathogens

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo

(2015) Stacy R. Finkbeiner et al.   Stem Cell Reports

First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans

(2014) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

Mutations in Tetratricopeptide Repeat Domain 7A Result in a Severe Form of Very Early Onset Inflammatory Bowel Disease

(2014) Yaron Avitzur et al.   GASTROENTEROLOGY

Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays

(2014) Kelli L VanDussen et al.   GUT

A microfluidic-based platform for tumour spheroid culture, monitoring and drug screening

(2014) K. Kwapiszewska et al.   LAB ON A CHIP

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Mice are not men

(2014) H. Shaw Warren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult Stem Cells in the Small Intestine Are Intrinsically Programmed with Their Location-Specific Function

(2014) Sabine Middendorp et al.   STEM CELLS

Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy

(2014) T Grabinger et al.   Cell Death & Disease

Drug Discovery and Regulatory Considerations for Improving In Silico and In Vitro Predictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements

(2013) Caroline A. Larregieu et al.   AAPS Journal

Microfluidic cell culture

(2013) Matthias Mehling et al.   CURRENT OPINION IN BIOTECHNOLOGY

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

A Cut above the Rest: Targeted Genome Editing Technologies in Human Pluripotent Stem Cells

(2013) Mo Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Micro Total Bioassay System for Oral Drugs: Evaluation of Gastrointestinal Degradation, Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2012) Yuki IMURA et al.   ANALYTICAL SCIENCES

Long-term three-dimensional cell culture and anticancer drug activity evaluation in a microfluidic chip

(2012) Karina Ziółkowska et al.   BIOSENSORS & BIOELECTRONICS

Can animal data predict human outcome? Problems and pitfalls of translational animal research

(2012) Marianne I. Martić-Kehl et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Burden of Gastrointestinal Disease in the United States: 2012 Update

(2012) Anne F. Peery et al.   GASTROENTEROLOGY

Organs-on-chips: breaking the in vitro impasse

(2012) Andries D. van der Meer et al.   Integrative Biology

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device

(2012) Dan Gao et al.   LAB ON A CHIP

Systems Biological Approach of Molecular Descriptors Connectivity: Optimal Descriptors for Oral Bioavailability Prediction

(2012) Shiek S. S. J. Ahmed et al.   PLoS One

Designing Cell-Compatible Hydrogels for Biomedical Applications

(2012) D. Seliktar   SCIENCE

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering

(2011) Bong Geun Chung et al.   LAB ON A CHIP

Microfluidic hydrogels for tissue engineering

(2011) Guo You Huang et al.   Biofabrication

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

A Three-Dimensional Coculture of Enterocytes, Monocytes and Dendritic Cells To Model Inflamed Intestinal Mucosa in Vitro

(2010) Fransisca Leonard et al.   MOLECULAR PHARMACEUTICS

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Modelling of Drug Disposition Kinetics inIn VitroIntestinal Absorption Cell Models

(2009) Aki T. Heikkinen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Alteration of the Mitochondrial Apoptotic Pathway Is Key to Acquired Paclitaxel Resistance and Can Be Reversed by ABT-737

(2008) O. Kutuk et al.   CANCER RESEARCH