Pharmacokinetic and pharmacodynamic insights from microfluidic intestine-on-a-chip models

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

(2019) Christopher W. McAleer et al.   Science Translational Medicine

On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

(2019) Christopher W. McAleer et al.   Scientific Reports

Gut-liver on a chip towards an in vitro model of hepatic steatosis

(2018) Seung Yeon Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Clinical Pharmacodynamics: Principles of Drug Response and Alterations in Kidney Disease

(2018) Frieder Keller et al.   Clinical Journal of the American Society of Nephrology

A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform

(2018) T. Satoh et al.   LAB ON A CHIP

Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies

(2018) Christian Maass et al.   Scientific Reports

Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women

(2018) S. Mörkl et al.   EUROPEAN JOURNAL OF NUTRITION

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

Self-contained, low-cost Body-on-a-Chip systems for drug development

(2017) Ying I Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy

(2017) Uday C. Ghoshal et al.   Gut and Liver

Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip

(2017) Yu Du et al.   LAB ON A CHIP

Organ-on-a-Chip Technology for Reproducing Multiorgan Physiology

(2017) Seung Hwan Lee et al.   Advanced Healthcare Materials

Leaky Gut As a Danger Signal for Autoimmune Diseases

(2017) Qinghui Mu et al.   Frontiers in Immunology

Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro

(2017) Remi Villenave et al.   PLoS One

Design and demonstration of a pumpless 14 compartment microphysiological system

(2016) Paula G. Miller et al.   BIOTECHNOLOGY AND BIOENGINEERING

A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model

(2016) Hyuna Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microtechnology-based organ systems and whole-body models for drug screening

(2016) Seung Hwan Lee et al.   Biotechnology Journal

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

(2016) Mandy B. Esch et al.   LAB ON A CHIP

A microfluidics-based in vitro model of the gastrointestinal human–microbe interface

(2016) Pranjul Shah et al.   Nature Communications

Microtechnology-based organ systems and whole-body models for drug screening

(2016) Seung Hwan Lee et al.   Biotechnology Journal

A microfluidic cell culture device (μFCCD) to culture epithelial cells with physiological and morphological properties that mimic those of the human intestine

(2015) Meiying Chi et al.   BIOMEDICAL MICRODEVICES

Investigation of omeprazole and phenacetin first-pass metabolism in humans using a microscale bioreactor and pharmacokinetic models

(2015) Thibault Bricks et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Cell-based microfluidic platform for mimicking human olfactory system

(2015) Seung Hwan Lee et al.   BIOSENSORS & BIOELECTRONICS

Bioelectronic nose combined with a microfluidic system for the detection of gaseous trimethylamine

(2015) Seung Hwan Lee et al.   BIOSENSORS & BIOELECTRONICS

Long-term maintenance of a microfluidic 3D human liver sinusoid

(2015) Ljupcho Prodanov et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

(2015) Ilka Maschmeyer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut

(2015) Andrea Michielan et al.   MEDIATORS OF INFLAMMATION

Assessing drug safety in human tissues — what are the barriers?

(2015) Anthony Holmes et al.   NATURE REVIEWS DRUG DISCOVERY

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A simple coculture system shows mutualism between anaerobic faecalibacteria and epithelial Caco-2 cells

(2015) Mehdi Sadaghian Sadabad et al.   Scientific Reports

Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology

(2015) Jeremy D. Caplin et al.   Advanced Healthcare Materials

Microfluidic bead-based sensing platform for monitoring kinase activity

(2014) Seung Hwan Lee et al.   BIOSENSORS & BIOELECTRONICS

First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans

(2014) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

Organs-on-a-chip: a new tool for drug discovery

(2014) Alessandro Polini et al.   Expert Opinion on Drug Discovery

Three-dimensional intestinal villi epithelium enhances protection of human intestinal cells from bacterial infection by inducing mucin expression

(2014) Si Hyun Kim et al.   Integrative Biology

In vitro generation of colonic epithelium from primary cells guided by microstructures

