In vitro models to evaluate ingestible devices: Present status and current trends
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Title
In vitro models to evaluate ingestible devices: Present status and current trends
Authors
Keywords
In vitro model, Stomach, Small intestine, Colon, Macroenvironment microenvironment, Organoid, Organ-on-a-chip
Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 178, Issue -, Pages 113924
Publisher
Elsevier BV
Online
2021-08-12
DOI
10.1016/j.addr.2021.113924
References
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- Micromanagement in the gut: microenvironmental factors govern colon mucosal biofilm structure and functionality
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- Simulated Biological Fluids with Possible Application in Dissolution Testing
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- Synthetic small intestinal scaffolds for improved studies of intestinal differentiation
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- The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro
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- A Formulation Case Study Comparing the Dynamic Gastric Model with Conventional Dissolution Methods
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- Human and simulated intestinal fluids as solvent systems to explore food effects on intestinal solubility and permeability
- (2014) Jef Stappaerts et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- A novel human gastric primary cell culture system for modellingHelicobacter pyloriinfection in vitro
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- Helicobacter pyloritargets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells
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- Three-dimensional intestinal villi epithelium enhances protection of human intestinal cells from bacterial infection by inducing mucin expression
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- Predicting the gastrointestinal behaviour of modified-release products: Utility of a novel dynamic dissolution test apparatus involving the use of bicarbonate buffers
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- Dissolution of mesalazine modified release tablets under standard and bio-relevant test conditions
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- 3-D Intestinal Scaffolds for Evaluating the Therapeutic Potential of Probiotics
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- Intragastric Volume Changes after Intake of a High-Caloric, High-Fat Standard Breakfast in Healthy Human Subjects Investigated by MRI
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- Quantification of Gastrointestinal Liquid Volumes and Distribution Following a 240 mL Dose of Water in the Fasted State
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- Synthetic micro/nanomotors in drug delivery
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- Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
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- Quantification ofin vivocolonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry
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- Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI: comparison of splitvssingle dose
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- Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo
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- Surface area of the digestive tract – revisited
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- Effect of gel structure on the gastric digestion of whey protein emulsion gels
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- A standardised static in vitro digestion method suitable for food – an international consensus
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- Planar Microdevices for Enhanced In Vivo Retention and Oral Bioavailability of Poorly Permeable Drugs
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- Cellular Heterogeneity in the Mouse Esophagus Implicates the Presence of a Nonquiescent Epithelial Stem Cell Population
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- Purification and Ex Vivo Expansion of Fully Functional Salivary Gland Stem Cells
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- An Automated System for Monitoring and Regulating the pH of Bicarbonate Buffers
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- Do you know the sex of your cells?
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- Self-Propelled Polymer-Based Multilayer Nanorockets for Transportation and Drug Release
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- Experimental models of the gut microbiome
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- Immunosurveillance against tetraploidization-induced colon tumorigenesis
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- Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
- (2013) Gerald Schwank et al. Cell Stem Cell
- Exploring food effects on indinavir absorption with human intestinal fluids in the mouse intestine
- (2013) Nico Holmstock et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- A dynamic system for the simulation of fasting luminal pH-gradients using hydrogen carbonate buffers for dissolution testing of ionisable compounds
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- Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities
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- A novel coating concept for ileo-colonic drug targeting: Proof of concept in humans using scintigraphy
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- Validation of a new in vitro dynamic system to simulate infant digestion
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- Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
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- Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation
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- Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny
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- Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea-predominant irritable bowel syndrome measured using serial MRI
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- Establishment of a Novel Lingual Organoid Culture System: Generation of Organoids Having Mature Keratinized Epithelium from Adult Epithelial Stem Cells
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- An Investigation into the Utility of a Multi-compartmental, Dynamic, System of the Upper Gastrointestinal Tract to Support Formulation Development and Establish Bioequivalence of Poorly Soluble Drugs
- (2012) Paul A. Dickinson et al. AAPS Journal
- The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea
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- A nomenclature for intestinal in vitro cultures
- (2012) Matthias Stelzner et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Antral recirculation in the stomach during gastric mixing
- (2012) Yohsuke Imai et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Enterohemorrhagic Escherichia coli O157:H7 Survival in anIn VitroModel of the Human Large Intestine and Interactions with Probiotic Yeasts and Resident Microbiota
- (2012) Jonathan Thévenot et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Survival and Germination of Bacillus cereus Spores without Outgrowth or Enterotoxin Production duringIn VitroSimulation of Gastrointestinal Transit
- (2012) Siele Ceuppens et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices
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- In vitro 3D human small intestinal villous model for drug permeability determination
- (2012) Jiajie Yu et al. BIOTECHNOLOGY AND BIOENGINEERING
- Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches
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- Survival of Lactobacillus rhamnosus strains inoculated in cheese matrix during simulated human digestion
- (2012) Iole Pitino et al. FOOD MICROBIOLOGY
- Formation of Phenolic Microbial Metabolites and Short-Chain Fatty Acids from Rye, Wheat, and Oat Bran and Their Fractions in the Metabolical in Vitro Colon Model
- (2012) Emilia Nordlund et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
- (2012) Hyun Jung Kim et al. LAB ON A CHIP
- Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device
- (2012) Dan Gao et al. LAB ON A CHIP
- Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell
- (2012) Shiro Yui et al. NATURE MEDICINE
- Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses
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- Top-Down Fabrication of Polyelectrolyte-Thermoplastic Hybrid Microparticles for Unidirectional Drug Delivery to Single Cells
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- Evolution of a physiological pH6.8 bicarbonate buffer system: Application to the dissolution testing of enteric coated products
- (2011) Fang Liu et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
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- Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model
- (2011) M. Vardakou et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Use of Artificial Digestive Systems to Investigate the Biopharmaceutical Factors Influencing the Survival of Probiotic Yeast During Gastrointestinal Transit in Humans
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- Development of a simple model device for in vitro gastric digestion investigation
- (2011) Jianshe Chen et al. Food & Function
- PillCam COLON capsule endoscopy: recent advances and new insights
- (2011) Samuel N. Adler et al. Therapeutic Advances in Gastroenterology
- Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli
- (2011) Pieter Van den Abbeele et al. Microbial Biotechnology
- The Use of Biorelevant Dissolution Media to Forecast the In Vivo Performance of a Drug
- (2010) Sandra Klein AAPS Journal
- Feasibility of stomach exploration with a guided capsule endoscope
- (2010) J. Rey et al. ENDOSCOPY
- In vitro evaluation of the prebiotic properties of almond skins (Amygdalus communisL.)
- (2010) Giuseppina Mandalari et al. FEMS MICROBIOLOGY LETTERS
- Remote magnetic manipulation of a wireless capsule endoscope in the esophagus and stomach of humans (with )
- (2010) Paul Swain et al. GASTROINTESTINAL ENDOSCOPY
- Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6.8 and human intestinal fluid
- (2010) Tiina Heikkilä et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Mass Transfer and Nutrient Absorption in a Simulated Model of Small Intestine
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- A Human Gastric Simulator (HGS) to Study Food Digestion in Human Stomach
- (2010) Fanbin Kong et al. JOURNAL OF FOOD SCIENCE
- Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model
- (2010) Jong Hwan Sung et al. LAB ON A CHIP
- Dynamic Dissolution: A Step Closer to Predictive Dissolution Testing?
- (2010) Mark McAllister MOLECULAR PHARMACEUTICS
- Use of Artificial Stomach−Duodenum Model for Investigation of Dosing Fluid Effect on Clinical Trial Variability
- (2010) Christopher S. Polster et al. MOLECULAR PHARMACEUTICS
- Biorelevant Media to Simulate Fluids in the Ascending Colon of Humans and Their Usefulness in Predicting Intracolonic Drug Solubility
- (2010) Maria Vertzoni et al. PHARMACEUTICAL RESEARCH
- A Microfluidic System to Evaluate Intestinal Absorption
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- Estimation of intragastric drug solubility in the fed state: comparison of various media with data in aspirates
- (2009) A. Diakidou et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Postprandial Changes in Small Bowel Water Content in Healthy Subjects and Patients With Irritable Bowel Syndrome
- (2009) Luca Marciani et al. GASTROENTEROLOGY
- Physiological bicarbonate buffers: stabilisation and use as dissolution media for modified release systems
- (2009) Hala M. Fadda et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Colonic transit studies: normal values for adults and children with comparison of radiological and scintigraphic methods
- (2009) Bridget R. Southwell et al. PEDIATRIC SURGERY INTERNATIONAL
- In Vitro Gastrointestinal Lipolysis of Four Formulations of Piroxicam and Cinnarizine with the Self Emulsifying Excipients Labrasol® and Gelucire® 44/14
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- Characterization of the Contents of Ascending Colon to Which Drugs are Exposed After Oral Administration to Healthy Adults
- (2009) Amalia Diakidou et al. PHARMACEUTICAL RESEARCH
- Microfabricated Devices for Enhanced Bioadhesive Drug Delivery: Attachment to and Small-Molecule Release Through a Cell Monolayer Under Flow
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- Factors affecting the conversion of apple polyphenols to phenolic acids and fruit matrix to short-chain fatty acids by human faecal microbiota in vitro
- (2008) Sarah Bazzocco et al. EUROPEAN JOURNAL OF NUTRITION
- Irregular absorption profiles observed from diclofenac extended release tablets can be predicted using a dissolution test apparatus that mimics in vivo physical stresses
- (2008) Grzegorz Garbacz et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- The intestinal stem cell
- (2008) N. Barker et al. GENES & DEVELOPMENT
- Postprandial Evolution in Composition and Characteristics of Human Duodenal Fluids in Different Nutritional States
- (2008) S. Clarysse et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Microfabrication of an asymmetric, multi-layered microdevice for controlled release of orally delivered therapeutics
- (2008) Kristy M. Ainslie et al. LAB ON A CHIP
- Catalytic Motors for Transport of Colloidal Cargo
- (2008) Shakuntala Sundararajan et al. NANO LETTERS
- Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update
- (2008) Ekarat Jantratid et al. PHARMACEUTICAL RESEARCH
- Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora
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