Gut-on-chip for ecological and causal human gut microbiome research

Patient-derived organoid (PDO) platforms to facilitate clinical decision making

(2021) Lisa Liu et al.   Journal of Translational Medicine

Conducting research on diet–microbiome interactions: A review of current challenges, essential methodological principles, and recommendations for best practice in study design

(2021) Erin R. Shanahan et al.   JOURNAL OF HUMAN NUTRITION AND DIETETICS

The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk

(2021) Dong D. Wang et al.   NATURE MEDICINE

Advancement of Sensor Integrated Organ-on-Chip Devices

(2021) Gabriel A. Clarke et al.   SENSORS

Modeling the Human Body on Microfluidic Chips

(2021) Sasan Jalili-Firoozinezhad et al.   TRENDS IN BIOTECHNOLOGY

Refining Host-Pathogen Interactions: Organ-on-Chip Side of the Coin

(2021) Buket Baddal et al.   Pathogens

Organ‐on‐chip to investigate host‐pathogens interactions

(2021) Thomas Feaugas et al.   CELLULAR MICROBIOLOGY

Towards a mechanistic understanding of reciprocal drug–microbiome interactions

(2021) Michael Zimmermann et al.   Molecular Systems Biology

An Overview of Biological and Computational Methods for Designing Mechanism-Informed Anti-biofilm Agents

(2021) Andy Y. An et al.   Frontiers in Microbiology

Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes

(2021) Laila Silamiķele et al.   Frontiers in Endocrinology

Mimicking and surpassing the xenograft model with cancer-on-chip technology

(2021) Job Komen et al.   EBioMedicine

Caloric restriction disrupts the microbiota and colonization resistance

(2021) Reiner Jumpertz von Schwartzenberg et al.   NATURE

Can microfluidics be used to create a more realistic in vitro model of the vaginal ectocervix to better understand bacterial vaginosis?

(2021) Ashley Houlden et al.   SEXUALLY TRANSMITTED INFECTIONS

Unravelling the collateral damage of antibiotics on gut bacteria

(2021) Lisa Maier et al.   NATURE

Mining the infant gut microbiota for therapeutic targets against atopic disease

(2020) Rozlyn C.T Boutin et al.   ALLERGY

Organ-on-a-chip: recent breakthroughs and future prospects

(2020) Qirui Wu et al.   Biomedical Engineering Online

Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents

(2020) Jens Walter et al.   CELL

Self-reinoculation with fecal flora changes microbiota density and composition leading to an altered bile-acid profile in the mouse small intestine

(2020) Said R. Bogatyrev et al.   Microbiome

Dual and Triple Epithelial Coculture Model Systems with Donor-Derived Microbiota and THP-1 Macrophages To Mimic Host-Microbe Interactions in the Human Sinonasal Cavities

(2020) Charlotte De Rudder et al.   mSphere

Development of a scalable co-culture system for gut anaerobes and human colon epithelium

(2020) Nobuo Sasaki et al.   GASTROENTEROLOGY

Intestine-Liver Axis On-Chip Reveals the Intestinal Protective Role on Hepatic Damage by Emulating Ethanol First-Pass Metabolism

(2020) Vincenza De Gregorio et al.   Frontiers in Bioengineering and Biotechnology

A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma

(2020) Janna C Nawroth et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs)

(2020) Amy M. Avila et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Human Organs-on-Chips for Virology

(2020) Huaqi Tang et al.   TRENDS IN MICROBIOLOGY

Development of a human primary gut-on-a-chip to model inflammatory processes

(2020) Claudia Beaurivage et al.   Scientific Reports

A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

(2020) Vivek V Thacker et al.   eLife

Organ-on-a-Chip: A New Paradigm for Drug Development

(2020) Chao Ma et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites

(2019) Alessio Tovaglieri et al.   Microbiome

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

(2019) Sasan Jalili-Firoozinezhad et al.   Nature Biomedical Engineering

Mapping human microbiome drug metabolism by gut bacteria and their genes

(2019) Michael Zimmermann et al.   NATURE

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

(2019) Mary Ellen Sanders et al.   Nature Reviews Gastroenterology & Hepatology

Laboratory mice born to wild mice have natural microbiota and model human immune responses

(2019) Stephan P. Rosshart et al.   SCIENCE

Simple animal models for microbiome research

(2019) Angela E. Douglas   NATURE REVIEWS MICROBIOLOGY

How causal are microbiomes? A comparison with the Helicobacter pylori explanation of ulcers

(2019) Kate E. Lynch et al.   BIOLOGY & PHILOSOPHY

Organs‐on‐Chips in Clinical Pharmacology: Putting the Patient Into the Center of Treatment Selection and Drug Development

(2019) Richard W. Peck et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips

(2018) Rachelle Prantil-Baun et al.   Annual Review of Pharmacology and Toxicology

Leukotriene B4-Mediated Neutrophil Recruitment Causes Pulmonary Capillaritis during Lethal Fungal Sepsis

(2018) Esther K.S. Lee et al.   Cell Host & Microbe

How to determine the role of the microbiome in drug disposition

(2018) Jordan E Bisanz et al.   DRUG METABOLISM AND DISPOSITION

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

You are what you eat: diet, health and the gut microbiota

(2018) Niv Zmora et al.   Nature Reviews Gastroenterology & Hepatology

Understanding how microbiomes influence the systems they inhabit

(2018) Ed K. Hall et al.   Nature Microbiology

Gut microbiota and IBD: causation or correlation?

(2017) Josephine Ni et al.   Nature Reviews Gastroenterology & Hepatology

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiome interactions with drug metabolism, efficacy, and toxicity

(2017) Ian D. Wilson et al.   Translational Research

Dysbiosis and Its Discontents

(2017) Katarzyna B. Hooks et al.   mBio

A microfluidic optical platform for real-time monitoring of pH and oxygen in microfluidic bioreactors and organ-on-chip devices

(2016) Seyed Ali Mousavi Shaegh et al.   Biomicrofluidics

Human Microbiota-Associated Mice: A Model with Challenges

(2016) Marie-Claire Arrieta et al.   Cell Host & Microbe

Precision-cut intestinal slices: alternative model for drug transport, metabolism, and toxicology research

(2016) Ming Li et al.   Expert Opinion on Drug Metabolism & Toxicology

Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities

(2016) Philipp Rausch et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

A microfluidics-based in vitro model of the gastrointestinal human–microbe interface

(2016) Pranjul Shah et al.   Nature Communications

Microfluidic-Based Multi-Organ Platforms for Drug Discovery

(2016) Ahmad Rezaei Kolahchi et al.   Micromachines

How informative is the mouse for human gut microbiota research?

(2015) T. L. A. Nguyen et al.   Disease Models & Mechanisms

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variable responses of human and non-human primate gut microbiomes to a Western diet

(2015) Katherine R. Amato et al.   Microbiome

Variation in Taxonomic Composition of the Fecal Microbiota in an Inbred Mouse Strain across Individuals and Time

(2015) Yana Emmy Hoy et al.   PLoS One

The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro

(2014) Massimo Marzorati et al.   BMC MICROBIOLOGY

From meta-omics to causality: experimental models for human microbiome research

(2013) Joëlle V Fritz et al.   Microbiome

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Culture History and Population Heterogeneity as Determinants of Bacterial Adaptation: the Adaptomics of a Single Environmental Transition

(2012) B. Ryall et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Advances and perspectives in in vitro human gut fermentation modeling

(2011) Amanda N. Payne et al.   TRENDS IN BIOTECHNOLOGY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Individuality in Bacteria

(2008) Carla J. Davidson et al.   Annual Review of Genetics