(2014) Yuli Wang et al.   LAB ON A CHIP

3-D Intestinal Scaffolds for Evaluating the Therapeutic Potential of Probiotics

(2014) Cait M. Costello et al.   MOLECULAR PHARMACEUTICS

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines

(2014) Thibault Bricks et al.   TOXICOLOGY IN VITRO

Microbiota and the gut-liver axis: Bacterial translocation, inflammation and infection in cirrhosis

(2014) Valerio Giannelli   WORLD JOURNAL OF GASTROENTEROLOGY

Organ-on-a-chip technology and microfluidic whole-body models for pharmacokinetic drug toxicity screening

(2013) Jong Bum Lee et al.   Biotechnology Journal

Physiologically relevant organs on chips

(2013) Kyungsuk Yum et al.   Biotechnology Journal

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

A Microfluidic Device with 3-D Hydrogel Villi Scaffold to Simulate Intestinal Absorption

(2013) Si Hyeon Kim et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

(2013) Caitriona M. Guinane et al.   Therapeutic Advances in Gastroenterology

Micro Total Bioassay System for Oral Drugs: Evaluation of Gastrointestinal Degradation, Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2012) Yuki IMURA et al.   ANALYTICAL SCIENCES

Microtechnology for Mimicking In Vivo Tissue Environment

(2012) Jong Hwan Sung et al.   ANNALS OF BIOMEDICAL ENGINEERING

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices

(2012) Mandy Brigitte Esch et al.   BIOMEDICAL MICRODEVICES

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip

(2012) Leila Choucha-Snouber et al.   BIOTECHNOLOGY AND BIOENGINEERING

In vitro 3D human small intestinal villous model for drug permeability determination

(2012) Jiajie Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Parallel Artificial Membrane Permeability Assay (PAMPA) - Is it Better than Caco-2 for Human Passive Permeability Prediction?

(2012) J. M. Reis et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

(2012) Xochitl C Morgan et al.   GENOME BIOLOGY

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Improvement of HepG2/C3a cell functions in a microfluidic biochip

(2011) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

(2011) Jean-Matthieu Prot et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Kinetic modelling of in vitro cell-based assays to characterize non-specific bindings and ADME processes in a static and a perfused fluidic system

(2011) Djomangan A. Ouattara et al.   TOXICOLOGY LETTERS

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

Synergic effects of crypt-like topography and ECM proteins on intestinal cell behavior in collagen based membranes

(2010) Lin Wang et al.   BIOMATERIALS

Integration ofin silicoandin vitroplatforms for pharmacokinetic–pharmacodynamic modeling

(2010) Jong Hwan Sung et al.   Expert Opinion on Drug Metabolism & Toxicology

Promises, challenges and future directions of μCCAs

(2010) Mandy B. Esch et al.   JOURNAL OF BIOTECHNOLOGY

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

(2010) Paul M. van Midwoud et al.   LAB ON A CHIP

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Drug Permeability Assay Using Microhole-Trapped Cells in a Microfluidic Device

(2009) Ju Hun Yeon et al.   ANALYTICAL CHEMISTRY

A Microfluidic System to Evaluate Intestinal Absorption

(2009) Yuki IMURA et al.   ANALYTICAL SCIENCES

Influence of micro-well biomimetic topography on intestinal epithelial Caco-2 cell phenotype

(2009) Lin Wang et al.   BIOMATERIALS

In vitro microscale systems for systematic drug toxicity study

(2009) Jong Hwan Sung et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Co-culture of epithelial cells and bacteria for investigating host–pathogen interactions

(2009) Jeongyun Kim et al.   LAB ON A CHIP

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

The Caco-2 cell monolayer: usefulness and limitations

(2008) Huadong Sun et al.   Expert Opinion on Drug Metabolism & Toxicology

A Combined Pharmacokinetic–Pharmacodynamic (PK–PD) Model for Tumor Growth in the Rat with UFT Administration

(2008) Jong Hwan Sung et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models

(2008) Hiroshi Kimura et al.   LAB ON A CHIP

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS